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  1. AU="Mahmoudi, Hassan"
  2. AU="Catharine Sturgeon"
  3. AU=Bhardwaj Neeru
  4. AU=Hamdani Muhammad Afzal
  5. AU="Wen, O"
  6. AU="de Oliveira, Luciana Maia Nogueira"
  7. AU="Sanabria, Mauricio"
  8. AU="Tronnier, Michael"
  9. AU="Yu, Yaonan"
  10. AU="Gradl, W"
  11. AU="Grossklags, Jens"
  12. AU="Andreas M. Köster"
  13. AU="Diana Karolina Maniak"
  14. AU="Cahuana-Hurtado, Lucero"
  15. AU="Ebert, Christoph"
  16. AU="Köhler, Matthias"
  17. AU=Fitzgerald Amelia Lucy AU=Fitzgerald Amelia Lucy
  18. AU="Yang, Charles"
  19. AU="Fraser, Alice j"
  20. AU=MacKenzie James A
  21. AU=Guettari Moez AU=Guettari Moez
  22. AU=McLeod Carolyn
  23. AU="Patel P.M"
  24. AU="Patel N.M"
  25. AU="Naganawa, Mika"
  26. AU="Viecelli, Claudio"
  27. AU=Valls Joan
  28. AU="Yang, Qizhang"
  29. AU=Wilt Timothy J
  30. AU="Dene R. Littler" AU="Dene R. Littler"
  31. AU="Petrenko, Andrei"
  32. AU=Valentino Kristin
  33. AU=Swash M
  34. AU="Adedipe, Ifeoluwa"
  35. AU=Shen Hongcheng
  36. AU="Padhy, Biswajit"
  37. AU="Kruglikov, Alibek"
  38. AU="Tasu, Jean Pierre"
  39. AU="Floate, Kevin D"
  40. AU="Mark Rijpkema"
  41. AU="Gjeloshi, Klodian"
  42. AU="Lucie Beaudoin"

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  1. Artikel: Assessment of knowledge, attitudes, and practice regarding antibiotic self-treatment use among COVID-19 patients.

    Mahmoudi, Hassan

    GMS hygiene and infection control

    2022  Band 17, Seite(n) Doc12

    Abstract: Background: Self-medication with antibiotics is a common practice across different age groups and different cultures that can cause problems such as drug resistance, side effects, and rising costs for the healthcare system community. During the ... ...

    Abstract Background: Self-medication with antibiotics is a common practice across different age groups and different cultures that can cause problems such as drug resistance, side effects, and rising costs for the healthcare system community. During the coronavirus pandemic (COVID-19), people with mild symptoms have avoided seeing a doctor, preferring to self-medicate. The impact of self-medication in COVID-19 patients is an important public health issue. The aim of this study was to evaluate the knowledge of, attitudes toward, and performance of self-medication with antibiotics in COVID-19 patients.
    Methods: This cross-sectional study was conducted among patients with COVID-19. Participants were selected by random sampling. A survey of knowledge, attitude and practice of taking antibiotics in patients with COVID-19 was conducted. Data were analyzed using SPSS version 22 software.
    Results: The prevalence of self-medication with antibiotics in patients with COVID-19 was 56.1%. Most COVID-19 patients have the overall knowledge, attitude and practice score of self-medication with antibiotics. There was a significant difference between the knowledge and attitudes of educated and uneducated patients (p<0.01). Of the demographic variables, there was no significant difference between sexes in terms of attitude and practice of antibiotic self-medication in COVID-19 patients (p>0.05).
    Conclusion: Considering the high prevalence of antibiotic self-medication in COVID-19 patients, it is recommended to provide the necessary education and practical means of reducing the amount of antibiotic self-medication.
    Sprache Englisch
    Erscheinungsdatum 2022-07-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2717852-3
    ISSN 2196-5226
    ISSN 2196-5226
    DOI 10.3205/dgkh000415
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Assessment of knowledge, attitudes, and practice regarding antibiotic self-treatment use among COVID-19 patients

    Mahmoudi, Hassan

    GMS Hygiene and Infection Control, Vol 17, p Doc

    2022  Band 12

    Abstract: Background: Self-medication with antibiotics is a common practice across different age groups and different cultures that can cause problems such as drug resistance, side effects, and rising costs for the healthcare system community. During the ... ...

