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Article ; Online: Psychotic pregnancy denial: a review of the literature and its clinical considerations.

Chase, Tess / Shah, Akash / Maines, Jaimie / Fusick, Adam

Journal of psychosomatic obstetrics and gynaecology

2020 Volume 42, Issue 3, Page(s) 253–257

Abstract: Background: Pregnancy denial can be broken into two major types, non-psychotic and psychotic deniers, and further classified into pervasive, affective and persistent sub-types. It can lead to increased morbidity and mortality of the mother and neonate. ... ...

Abstract	Background: Pregnancy denial can be broken into two major types, non-psychotic and psychotic deniers, and further classified into pervasive, affective and persistent sub-types. It can lead to increased morbidity and mortality of the mother and neonate. Psychotic pregnancy denial is rare and the medical literature existing on the subject is limited to a small number of case reports and case series. No formal recommendation exists on the clinical management of psychotic pregnancy denial in the antenatal or postpartum period. The authors provide a comprehensive review of the literature regarding psychotic pregnancy denial, present an example of an unpublished case and provide suggestions for clinical management. Case: A 33-year-old primigravida at 37 6/7 weeks gestation presented with new-onset psychotic pregnancy denial with no prior history of psychosis. She had a negative medical work-up for organic causes of psychosis. Using a multidisciplinary approach, the decision was made to deliver the fetus at 38 1/7 weeks Conclusion: Psychotic pregnancy denial is rare and potentially dangerous. Delivery prior to 39 weeks gestation is reasonable for worsening psychiatric disease but careful consideration of the risk-benefit analysis and ethical framework must be deliberated.
MeSH term(s)	Adult ; Cesarean Section ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Mental Disorders ; Pregnancy ; Pregnancy Complications/therapy ; Psychotic Disorders/therapy
Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604816-x
ISSN	1743-8942 ; 0167-482X
ISSN (online)	1743-8942
ISSN	0167-482X
DOI	10.1080/0167482X.2020.1789584
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Article ; Online: Comparative levels of carbonyl delivery between mass-market cigars and cigarettes.

Jablonski, Joseph J / Maines, J Hunter / Cheetham, Andrew G / Gillman, I Gene

Regulatory toxicology and pharmacology : RTP

2019 Volume 108, Page(s) 104453

Abstract: The recent 2016 deeming of cigars by the US Food and Drug Administration (FDA) has led to increased interest in cigar science, including ways to accurately measure the harmful and potentially harmful constituents (HPHCs) found within mainstream cigar ... ...

Abstract	The recent 2016 deeming of cigars by the US Food and Drug Administration (FDA) has led to increased interest in cigar science, including ways to accurately measure the harmful and potentially harmful constituents (HPHCs) found within mainstream cigar smoke. At present, there are standardized methods for evaluating HPHCs in mainstream cigarette smoke but none specific to cigar analysis except for nicotine and carbon monoxide. This study sought to analyze carbonyl delivery in marketed cigars and cigarillos and compare them against levels found in cigarettes. To accomplish this the standard cigarette method, CORESTA recommended method 74 (CRM-74), was optimized for cigar smoking including an evaluation of the trapping efficiency and the stability of the carbonyl-hydrazone adducts due to the increased smoke time required for cigar collection. On a per product basis, carbonyl delivery from cigars smoked under CRM-64 conditions was found to yield similar levels of formaldehyde and greater levels of acetaldehyde, acrolein and crotonaldehyde than measured in mainstream cigarette smoke collected under conditions prescribed under ISO standard 3308. Furthermore, on a per product basis, cigarettes smoked under the ISO 20778 intense smoking regime delivered higher levels of formaldehyde, acrolein and crotonaldehyde as compared to cigars smoked under the CORESTA regime, while acetaldehyde was found to be higher in mainstream cigar smoke. Given the recent deeming, this work expands upon previously reported work, limited in scope by either number of products or analytes reported, through the analysis of carbonyl delivery found in the mainstream smoke for 12 brands of cigars and cigarillos.
MeSH term(s)	Aldehydes/analysis ; Cigar Smoking ; Cigarette Smoking ; Inhalation Exposure ; Smoke/analysis ; Tobacco Products
Chemical Substances	Aldehydes ; Smoke
Language	English
Publishing date	2019-08-29
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2019.104453
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Zs.A 1711: Show issues

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Article: Just a mirage: heterotopic intrauterine and twin ectopic pregnancy mimicked by mirror imaging on ultrasound.

