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  1. Article ; Online: Urinary C4d in crescentic IgA nephropathy: expectancy and hope for a non-invasive lectin pathway biomarker.

    Maillard, Nicolas / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 37, Issue 11, Page(s) 2042–2043

    MeSH term(s) Humans ; Glomerulonephritis, IGA/complications ; Cohort Studies ; Lectins ; Disease Progression ; Biomarkers
    Chemical Substances Lectins ; Biomarkers
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac168
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  2. Article ; Online: Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy.

    Ștefan, Gabriel / Alamartine, Eric / Mariat, Christophe / Maillard, Nicolas

    Kidney international reports

    2023  Volume 9, Issue 2, Page(s) 356–369

    Abstract: Introduction: IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review.! ...

    Abstract Introduction: IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review.
    Methods: We adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and conducted a systematic review, utilizing databases like MEDLINE (PubMed), Embase, Scopus, and Cochrane from January 2016 (year of updated MEST-C classification) to January 2023. We specifically selected studies that employed established methods to evaluate complement activation and the MEST-C classification.
    Results: A total of 34 studies with 10,082 patients were included. Among these, 7 studies focused on the pediatric population (500 patients), and 22 studies involved 8128 patients from Asian populations. C4d, C3, C5b9, MBL, C4, and factor H-related protein 5 (FHR5) were the most frequently studied complement proteins in relation to the MEST-C classification. Complement activation assessment was primarily conducted using immunofluorescence and immunohistochemistry on kidney biopsy specimens. All complement proteins investigated showed associations with the C1-2 class. Notably, FB, FH, MASP1/3, MASP2, C5a, and C5b9 from the alternative, lectin, and terminal pathways were uniquely present in the C1-2 class. Whereas C3, FHR5, C4, and C4d were associated with all the MEST-C classes.
    Conclusion: We found evidence supporting the involvement of alternative and lectin complement pathways across all MEST-C classes. All examined complement factors were associated with the C1-2 class, emphasizing the critical role of complement activation, possibly at the endothelial surface. These findings may guide the development of personalized treatment strategies targeting complement pathways in relation to the MEST-C lesions.
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.11.005
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  3. Article ; Online: Transplantation rénale en France, avantages liés au donneur vivant.

    Maillard, Nicolas / Mariat, Christophe

    La Revue du praticien

    2020  Volume 71, Issue 6, Page(s) 617–620

    Abstract: Renal transplantation and living donation in France. While renal transplantation remains the best option for patients with end-stage renal disease, it does not cover the needs of the population. Transplantation from living donors is becoming the strategy ...

    Title translation Renal transplantation and living donation in France.
    Abstract Renal transplantation and living donation in France. While renal transplantation remains the best option for patients with end-stage renal disease, it does not cover the needs of the population. Transplantation from living donors is becoming the strategy of first choice to address the numerous challenges faced by both the patients and the transplant community. However, living kidney donor transplantation remains marginal in France and concerns only 15% of the transplanted patients. Herein, after reviewing the main epidemiological trends of renal transplantation in France, we discuss the reasons and opportunities of further developing living kidney donation.
    MeSH term(s) France/epidemiology ; Humans ; Kidney ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Living Donors
    Language French
    Publishing date 2020-12-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article ; Online: The New 2021 CKD-EPI Equation Without Race in a European Cohort of Renal Transplanted Patients.

    Delanaye, Pierre / Masson, Ingrid / Maillard, Nicolas / Pottel, Hans / Mariat, Christophe

    Transplantation

    2022  Volume 106, Issue 12, Page(s) 2443–2447

    Abstract: Background: Whether the new chronic kidney disease-epidemiology (CKD-EPI) equation without the race variable remains accurate enough for glomerular filtration rate (GFR) estimation in non-US kidney transplant recipients (KTRs) is unclear. We sought to ... ...

    Abstract Background: Whether the new chronic kidney disease-epidemiology (CKD-EPI) equation without the race variable remains accurate enough for glomerular filtration rate (GFR) estimation in non-US kidney transplant recipients (KTRs) is unclear. We sought to compare the predictive performance between this equation and the classical CKD-EPI equation in a French cohort of KTRs. We also evaluated the performance of the European Kidney Function Consortium (EKFC) equation, an estimate that has proved very accurate in nontransplant patients and that does not include race variable.
    Methods: We retrospectively selected 489 KTRs for whom GFR was measured by inulin clearance. Performances of GFR equations were compared according to median bias, imprecision, and accuracy within 30% (P30) and 20% (P20). Differences in P20/P30 were tested using the exact McNemar test.
    Results: Although the 4 equations exhibited a similar level of imprecision, the bias of the new CKD-EPI equation was +5.5 (4.0; 6.6) mL/min/1.73 m², much higher than the bias of the classical CKD-EPI, EKFC, and Modified Diet in Renal Diseases (MDRD) equation (2.4 [1.7;3.5], 2.2 [1.1;3.1], and -0.5 [-1.5; 1.0] mL/min/1.73 m², respectively). The new CKD-EPI equation was significantly less accurate with a P30 of 68.3% as compared with 74.2%, 75.3%, and 77.1% for the classical CKD-EPI, EKFC, and MDRD equation, respectively. The EKFC equation outperformed both versions of the CKD-EPI equation in terms of P20.
    Conclusions: The new CKD-EPI equation is suboptimal for the care and follow-up of European transplanted patients. The EKFC equation shows at least a similar performance to the MDRD and the classical CKD-EPI equation. Further validation of the EKFC equation in KTRs from a diverse ethnic background is needed.
    MeSH term(s) Humans ; Creatinine ; Retrospective Studies ; Glomerular Filtration Rate ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/surgery ; Kidney Function Tests
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004234
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  5. Article ; Online: The Oxford Classification for immunoglobulin A nephropathy: a common language blurred by dissonant voices.