    Abstract Background: Self-medication with antibiotics is a common practice across different age groups and different cultures that can cause problems such as drug resistance, side effects, and rising costs for the healthcare system community. During the coronavirus pandemic (COVID-19), people with mild symptoms have avoided seeing a doctor, preferring to self-medicate. The impact of self-medication in COVID-19 patients is an important public health issue. The aim of this study was to evaluate the knowledge of, attitudes toward, and performance of self-medication with antibiotics in COVID-19 patients.Methods: This cross-sectional study was conducted among patients with COVID-19. Participants were selected by random sampling. A survey of knowledge, attitude and practice of taking antibiotics in patients with COVID-19 was conducted. Data were analyzed using SPSS version 22 software.Results: The prevalence of self-medication with antibiotics in patients with COVID-19 was 56.1%. Most COVID-19 patients have the overall knowledge, attitude and practice score of self-medication with antibiotics. There was a significant difference between the knowledge and attitudes of educated and uneducated patients (p<0.01). Of the demographic variables, there was no significant difference between sexes in terms of attitude and practice of antibiotic self-medication in COVID-19 patients (p>0.05).Conclusion: Considering the high prevalence of antibiotic self-medication in COVID-19 patients, it is recommended to provide the necessary education and practical means of reducing the amount of antibiotic self-medication.
    Schlagwörter knowledge ; attitude ; practice ; self-medication ; antibiotics ; covid-19 ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Microbiology ; QR1-502
    Thema/Rubrik (Code) 150
    Sprache Deutsch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag German Medical Science GMS Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Assessment of knowledge, attitudes, and practice regarding antibiotic self-treatment use among COVID-19 patients

    Mahmoudi, Hassan

    GMS Hygiene and Infection Control

    2022  Band 17, Seite(n) 12

    Abstract: Zielsetzung: Die Selbstmedikation mit Antibiotika ist in verschiedenen Altersgruppen und Kulturen gängige Praxis, die Probleme wie Arzneimittelresistenzen, Nebenwirkungen und steigende Kosten für das Gesundheitssystems mit sich bringen kann. Nach dem ... ...

