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Article: Vitamine D et grossesse.

Eggel-Hort, Béatrice / Maisonneuve, Emeline / Gonzalez Rodriguez, Elena / Baud, David

2021 Volume 17, Issue 755, Page(s) 1774–1778

Abstract: Vitamin D deficiency affects more than half of the general population. During pregnancy vitamin D insufficiency is associated with a higher risk of complications such as an increased incidence of miscarriages. Preterm delivery, preeclampsia, gestational ... ...

Title translation	Vitamin D and pregnancy.
Abstract	Vitamin D deficiency affects more than half of the general population. During pregnancy vitamin D insufficiency is associated with a higher risk of complications such as an increased incidence of miscarriages. Preterm delivery, preeclampsia, gestational diabetes, growth retardation and low birth weight as well as postpartum hemorrhage are all pathologies whose incidence seems to be increased with hypovitaminosis D. This could be linked to the pregnancy changes of the immune system, on which vitamin D plays a well-known modulating role. Substitution, even if its benefit is not clearly established, should be considered as there are no side effects. Although lack of evidence regarding the timing of the introduction of treatment, substitution may be proposed before conception.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications/epidemiology ; Premature Birth/epidemiology ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	French
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Subamniotic Haemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia.

Maisonneuve, Emeline / Winer, Norbert / Debarge, Véronique / Fuchs, Florent / Makowski, Caroline / Petermann, Rachel / Bertrand, Gérald

Fetal diagnosis and therapy

2022 Volume 49, Issue 7-8, Page(s) 368–382

MeSH term(s)	Infant, Newborn ; Humans ; Pregnancy ; Female ; Thrombocytopenia, Neonatal Alloimmune/diagnosis ; Thrombocytopenia, Neonatal Alloimmune/therapy ; Antigens, Human Platelet ; Maternal-Fetal Exchange ; Fetus ; Hemorrhage
Chemical Substances	Antigens, Human Platelet
Language	English
Publishing date	2022-08-15
Publishing country	Switzerland
Document type	Letter
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000526505
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Article ; Online: Management of fetal and neonatal alloimmunization thrombocytopenia: About the Francophone working group on fetomaternal platelet alloimmunization.

Winer, Norbert / Maisonneuve, Emeline / Debarge, Veronique / Levine, Emmanuelle / Taillefer, Catherine / Petermann, Rachel / Bertrand, Gerald

Journal of gynecology obstetrics and human reproduction

2022 Volume 51, Issue 4, Page(s) 102345

MeSH term(s)	Blood Platelets ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Thrombocytopenia, Neonatal Alloimmune/therapy
Language	English
Publishing date	2022-02-24
Publishing country	France
Document type	Letter
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2022.102345
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Article ; Online: Clinical Chorioamnionitis and Neurodevelopment at 5 Years of Age in Children Born Preterm: The EPIPAGE-2 Cohort Study.

Salmon, Fanny / Kayem, Gilles / Maisonneuve, Emeline / Foix-L'Hélias, Laurence / Benhammou, Valérie / Kaminski, Monique / Marchand-Martin, Laetitia / Kana, Gildas / Subtil, Damien / Lorthe, Elsa / Ancel, Pierre-Yves / Letouzey, Mathilde

The Journal of pediatrics

2024 Volume 267, Page(s) 113921

Abstract: Objective: To assess the association between clinical chorioamnionitis and neurodevelopmental disorders at 5 years of age in children born preterm.: Study design: EPIPAGE 2 is a national, population-based cohort study of children born before 35 weeks ...

Abstract	Objective: To assess the association between clinical chorioamnionitis and neurodevelopmental disorders at 5 years of age in children born preterm. Study design: EPIPAGE 2 is a national, population-based cohort study of children born before 35 weeks of gestation in France in 2011. We included infants born alive between 24 Results: Among 2927 children alive at 5 years of age, 124 (3%) were born in a context of clinical chorioamnionitis. Overall, 8.2% and 9.6% of children exposed and unexposed, respectively, to clinical chorioamnionitis had moderate-to-severe neurodevelopmental disorders. After multiple imputations and multivariable analysis, clinical chorioamnionitis was not associated with the occurrence of moderate-to-severe neurodevelopmental disorders (aOR, 0.9; 95% CI, 0.5-1.8). Conclusions: We did not find any association between clinical chorioamnionitis and neurodevelopmental disorders at 5 years of age in children born at <35 weeks of gestation after preterm labor or preterm premature rupture of membrane.
MeSH term(s)	Infant, Newborn ; Infant ; Pregnancy ; Child ; Female ; Humans ; Aged, 80 and over ; Chorioamnionitis/epidemiology ; Cohort Studies ; Gestational Age ; Premature Birth ; Tachycardia ; Fetal Membranes, Premature Rupture/epidemiology
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2024.113921
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Article ; Online: Intravenous Immunoglobulin for the Treatment of Severe Maternal Alloimmunization: Individual Patient Data Meta-Analysis.

