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Article ; Online: Multi-vehicle safety functions for freeway weaving segments using lane-level traffic data.

Rim, Heesub / Abdel-Aty, Mohamed / Mahmoud, Nada

2023 Volume 188, Page(s) 107113

Abstract: This study develops Safety Performance Functions (SPFs) for freeway weaving segments. Due to the coexistence of three different movements including through, merging, and divering traffic, the probability of crashes in weaving segments is higher compared ... ...

Abstract	This study develops Safety Performance Functions (SPFs) for freeway weaving segments. Due to the coexistence of three different movements including through, merging, and divering traffic, the probability of crashes in weaving segments is higher compared to other segment types. Further, the traffic flow in this section is the most unstable. Hence, to analyze detailed traffic conditions, this study utilized lane-level traffic data. The SPFs were developed using the Poisson Lognormal (PLN) regression model technique. The results showed that different traffic parameters were significant based on the types of crashes. For the rear-end crashes model, more general traffic conditions of the weaving segment were found to be significantly associated with the crash frequency such as the natural logarithm of average speed of through lanes. Nevertheless, for the sideswipe and angle crashes models, the traffic variables which are directly related to the weaving movements were selected as significant factors such as the off-ramp volume ratio, and standard deviation of speed of the rightmost lane. The results presented in this study can be meaningful in that they can serve as a basis for the weaving segments related safety evaluation studies. In addition, the developed models' results can be a great source to establish operational strategies to improve traffic safety on freeway weaving segments.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Regression Analysis ; Probability ; Safety
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2023.107113
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Article ; Online: The impact of target speed on pedestrian, bike, and speeding crash frequencies.

Mahmoud, Nada / Abdel-Aty, Mohamed / Abdelraouf, Amr

Accident; analysis and prevention

2023 Volume 192, Page(s) 107263

Abstract: This research aims to investigate the influence of adopting the target speed concept on different types of crashes including pedestrian, bike, and speeding-related crashes. The Target speed is the highest speed that vehicles should operate on a roadway ... ...

Abstract	This research aims to investigate the influence of adopting the target speed concept on different types of crashes including pedestrian, bike, and speeding-related crashes. The Target speed is the highest speed that vehicles should operate on a roadway segment in a specific context. Based on the reviewed literature, this is the first study to investigate the relationship between target speed and crash frequency. Hence, big data including probe-vehicle data, traffic characteristics, geometric features, and land use attributes were utilized to develop crash prediction models. The main contributions of this research are to quantify the impacts of target speed on traffic safety considering context categories and to conclude the potential recommendations to lower different types of crashes. The 85th percentile speed was calculated and utilized in the developed models. Three crash prediction models were developed for pedestrian, bike, and speeding-related crashes. They were used in the analysis to quantify the impact of adopting target speed on different crash types. The results showed a significant reduction in the three crash types when using the target speed. Most of the improvements took place in three context categories: C3C: Suburban Commercial Segments, C3R: Suburban Residential Segments, and C4: Urban General Segments. Hence, this research recommends adopting target speed specifically in urban and suburban areas. Further, it suggests considering some measures to lower vulnerable road users' and speeding-related crashes. Following the recommendations of this research would help to reduce different types of crash frequency, hence, improving the mobility and safety for all users in different context classifications.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Automobile Driving ; Safety ; Bicycling ; Pedestrians
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2023.107263
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Article ; Online: Effect of foam and liquid bleomycin in the management of venous malformations in head and neck region: A comparative study.

Helal, Hesham A / Mahmoud, Nada A

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2019 Volume 73, Issue 1, Page(s) 90–97

Abstract: Background: Many treatment options for venous malformations (VMs) have been documented in the literature, but injection sclerotherapy has been considered a current mainstay for their treatment. We conducted this study to determine the efficacy and ... ...

Abstract	Background: Many treatment options for venous malformations (VMs) have been documented in the literature, but injection sclerotherapy has been considered a current mainstay for their treatment. We conducted this study to determine the efficacy and durability of injection of different forms of bleomycin sclerotherapy in the treatment of VMs in the cervico-facial region. Patients and methods: Thirty patients with clinically diagnosed VMs of the head and neck region, confirmed by magnetic resonance imaging, had been injected with the bleomycin sclerosing material. They were divided into 2 groups according to the form of bleomycin injected: in Group A, the foam form was injected, and in Group B, the liquid form was injected. Data of patients' demographics, anatomical sites, type and volume of the VMs, number of injection sessions and the average dose of injected agents were documented and statistically compared between the 2 groups. Results: MRI showed a decline of more than 90% from the initial size of the lesions in 66.7% of the cases and considerable decline (60-90%) in 33.3% of the cases. In Group A, the number of sessions and the amount of sclerosant material injected were lower than those in Group B. The cumulative dose in the equal-sized lesions was lower in the foam form than in the liquid form. Conclusion: We recommend using bleomycin in its foam form on a greater number of patients with larger VMs and in different sites, as the results are more promising in this form than in the liquid form.
MeSH term(s)	Adolescent ; Bleomycin/administration & dosage ; Child ; Child, Preschool ; Female ; Head/blood supply ; Humans ; Injections ; Magnetic Resonance Imaging ; Male ; Neck/blood supply ; Prospective Studies ; Research Design ; Sclerosing Solutions/administration & dosage ; Sclerotherapy/methods ; Treatment Outcome ; Vascular Malformations/diagnosis ; Vascular Malformations/therapy ; Young Adult
Chemical Substances	Sclerosing Solutions ; Bleomycin (11056-06-7)
Language	English
Publishing date	2019-05-22
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2019.05.034
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Article ; Online: Safety and efficacy of extended versus standard interval dosing of natalizumab in multiple sclerosis patients: a systematic review and meta-analysis.

