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  1. Article ; Online: Tear Film Dynamics in Visual Display Terminal Users: A Review of Impact on Goblet Cells, Lacrimal and Meibomian Gland Function.

    Maity, Moumi / Galor, Anat / Basu, Sayan / Singh, Swati

    Seminars in ophthalmology

    2024  , Page(s) 1–14

    Abstract: Purpose: The prevalence of dry eye disease (DED) is rising among visual display terminal (VDT) users, a trend that correlates with the growing use of digital devices. The prevalence of VDT-associated DED is reported based on dry eye questionnaires; ... ...

    Abstract Purpose: The prevalence of dry eye disease (DED) is rising among visual display terminal (VDT) users, a trend that correlates with the growing use of digital devices. The prevalence of VDT-associated DED is reported based on dry eye questionnaires; however, VDT's impact on tear film parameters is less understood.
    Methods: A review of published literature on both the alterations in tear film observed in VDT users and the impact of various interventions on their tear film.
    Results: Most studies show reduction in tear stability as well as reduction in the blink rate. The role of lacrimal gland hypofunction in visual display terminal (VDT) users is a subject of ongoing debate. Schirmer test values typically exceed the 10 mm threshold, suggesting normal tear production, and tear osmolarity remains within normal ranges but VDT users consistently present with lower Schirmer values compared to non-VDT users. The effects on Meibomian glands and mucin levels need more research as the numbers studied are small. Very few studies have analysed mucin levels in VDT users with reports of normal or reduced values. Even asymptomatic users can have tear film instability; hence, the diagnostic criteria need to be formulated and validated. Different interventions such as neurostimulation, blink improving apps, eyelid warming devices, moist goggles, and lubricants have been explored in VDT users but without a control arm and in asymptomatic VDT users in most studies.
    Conclusion: The alterations have been observed on aqueous, lipid and mucin components of the tear film, although the extent of the impact is variable across studies. There is urgent need of well-designed studies for studying the tear film changes and management options for the upcoming lifestyle epidemic in VDT users.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.1080/08820538.2024.2332355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress.

    Balkrishna, Acharya / Sinha, Sandeep / Manik, Moumita / Pandey, Anupam / Maity, Madhulina / Dev, Rishabh / Varshney, Anurag

    Discovery medicine

    2024  Volume 36, Issue 183, Page(s) 799–815

    Abstract: Background: Calcium oxalate monohydrate (COM) forms the most common type of kidney stones observed in clinics, elevated levels of urinary oxalate being the principal risk factor for such an etiology. The objective of the present study was to evaluate ... ...

    Abstract Background: Calcium oxalate monohydrate (COM) forms the most common type of kidney stones observed in clinics, elevated levels of urinary oxalate being the principal risk factor for such an etiology. The objective of the present study was to evaluate the anti-nephrolithiatic effect of herbo-mineral formulation, Lithom.
    Methods: The
    Results: The presence of Lithom during COM crystals synthesis significantly reduced the average crystal area, feret's diameter, and area-perimeter ratio, in a dose-dependent manner. SEM analysis revealed that COM crystals synthesized in the presence of 100 and 300 μg/mL of Lithom exhibited a veritable morphological transition from irregular polygons with sharp edges to smoothened smaller cuboid polygons. UHPLC analysis of Lithom revealed the presence of Trigonelline, Bergenin, Xanthosine, Adenosine, Bohoervinone B, Vanillic acid, and Ellagic acid as key phytoconstituents. In EG-induced SD rats, the Lithom-treated group showed a decrease in elevated urinary oxalate levels, oxidative stress, and renal inflammation. Von Kossa staining of kidney tissue also exhibited a marked reduction in crystal depositions in Lithom-treated groups.
    Conclusion: Taken together, Lithom could be a potential clinical-therapeutic alternative for management of nephrolithiasis.
    MeSH term(s) Animals ; Calcium Oxalate/metabolism ; Calcium Oxalate/chemistry ; Hyperoxaluria/chemically induced ; Hyperoxaluria/metabolism ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Rats ; Disease Models, Animal ; Nephrolithiasis/chemically induced ; Nephrolithiasis/metabolism ; Nephrolithiasis/pathology ; Male ; Crystallization ; Ethylene Glycol/toxicity ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
    Chemical Substances Calcium Oxalate (2612HC57YE) ; Ethylene Glycol (FC72KVT52F) ; Plant Extracts
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415544-5
    ISSN 1944-7930 ; 1944-7930
    ISSN (online) 1944-7930
    ISSN 1944-7930
    DOI 10.24976/Discov.Med.202436183.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of Prebiotic Properties of Galactooligosaccharides Produced by Transgalactosylation Using Partially Purified β-Galactosidase from Enterobacter aerogenes KCTC2190