Mustafa, Hiba J / Sambatur, Enaja V / Pagani, Giorgio / D'Antonio, Francesco / Maisonneuve, Emeline / Maurice, Paul / Zwiers, Carolien / Verweij, E J T Joanne / Flood, Anna / Shamshirsaz, Alireza A / Jouannic, Jean-Marie / Khalil, Asma

American journal of obstetrics and gynecology

2024

Abstract: Objective: To investigate the outcomes associated with the administration of maternal intravenous immunoglobulin (IVIG) in high-risk red blood cell (RBC) alloimmunized pregnancies.: Data sources: We systematically searched Medline, Embase, and ... ...

Abstract	Objective: To investigate the outcomes associated with the administration of maternal intravenous immunoglobulin (IVIG) in high-risk red blood cell (RBC) alloimmunized pregnancies. Data sources: We systematically searched Medline, Embase, and Cochrane Library until June 2023. Study eligibility criteria: We included studies reporting on pregnancies with severe RBC alloimmunization, defined as either a previous fetal or neonatal death or the need for IUT before 24 weeks in the previous pregnancy as a result of hemolytic disease of fetus and newborn (HDFN). Study appraisal and synthesis methods: Cases were pregnancies that received IVIG, while controls did not. Individual patient data (IPD) meta-analysis was performed using the Bayesian framework. Results: IPD analysis included eight studies comprising 97 cases and 97 controls. IVIG was associated with prolonged delta GA at first IUT (GA of current pregnancy - GA at prior pregnancy) (Mean Difference (MD): 3.19 weeks, 95% CrI 1.28, 5.05), prolonged GA at first IUT (MD: 1.32 weeks, 95% CrI 0.08, 2.5), reduced risk of fetal hydrops at time of first IUT (Incidence Rate Ratio (IRR): 0.19, 95% CrI 0.07, 0.45), reduced risk of fetal demise (IRR: 0.23, 95% CrI 0.10, 0.47), higher chances of live birth ≥28 weeks, ≥32 weeks, and survival at birth (IRR: 1.88, 95% CrI 1.31, 2.69; IRR: 1.93, 95% CrI 1.32, 2.83; IRR: 1.82, 9% CrI 1.30 to 2.61, respectively). There were no significant differences in numbers of IUT, hemoglobin level at birth, bilirubin level at birth, or survival at hospital discharge for live births. Conclusion: IVIG treatment in pregnancies at risk of severe early HDFN seems to have a clinically relevant beneficial effect on the course and severity of the disease.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2024.03.044
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Article ; Online: Description of a late miscarriage case at 16 Weeks of Gestation associated with a SARS-CoV-2 infection.

Michel, Anne-Sophie / De Logiviere, Victoire / Schnuriger, Aurélie / Lefebvre, Mathilde / Maisonneuve, Emeline / Kayem, Gilles

Journal of gynecology obstetrics and human reproduction

2021 Volume 50, Issue 3, Page(s) 102064

Abstract: Background: Data about obstetric complications of maternal infection by SARS-CoV-2 remain sparse.: Case: A 40-year-old pregnant woman, gravida 3 para 1 with no previous obstetric complications, presented a late miscarriage at 16 weeks of gestation on ...

Abstract	Background: Data about obstetric complications of maternal infection by SARS-CoV-2 remain sparse. Case: A 40-year-old pregnant woman, gravida 3 para 1 with no previous obstetric complications, presented a late miscarriage at 16 weeks of gestation on day 9 of COVID-19 disease. The results of her nasopharyngeal swab for SARS-CoV-2, tested the same day, were negative, but the placenta was infected by SARS-CoV-2 and serology was positive 11 days later. No other obstetric or infectious cause was found to explain this outcome. Conclusion: This case strongly suggests that SARS-CoV-2 may lead to a late miscarriage.
MeSH term(s)	Abortion, Spontaneous/virology ; Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Serological Testing ; COVID-19 Testing/methods ; Female ; Fetus/virology ; Gestational Age ; Humans ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-01-13
Publishing country	France
Document type	Case Reports
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2021.102064
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Article ; Online: Prenatal management of fetal anemia due to pyruvate kinase deficiency: A case report.

