LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Phytoconstituent Isolation and Cytotoxicity Evaluation of the Egyptian Cassia occidentalis L. Possessing Selective Activity against Lung Carcinoma

    Hanaa M. Sayed / Mahmoud A. Ramadan / Heba H. Salem / Marwa A. A. Fayed

    Journal of Chemistry, Vol

    2023  Volume 2023

    Abstract: Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) ... ...

    Abstract Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) and a flavonoidal glycoside, chrysin-7-O-α-L-rhamnopyranosyl (10), were identified, while silybin A (8) was the first flavonolignan to be isolated from the Fabaceae family. Four compounds, including β-sitosterol-3-O-β-D-glucopyranoside (1), stigmasterol-3-O-β-D-glucopyranoside (2), betulinic acid (3), and vanillic acid (4) were isolated from C. occidentalis for the first time. In addition, four known compounds, cinnamic acid (5), p-hydroxybenzoic acid (6), β- resorcylic acid (7), and citric acid (11), were also detected. The in-vitro cytotoxicity assessment of the methanolic extract of C. occidentalis on seven cancer cell lines, including A-549, Colo-205, Huh-7, HCT-116, PANC-1, SKOV-3, and BNL, demonstrated its selective potent cytotoxicity on lung cancer cells without affecting normal BNL cells. In contrast, the methanolic extract showed moderate activity on Colo-205 and Huh-7 and nearly no activity on HCT-116, PANC-1, and SKOV-3 cell lines. These results suggest that the methanolic extract of C. occidentalis is an excellent candidate with potential antiproliferative activity against lung cancer; however, further studies are necessary to clarify its mechanism of action.
    Keywords Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: CRINUM ; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES

    John Refaat*, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

    International Journal of Pharmaceutical Sciences and Research, Vol 4, Iss 4, Pp 1239-

    A REVIEW. PART V. BIOLOGICAL PROFILE

    2013  Volume 1252

    Abstract: ABSTRACT: Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known ... ...

    Abstract ABSTRACT: Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known biofactories for the unique Amaryllidaceae alkaloids. But to the significant phytoconstituents produced by this plant as well as their therapeutic potentials, many Crinum species have been subjected to extensive chemical, cytological and pharmacological investigations. This part of our comprehensive review work on the chemical and biological profiles of Crinums describes the results of biological and toxicological studies conducted on different species. In addition, general analytical conclusions as well as some suggestions for future phytochemical and biological work on Crinums are discussed.
    Keywords Amaryllidaceae ; Biological Activities ; Crinum ; Toxicological Studies ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 612
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Society of Pharmaceutical Sciences and Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES

    John Refaat *, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

    International Journal of Pharmaceutical Sciences and Research, Vol 4, Iss 3, Pp 941-

    A REVIEW. PART IV: NON-ALKALOIDAL CONSTITUENTS

    2013  Volume 948

    Abstract: ABSTRACT: Crinum is an important and fascinating genus of the large and equally captivating Amaryllidaceae family. Owing to the valuable biological effects and therapeutic potentials of its chemical constituents, many Crinum species have a worldwide ... ...

    Abstract ABSTRACT: Crinum is an important and fascinating genus of the large and equally captivating Amaryllidaceae family. Owing to the valuable biological effects and therapeutic potentials of its chemical constituents, many Crinum species have a worldwide folkloric reputation. Additionally, Crinum species have been subjected to extensive chemical, cytological and pharmacological investigations. The present part of our comprehensive review work on the phytochemical and biological studies conducted on Crinum plants reviews the non-alkaloidal principles isolated up till now in addition to their distribution in different Crinum species.
    Keywords Amaryllidaceae ; Crinum ; NonAlkaloidal Constituents ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-03-01T00:00:00Z
    Publisher Society of Pharmaceutical Sciences and Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES

    John Refaat*, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

    International Journal of Pharmaceutical Sciences and Research, Vol 3, Iss 7, Pp 1883-

    A REVIEW. PART 1- CRINUM ALKALOIDS: LYCORINE-TYPE ALKALOIDS

    2012  Volume 1890

    Abstract: Crinum is an important Amaryllidaceous plant thanks to the valuable biological and therapeutic activities of its chemical constituents, especially alkaloids. Many Crinum species have been commonly used in traditional medicines worldwide. Long ago, they ... ...