Ahmed, Rimsha / Samardzic, Dejan / Santos, Michael A / Mesina, Anna / Maines, Jaimie

Radiology case reports

2017 Volume 12, Issue 2, Page(s) 422–426

Abstract: Heterotopic pregnancies are rare and are usually diagnosed by transvaginal ultrasound. Despite the routine use of sonography in early pregnancy, artifact created by mirror imaging can drastically and erroneously alter medical decision making by ... ...

Abstract	Heterotopic pregnancies are rare and are usually diagnosed by transvaginal ultrasound. Despite the routine use of sonography in early pregnancy, artifact created by mirror imaging can drastically and erroneously alter medical decision making by interfering with image interpretation. A heterotopic pregnancy with a single intrauterine gestation and twin left adnexal ectopic gestational sacs was observed on ultrasound in a woman presenting with abdominal pain. During laparoscopy, an ectopic pregnancy was not identified, and subsequent intraoperative ultrasound reproduced the heterotopic pregnancy through manipulation of bowel, confirming mirror image artifact. This phenomenon is rarely seen in obstetric imaging; therefore, lack of awareness can lead to false diagnosis of heterotopic pregnancy. Techniques to verify correct diagnosis should be used to resolve potential mirror artifact before proceeding with surgical management.
Language	English
Publishing date	2017-04-08
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2017.03.009
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Article: Regulation and execution of meiosis in Drosophila males.

Maines, J / Wasserman, S

Current topics in developmental biology

1998 Volume 37, Page(s) 301–332

Abstract: In this chapter we review the regulation and execution of the meiotic cell divisions in the context of the developmental program that comprises Drosophila spermatogenesis. Male germ line cells undergoing meiosis are readily identifiable and are of a size ...

Abstract	In this chapter we review the regulation and execution of the meiotic cell divisions in the context of the developmental program that comprises Drosophila spermatogenesis. Male germ line cells undergoing meiosis are readily identifiable and are of a size and abundance that makes this system well suited for morphological characterizations of cell division. Furthermore, a wide range of molecular genetic techniques are available, facilitating mechanistic investigations. We present an overview of key stages in spermatogenesis and, in particular, meiosis. We consider the pathways controlling entry into the meiotic divisions in the context of established cell cycle regulators as well as newly identified loci required for meiotic entry. We then review the assembly and function of both the meiotic spindle and the contractile ring. We conclude with a consideration of questions and problems that await further investigation.
MeSH term(s)	Animals ; Cell Cycle/physiology ; Cell Differentiation/physiology ; Cell Division/physiology ; Drosophila/physiology ; Male ; Meiosis/physiology ; Mutation ; Spermatogenesis/physiology ; Spindle Apparatus/physiology
Language	English
Publishing date	1998
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/s0070-2153(08)60178-7
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Article: DINAMAP blood pressure monitor.

Maines, J G

The Journal of family practice

1988 Volume 27, Issue 4, Page(s) 357, 360

MeSH term(s)	Blood Pressure Determination/instrumentation ; Humans ; Monitoring, Physiologic/instrumentation
Language	English
Publishing date	1988-10
Publishing country	United States
Document type	Letter
ZDB-ID	197883-4
ISSN	0094-3509
ISSN	0094-3509
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Zs.A 1274: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 444: Show issues

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Article: Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule.

Maines, J Z / Wasserman, S A

Nature cell biology

1999 Volume 1, Issue 3, Page(s) 171–174

Abstract: Boule, a Drosophila orthologue of the vertebrate Dazl fertility factors, is a testis-specific regulator of meiotic entry and germline differentiation. Mutations inactivating either Boule, which is an RNA-binding protein, or Twine, which is a Cdc25-type ... ...