    Titelübersetzung Bewertung von Kenntissen, Einstellung und Praxis in Bezug auf den Einsatz von Antibiotika bei an COVID-19 Erkrankten
    Abstract Zielsetzung: Die Selbstmedikation mit Antibiotika ist in verschiedenen Altersgruppen und Kulturen gängige Praxis, die Probleme wie Arzneimittelresistenzen, Nebenwirkungen und steigende Kosten für das Gesundheitssystems mit sich bringen kann. Nach dem Auftreten von COVID-19 haben Menschen mit leichten Symptomen den Gang zum Arzt vermieden und vorgezogen, sich selbst zu behandeln. Die Auswirkungen der Selbstmedikation bei an COVID-19 Erkrankten ist ein wichtiges Thema für die öffentliche Gesundheit. Ziel der Studie war es, Wissen, Einstellung und Verhalten von an COVID-19 Erkrankten in Bezug auf die Selbstmedikation mit Antibiotika zu bewerten.
    Methode: Die Querschnittsstudie wurde bei an COVID-19 Erkrankten durchgeführt. Die Teilnehmer wurden nach dem Zufallsprinzip ausgewählt. Es wurde eine Umfrage zu Wissen, Einstellung und Praxis der Antibiotikaeinnahme durchgeführt. Die Daten wurden mit der Software SPSS Version 22 ausgewertet.
    Ergebnisse: Die Prävalenz der Selbstmedikation mit Antibiotika bei Erkrankten mit COVID-19 betrug 56,1%. Die meisten Patienten waren in Bezug auf die Selbstmedikation mit Antibiotika durchschnittlich informiert. Es bestand ein signifikanter Unterschied zwischen dem Wissen und der Einstellung gebildeter und ungebildeter Patienten (p<0,01). Zwischen demographischen Variablen und Geschlecht gab es keinen Unterschied (p >0,05).
    Schlussfolgerung: In Anbetracht der hohen Prävalenz der Antibiotika-Selbstmedikation bei an COVID-19 Erkrankten wird eine Aufklärung einschließlich praktischer Angebote empfohlen, um die Selbstmedikation mit Antibiotika zu reduzieren. ; Background: Self-medication with antibiotics is a common practice across different age groups and different cultures that can cause problems such as drug resistance, side effects, and rising costs for the healthcare system community. During the coronavirus pandemic (COVID-19), people with mild symptoms have avoided seeing a doctor, preferring to self-medicate. The impact of self-medication in COVID-19 patients is an important public health issue. The aim of this study was to evaluate the knowledge of, attitudes toward, and performance of self-medication with antibiotics in COVID-19 patients.
    Methods: This cross-sectional study was conducted among patients with COVID-19. Participants were selected by random sampling. A survey of knowledge, attitude and practice of taking antibiotics in patients with COVID-19 was conducted. Data were analyzed using SPSS version 22 software.
    Results: The prevalence of self-medication with antibiotics in patients with COVID-19 was 56.1%. Most COVID-19 patients have the overall knowledge, attitude and practice score of self-medication with antibiotics. There was a significant difference between the knowledge and attitudes of educated and uneducated patients (p<0.01). Of the demographic variables, there was no significant difference between sexes in terms of attitude and practice of antibiotic self-medication in COVID-19 patients (p>0.05).
    Conclusion: Considering the high prevalence of antibiotic self-medication in COVID-19 patients, it is recommended to provide the necessary education and practical means of reducing the amount of antibiotic self-medication.
    Schlagwörter Medizin, Gesundheit ; knowledge ; attitude ; practice ; self-medication ; antibiotics ; COVID-19 ; Wissen ; Einstellung ; Selbstmedikation ; Antibiotika ; Aufklärungsprogramm ; COVID-19
    Erscheinungsdatum 2022-07-01
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Artikel ; Online
    ZDB-ID 2717852-3
    ISSN 2196-5226 ; 2196-5226
    ISSN (online) 2196-5226
    ISSN 2196-5226
    DOI 10.3205/dgkh000415
    Datenquelle German Medical Science

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  4. Artikel: Bacterial co-infections and antibiotic resistance in patients with COVID-19.

    Mahmoudi, Hassan

    GMS hygiene and infection control

    2020  Band 15, Seite(n) Doc35

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2020-12-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2717852-3
    ISSN 2196-5226
    ISSN 2196-5226
    DOI 10.3205/dgkh000370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Bacterial co-infections and antibiotic resistance in patients with COVID-19

    Mahmoudi, Hassan

    GMS Hygiene and Infection Control, Vol 15, p Doc

    2020  Band 35

    Abstract: Background: Bacterial co-infections are frequently identified in viral respiratory infections and are significant reasons for morbidity and mortality. Information on the prevalence of bacterial co-infection in patients infected with severe acute ... ...