    Abstract Crinum is an important Amaryllidaceous plant thanks to the valuable biological and therapeutic activities of its chemical constituents, especially alkaloids. Many Crinum species have been commonly used in traditional medicines worldwide. Long ago, they have been subjected to extensive chemical, cytological and pharmacological investigations. Accordingly, this work comprehensively comprises both the alkaloidal and non-alkaloidal principles of Crinums isolated from 1950 and up to now, together with various biological and toxicological studies conducted on both the total extracts and individual compounds. As being a major common class of Crinum alkaloids, the current part of this review work highlights the lycorine-type alkaloids isolated so far from this plant in addition to their distribution in different Crinum species.
    Keywords Alkaloids ; Amaryllidaceae ; Chemical constituents ; Crinum ; Lycorine ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 540
    Language English
    Publishing date 2012-07-01T00:00:00Z
    Publisher Society of Pharmaceutical Sciences and Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors

    Khedr, Amgad I. M / Sabrin R. M. Ibrahim / Gamal A. Mohamed / Hany E. A. Ahmed / Amany S. Ahmad / Mahmoud A. Ramadan / Atef E. Abd El-Baky / Koji Yamada / Samir A. Ross

    Archives of pharmacal research. 2016 July, v. 39, no. 7

    2016  

    Abstract: Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1β-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (11) and ficupanduratin B [21α-hydroxy-3β-acetoxy-11α-methoxy- ... ...

    Abstract Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1β-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (11) and ficupanduratin B [21α-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (17), along with 20 known compounds: α-amyrin acetate (1), α-amyrin (2), 3β-acetoxy-20-taraxasten-22-one (3), 3β-acetoxy-11α-methoxy-olean-12-ene (4), 3β-acetoxy-11α-methoxy-12-ursene (5), 11-oxo-α-amyrin acetate (6), 11-oxo-β-amyrin acetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione (9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), β-sitosterol (13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3β,21β-dihydroxy-11α-methoxy-olean-12-ene (16), 3β-hydroxy-11α-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11α,21α-dihydroxy-3β-acetoxy-urs-12-ene (21), and β-sitosterol-3-O-β-D-glucopyranoside (22). Compound 21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on the basis of IR, 1D (¹H and ¹³C), 2D (¹H–¹H COSY, HSQC, HMBC and NOESY) NMR and MS spectroscopic data, in addition to comparison with literature data. The isolated compounds were evaluated for their anti-microbial, anti-malarial, anti-leishmanial, and cytotoxic activities. In addition, their radioligand displacement affinity on opioid and cannabinoid receptors was assessed. Compounds 4, 11, and 15 exhibited good affinity towards the CB2 receptor, with displacement values of 69.7, 62.5 and 86.5 %, respectively. Furthermore, the binding mode of the active compounds in the active site of the CB2 cannabinoid receptors was investigated through molecular modelling.
    Keywords Ficus pandurata ; acetates ; active ingredients ; active sites ; antimalarials ; beta-sitosterol ; binding capacity ; cannabinoid receptors ; cannabinoids ; cytotoxicity ; fruits ; humans ; models ; nuclear magnetic resonance spectroscopy ; palmitic acid ; spectral analysis ; stable isotopes ; stigmasterol ; triterpenoids
    Language English
    Dates of publication 2016-07
    Size p. 897-911.
    Publishing place Pharmaceutical Society of Korea
    Document type Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-016-0784-y
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Antifouling Alkaloids from Crinum augustum (Amaryllidaceae)

    John Refaat / Ahmed Abdel-Lateff / Mohamed S Kamel / Ahmed A Ali / Mahmoud A Ramadan / Tatsufumi Okino / Yasuyuki Nogata

    Pharmacognosy Research, Vol 1, Iss 2, Pp 43-

    2009  Volume 52

    Abstract: Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1) , crinamine (2) , buphanisine (3) , ungeremine (4) , and hippadine (5) ... two ... ...

    Abstract Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1) , crinamine (2) , buphanisine (3) , ungeremine (4) , and hippadine (5)

    two fatty acid derivatives: myristic acid ethyl ester (6) and palmitic acid ethyl ester (7)

    four terpenoidal and steroidal compounds: ursolic acid (8) , β-sitosterol-O- β glucopyranoside (9) and mixture of β--sitosterol (10) and stigmasterol (11) . The structures of all compounds were determined by interpretation of their spectroscopic data; 1D ( 1 H and 13 C), 2D (HSQC, COSY, DQF, NOE and HMBC) NMR; MS and UV analyses. The compounds (1 -4) and (6-8) were tested towards biofouling activity using larvae of barnacle Balance amphitrie. Significant activities of 1, 2 and 3 with EC 50 1.8, 1.2 and 0.75 μg/mL respectively, were observed.
    Keywords Crinum augustum ; Amaryllidaceous ; anti-fouling ; natural products ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top