Maisonneuve, Emeline / Sohier Lepine, Marlène / Maurice, Paul / Pissard, Serge / Lafon, Bertrand / Mailloux, Agnès / Dhombres, Ferdinand / Leverger, Guy / Jouannic, Jean-Marie

Transfusion

2022 Volume 63, Issue 1, Page(s) 257–262

Abstract: Background: Pyruvate Kinase (PK) deficiency is the most common enzyme defect of glycolysis, leading to congenital hemolytic anemia, which can occur during the neonatal period.: Study design and methods: We report the prenatal management of fetal ... ...

Abstract	Background: Pyruvate Kinase (PK) deficiency is the most common enzyme defect of glycolysis, leading to congenital hemolytic anemia, which can occur during the neonatal period. Study design and methods: We report the prenatal management of fetal anemia related to PK deficiency in a family with a severe proband. Results: The couple had a first child born with hydrops, whose PK deficiency was diagnosed at 18 months of life. He was treated with allogeneic bone marrow transplantation. The second child was free from disease. For the third pregnancy, the amniocentesis revealed a PK deficiency. Weekly ultrasound monitoring of the middle cerebral artery velocity allowed the detection of severe fetal anemia. Two intrauterine red blood cell transfusions (IUTs) were performed, raising the fetal hemoglobin from 6.6 to 14.5 g/dl at 28 weeks' gestation and from 8.9 to 15.3 g/dl at 31 weeks. A hematopoietic stem cell allograft was discussed prenatally but not chosen, as it would not have significantly changed the perinatal prognosis. The patient delivered a 2730 g girl at 37 weeks, with hemoglobin of 13.6 g/dl. The child presented with neonatal jaundice treated with phototherapy and received postnatal transfusions. Discussion: When a proband is identified in a family, fetal investigation is warranted, to set up third-trimester ultrasound surveillance and perinatal management. In case of fetal severe anemia of unknown etiology, the workup on fetal blood sampling before IUT should comprise the search for erythrocytes enzymopathies, such as PK deficiency. IUTs allow safer full-term delivery in cases with PK deficiency.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Male ; Child ; Female ; Humans ; Pyruvate Kinase ; Blood Transfusion, Intrauterine/adverse effects ; Anemia/etiology ; Anemia/therapy ; Anemia, Hemolytic, Congenital Nonspherocytic/complications ; Anemia, Hemolytic, Congenital Nonspherocytic/therapy ; Anemia, Hemolytic, Congenital Nonspherocytic/diagnosis ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/therapy
Chemical Substances	Pyruvate Kinase (EC 2.7.1.40)
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.17177
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Article ; Online: Determinants of Vaccination and Willingness to Vaccinate against COVID-19 among Pregnant and Postpartum Women during the Third Wave of the Pandemic: A European Multinational Cross-Sectional Survey.

Maisonneuve, Emeline / Gerbier, Eva / Tauqeer, Fatima / Pomar, Léo / Favre, Guillaume / Winterfeld, Ursula / Passier, Anneke / Oliver, Alison / Baud, David / Nordeng, Hedvig / Ceulemans, Michael / Panchaud, Alice

Viruses

2023 Volume 15, Issue 5

Abstract: With COVID-19 vaccination hesitancy at around 50% in the obstetric population, it is critical to identify which women should be addressed and how. Our study aimed to assess COVID-19 vaccination willingness among pregnant and postpartum women in Europe ... ...

Abstract	With COVID-19 vaccination hesitancy at around 50% in the obstetric population, it is critical to identify which women should be addressed and how. Our study aimed to assess COVID-19 vaccination willingness among pregnant and postpartum women in Europe and to investigate associated determinants. This study was a cross-sectional, web-based survey conducted in Belgium, Norway, Switzerland, The Netherlands, and United Kingdom (UK) in June-August 2021. Among 3194 pregnant women, the proportions of women vaccinated or willing to be vaccinated ranged from 80.5% in Belgium to 21.5% in Norway. The associated characteristics were country of residence, chronic illness, history of flu vaccine, trimester of pregnancy, belief that COVID-19 is more severe during pregnancy, and belief that the COVID-19 vaccine is effective and safe during pregnancy. Among 1659 postpartum women, the proportions of women vaccinated or willing to be vaccinated ranged from 86.0% in the UK to 58.6% in Switzerland. The associated determinants were country of residence, chronic illness, history of flu vaccine, breastfeeding, and belief that the COVID-19 vaccine is safe during breastfeeding. Vaccine hesitancy in the obstetric population depends on medical history and especially on the opinion that the vaccine is safe and on the country of residence.
MeSH term(s)	Pregnancy ; Humans ; Female ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Pandemics ; Influenza Vaccines ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines
Language	English
Publishing date	2023-04-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051090
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Article: Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020-2022: A Scoping Review.