Rabea, Eslam Mohammed / Belal, Mohamed Mohamed / Hafez, Abdelrahman H / Elbanna, Ashraf Hassan / Khalifa, Mahmoud Ahmed / Nourelden, Anas Zakarya / Mahmoud, Nada H / Zaazouee, Mohamed Sayed

Acta neurologica Belgica

2024 Volume 124, Issue 2, Page(s) 407–417

Abstract: Background: Multiple sclerosis (MS) is a chronic inflammatory, immune-mediated disease affecting the central nervous system. Natalizumab, an FDA-approved monoclonal antibody for MS, has been explored for its off-label extended interval dosing (EID), ... ...

Abstract	Background: Multiple sclerosis (MS) is a chronic inflammatory, immune-mediated disease affecting the central nervous system. Natalizumab, an FDA-approved monoclonal antibody for MS, has been explored for its off-label extended interval dosing (EID), suggesting a potential reduction in the risk of progressive multifocal leukoencephalopathy (PML) compared to standard interval dosing (SID). Our objective was to assess the efficacy and safety of EID in comparison to SID for natalizumab treatment in patients with MS. Methods: We searched PubMed, Embase, WOS, Scopus, Ovid, Science Direct, Clinical trials.gov, and Cochrane Library. Our assessed outcomes were clinical relapses, MRI activity, change in expanded disability status scale [EDSS], and the risk of PML. The EID group was defined as 5 to 8 weeks [EID (Q5-8W)]. The analysis was conducted using RevMan ver. 5.4. The effect estimates were presented as a risk ratio [RR] or mean difference with 95% confidence intervals [CI] using SID group as the reference for comparisons. Results: Fourteen studies met our inclusion criteria: 2 RCTs, 1 switched single-arm trial, and 12 observational studies. No significant differences were found in all efficacy outcomes of interest. Risk of clinical relapses [RR = 0.90, (95%CI 0.80, 1.02)], risk of new or newly enlarging T2 hyperintense MRI lesions [RR = 0.78, (95%CI 0.59, 1.04)], risk gadolinium enhancing lesions [RR = 1.30, (95%CI 0.98, 1.72)], change in EDSS [MD = 0.09 (95%CI - 0.57, 0.76)], risk of PML [RR = 1.09, 95%CI (0.24, 4.94)]. Conclusion: In summary, our meta-analysis indicates that natalizumab maintains its effectiveness under extended interval dosing [up to 8 weeks], presenting comparable risks for clinical relapses, MRI lesions, EDSS, and PML. Caution is advised given study limitations and heterogeneity. Robust conclusions necessitate well-designed high-quality prospective studies.
MeSH term(s)	Humans ; Natalizumab/adverse effects ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy ; Prospective Studies ; Antibodies, Monoclonal/therapeutic use ; Leukoencephalopathy, Progressive Multifocal/drug therapy ; Recurrence ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Immunologic Factors/adverse effects ; Observational Studies as Topic
Chemical Substances	Natalizumab ; Antibodies, Monoclonal ; Immunologic Factors
Language	English
Publishing date	2024-03-08
Publishing country	Italy
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-024-02480-6
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Article ; Online: Anatomical variability of the infra-mammary fold and its dynamics in relation to Lejour mammoplasty.

Helal, Hesham A / Mahmoud, Nada A

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2018 Volume 71, Issue 9, Page(s) 1362–1380

MeSH term(s)	Adult ; Anthropometry ; Breast/anatomy & histology ; Breast/surgery ; Breast Implants ; Female ; Humans ; Mammaplasty/methods
Language	English
Publishing date	2018-06-19
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2018.05.040
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Article ; Online: Vulnerable road users' crash hotspot identification on multi-lane arterial roads using estimated exposure and considering context classification.