    Abstract Background: Bacterial co-infections are frequently identified in viral respiratory infections and are significant reasons for morbidity and mortality. Information on the prevalence of bacterial co-infection in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is lacking. The purpose of this study was to determine the prevalence of bacterial infections and antibiotic resistance in patients with coronavirus disease (COVID-19).Methods: In a cross-sectional study, blood culture (BC) and endotracheal aspirate (ETA) were obtained from COVID-19 patients (RT-PCR positive for SARS-CoV-2). The bacterial isolates were confirmed by the standard microbiological methods. Antibiotic resistance was determined using the disk diffusion method.Results: Among these 340 patients with COVID-19, a total of 43 (12.46%) patients had secondary bacterial infections. The most common bacteria isolated through ETA and BC included Klebsiella species 11 (25.59%), methicillin-sensitive (MSSA) 9 (20.93%), 7 (16.28%), methicillin-resistant (MRSA) 6 (13.95%), 5 (11.63%), 1 (2.32%), and 4 (9.30%). The results showed that Enterobacteriaceae isolates from COVID-19 patients had the highest resistance to cotrimoxazole (74%), piperacillin (67.5%), ceftazidime (47.5%), and cefepime (42.5%). All isolates were susceptible to amikacin (100%). isolates were susceptible to vancomycin (100%) and the rates of resistance to oxacillin, erythromycin and clindamycin were over (90%). was susceptible (90%) to imipenem.Conclusions: Bacterial co-infection is relatively infrequent in hospitalized COVID-19 patients. According to the results, one of the causes of death of these patients could be a secondary infections.
    Schlagwörter covid-19 ; bacterial co-infections ; antibiotic resistance ; viral respiratory infections ; sars-cov-2 ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Microbiology ; QR1-502
    Thema/Rubrik (Code) 610
    Sprache Deutsch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag German Medical Science GMS Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Bacterial co-infections and antibiotic resistance in patients with COVID-19

    Mahmoudi, Hassan

    GMS Hygiene and Infection Control

    2020  Band 15, Seite(n) 35

    Abstract: Hintergrund: Bakterielle Co-Infektionen werden häufig bei viralen Atemwegsinfektionen identifiziert und sind wesentliche Gründe für Morbidität und Mortalität. Es fehlen Informationen über die Prävalenz bakterieller Co-Infektionen bei Patienten mit COVID- ...

    Titelübersetzung Bakterielle Co-Infektionen und Antibiotikaresistenz bei Patienten mit COVID-19
    Abstract Hintergrund: Bakterielle Co-Infektionen werden häufig bei viralen Atemwegsinfektionen identifiziert und sind wesentliche Gründe für Morbidität und Mortalität. Es fehlen Informationen über die Prävalenz bakterieller Co-Infektionen bei Patienten mit COVID-19.. Ziel dieser Studie war es, die Prävalenz von bakteriellen Infektionen und Antibiotikaresistenzen bei an COVID-19 erkrankten Patienten zu bestimmen.
    Methoden: In einer Querschnittsstudie wurden Blutkulturen (BC) und endotracheale Aspirate (ETA) von COVID-19-Patienten (RT-PCR positiv für SARS-CoV-2) gewonnen. Die bakteriellen Isolate wurden mit den mikrobiologischen Standardmethoden bestätigt. Die Antibiotikaresistenz wurde im Plattendiffusionstest bestimmt.
    Ergebnisse: Unter 340 Patienten mit COVID-19 hatten insgesamt 43 (12,46 %) Patienten bakterielle Sekundärinfektionen. Die häufigsten Bakterien, die durch ETA und BC isoliert wurden, waren Klebsiella-Spezies 11 (25,59%), Methicillin-sensitiver Staphylococcus aureus (MSSA) 9 (20,93%) und Escherichia coli 7 (16. 28%), Methicillin-resistenter Staphylococcus aureus (MRSA) 6 (13,95%), und Enterobacter-Arten 5 (11,63%) sowie Streptococcus pneumoniae 1 (2,32%) und Pseudomonas aeruginosa 4 (9,30%). Die Ergebnisse zeigten, dass Enterobacteriaceae-Isolate von COVID-19-Patienten die höchste Resistenz gegen Cotrimoxazol (74%), Piperacillin (67,5%), Ceftazidim (47,5%) und Cefepime (42,5%) aufwiesen. Alle Isolate waren empfindlich gegenüber Amikacin (100%). S. aureus-Isolate waren empfindlich gegenüber Vancomycin (100%) und die Resistenzraten gegenüber Oxacillin, Erythromycin und Clindamycin waren über 90%. P. aeruginosa war empfindlich (90%) gegenüber Imipenem.
    Schlussfolgerungen: Bakterielle Co-Infektionen sind bei hospitalisierten COVID-19-Patienten relativ selten. Nach den Ergebnissen könnte eine der Todesursachen dieser Patienten eine Sekundärinfektion sein. ; Background: Bacterial co-infections are frequently identified in viral respiratory infections and are significant reasons for morbidity and mortality. Information on the prevalence of bacterial co-infection in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is lacking. The purpose of this study was to determine the prevalence of bacterial infections and antibiotic resistance in patients with coronavirus disease (COVID-19).
    Methods: In a cross-sectional study, blood culture (BC) and endotracheal aspirate (ETA) were obtained from COVID-19 patients (RT-PCR positive for SARS-CoV-2). The bacterial isolates were confirmed by the standard microbiological methods. Antibiotic resistance was determined using the disk diffusion method.
    Results: Among these 340 patients with COVID-19, a total of 43 (12.46%) patients had secondary bacterial infections. The most common bacteria isolated through ETA and BC included Klebsiella species 11 (25.59%), methicillin-sensitive Staphylococcus aureus (MSSA) 9 (20.93%), Escherichia coli 7 (16.28%), methicillin-resistant Staphylococcus aureus (MRSA) 6 (13.95%), Enterobacter species 5 (11.63%), Streptococcus pneumoniae 1 (2.32%), and Pseudomonas aeruginosa 4 (9.30%). The results showed that Enterobacteriaceae isolates from COVID-19 patients had the highest resistance to cotrimoxazole (74%), piperacillin (67.5%), ceftazidime (47.5%), and cefepime (42.5%). All isolates were susceptible to amikacin (100%). S. aureus isolates were susceptible to vancomycin (100%) and the rates of resistance to oxacillin, erythromycin and clindamycin were over (90%). P. aeruginosa was susceptible (90%) to imipenem.
    Conclusions: Bacterial co-infection is relatively infrequent in hospitalized COVID-19 patients. According to the results, one of the causes of death of these patients could be a secondary infections.
    Schlagwörter Medizin, Gesundheit ; COVID-19 ; bacterial co-infections ; antibiotic resistance ; viral respiratory infections ; SARS-CoV-2 ; COVID-19 ; bakterielle Co-Infektionen ; Antibiotika-Resistenz ; virale Atemwegsinfektionen ; SARS-CoV-2
    Erscheinungsdatum 2020-12-17
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Artikel ; Online
    ZDB-ID 2717852-3
    ISSN 2196-5226 ; 2196-5226
    ISSN (online) 2196-5226
    ISSN 2196-5226
    DOI 10.3205/dgkh000370
    Datenquelle German Medical Science