Abstract	Boule, a Drosophila orthologue of the vertebrate Dazl fertility factors, is a testis-specific regulator of meiotic entry and germline differentiation. Mutations inactivating either Boule, which is an RNA-binding protein, or Twine, which is a Cdc25-type phosphatase, block meiotic entry in males. Here we show that twine and boule interact genetically. We also find that protein expression from twine messenger RNA correlates with cytoplasmic accumulation of Boule and is markedly reduced by boule mutations. Remarkably, heterologous expression of Twine rescues the boule meiotic-entry defect, indicating that the essential function of Boule at the transition from G2 to M phase during meiosis is in the control of Twine translation.
MeSH term(s)	Animals ; Cell Cycle ; Centrosome/physiology ; Centrosome/ultrastructure ; Deleted in Azoospermia 1 Protein ; Drosophila/physiology ; Drosophila Proteins ; Insect Proteins/metabolism ; Male ; Meiosis ; Oligospermia ; Protein Tyrosine Phosphatases/metabolism ; Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Spermatocytes/cytology ; Testis/physiology ; beta-Galactosidase/analysis ; beta-Galactosidase/genetics
Chemical Substances	DAZ1 protein, human ; DAZL protein, human ; Deleted in Azoospermia 1 Protein ; Drosophila Proteins ; Insect Proteins ; Proteins ; RNA-Binding Proteins ; bol protein, Drosophila ; twe protein, Drosophila ; Protein Tyrosine Phosphatases (EC 3.1.3.48) ; beta-Galactosidase (EC 3.2.1.23)
Language	English
Publishing date	1999-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/11091
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.

Lahoz, Agustín / Vilà, Maya R / Fabre, Myriam / Miquel, Josep M / Rivas, Manuel / Maines, Jessica / Castell, José V / Gómez-Lechón, M José

Toxicology in vitro : an international journal published in association with BIBRA

2013 Volume 27, Issue 4, Page(s) 1410–1415

Abstract: Many adverse drug reactions leading to hepatotoxicity are caused by the cytochrome P450-dependent activation of non-toxic drugs or chemicals into reactive metabolites. To this end, adenoviruses were used as a tool to efficiently deliver specific CYP ... ...

Abstract	Many adverse drug reactions leading to hepatotoxicity are caused by the cytochrome P450-dependent activation of non-toxic drugs or chemicals into reactive metabolites. To this end, adenoviruses were used as a tool to efficiently deliver specific CYP genes into cultured cells (i.e., human hepatoma cell line HepG2). Recombinant-defective adenoviral vectors encoding for genes CYP3A4 (Adv-CYP3A4), CYP2E1 (Adv-CYP2E1), CYP2A6 (Adv-CYP2A6) and CYP1A2 (Adv-CYP1A2) were used to confer specific CYP drug metabolic capabilities to HepG2 cells. Upgraded cells transiently expressed single specific cytochrome P450 enzymatic activities in terms of the number of the infecting virus particles used in their transduction. HepG2 cells transduced with adenoviruses and wild HepG2 cells cultured in 96 well-plates were incubated in the presence of model compounds, some of which can be metabolized to reactive metabolites. After compound exposure, cell viability was assessed by the commonly used MTT assay. The results confirm that the cell-based assay is a valuable tool in toxicology assessments and high-throughput screenings to detect cytotoxicity mediated by cytochrome P450 biotransformation in preclinical drug development. The assay also has a potential applicability in other industrial sectors such as the chemical industry.
MeSH term(s)	Adenoviridae/genetics ; Biotransformation ; Cell Survival ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Genetic Vectors ; Hep G2 Cells ; Humans ; Pharmaceutical Preparations/metabolism ; Toxicity Tests, Acute/methods ; Transduction, Genetic
Chemical Substances	Pharmaceutical Preparations ; Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2012.08.001
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Zs.A 2223: Show issues

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Article ; Online: A multi-center randomized trial of two different intravenous fluids during labor.

Dapuzzo-Argiriou, Lisa M / Smulian, John C / Rochon, Meredith L / Galdi, Luisa / Kissling, Jessika M / Schnatz, Peter F / Gonzalez Rios, Angel / Airoldi, James / Carrillo, Mary Anne / Maines, Jaimie / Kunselman, Allen R / Repke, John / Legro, Richard S

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2016 Volume 29, Issue 2, Page(s) 191–196

Abstract: Objective: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.: Methods: This was a multi-center, prospective, single (patient) blind, ... ...