Mahmoud, Nada / Abdel-Aty, Mohamed / Cai, Qing / Zheng, Ou

Accident; analysis and prevention

2021 Volume 159, Page(s) 106294

Abstract: This research develops safety performance functions and identifies the crash hotspots based on estimated vulnerable road users' exposure at intersections and along the roadway segments. The study utilized big data including Automated Traffic Signal ... ...

Abstract	This research develops safety performance functions and identifies the crash hotspots based on estimated vulnerable road users' exposure at intersections and along the roadway segments. The study utilized big data including Automated Traffic Signal Performance Measures (ATSPM) data, crowdsourced data (Strava), Closed Circuit Television (CCTV) surveillance camera videos, crash data, traffic information, roadway features, land use attributes, and socio-demographic characteristics. It comprises an extensive comparison between a wide array of statistical and machine learning models that were developed to estimate pedestrian and bike exposure. The results indicated that the XGBoost approach was the best to estimate vulnerable road users' exposure at intersections as well as bike exposure along the roadway segments. Afterwards, the estimated exposure was utilized as input variables to develop crash prediction models that relate different crash types to potential explanatory variables. Negative Binomial approach was followed to develop crash prediction models to be consistent with the Highway Safety Manual. The results show that the exposure variables (i.e., AADT, bike exposure, and the interaction between them) have significant influences on the two types of crashes (i.e., crashes of vulnerable road users at intersections and bike crashes along the segments). Further, the results indicated that the context classification is significantly related to crashes. Based on the developed models, the PSIs were calculated and the hotspots were identified for the two crash types. It was found that hotspots were more likely to be located near the city of Orlando. Coastal roadways were classified as cold categories regarding bike crashes. Further, C4 roadway segments were found to be significantly related to the increase of vulnerable road users' crashes at intersections and bike crashes along the segments.
MeSH term(s)	Accidents, Traffic ; Environment Design ; Humans ; Models, Statistical ; Pedestrians ; Safety
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2021.106294
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Article ; Online: Developing a grouped random parameter beta model to analyze drivers' speeding behavior on urban and suburban arterials with probe speed data.

Cai, Qing / Abdel-Aty, Mohamed / Mahmoud, Nada / Ugan, Jorge / Al-Omari, Ma'en M A

Accident; analysis and prevention

2021 Volume 161, Page(s) 106386

Abstract: Speeding is one of the major contributing factors to traffic fatalities. Various speed management strategies have been proposed to encourage drivers to select more appropriate speeds. This study aims to explore the different effects of the speed ... ...

Abstract	Speeding is one of the major contributing factors to traffic fatalities. Various speed management strategies have been proposed to encourage drivers to select more appropriate speeds. This study aims to explore the different effects of the speed management strategies on the speeding proportions at urban and suburban arterials. Probe speed data was used to calculate the speeding proportions. To overcome the variability of probe speed data caused by the signalized intersections, a new method was suggested to calculate the speeding proportion, and a fractional split model was estimated to adjust the probe speed data. A Beta regression model was developed to analyze the speeding proportion. A grouped random parameter modeling structure was adopted to realize the different effects of speed management strategies and other road attributes on speeding proportions by different road types. Besides, a fixed beta model was developed for the comparison. The results suggested the grouped random parameter model could provide better performance over the counterpart and could realize the different effects of road features and other contributing factors on the speeding of different roads. It is expected that the findings could help inform more appropriate road design in order to reduce speed limit violations on urban and suburban arterials.
MeSH term(s)	Accidents, Traffic/prevention & control ; Automobile Driving ; Humans ; Risk-Taking
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2021.106386
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Article ; Online: Does ramadan fasting affect the therapeutic and clinical outcomes of warfarin? a systematic review and meta-analysis.

Rabea, Eslam Mohammed / Abbas, Kirellos Said / Awad, Dina M / Elgoweini, Nancy H / El-Sakka, Amro Ahmed / Mahmoud, Nada H / Abdelazeem, Basel

European journal of clinical pharmacology

2022 Volume 78, Issue 5, Page(s) 755–763

Abstract: Background: Warfarin's therapeutic effect is affected by many factors, including diet modifications. The impact of Ramadan fasting on warfarin is controversial. The aim of this systematic review and meta-analysis was to investigate the effect of Ramadan ...