    Maity, Manisha / Majumdar, Sayari / Bhattacharyya, Dipak K. / Bhowal, Jayati / Das, Ankita / Barui, Ananya

    Appl Biochem Biotechnol. 2023 Apr., v. 195, no. 4 p.2294-2316

    2023  

    Abstract: Transgalactosylation reaction is the penultimate step in the production of galactooligosaccharides (GOSs) which has prominent applications in the treatment of disorders. In the present study, partially purified β-galactosidase from Enterobacter aerogenes ...

    Abstract Transgalactosylation reaction is the penultimate step in the production of galactooligosaccharides (GOSs) which has prominent applications in the treatment of disorders. In the present study, partially purified β-galactosidase from Enterobacter aerogenes KCTC2190 was used for the synthesis of prebiotic GOSs. GOSs were produced using lactose as substrate. Structural elucidation of collected fractions of GOSs by liquid chromatography electrospray ionization mass spectrometry exhibited the appearance of major peaks of produced GOSs at m/z 241.20, 481.39, 365.11, 527.17, and 701.51 respectively. GOSs facilitated the growth of potential probiotic strains (Lactobacillus delbrueckii ssp. helveticus, Bifidobacterium bifidum, and Lactiplantibacillus plantarum) and liberated propionate and butyrate as principal short-chain fatty acids which established its prebiotic potency. Synbiotic combinations exhibited good antioxidant activities. Synbiotic combinations also exhibited antimicrobial activities against pathogenic microorganisms namely Staphylococcus aureus and Escherichia coli. Synbiotic combinations of GOSs and the respective probiotic microorganisms were able to decrease viable human bone cancer cells (MG-63).
    Keywords Bifidobacterium bifidum ; Enterobacter aerogenes ; Escherichia coli ; Lactobacillus delbrueckii ; Staphylococcus aureus ; antioxidants ; butyrates ; electrospray ionization mass spectrometry ; galactooligosaccharides ; humans ; lactose ; liquid chromatography ; prebiotics ; probiotics ; propionic acid
    Language English
    Dates of publication 2023-04
    Size p. 2294-2316.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 392344-7
    ISSN 0273-2289
    ISSN 0273-2289
    DOI 10.1007/s12010-022-04073-6
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Production and immobilization of β-galactosidase isolated from Enterobacter aerogenes KCTC2190 by entrapment method using agar-agar organic matrix.

    Maity, Manisha / Bhattacharyya, Aparupa / Bhowal, Jayati

    Applied biochemistry and biotechnology

    2021  Volume 193, Issue 7, Page(s) 2198–2224

    Abstract: In the present study, Enterobacter aerogenes KCTC2190 was isolated from soil around a cattle shed area, which was capable of producing intracellular β-galactosidase. Partially purified β-galactosidase was immobilized by entrapment method in agar-agar gel ...

    Abstract In the present study, Enterobacter aerogenes KCTC2190 was isolated from soil around a cattle shed area, which was capable of producing intracellular β-galactosidase. Partially purified β-galactosidase was immobilized by entrapment method in agar-agar gel matrix. Agar-agar entrapped beads were prepared by dropping the enzyme-agar solution to ice-cooled toluene-chloroform ((3:1 (v/v)). 45.88±0.11% activity of partially purified β-galactosidase was retained after immobilization (bead shape). Maximum immobilization yield was observed in the presence of 2.5% agar-agar concentration. After immobilization, optimum temperature required for the enzyme-substrate reaction was shifted from 50 to 60 °C and the optimum reaction time was shifted from 15 to 25 min. The optimum pH for both free and immobilized β-galactosidase was pH 7. Free enzyme showed lower activation energy in comparison with the immobilized one. For free as well as immobilized β-galactosidase thermal deactivation, rate constant (k
    MeSH term(s) Agar/chemistry ; Bacterial Proteins/chemistry ; Enterobacter aerogenes/enzymology ; Enzymes, Immobilized/chemistry ; beta-Galactosidase/chemistry
    Chemical Substances Bacterial Proteins ; Enzymes, Immobilized ; Agar (9002-18-0) ; beta-Galactosidase (EC 3.2.1.23)
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-021-03534-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High Electrical Conductivity and Hole Transport in an Insightfully Engineered Columnar Liquid Crystal for Solution-Processable Nanoelectronics.

