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  1. Article: Acromegaly and Colorectal Neoplasm: An Update.

    Kasuki, Leandro / Maia, Bernardo / Gadelha, Mônica R

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 924952

    Abstract: Acromegaly is a systemic disease caused by excessive inappropriate secretion of GH and IGF-I levels, resulting in many systemic complications, including cardiovascular, respiratory, metabolic diseases, and a possible increased risk of some neoplasias. ... ...

    Abstract Acromegaly is a systemic disease caused by excessive inappropriate secretion of GH and IGF-I levels, resulting in many systemic complications, including cardiovascular, respiratory, metabolic diseases, and a possible increased risk of some neoplasias. Although many studies on acromegaly and cancer remain uncertain, most data indicate that colorectal cancer (CRC) incidence is increased in this population. The exact mechanism involved in the role of GH-IGF-I axis in CRC has not been fully explained, yet it is associated with local and circulating effects of GH and IGF-I on the colon, promoting angiogenesis, cell proliferation, risk of mutation, inhibition of tumor-suppressor genes and apoptosis, thus facilitating a tumor microenvironment. Nevertheless, population-based studies present controversial findings on CRC incidence and mortality. All worldwide guidelines and expert consensuses agree with the need for colonoscopic screening and surveillance in acromegaly, although there is no consensus regarding the best period to do this. This review aims to analyze the existing data on CRC and acromegaly, exploring its pathophysiology, epidemiological studies and their limitations, colonic polyp characteristics, overall cancer and CRC incidences and mortality, risk factors for colon cancer pathophysiology, and recommendation guideline aspects.
    MeSH term(s) Acromegaly/complications ; Cell Proliferation ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Humans ; Insulin-Like Growth Factor I ; Tumor Microenvironment
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.924952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel therapies for acromegaly.

    Maia, Bernardo / Kasuki, Leandro / Gadelha, Mônica R

    Endocrine connections

    2020  Volume 9, Issue 12, Page(s) R274–R285

    Abstract: Acromegaly is a systemic disease associated with increased morbidity and mortality. Most of these comorbidities can be prevented or delayed with adequate disease treatment. Although three modalities of treatment (surgery, medical treatment, and ... ...

    Abstract Acromegaly is a systemic disease associated with increased morbidity and mortality. Most of these comorbidities can be prevented or delayed with adequate disease treatment. Although three modalities of treatment (surgery, medical treatment, and radiotherapy) are available and new drugs were approved in the last decades, there are still some patients that maintain disease activity despite treatment. Therefore, there is a need for novel therapies for acromegaly and for that purpose new formulations of currently used drugs and also new drugs are currently under study. In this review, we summarize the novel therapies for acromegaly.
    Language English
    Publishing date 2020-12-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-20-0433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy, safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir for HIV pre-exposure prophylaxis in transgender women: a secondary analysis of the HPTN 083 trial.

    Marzinke, Mark A / Hanscom, Brett / Wang, Zhe / Safren, Steven A / Psaros, Christina / Donnell, Deborah / Richardson, Paul A / Sullivan, Philip / Eshleman, Susan H / Jennings, Andrea / Feliciano, Kailazarid Gomez / Jalil, Emilia / Coutinho, Carolina / Cardozo, Nadir / Maia, Bernardo / Khan, Taimur / Singh, Yashna / Middelkoop, Keren / Franks, Julie /
    Valencia, Javier / Sanchez, Naiymah / Lucas, Jonathan / Rooney, James F / Rinehart, Alex R / Ford, Susan / Adeyeye, Adeola / Cohen, Myron S / McCauley, Marybeth / Landovitz, Raphael J / Grinsztejn, Beatriz

    The lancet. HIV

    2023  Volume 10, Issue 11, Page(s) e703–e712

    Abstract: Background: The HIV Prevention Trials Network (HPTN) 083 trial showed that long-acting injectable cabotegravir was more effective than tenofovir disoproxil fumarate plus emtricitabine in preventing HIV in cisgender men and transgender women who have sex ...