Abstract	Objective: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor. Methods: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications. Results: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications. Conclusions: The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.
MeSH term(s)	Adult ; Cesarean Section/statistics & numerical data ; Female ; Glucose/administration & dosage ; Humans ; Infant, Newborn ; Isotonic Solutions ; Labor, Obstetric ; Male ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; Young Adult
Chemical Substances	Isotonic Solutions ; Ringer's lactate (8022-63-7) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2016
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.3109/14767058.2014.998190
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Article: Cytotoxic effects of activated bromine on human fetal osteoblasts in vitro.

Maines, Jason / Khurana, Neerja R / Roman, Karla / Knaup, Deborah / Ahmad, Mansur

Journal of endodontics

2006 Volume 32, Issue 9, Page(s) 886–889

Abstract: Although sodium hypochlorite is routinely used as an irrigant, the scope and limitation of another hypohalide sodium hypobromite has not been adequately studied. The objective of this study was to compare the cytotoxic effects of sodium hypobromite and ... ...

Abstract	Although sodium hypochlorite is routinely used as an irrigant, the scope and limitation of another hypohalide sodium hypobromite has not been adequately studied. The objective of this study was to compare the cytotoxic effects of sodium hypobromite and sodium hypochlorite on human osteoblasts by evaluating cell proliferation. One day after plating and every other day after that, cells were treated with a combination of sodium hypochlorite and sodium bromide, resulting into three molar ratios of activated sodium hypobromite. Positive control cells were not treated with hypohalides, while negative controls were separately treated with hypochlorite or bromide alone. Photomicrographic analysis of the cultures was done on days 1 and 6 of treatment. Trypsinized cells were counted to determine cell proliferation. Our results show that sodium bromide is more cytotoxic compared to sodium hypochlorite or activated sodium hypobromite. In activated sodium hypobromite, 4:1 molar ratio was less cytotoxic compared to other molar ratios.
MeSH term(s)	Analysis of Variance ; Bromates/toxicity ; Bromides/toxicity ; Cell Proliferation/drug effects ; Cells, Cultured ; Fetus/cytology ; Humans ; Osteoblasts/drug effects ; Root Canal Irrigants/toxicity ; Sodium Compounds/toxicity ; Sodium Hypochlorite/toxicity ; Statistics, Nonparametric
Chemical Substances	Bromates ; Bromides ; Root Canal Irrigants ; Sodium Compounds ; Sodium Hypochlorite (DY38VHM5OD) ; hypobromous acid (GHT9BV419J) ; sodium bromide (LC1V549NOM)
Language	English
Publishing date	2006-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2006.03.006
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Article: Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.

Cheng, M H / Maines, J Z / Wasserman, S A

Developmental biology

1998 Volume 204, Issue 2, Page(s) 567–576

Abstract: The Drosophila boule gene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes. Mutation of boule blocks ... ...

Abstract	The Drosophila boule gene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes. Mutation of boule blocks both meiotic divisions. Differentiation nonetheless continues, resulting in tetraploid spermatids that fail to mature into sperm. We have found that Boule localizes premeiotically to a perinucleolar region and then translocates to the cytoplasm at the onset of meiosis. We show that deletion of the Y chromosome ks-1 fertility locus eliminates Boule nuclear localization, although it does not perturb entry into meiosis. Based on these observations we propose that Boule acts in the cytoplasm to regulate the stability or translation of messenger RNA encoding an essential meiotic factor.
MeSH term(s)	Animals ; Deleted in Azoospermia 1 Protein ; Drosophila/cytology ; Drosophila/physiology ; Drosophila Proteins ; Fluorescent Antibody Technique, Indirect ; Male ; RNA-Binding Proteins/analysis ; RNA-Binding Proteins/physiology ; Spermatogenesis
Chemical Substances	DAZ1 protein, human ; Deleted in Azoospermia 1 Protein ; Drosophila Proteins ; RNA-Binding Proteins ; bol protein, Drosophila
Language	English
Publishing date	1998-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1006/dbio.1998.9098
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