    De, Ritobrata / Maity, Madhusudan / Joseph, Alvin / Gupta, Santosh Prasad / Nailwal, Yogendra / Namboothiry, Manoj A G / Pal, Santanu Kumar

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2308983

    Abstract: Discotic liquid crystals (DLCs) are widely acknowledged as a class of organic semiconductors that can harmonize charge carrier mobility and device processability through supramolecular self-assembly. In spite of circumventing such a major challenge in ... ...

    Abstract Discotic liquid crystals (DLCs) are widely acknowledged as a class of organic semiconductors that can harmonize charge carrier mobility and device processability through supramolecular self-assembly. In spite of circumventing such a major challenge in fabricating low-cost charge transport layers, DLC-based hole transport layers (HTLs) have remained elusive in modern organo-electronics. In this work, a minimalistic design strategy is envisioned to effectuate a cyanovinylene-integrated pyrene-based discotic liquid crystal (PY-DLC) with a room-temperature columnar hexagonal mesophase and narrow bandgap for efficient semiconducting behavior. Adequately combined photophysical, electrochemical, and theoretical studies investigate the structure-property relations, logically correlating them with efficient hole transport. With a low reorganization energy of 0.2 eV, PY-DLC exhibits superior charge extraction ability from the contact electrodes at low values of applied voltage, achieving an electrical conductivity of 3.22 × 10
    Language English
    Publishing date 2024-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Multifaceted Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on ST-Elevation Myocardial Infarction (STEMI): A Literature Review of Incidence, Treatment Modalities, and Outcomes.

    Choi, Hoi K / Maity, Madhurima / Qureshi, Mohammed / Haider, Ali / Kapadia, Sagar / Fuerte, Sofia / Antony, Simon / Razzaq, Waleed / Akbar, Anum

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57288

    Abstract: The global repercussions of coronavirus disease 2019 (COVID-19) include substantial worldwide mortality and have brought to light existing gaps in healthcare systems. Particularly, diseases requiring time-sensitive treatment, such as ST-elevation ... ...

    Abstract The global repercussions of coronavirus disease 2019 (COVID-19) include substantial worldwide mortality and have brought to light existing gaps in healthcare systems. Particularly, diseases requiring time-sensitive treatment, such as ST-elevation myocardial infarction (STEMI), have faced significant challenges due to the impact and revelations of the COVID-19 pandemic on healthcare infrastructure. This review addresses the impact of the pandemic on STEMI, exploring incidence, treatment modalities, and clinical outcomes. Through a critical examination of existing literature, the intricate relationship between the pandemic and cardiovascular health, specifically STEMI, is elucidated. The COVID-19 pandemic has had a significant impact on the management of STEMI, with changes in hospitalization rates, treatment strategies, and the presentation of the disease posing significant challenges. The contradictory results of COVID-19 and post-vaccine myocardial infarction, as well as gender differences in reported cases, highlight the need for further research to clarify these relationships.
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Opportunistic Fungal Invasion in COVID-19 Pandemic: A Critical Review in Diagnosis and Management.

    Sharma, Abhishek / Bano, Gulnaz / Malik, Abdul / Rasool, Yuman / Manzar, Samrina / Singh, Tarun / Maity, Manish

    Avicenna journal of medicine

    2023  Volume 13, Issue 3, Page(s) 131–137

    Abstract: Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is the culprit behind the pandemic across the globe in recent decades. Variants of SARS-CoV especially coronavirus disease 2019 (COVID-19)-related fungus might not be identified or might be ... ...

    Abstract Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is the culprit behind the pandemic across the globe in recent decades. Variants of SARS-CoV especially coronavirus disease 2019 (COVID-19)-related fungus might not be identified or might be misdiagnosed on a worldwide scale. Patients of COVID-19 acquired invasive mycoses, especially if they are very ill or immunosuppressed. Clinical intervention based on various standard guidelines would be necessary to guarantee that
    Language English
    Publishing date 2023-07-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2664414-9
    ISSN 2249-4464 ; 2231-0770
    ISSN (online) 2249-4464
    ISSN 2231-0770
    DOI 10.1055/s-0043-1770921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tailoring Chiral Discotic Liquid Crystals: Mesophase Engineering through Alternative Approaches and Chain Lengths.