    Abstract Background: The HIV Prevention Trials Network (HPTN) 083 trial showed that long-acting injectable cabotegravir was more effective than tenofovir disoproxil fumarate plus emtricitabine in preventing HIV in cisgender men and transgender women who have sex with men. We aimed to characterise the cohort of transgender women included in HPTN 083.
    Methods: HPTN 083 is an ongoing, phase 2b/3, randomised, multicentre, double-blind, double-dummy clinical trial done at 43 sites in seven countries (Argentina, Brazil, Peru, the USA, South Africa, Thailand, and Viet Nam). HIV-negative participants were randomly assigned (1:1) to receive injectable cabotegravir or tenofovir disoproxil fumarate plus emtricitabine. The study design and primary outcomes of the blinded phase of HPTN 083 have already been reported. An enrolment minimum of 10% transgender women was set for the trial. Here we characterise the cohort of transgender women enrolled from Dec 6, 2016, to May 14, 2020, when the study was unblinded. We report sociodemographic characteristics, use of gender affirming hormone therapy, and behavioural assessments of the transgender women participants. Laboratory testing and safety evaluations are also reported. The trial is registered at ClinicalTrials.gov, NCT02720094.
    Findings: HPTN 083 enrolled 570 transgender women (304 tenofovir disoproxil fumarate plus emtricitabine; 266 injectable cabotegravir). Transgender women were primarily from Asia (225 [39%]) and Latin America (205 [36%]); 330 (58%) reported using gender affirming hormone therapy. Intimate partner violence was common (270 [47%] reported emotional abuse and 172 [30%] reported physical abuse) and 323 (57%) reported a history of childhood sexual abuse. 159 (28%) transgender women disagreed that they were at risk for HIV, and 142 (25%) screened positive for depressive symptoms. During study follow-up, incidence of syphilis was 16·25% (95% CI 13·28-19·69), rectal gonorrhoea was 11·66% (9·14-14·66), and chlamydia was 20·61% (17·20-24·49). Frequency of adverse events was similar between the treatment groups. Nine seroconversions occurred among transgender women during the blinded phase of the study (seven in the tenofovir disoproxil fumarate plus emtricitabine group and two in the injectable cabotegravir group); overall incidence was 1·19 per 100 person-years (95% CI 0·54-2·25): 1·80 per 100 person-years (0·73-3·72) in the tenofovir disoproxil fumarate plus emtricitabine group and 0·54 per 100 person-years (0·07-1·95) in the injectable cabotegravir group (hazard ratio 0·34 [95% CI 0·08-1·56]). Cabotegravir concentrations did not differ by gender affirming hormone therapy use.
    Interpretation: HIV prevention strategies for transgender women cannot be addressed separately from social and structural vulnerabilities. Transgender women were well represented in HPTN 083 and should continue to be prioritised in HIV prevention studies. Our results suggest that injectable cabotegravir is a safe and effective pre-exposure prophylaxis option for transgender women.
    Funding: National Institute of Allergy and Infectious Diseases and ViiV Healthcare.
    MeSH term(s) Female ; Humans ; Male ; Acquired Immunodeficiency Syndrome/drug therapy ; Anti-HIV Agents/adverse effects ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; HIV-1 ; Hormones/therapeutic use ; Pre-Exposure Prophylaxis/methods ; Tenofovir/therapeutic use ; Thailand ; Transgender Persons
    Chemical Substances Anti-HIV Agents ; cabotegravir (HMH0132Z1Q) ; Emtricitabine (G70B4ETF4S) ; Hormones ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2023-09-29
    Publishing country Netherlands
    Document type Clinical Trial, Phase II ; Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00200-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intake, digestibility, performance, and carcass traits of beef cattle of different gender

    Lage, Igor Nero Kelles / Paulino, Pedro Veiga Rodruigues / Pires, Christiano Vieira / Villela, Severino Delmar Junqueira / de Souza Duarte, Marcio / de Campos Valadares Filho, Sebastião / Paulino, Mario Fonseca / Maia, Bernardo Alves / Silva, Luiz Henrique Pereira / Teixeira, Cesar Roberto Vianna

    Tropical animal health and production. 2012 Feb., v. 44, no. 2

    2012  

    Abstract: The performance, intake, feed efficiency, and carcass traits of beef cattle from different gender profile were assessed. Fifteen animals (five steers, five spayed heifers, and five intact heifers) with ±250 kg of initial body weight were randomly ... ...