    Maillard, Nicolas / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2019  Volume 34, Issue 10, Page(s) 1617–1618

    MeSH term(s) Biopsy ; Glomerulonephritis, IGA ; Humans ; Immunoglobulin A ; Language ; Reproducibility of Results
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz009
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  6. Article: Therapeutic plasma exchange in nephrology. Where it applies?

    Alamartine, Eric / Maillard, Nicolas

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2019  Volume 58, Issue 3, Page(s) 262–265

    Abstract: Plasma exchange had been proposed to treat many kidney diseases. A few controlled studies, observational studies, and mechanistic evidence have specified the better indications, which are thrombotic microangiopathies, kidney transplantation and ANCA- ... ...

    Abstract Plasma exchange had been proposed to treat many kidney diseases. A few controlled studies, observational studies, and mechanistic evidence have specified the better indications, which are thrombotic microangiopathies, kidney transplantation and ANCA-associated vasculitides. Plasma removal can be realized by filtration, centrifugation, or immunoadsorption, with differences in efficacy, but these also impact on volume load and anticoagulation in patients with renal failure.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy ; Humans ; Kidney Diseases/therapy ; Plasma Exchange ; Thrombotic Microangiopathies/therapy
    Language English
    Publishing date 2019-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2019.04.010
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  7. Article ; Online: Circulating alternative pathway complement cleavage factor Bb is associated with vascular lesions and outcomes in IgA nephropathy.

    Ștefan, Gabriel / Jullien, Perrine / Masson, Ingrid / Alamartine, Eric / Mariat, Christophe / Maillard, Nicolas

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue Supplement_2, Page(s) ii11–ii18

    Abstract: Background: Complement alternative pathway (AP) activation is linked to immunoglobulin A nephropathy (IgAN) prognosis severity, but Bb fragment's role is unclear. We examined the relationship between serum Bb fragment concentration at IgAN diagnosis and ...

    Abstract Background: Complement alternative pathway (AP) activation is linked to immunoglobulin A nephropathy (IgAN) prognosis severity, but Bb fragment's role is unclear. We examined the relationship between serum Bb fragment concentration at IgAN diagnosis and disease activity and outcomes.
    Methods: This retrospective study included 125 biopsy-proven IgAN patients [age 39.9 years, 75% male, estimated glomerular filtration rate (eGFR) 82 ml/min, proteinuria 0.5 g/day] enrolled from 1984 to 2010 and followed for a minimum of 18 months. Monitoring continued until the last follow-up, end-stage kidney disease (ESKD) or death. Serum Bb fragment was measured using an enzyme-linked immunosorbent assay at diagnosis. Oxford classification and global optical score (GOS) were utilized for pathology assessment.
    Results: Patients were followed for a median of 16 years; 42% developed chronic kidney disease stage ≥3, 19% reached ESKD and 9% died. Serum Bb fragment concentration negatively correlated with eGFR values at the last follow-up and positively with vascular and tubular histopathological indices. In univariate Cox regression analyses, higher Bb fragment concentration was associated with ESKD alongside older age, increased body mass index, arterial hypertension, lower eGFR, higher proteinuria, E1, S1, T1-2, GOS and corticotherapy. Patients with Bb levels ≥14.3 μg/ml had shorter mean kidney survival time (19.5 versus 22.7 years, P = .07); after adjusting for progression risk factors, the association persisted [hazard ratio 4.76 (95% confidence interval 1.56-14.43)].
    Conclusions: Serum Bb fragment concentration at diagnosis may predict long-term IgAN outcomes, potentially due to AP activation at the endothelial surface. Further research is needed to confirm these results and evaluate Bb fragment's role in IgAN management.
    MeSH term(s) Humans ; Male ; Adult ; Female ; Glomerulonephritis, IGA/pathology ; Retrospective Studies ; Complement Factor B ; Disease Progression ; Prognosis ; Kidney Failure, Chronic/complications ; Proteinuria/complications ; Glomerular Filtration Rate
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad163
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  8. Article: 20-year longitudinal follow-up of measured and estimated glomerular filtration rate in kidney transplant patients.