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  7. Artikel ; Online: Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.

    Mahmoudi, Hassan / Hossainpour, Hadi

    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

    2022  Band 29, Heft 1, Seite(n) 3–11

    Abstract: Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD) ...

    Abstract Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation, as well as a variety of non-GI disorders. The purpose of this review is to discuss gut microbiota and FMT treatment of GI and non-GI diseases. An imbalanced gut microbiota is known to predispose one to Clostridium difficile infections (CDI), IBD, and IBS. However, the complex role of the gut microbiota in maintaining health is a newer concept that is being increasingly studied. The microbiome plays a major role in cellular immunity and metabolism and has been implicated in the pathogenesis of non-GI autoimmune diseases, chronic fatigue syndrome, obesity, and even some neuropsychiatric disorders. Many recent studies have reported that viral gastroenteritis can affect intestinal epithelial cells, and SARS-CoV-2 virus has been identified in the stool of infected patients. FMT is a highly effective cure for RCDI, but a better understanding of the gut microbiota in maintaining health and controlled studies of FMT in a variety of conditions are needed before FMT can be accepted and used clinically.
    Mesh-Begriff(e) Humans ; Fecal Microbiota Transplantation ; Irritable Bowel Syndrome/therapy ; Clostridioides difficile ; COVID-19 ; SARS-CoV-2 ; Feces ; Gastrointestinal Diseases/therapy ; Inflammatory Bowel Diseases/therapy ; Clostridium Infections ; Metabolic Diseases ; Treatment Outcome ; Recurrence
    Sprache Englisch
    Erscheinungsdatum 2022-11-23
    Erscheinungsland India
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2299174-8
    ISSN 1998-4049 ; 1319-3767
    ISSN (online) 1998-4049
    ISSN 1319-3767
    DOI 10.4103/sjg.sjg_131_22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Effect of glutathione-stabilized silver nanoparticles on expression of las I and las R of the genes in Pseudomonas aeruginosa strains.