    Abstract The performance, intake, feed efficiency, and carcass traits of beef cattle from different gender profile were assessed. Fifteen animals (five steers, five spayed heifers, and five intact heifers) with ±250 kg of initial body weight were randomly assigned in individual pens and fed the same diet for 106 days. At the end of the trial, all the animals were slaughtered and the pH, temperature, and weight of the carcass were recorded. The right side of each carcass was then separated into chuck, shoulder, flank sirloin, and round for evaluation of commercial cuts yield. The left carcass sides were ribbed between the 12th and 13th ribs where the rib eye area and fat thickness measurements were taken. The 9th–11th rib section was removed from the left half carcass and then dissected into muscle, fat, and bones in order to estimate carcass composition. Gender had no effect (P > 0.05) on performance, intake, digestibility of dry matter and all the nutrients evaluated, feed efficiency, and carcass characteristics. It can be concluded that steers and heifers (spayed or not) have the same potential to produce beef. From a productive and welfare standpoint, there is no reason to spay heifers.
    Keywords beef ; beef carcasses ; beef cattle ; body weight ; carcass composition ; carcass weight ; diet ; digestibility ; fat thickness ; feed conversion ; heifers ; lipids ; meat cuts ; muscles ; nutrients ; pH ; ribs ; shoulders ; spaying ; steers ; temperature
    Language English
    Dates of publication 2012-02
    Size p. 361-367.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-011-0030-z
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2667: Show issues

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  5. Article ; Online: Intake, digestibility, performance, and carcass traits of beef cattle of different gender.

    Lage, Igor Nero Kelles / Paulino, Pedro Veiga Rodruigues / Pires, Christiano Vieira / Villela, Severino Delmar Junqueira / Duarte, Marcio de Souza / Valadares Filho, Sebastião de Campos / Paulino, Mario Fonseca / Maia, Bernardo Alves / Silva, Luiz Henrique Pereira / Teixeira, Cesar Roberto Vianna

    Tropical animal health and production

    2011  Volume 44, Issue 2, Page(s) 361–367

    Abstract: The performance, intake, feed efficiency, and carcass traits of beef cattle from different gender profile were assessed. Fifteen animals (five steers, five spayed heifers, and five intact heifers) with ±250 kg of initial body weight were randomly ... ...

    Abstract The performance, intake, feed efficiency, and carcass traits of beef cattle from different gender profile were assessed. Fifteen animals (five steers, five spayed heifers, and five intact heifers) with ±250 kg of initial body weight were randomly assigned in individual pens and fed the same diet for 106 days. At the end of the trial, all the animals were slaughtered and the pH, temperature, and weight of the carcass were recorded. The right side of each carcass was then separated into chuck, shoulder, flank sirloin, and round for evaluation of commercial cuts yield. The left carcass sides were ribbed between the 12th and 13th ribs where the rib eye area and fat thickness measurements were taken. The 9th-11th rib section was removed from the left half carcass and then dissected into muscle, fat, and bones in order to estimate carcass composition. Gender had no effect (P > 0.05) on performance, intake, digestibility of dry matter and all the nutrients evaluated, feed efficiency, and carcass characteristics. It can be concluded that steers and heifers (spayed or not) have the same potential to produce beef. From a productive and welfare standpoint, there is no reason to spay heifers.
    MeSH term(s) Animals ; Cattle/physiology ; Digestion/physiology ; Eating/physiology ; Female ; Least-Squares Analysis ; Male ; Meat/standards ; Muscle, Skeletal/physiology ; Random Allocation ; Sex Factors
    Language English
    Publishing date 2011-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-011-0030-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2159: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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