    Pottel, Hans / Delay, Agnès / Maillard, Nicolas / Mariat, Christophe / Delanaye, Pierre

    Clinical kidney journal

    2020  Volume 14, Issue 3, Page(s) 909–916

    Abstract: Background: The slopes of estimated glomerular filtration rate (eGFR) equations are used in the longitudinal follow-up of transplant patients. A 30% reduction in eGFR over 2 years is often used to predict the subsequent risk of mortality or end-stage ... ...

    Abstract Background: The slopes of estimated glomerular filtration rate (eGFR) equations are used in the longitudinal follow-up of transplant patients. A 30% reduction in eGFR over 2 years is often used to predict the subsequent risk of mortality or end-stage renal disease. Whether, at the individual level, such changes in eGFR correspond to changes in measured GFR (mGFR) is actually unknown.
    Methods: The performance of serum creatinine-based eGFR equations was compared with mGFR during the longitudinal follow-up of 20 years in a monocentric study of 417 transplanted patients.
    Results: The accuracy within 30% for the eGFR equations varied between 70 and 75%. All eGFR equations showed a similar pattern, very like the mGFR time profiles. Individual changes (slopes) of mGFR or eGFR were predictive of graft loss in the next months or years, following the decline in GFR, with no evidence for a difference. However, although the tendency is the same as for mGFR, the percentage of transplant patients with a >30% GFR decrease in the last period before graft loss is significantly lower for eGFR than for mGFR, with discordant results from mGFR in ~25% of the cases.
    Conclusions: All eGFR equations showed similar trends as mGFR, but eGFR predictions may not be very useful at the individual patient level.
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfaa034
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  9. Article ; Online: Dose and efficacy of repeated administrations of digoxin-specific antibody fragments: Case report of foxglove poisoning.

    Rouault, Elise / Ghnassia, Corinne / Filippi-Codaccioni, Emmanuelle / Maillard, Nicolas

    Basic & clinical pharmacology & toxicology

    2020  Volume 128, Issue 1, Page(s) 183–186

    MeSH term(s) Aged ; Digitalis/poisoning ; Dose-Response Relationship, Drug ; Female ; Humans ; Immunoglobulin Fab Fragments/administration & dosage ; Plant Poisoning/drug therapy ; Treatment Outcome
    Chemical Substances Immunoglobulin Fab Fragments ; digoxin antibodies Fab fragments
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13473
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  10. Article ; Online: Relevance of Anti-HLA Antibody Strength Underestimation in Single Antigen Bead Assay for Shared Eplets.

    Claisse, Guillaume / Devriese, Magali / Lion, Julien / Maillard, Nicolas / Caillat-Zucman, Sophie / Mooney, Nuala / Taupin, Jean Luc

    Transplantation

    2022  Volume 106, Issue 12, Page(s) 2456–2461

    Abstract: Background: HLAs contain combinations of multiple eplets, sometimes shared between numerous HLA alleles. Some authors suggested that single antigen bead (SAB) assays may underestimate the signal of anti-HLA antibodies (Ab) when several beads share the ... ...

    Abstract Background: HLAs contain combinations of multiple eplets, sometimes shared between numerous HLA alleles. Some authors suggested that single antigen bead (SAB) assays may underestimate the signal of anti-HLA antibodies (Ab) when several beads share the targeted eplet. However, this assumption has not yet been validated experimentally.
    Methods: We selected 5 eplets shared by 1-24 beads of the routine SAB kits: the eplet 163LS/G; the 3 eplets 127K, 62GE, and 62GRN thereafter called cross-reactive group 2C; the 82LR eplet, well-known as Bw4; the locally called QB2A5 eplet associated with the DQA1*05:01/DQB1*02:01 combination; and the 40GR DQ eplet. We selected a dozen of sera for each eplet with Ab mean fluorescence intensity (MFI) between 1000 and 15 000 for the beads carrying the targeted eplet. We tested them with the classical SAB panel (SABp), with an isolated bead carrying the eplet (isolated SAB [SABi]) and with a mixture of both (SABp+i).
    Results: No significant difference in MFI was detected among SABi, SABp, and SABp+i conditions for all the eplets.
    Conclusions: We noticed only a nonsignificant difference in the Ab MFI signal due to eplet sharing on the SAB assay. We, therefore, conclude that this phenomenon should no longer be considered as a significant risk factor during patient follow-up pre- or posttransplantation.
    MeSH term(s) Humans ; HLA Antigens ; Antilymphocyte Serum ; Histocompatibility Testing ; Isoantibodies ; Graft Rejection/diagnosis ; Graft Rejection/prevention & control
    Chemical Substances HLA Antigens ; Antilymphocyte Serum ; Isoantibodies
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004247
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