    Pourmbarak Mahnaie, Mina / Mahmoudi, Hassan

    European journal of medical research

    2020  Band 25, Heft 1, Seite(n) 17

    Abstract: Background: Biofilm formation is regarded as a significant factor in the establishment of infections caused by Pseudomonas aeruginosa. P. aeruginosa is one of the most important causes of nosocomial infections. Today silver nanoparticles (Ag-NPs) are ... ...

    Abstract Background: Biofilm formation is regarded as a significant factor in the establishment of infections caused by Pseudomonas aeruginosa. P. aeruginosa is one of the most important causes of nosocomial infections. Today silver nanoparticles (Ag-NPs) are used as antimicrobials due to their well-known, chemical, biological, and physical properties. Exposure to nanoparticles could inhibit colonization of new bacteria onto the biofilm.
    Methods: In the present work, the green synthesis of Ag-NPs was performed using the alcoholic extract of Eucalyptus camaldulensis. Ag-NPs and glutathione-stabilized silver nanoparticles (GSH-Ag-NPs) were characterized using X-ray diffraction (XRD), dynamic light scattering (DLS), scanning electron microscope (SEM), and carbon, nitrogen, and hydrogen (CNH) and Fourier transform infrared spectroscopy (FTIR) techniques were applied to investigate the structure of the modified nanoparticles. Then, the antimicrobial and antibiofilm potential of the prepared Ag-NPs and GSH-Ag-NPs against P. aeruginosa strains was evaluated using microbroth dilution method and their effects on the expression of las I and las R genes.
    Results: In this study, a total of 50 P. aeruginosa isolates were recovered from clinical samples. According to the results, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) value of Ag-NPs against P. aeruginosa was determined to be 512-256 μg/ml, respectively, while the MIC and MBC value of GS-Ag-NPs against P. aeruginosa clinical strains was determined in a range of 128-256 μg/ml and 256-512 μg/ml, respectively. The mean expression level in las R, las I genes in P. aeruginosa strains treated with ½ MIC of Ag-NPs was decreased by -5.7 and -8fold, respectively. The mean expression levels of las R, las I genes in P. aeruginosa strains treated with ½ MIC of GS-Ag-NPs were decreased by -8.7 and -10fold, respectively (P < 0.05).
    Conclusions: The results of our study showed that Ag-NPs and GS-Ag-NPs are highly effective against P. aeruginosa strains. Moreover, this study also proves the promising potential of using nanoparticles as anti-biofilm formation and antibacterial agents.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Glutathione/metabolism ; Glutathione/pharmacology ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; Plant Extracts/pharmacology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism ; Silver/chemistry ; Silver/metabolism ; Silver/pharmacology ; Spectroscopy, Fourier Transform Infrared/methods
    Chemische Substanzen Anti-Bacterial Agents ; Plant Extracts ; Silver (3M4G523W1G) ; Glutathione (GAN16C9B8O)
    Sprache Englisch
    Erscheinungsdatum 2020-05-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-020-00415-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Artikel ; Online: Polymorphisms in vitamin D receptor genes and its relation with susceptibility to brucellosis: a case-control study

    Mahmoudi, Hassan / keramat, Fariba / Saidijam, Massoud / Mohammadi, Younes / Khodavirdipour, Amir / Alikhani, Mohammad Yousef

    Mol Biol Rep. 2023 Mar., v. 50, no. 3 p.2077-2083

    2023  

    Abstract: OBJECTIVE: One of the systemic infections is Brucellosis which is caused by facultative intracellular bacteria of the genus Brucella. Vitamin D is a fat-soluble prohormone, that metabolizes enzymes and its intracellular receptor creates the active ... ...

