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  1. Book ; Thesis: DEAR-Kids-Studie

    Maier, Lisa

    Messung der funktionellen Intima-Media-Dicke der Arteria carotis communis, 24-Stunden-Blutdruck-Messung, statische retinale Gefäßanalyse und Bestimmung laborchemischer Marker zur Evaluation einer frühen Atherosklerose bei Kindern und Jugendlichen mit Diabetes mellitus Typ 1

    2021  

    Author's details vorgelegt 2020 von Lisa Maria Maier
    Language German
    Size X, 94 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Freiburg i. Br
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg i. Br., 2021
    HBZ-ID HT021218022
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 E 123 order for loan Magazin

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  2. Article ; Online: Pioneering microbiome engineering.

    Maier, Lisa

    Nature reviews. Microbiology

    2023  Volume 21, Issue 10, Page(s) 630

    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-023-00949-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Promising Biomarker for Pulmonary Sarcoidosis That Must Cross the Finish Line.

    Maier, Lisa / Drake, Wonder P

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202404-0750ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gut bacteria thwart the blood sugar-lowering effect of acarbose.

    Brauny, Melanie M / Maier, Lisa

    Nature metabolism

    2023  Volume 5, Issue 5, Page(s) 732–734

    MeSH term(s) Humans ; Acarbose/pharmacology ; Acarbose/therapeutic use ; Blood Glucose ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Bacteria
    Chemical Substances Acarbose (T58MSI464G) ; Blood Glucose ; Hypoglycemic Agents
    Language English
    Publishing date 2023-05-08
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00798-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Developmental drugs for sarcoidosis.

    Obi, Ogugua Ndili / Saketkoo, Lesley Ann / Maier, Lisa A / Baughman, Robert P

    Journal of autoimmunity

    2024  , Page(s) 103179

    Abstract: Sarcoidosis is a multi-organ granulomatous inflammatory disease of unknown etiology. Over 50% of patients will require treatment at some point in their disease and 10%-30% will develop a chronic progressive disease with pulmonary fibrosis leading to ... ...

    Abstract Sarcoidosis is a multi-organ granulomatous inflammatory disease of unknown etiology. Over 50% of patients will require treatment at some point in their disease and 10%-30% will develop a chronic progressive disease with pulmonary fibrosis leading to significant morbidity and mortality. Recently published guidelines recommend immunosuppressive therapy for sarcoidosis patients at risk of increased disease-related morbidity and mortality, and in whom disease has negatively impacted quality of life. Prednisone the currently recommended first line therapy is associated with significant toxicity however none of the other guideline recommended steroid sparing therapy is approved by regulatory agencies for use in sarcoidosis, and data in support of their use is weak. For patients with severe refractory disease requiring prolonged therapy, treatment options are limited. The need for expanding treatment options in sarcoidosis has been emphasized. Well conducted large, randomized trials evaluating currently available therapeutic options as well as novel pathways for targeting disease are necessary to better guide treatment decisions. These trials will not be without significant challenges. Sarcoidosis is a rare disease with heterogenous presentation and variable progression and clinical outcome. There are no universally agreed upon biomarkers of disease activity and measurement of outcomes is confounded by the need to balance patient centric measures and objective measures of disease activity. Our paper provides an update on developmental drugs in sarcoidosis and outlines several novel pathways that may be targeted for future drug development. Currently available trials are highlighted and ongoing challenges to drug development and clinical trial design are briefly discussed.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2024.103179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genome and Transcriptome-Wide Association Study of Fibrotic Sarcoidosis in European Americans.

    Liao, Shu-Yi / Maier, Lisa A / Fingerlin, Tasha E

    American journal of respiratory and critical care medicine

    2023  Volume 209, Issue 3, Page(s) 334–337

    MeSH term(s) Humans ; Transcriptome ; Sarcoidosis/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1331LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic predisposition to sarcoidosis.

    Liao, Shu-Yi / Fingerlin, Tasha / Maier, Lisa

    Journal of autoimmunity

    2023  , Page(s) 103122

    Abstract: Sarcoidosis is a complex systemic disease with clinical heterogeneity based on varying phenotypes and natural history. The detailed etiology of sarcoidosis remains unknown, but genetic predisposition as well as environmental exposures play a significant ... ...

    Abstract Sarcoidosis is a complex systemic disease with clinical heterogeneity based on varying phenotypes and natural history. The detailed etiology of sarcoidosis remains unknown, but genetic predisposition as well as environmental exposures play a significant role in disease pathogenesis. We performed a comprehensive review of germline genetic (DNA) and transcriptomic (RNA) studies of sarcoidosis, including both previous studies and more recent findings. In this review, we provide an assessment of the following: genetic variants in sarcoidosis susceptibility and phenotypes, ancestry- and sex-specific genetic variants in sarcoidosis, shared genetic architecture between sarcoidosis and other diseases, and gene-environment interactions in sarcoidosis. We also highlight the unmet needs in sarcoidosis genetic studies, including the pressing requirement to include diverse populations and have consistent definitions of phenotypes in the sarcoidosis research community to help advance the application of genetic predisposition to sarcoidosis disease risk and manifestations.
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2023.103122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Confounder or Confederate? The Interactions Between Drugs and the Gut Microbiome in Psychiatric and Neurological Diseases.