Maisonneuve, Emeline / de Bruin, Odette / Favre, Guillaume / Goncé, Anna / Donati, Serena / Engjom, Hilde / Hurley, Eimir / Al-Fadel, Nouf / Siiskonen, Satu / Bloemenkamp, Kitty / Nordeng, Hedvig / Sturkenboom, Miriam / Baud, David / Panchaud, Alice

Journal of clinical medicine

2023 Volume 12, Issue 13

Abstract: The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the ... ...

Abstract	The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists' societies in thirteen countries in 2020-2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir-ritonavir and azithromycin. Guidelines for remdesivir differed completely between countries, from compassionate or conditional use to recommendation against. Nirmatrelvir-ritonavir was authorized in Australia and the UK only in research settings and was no longer recommended in the UK at the end of 2022. After initial reluctance to use corticosteroids, the results of the RECOVERY trial have enabled the recommendation of dexamethasone in case of severe COVID-19 since mid-2020. Some societies recommended prescribing tocilizumab to pregnant patients with hypoxia and systemic inflammation from June 2021. Anti-SARS-CoV-2 monoclonal antibodies were authorized at the end of 2021 with conditional use in some countries, and then no longer recommended in Belgium and the USA at the end of 2022. The gradual convergence of the recommendations, although delayed compared to the general population, highlights the importance of the inclusion of pregnant women in clinical trials and of international collaboration to improve the pharmacological treatment of pregnant women with COVID-19.
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12134519
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Article ; Online: Antidiabetic Medication Utilisation before and during Pregnancy in Switzerland between 2012 and 2019: An Administrative Claim Database from the MAMA Cohort.

Gerbier, Eva / Favre, Guillaume / Maisonneuve, Emeline / Ceulemans, Michael / Winterfeld, Ursula / Dao, Kim / Schmid, Christian P R / Jenkinson, Stephen P / Niznik, Bartlomiej / Baud, David / Spoendlin, Julia / Panchaud, Alice

Journal of diabetes research

2023 Volume 2023, Page(s) 4105993

Abstract: Background: The incidence of diabetes mellitus (both pregestational and gestational) is increasing worldwide, and hyperglycemia during pregnancy is associated with adverse pregnancy outcomes. Evidence on the safety and efficacy of metformin during ... ...

Abstract	Background: The incidence of diabetes mellitus (both pregestational and gestational) is increasing worldwide, and hyperglycemia during pregnancy is associated with adverse pregnancy outcomes. Evidence on the safety and efficacy of metformin during pregnancy has accumulated resulting in an increase in its prescription in many reports. Aims: We aimed to determine the prevalence of antidiabetic drug use (insulins and blood glucose-lowering drugs) before and during pregnancy in Switzerland and the changes therein during pregnancy and over time. Methods: We conducted a descriptive study using Swiss health insurance claims (2012-2019). We established the MAMA cohort by identifying deliveries and estimating the last menstrual period. We identified claims for any antidiabetic medication (ADM), insulins, blood glucose-lowering drugs, and individual substances within each class. We defined three groups of pattern use based on timing of dispensation: (1) dispensation of at least one ADM in the prepregnancy period and in or after trimester 2 (T2) (pregestational diabetes); (2) dispensation for the first time in or after T2 (GDM); and (3) dispensation in the prepregnancy period and no dispensation in or after T2 (discontinuers). Within the pregestational diabetes group, we further defined continuers (dispensation for the same group of ADM) and switchers (different ADM group dispensed in the prepregnancy period and in or after T2). Results: MAMA included 104,098 deliveries with a mean maternal age at delivery of 31.7. Antidiabetic dispensations among pregnancies with pregestational and gestational diabetes increased over time. Insulin was the most dispensed medication for both diseases. Between 2017 and 2019, less than 10% of pregnancies treated for pregestational diabetes continued metformin rather than switching to insulin. Metformin was offered to less than 2% of pregnancies to treat gestational diabetes (2017-2019). Conclusion: Despite its position in the guidelines and the attractive alternative that metformin represents to patients who may encounter barriers with insulin therapy, there was reluctance to prescribe it.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetes, Gestational/drug therapy ; Diabetes, Gestational/epidemiology ; Switzerland/epidemiology ; Blood Glucose ; Hypoglycemic Agents/therapeutic use ; Metformin/therapeutic use ; Insulin/therapeutic use ; Pregnancy Outcome ; Glucose
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Metformin (9100L32L2N) ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2023/4105993
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