Abstract	Background: Warfarin's therapeutic effect is affected by many factors, including diet modifications. The impact of Ramadan fasting on warfarin is controversial. The aim of this systematic review and meta-analysis was to investigate the effect of Ramadan fasting on patients taking warfarin. Methods: A literature search was done in PubMed, WOS, Scopus, and Embase from inception to May 24, 2021. All relevant studies measuring the international normalized ratio (INR), time in therapeutic range (TTR), or the number of patients within therapeutic range before, during, and after Ramadan were assessed by full-text screening for achieving all of the inclusion criteria. We used the Newcastle-Ottawa Scale for quality assessment and RevMan 5.4 software for meta-analysis. Results: A total of five studies with 446 patients were included in the meta-analysis. The patients served as their own control. Our pooled analyses showed no significant difference during Ramadan compared to pre-Ramadan (MD: 0.08; 95% CI: - 0.00, 0.15; P = 0.06) and post-Ramadan (MD: - 0.00; 95% CI: - 0.14, 0.14; P = 1.00, respectively). There was only a significant increase in the risk ratio of supratherapeutic INR when comparing post-Ramadan vs. pre-Ramadan (RR: 1.69; 95% CI: 1.22, 2.33; P = 0.001). However, there was no significant risk for supratherapeutic INR during Ramadan compared to pre-Ramadan or post-Ramadan; the number of patients within the therapeutic range of INR during Ramadan compared to pre-Ramadan; and TTR during Ramadan, pre-Ramadan, and post-Ramadan. Conclusion: Ramadan fasting did not affect INR level, TTR, or the number of patients within the therapeutic range before, during, and after Ramadan. However, there was a possibility of achieving a supratherapeutic INR post-Ramadan compared to pre-Ramadan. Therefore, INR monitoring and warfarin dose adjustments accordingly are recommended after Ramadan.
MeSH term(s)	Anticoagulants/therapeutic use ; Fasting ; Humans ; International Normalized Ratio ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2022-02-18
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-022-03281-7
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Book ; Online: CitySim

Zheng, Ou / Abdel-Aty, Mohamed / Yue, Lishengsa / Abdelraouf, Amr / Wang, Zijin / Mahmoud, Nada

A Drone-Based Vehicle Trajectory Dataset for Safety Oriented Research and Digital Twins

2022

Abstract: The development of safety-oriented research ideas and applications requires fine-grained vehicle trajectory data that not only has high accuracy but also captures a substantial number of critical safety events. This paper introduces the CitySim Dataset, ... ...

Abstract	The development of safety-oriented research ideas and applications requires fine-grained vehicle trajectory data that not only has high accuracy but also captures a substantial number of critical safety events. This paper introduces the CitySim Dataset, which was devised with a core objective of facilitating safety-based research and applications. CitySim has vehicle trajectories extracted from 1140-minutes of drone videos recorded at 12 different locations. It covers a variety of road geometries including freeway basic segments, weaving segments, expressway merge/diverge segments, signalized intersections, stop-controlled intersections, and intersections without sign/signal control. CitySim trajectories were generated through a five-step procedure which ensured the trajectory accuracy. Furthermore, the dataset provides vehicle rotated bounding box information which is demonstrated to improve safety evaluation. Compared to other video-based trajectory datasets, the CitySim Dataset has significantly more critical safety events with higher severity including cut-in, merge, and diverge events. In addition, CitySim facilitates research towards digital twin applications by providing relevant assets like the recording locations'3D base maps and signal timings. These features enable more comprehensive conditions for safety research and applications such as autonomous vehicle safety and location-based safety analysis. The dataset is available online at https://github.com/ozheng1993/UCF-SST-CitySim-Dataset.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Statistics - Machine Learning
Subject code	629
Publishing date	2022-08-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Herpes simplex virus infection and the risk of dementia: a systematic review and meta-analysis.

Elhalag, Rowan H / Motawea, Karam R / Talat, Nesreen E / Rouzan, Samah S / Mahmoud, Nada / Hammad, Elsayed M / Reyad, Sarraa M / Mohamed, Mai S / Shah, Jaffer

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 10, Page(s) 5060–5074

Abstract: Aim: The authors aimed to perform a meta-analysis to evaluate the association between herpes simplex virus (HSV) infection and the risk of developing dementia.: Methods: The authors searched the following databases: PubMed, Scopus, Cochrane Library, ... ...

Abstract	Aim: The authors aimed to perform a meta-analysis to evaluate the association between herpes simplex virus (HSV) infection and the risk of developing dementia. Methods: The authors searched the following databases: PubMed, Scopus, Cochrane Library, and Web of Science. The authors included any randomized control trials and controlled observational studies that investigated the prevalence of dementia in HSV-infected patients and HSV-free control group. Also, if the studies measured the levels of HSV antibodies and incidence of these antibodies in patients with dementia compared with a healthy control group. Results: After a comprehensive literature search, 19 studies were included in the meta-analysis with 342 535 patients included in the analysis. The pooled analysis showed a statistically significant association between Alzheimer's disease (AD), mild cognitive impairment (MCI), and increased levels of IgG titer group [mean difference (MD) = 0.99, 95% confidence interval (CI) = 0.36-1.63, Conclusion: This study revealed that AD and MCI patients have increased levels of IgG antibodies titer against HSV infection. The study showed a significant association between HSV infection and increased incidence of dementia. Thus, regular follow-up of HSV patients' IgG titer levels could be useful in the prevention of dementia in these patients.
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000951
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