    Maity, Madhusudan / Bala, Indu / Kanakala, Madhu Babu / Gupta, Santosh Prasad / Yelamaggad, C V / Pal, Santanu Kumar

    Chemistry, an Asian journal

    2023  Volume 19, Issue 2, Page(s) e202300936

    Abstract: Hydrogen (H)-bonding is crucial in constructing superstructures in chemical (such as chiral discotic liquid crystals (DLCs)) as well as in biological systems due to its specific and directional nature. In this context, we achieved the successful ... ...

    Abstract Hydrogen (H)-bonding is crucial in constructing superstructures in chemical (such as chiral discotic liquid crystals (DLCs)) as well as in biological systems due to its specific and directional nature. In this context, we achieved the successful synthesis of two branches of heptazine-based H-bonded complexes using distinct strategies. Hpz*-Es-C
    Language English
    Publishing date 2023-12-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Production and immobilization of β-galactosidase isolated from Enterobacter aerogenes KCTC2190 by entrapment method using agar-agar organic matrix

    Maity, Manisha / Bhattacharyya, Aparupa / Bhowal, Jayati

    Applied biochemistry and biotechnology. 2021 July, v. 193, no. 7

    2021  

    Abstract: In the present study, Enterobacter aerogenes KCTC2190 was isolated from soil around a cattle shed area, which was capable of producing intracellular β-galactosidase. Partially purified β-galactosidase was immobilized by entrapment method in agar-agar gel ...

    Abstract In the present study, Enterobacter aerogenes KCTC2190 was isolated from soil around a cattle shed area, which was capable of producing intracellular β-galactosidase. Partially purified β-galactosidase was immobilized by entrapment method in agar-agar gel matrix. Agar-agar entrapped beads were prepared by dropping the enzyme-agar solution to ice-cooled toluene-chloroform ((3:1 (v/v)). 45.88±0.11% activity of partially purified β-galactosidase was retained after immobilization (bead shape). Maximum immobilization yield was observed in the presence of 2.5% agar-agar concentration. After immobilization, optimum temperature required for the enzyme-substrate reaction was shifted from 50 to 60 °C and the optimum reaction time was shifted from 15 to 25 min. The optimum pH for both free and immobilized β-galactosidase was pH 7. Free enzyme showed lower activation energy in comparison with the immobilized one. For free as well as immobilized β-galactosidase thermal deactivation, rate constant (kd) increased with increasing temperature while the values of decimal reduction time (D-values) and half-lives (t₁/₂) decreased. Immobilization process increased the t₁/₂ and D-values of β-galactosidase while it decreased the kd. Thermostability of immobilized β-galactosidase was higher as they showed higher enthalpy (ΔΗ⁰) and Gibb’s free energy (ΔG⁰)value than those of the free β-galactosidase. The negative entropy (ΔS⁰) of free and immobilized β-galactosidase established that both were in a more ordered state within the temperature range (50 to 70 °C) studied. Immobilized β-galactosidase was able to retain 51.65±1.61% of its initial activity after 7 batches of enzyme-substrate reaction. Immobilized β-galactosidase showed 78.09±3.69% of its initial activity even after 40 days of storage at 4 °C.
    Keywords Enterobacter aerogenes ; activation energy ; biotechnology ; cattle ; enthalpy ; entropy ; enzyme substrates ; gels ; half life ; pH ; soil ; thermal stability
    Language English
    Dates of publication 2021-07
    Size p. 2198-2224.
    Publishing place Springer US
    Document type Article
    ZDB-ID 392344-7
    ISSN 0273-2289
    ISSN 0273-2289
    DOI 10.1007/s12010-021-03534-8
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A Self-Assembled Palladium(II) Barrel for Binding of Fullerenes and Photosensitization Ability of the Fullerene-Encapsulated Barrel.

    Purba, Prioti Choudhury / Maity, Manoranjan / Bhattacharyya, Soumalya / Mukherjee, Partha Sarathi

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 25, Page(s) 14109–14116

    Abstract: Fullerene extracts obtained from fullerene soot lack their real application due to their poor solubility in common solvents and difficulty in purification. Encapsulation of these extracts in a suitable host is an important approach to address these ... ...

    Abstract Fullerene extracts obtained from fullerene soot lack their real application due to their poor solubility in common solvents and difficulty in purification. Encapsulation of these extracts in a suitable host is an important approach to address these issues. We present a new Pd
    Language English
    Publishing date 2021-05-14
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202103822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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