    Michaelis, Lena / Berg, Lara / Maier, Lisa

    Biological psychiatry

    2023  Volume 95, Issue 4, Page(s) 361–369

    Abstract: The gut microbiome is emerging as an important factor in signaling along the gut-brain axis. The intimate physiological connection between the gut and the brain allows perturbations in the microbiome to be directly transmitted to the central nervous ... ...

    Abstract The gut microbiome is emerging as an important factor in signaling along the gut-brain axis. The intimate physiological connection between the gut and the brain allows perturbations in the microbiome to be directly transmitted to the central nervous system and thereby contribute to psychiatric and neurological diseases. Common microbiome perturbations result from the ingestion of xenobiotic compounds including pharmaceuticals such as psychotropic drugs. In recent years, a variety of interactions between these drug classes and the gut microbiome have been reported, ranging from direct inhibitory effects on gut bacteria to microbiome-mediated drug degradation or sequestration. Consequently, the microbiome may play a critical role in influencing the intensity, duration, and onset of therapeutic effects, as well as in influencing the side effects that patients may experience. Furthermore, because the composition of the microbiome varies from person to person, the microbiome may contribute to the frequently observed interpersonal differences in the response to these drugs. In this review, we first summarize the known interactions between xenobiotics and the gut microbiome. Then, for psychopharmaceuticals, we address the question of whether these interactions with gut bacteria are irrelevant for the host (i.e., merely confounding factors in metagenomic analyses) or whether they may even have therapeutic or adverse effects.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/physiology ; Nervous System Diseases/drug therapy ; Brain ; Psychotropic Drugs/pharmacology
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2023-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.06.004
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  9. Article ; Online: Occupational exposures and sarcoidosis: current understanding and knowledge gaps.

    Lin, Nancy W / Maier, Lisa A

    Current opinion in pulmonary medicine

    2021  Volume 28, Issue 2, Page(s) 144–151

    Abstract: Purpose of review: Sarcoidosis is an idiopathic granulomatous disease that primarily affects the lungs. Several lines of evidence suggest that occupational exposures are associated with disease risk. This review critically evaluates studies using the ... ...

    Abstract Purpose of review: Sarcoidosis is an idiopathic granulomatous disease that primarily affects the lungs. Several lines of evidence suggest that occupational exposures are associated with disease risk. This review critically evaluates studies using the Bradford Hill criteria for causation to determine if a causal relationship can be established between occupational exposure and sarcoidosis.
    Recent findings: Large epidemiological studies have proposed multiple occupational exposures associated with sarcoidosis but lack consistency of results. Many convincing studies demonstrate an association between World Trade Center (WTC) dust and sarcoidosis, which illustrates a causal relationship based on the fulfillment of the Bradford Hill criteria. Studies describing an association between silica/metals and sarcoidosis are intriguing but fulfill a limited number of the Bradford Hill criteria and warrant further investigation before a causal relationship can be determined. Finally, we also discuss preliminary studies associating sarcoidosis phenotypes with specific occupational exposures.
    Summary: Using the Bradford Hill criteria for causation, we demonstrate that WTC dust has a causative relationship with sarcoidosis, which reinforces the theory that sarcoidosis is an exposure-related disease. More research is needed to determine other specific occupational exposures causing disease.
    MeSH term(s) Dust ; Humans ; Lung ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Exposure/adverse effects ; Sarcoidosis/epidemiology ; Sarcoidosis/etiology ; Silicon Dioxide/toxicity
    Chemical Substances Dust ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genetics in sarcoidosis.

    Spagnolo, Paolo / Maier, Lisa A

    Current opinion in pulmonary medicine

    2021  Volume 27, Issue 5, Page(s) 423–429

    Abstract: Purpose of review: Epidemiological and clinical observations as well as familial clustering support the existence of a genetic predisposition to sarcoidosis. In this article, we review the most recent findings in genetics of sarcoidosis and discuss how ... ...

    Abstract Purpose of review: Epidemiological and clinical observations as well as familial clustering support the existence of a genetic predisposition to sarcoidosis. In this article, we review the most recent findings in genetics of sarcoidosis and discuss how the identification of risk alleles may help advancing our understanding of disease etiology and development.
    Recent findings: Genetic studies of sarcoidosis phenotypes have identified novel and ancestry-specific associations. Gene-environment interaction studies highlighted the importance of integrating genetic information when assessing the relationship between sarcoidosis and environmental exposures. A case-control-family study revealed that the heritability of sarcoidosis is only 49%, suggesting the existence of additional important contributors to disease risk. The application of whole-exome sequencing has identified associations with disease activity and prognosis. Finally, gene expression studies of circulating immune cells have identified shared and unique pathways between sarcoidosis and other granulomatous diseases.
    Summary: Sarcoidosis genetic research has led to the identification of a number of associations with both sarcoidoses per se and disease phenotypes. Newer sequencing technologies are likely to increase the number of genetic variants associated with sarcoidosis. However, studying phenotypically and ethnically homogeneous patient subsets remains critically important regardless of the genetic approach used.
    MeSH term(s) Genetic Predisposition to Disease/genetics ; Humans ; Phenotype ; Sarcoidosis/genetics ; Whole Exome Sequencing
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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