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  1. Book ; Online ; E-Book: Sirtuin biology in cancer and metabolic disease

    Maiese, Kenneth

    cellular pathways for clinical discovery

    2021  

    Author's details edited by Kenneth Maiese
    Keywords Cancer/Molecular aspects
    Subject code 572.6
    Language English
    Size 1 online resource (301 pages) :, illustrations
    Publisher Elsevier
    Publishing place London, England ; San Diego, California
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-822484-3 ; 0-12-822467-3 ; 978-0-12-822484-7 ; 978-0-12-822467-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Sirtuin biology in medicine

    Maiese, Kenneth

    targeting new avenues of care in development, aging, and disease

    2021  

    Author's details edited by Kenneth Maiese
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvii, 401 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020893797
    ISBN 978-0-12-814119-9 ; 9780128141182 ; 0-12-814119-0 ; 0128141182
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Molecules to medicine with mTOR

    Maiese, Kenneth

    translating critical pathways into novel therapeutic strategies

    2016  

    Author's details edited by Kenneth Maiese
    Keywords Rapamycin
    Subject code 612.398
    Language English
    Size Online-Ressource
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018927631
    ISBN 978-0-12-802755-4 ; 978-0-12-802733-2 ; 0-12-802755-X ; 0-12-802733-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Mitochondria, Mitophagy, Mitoptosis, and Programmed Cell Death: Implications from Aging to Cancer.

    Maiese, Kenneth

    Current neurovascular research

    2024  

    Language English
    Publishing date 2024-01-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/1567202621999240118155618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6646: Show issues Location:
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  5. Article ; Online: Migraine Disorders, Neurovascular Disease, and the Underlying Role of Oxidative Stress.

    Maiese, Kenneth

    Current neurovascular research

    2024  

    Language English
    Publishing date 2024-02-23
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/1567202621999240223164624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6646: Show issues Location:
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  6. Article: Innovative therapeutic strategies for cardiovascular disease.

    Maiese, Kenneth

    EXCLI journal

    2023  Volume 22, Page(s) 690–715

    Abstract: As a significant non-communicable disease, cardiovascular disease is the leading cause of death for both men and women, comprises almost twenty percent of deaths in most racial and ethnic groups, can affect greater than twenty-five million individuals ... ...

    Abstract As a significant non-communicable disease, cardiovascular disease is the leading cause of death for both men and women, comprises almost twenty percent of deaths in most racial and ethnic groups, can affect greater than twenty-five million individuals worldwide over the age of twenty, and impacts global economies with far-reaching financial challenges. Multiple factors can affect the onset of cardiovascular disease that include high serum cholesterol levels, elevated blood pressure, tobacco consumption and secondhand smoke exposure, poor nutrition, physical inactivity, obesity, and concurrent diabetes mellitus. Yet, addressing any of these factors cannot completely eliminate the onset or progression of cardiovascular disorders. Novel strategies are necessary to target underlying cardiovascular disease mechanisms. The silent mating type information regulation 2 homolog 1
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2023-6306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cognitive Impairment in Multiple Sclerosis.

    Maiese, Kenneth

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 7

    Abstract: Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of ... ...

    Abstract Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of cognitive loss and dementia. Presently, disease modifying therapies can limit the rate of relapse and potentially reduce brain volume loss in patients with MS, but unfortunately cannot prevent disease progression or the onset of cognitive disability. Innovative strategies are therefore required to address areas of inflammation, immune cell activation, and cell survival that involve novel pathways of programmed cell death, mammalian forkhead transcription factors (FoxOs), the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), the silent mating type information regulation 2 homolog 1 (
    Language English
    Publishing date 2023-07-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10070871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System.

    Maiese, Kenneth

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is the knowledge that metabolic disease is intimately tied to ... ...

    Abstract It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is the knowledge that metabolic disease is intimately tied to neurodegenerative disorders, affecting both the central and peripheral nervous systems as well as leading to dementia, the seventh leading cause of death. New and innovative therapeutic strategies that address cellular metabolism, apoptosis, autophagy, and pyroptosis, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), and risk factors such as the apolipoprotein E (APOE-ε4) gene and coronavirus disease 2019 (COVID-19) can offer valuable insights for the clinical care and treatment of neurodegenerative disorders impacted by cellular metabolic disease. Critical insight into and modulation of these complex pathways are required since mTOR signaling pathways, such as AMPK activation, can improve memory retention in Alzheimer's disease (AD) and DM, promote healthy aging, facilitate clearance of β-amyloid (Aß) and tau in the brain, and control inflammation, but also may lead to cognitive loss and long-COVID syndrome through mechanisms that can include oxidative stress, mitochondrial dysfunction, cytokine release, and APOE-ε4 if pathways such as autophagy and other mechanisms of programmed cell death are left unchecked.
    MeSH term(s) Humans ; AMP-Activated Protein Kinases/metabolism ; Post-Acute COVID-19 Syndrome ; COVID-19 ; TOR Serine-Threonine Kinases/metabolism ; Diabetes Mellitus ; Alzheimer Disease/metabolism ; Neurodegenerative Diseases/metabolism ; Metabolic Diseases ; Brain/metabolism
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK.

    Maiese, Kenneth

    Cells

    2023  Volume 12, Issue 22

    Abstract: Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world and are insidious in onset, chronic in nature, and yield significant disability and death. Current therapies that address nutritional status, ... ...

    Abstract Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world and are insidious in onset, chronic in nature, and yield significant disability and death. Current therapies that address nutritional status, weight management, and pharmacological options may delay disability but cannot alter disease course or functional organ loss, such as dementia and degeneration of systemic bodily functions. Underlying these challenges are the onset of aging disorders associated with increased lifespan, telomere dysfunction, and oxidative stress generation that lead to multi-system dysfunction. These significant hurdles point to the urgent need to address underlying disease mechanisms with innovative applications. New treatment strategies involve non-coding RNA pathways with microRNAs (miRNAs) and circular ribonucleic acids (circRNAs), Wnt signaling, and Wnt1 inducible signaling pathway protein 1 (WISP1) that are dependent upon programmed cell death pathways, cellular metabolic pathways with AMP-activated protein kinase (AMPK) and nicotinamide, and growth factor applications. Non-coding RNAs, Wnt signaling, and AMPK are cornerstone mechanisms for overseeing complex metabolic pathways that offer innovative treatment avenues for metabolic disease and DM but will necessitate continued appreciation of the ability of each of these cellular mechanisms to independently and in unison influence clinical outcome.
    MeSH term(s) Humans ; AMP-Activated Protein Kinases/metabolism ; Wnt Signaling Pathway/genetics ; Diabetes Mellitus/metabolism ; Metabolic Diseases/genetics ; Apoptosis/physiology
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12222595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ferroptosis, Iron Metabolism, and Forkhead Transcription Factors (FoxOs).

    Maiese, Kenneth

    Current neurovascular research

    2023  Volume 20, Issue 3, Page(s) 291–295

    MeSH term(s) Forkhead Transcription Factors/metabolism ; Ferroptosis ; Forkhead Box Protein O1 ; Iron
    Chemical Substances Forkhead Transcription Factors ; Forkhead Box Protein O1 ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-07-06
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/1567202620666230706160056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6646: Show issues Location:
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