    Abstract OBJECTIVE: One of the systemic infections is Brucellosis which is caused by facultative intracellular bacteria of the genus Brucella. Vitamin D is a fat-soluble prohormone, that metabolizes enzymes and its intracellular receptor creates the active hormone and also mediate in responses of immune system. METHODS: Current research consists of 102 patients with brucellosis who were selected based on culture, PCR results serology, and clinical symptoms. The control group composed of 102 healthy people. The polymorphism of genes (Bsm I, Fok I, Taq I, Apa I) encoding Vitamin D receptor (VDR) were assessed by the PCR-RFLP method. RESULTS: The results showed that ff, tt, aa, and bb genotypes in Fok I, ApaI, TaqI, and BsmI were significant in case/control groups (P-value ≤ 0.0001). The genotype frequency AA in the control group is higher than that of the study group, while genotype frequency aa in the study group is more than the control. The odds ratio for brucellosis in individuals with ff genotype is 37 times higher than that of Ff genotype. Also, the odds ratio of brucellosis in individuals with genotype tt, aa, and bb was 12, 53, and 6 times higher than those of the Aa, Bb, and Tt genotypes. CONCLUSION: The genotypes aa and ff in the positions of the ApaI and FokI are of higher importance. The brucellosis risk in individuals accompanied aa genotype at Apa I is 53 times higher than that of the genotype AA, in other words, AA and BB, TT and FF genotypes are protective against the disease.
    Schlagwörter Brucella ; brucellosis ; case-control studies ; genotype ; immune system ; odds ratio ; people ; risk ; serology
    Sprache Englisch
    Erscheinungsverlauf 2023-03
    Umfang p. 2077-2083.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel ; Online
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08195-2
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Spectrum of Beta-Thalassemia Mutations in Potential Carriers with Microcytic Hypochromic Anemia from Mazandaran and Golestan, Northern Provinces of Iran.

    Mousavi, Seyed Saeed / Karami, Hossein / Tamadoni, Ahmad / Mahmoudi, Hassan / Shekarriz, Ramin / Siami, Rita / Hashemi-Soteh, Mohammad Bagher

    BioMed research international

    2024  Band 2024, Seite(n) 8664803

    Abstract: Introduction: β: Methods: 5425 microcytic and hypochromic individuals were investigated from Mazandaran and Golestan provinces. From these, 1323 beta carrier or affected individuals were selected where 938 persons were from Mazandaran and 385 people ... ...

    Abstract Introduction: β
    Methods: 5425 microcytic and hypochromic individuals were investigated from Mazandaran and Golestan provinces. From these, 1323 beta carrier or affected individuals were selected where 938 persons were from Mazandaran and 385 people were from Golestan province, respectively.
    Result: 53 different mutations were identified, IVSII-1 (G>A) was the most common (59.14%) followed by Cd 22/23/24 (-7 bp) (5.34%), Cd 8 (-AA) (4.93%), Cd30 (G>A) (4.00%), and IVSI-5 (G>C) (3.70%) with a total of 77.11% in Mazandaran Province, respectively. In Golestan Province, IVSI-5 (G>C) was the most frequent (44.62%) followed by IVSII-1 (G>A) (27.18%), Cd 15 (TGG>TAG) (4.36%), Fr 8/9(+G) (3.85%), and Cd 8(-AA) (2.05%) with a total of 82.06%, respectively. From the 53 different mutations, 22 numbers have been observed in both provinces. Two deletions of the beta gene named Sicilian and Asian-Indian have been detected in Mazandaran with a frequency of 0.72% each.
    Conclusion: The 53 different mutations identified in this study were the most ever reported mutations in the country. Due to diversity of different ethnic groups, there are many varieties of mutation in beta globin gene in Iran. It could be assumed that both founder effect and natural selection caused by migration from neighboring areas have complemented each other to produce the high frequency of unique alleles within each region.
    Mesh-Begriff(e) Humans ; beta-Thalassemia/genetics ; Iran ; Cadmium ; Mutation ; Anemia, Hypochromic
    Chemische Substanzen Cadmium (00BH33GNGH)
    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2024/8664803
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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