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  1. Article ; Online: Locally induced shockwaves for selective perforation of cargo loaded lipid vesicles with temporal and spatial control.

    Derganc, Jure / Zemljič-Jokhadar, Špela / Majaron, Boris / Kokot, Gašper

    RSC advances

    2023  Volume 13, Issue 35, Page(s) 24830–24834

    Abstract: Controlled poration of lipid membranes is crucial for numerous biomimetic applications such as targeted drug delivery. Although several chemical and physical mechanisms have been proposed for the poration of synthetic membranes, achieving good temporal ... ...

    Abstract Controlled poration of lipid membranes is crucial for numerous biomimetic applications such as targeted drug delivery. Although several chemical and physical mechanisms have been proposed for the poration of synthetic membranes, achieving good temporal and spatial control remains a challenge. In this study, we introduce a novel method for membrane poration that utilizes the mechanical shockwave generated by the photo-acoustic effect, which occurs when an optically opaque microparticle is illuminated by a near-infrared laser of optical tweezers. We show that the shockwave effectively porates membranes of giant unilamellar vesicles in close proximity to the microparticle without damaging nearby cells, which is a desirable outcome for potential targeted drug delivery. The poration effect is nonspecific and operates on both liquid and gel phase membranes. Since the photo-acoustic effect can be triggered by standard optical tweezers, this method holds broad applicability in various experimental settings within the field of soft matter research.
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03988a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Objective monitoring of laser tattoo removal in human volunteers using an innovative optical technique: A proof of principle.

    Golmajer Zima, Neža / Verdel, Nina / Lukač, Matjaž / Majaron, Boris

    Lasers in surgery and medicine

    2023  Volume 55, Issue 8, Page(s) 724–733

    Abstract: Objectives: Assess the suitability of the technique for objective monitoring of laser tattoo removal by an extended treatment protocol.: Materials and methods: One half of the tattoo in the first volunteer was treated with nanosecond and the other ... ...

    Abstract Objectives: Assess the suitability of the technique for objective monitoring of laser tattoo removal by an extended treatment protocol.
    Materials and methods: One half of the tattoo in the first volunteer was treated with nanosecond and the other half with picosecond laser pulses at 1064 nm. In the second subject, four test areas were treated repeatedly using different radiant exposures from 1.5 to 6 J/cm
    Results: The results clearly indicate a gradual reduction of the ink content and an increase of the subsurface depth of the tattoo layer with all treatments at a radiant exposure of 3 J/cm
    Conclusions: The presented methodology enables noninvasive characterization of tattoos in human skin and objective monitoring of the laser removal treatment.
    MeSH term(s) Humans ; Healthy Volunteers ; Monte Carlo Method ; Skin ; Tattoo Removal ; Lasers
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.23720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1603: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Noninvasive Monitoring of Dynamical Processes in Bruised Human Skin Using Diffuse Reflectance Spectroscopy and Pulsed Photothermal Radiometry.

    Marin, Ana / Verdel, Nina / Milanič, Matija / Majaron, Boris

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 1

    Abstract: We have augmented a recently introduced method for noninvasive analysis of skin structure and composition and applied it to monitoring of dynamical processes in traumatic bruises. The approach combines diffuse reflectance spectroscopy in visible spectral ...

    Abstract We have augmented a recently introduced method for noninvasive analysis of skin structure and composition and applied it to monitoring of dynamical processes in traumatic bruises. The approach combines diffuse reflectance spectroscopy in visible spectral range and pulsed photothermal radiometry. Data from both techniques are analyzed simultaneously using a numerical model of light and heat transport in a four-layer model of human skin. Compared to the earlier presented approach, the newly introduced elements include two additional chromophores (
    MeSH term(s) Bilirubin/analysis ; Bilirubin/metabolism ; Contusions/diagnosis ; Contusions/metabolism ; Contusions/therapy ; Female ; Humans ; Male ; Oxygen/blood ; Photothermal Therapy ; Pulsed Radiofrequency Treatment ; Radiometry/methods ; Skin/metabolism ; Skin/physiopathology ; Spectrophotometry ; beta Carotene
    Chemical Substances beta Carotene (01YAE03M7J) ; Bilirubin (RFM9X3LJ49) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21010302
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  4. Article: Predictive model for the quantitative analysis of human skin using photothermal radiometry and diffuse reflectance spectroscopy.

    Verdel, Nina / Tanevski, Jovan / Džeroski, Sašo / Majaron, Boris

    Biomedical optics express

    2020  Volume 11, Issue 3, Page(s) 1679–1696

    Abstract: We have recently introduced a novel methodology for the noninvasive analysis of the structure and composition of human ... ...

    Abstract We have recently introduced a novel methodology for the noninvasive analysis of the structure and composition of human skin
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.384982
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  5. Article ; Online: Optimisation of Amphiphilic-Polymer Coatings for Improved Chemical Stability of NaYF4-based Upconverting Nanoparticles.

    Černič, Tina / Koren, Monika / Majaron, Boris / Ponikvar-Svet, Maja / Lisjak, Darja

    Acta chimica Slovenica

    2022  Volume 69, Issue 2, Page(s) 448–457

    Abstract: NaYF4 nanoparticles codoped with Yb3+ and Tm3+ exhibit upconversion fluorescence in near-infrared and visible spectral range. Consequently, such upconverting nanoparticles (UCNPs) can be used as contrast agents in medical diagnostics and bioassays. ... ...

    Abstract NaYF4 nanoparticles codoped with Yb3+ and Tm3+ exhibit upconversion fluorescence in near-infrared and visible spectral range. Consequently, such upconverting nanoparticles (UCNPs) can be used as contrast agents in medical diagnostics and bioassays. However, they are not chemically stable in aqueous dispersions, especially in phosphate solutions. Protective amphiphilic-polymer coatings based on poly(maleic anhydride-alt-octadec-1-ene) (PMAO) and bis(hexamethylene)triamine (BHMT) were optimised to improve the chemical stability of UCNPs under simulated physiological conditions. Morphologies of the bare and coated UCNPs was inspected with transmission electron microscopy. All samples showed intense UC fluorescence at ~800 nm, typical for Tm3+. The colloidal stability of aqueous dispersions of bare and coated UCNPs was assessed by dynamic light scattering and measurements of zeta potential. The dissolution of UCNP in phosphate-buffered saline at 37 °C, was assessed potentiometrically by measuring the concentration of the dissolved fluoride. Protection against the dissolution of UCNPs was achieved by PMAO and PMAO crosslinked with BHMT.
    MeSH term(s) Fluorides ; Nanoparticles ; Phosphates ; Polymers ; Water
    Chemical Substances Fluorides (Q80VPU408O) ; Phosphates ; Polymers ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-06-14
    Publishing country Slovenia
    Document type Journal Article
    ZDB-ID 2029709-9
    ISSN 1580-3155 ; 1318-0207
    ISSN (online) 1580-3155
    ISSN 1318-0207
    DOI 10.17344/acsi.2021.7336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of crystal structure and oxygen vacancies on optical properties of nanostructured multi-stoichiometric tungsten suboxides.

    Višić, Bojana / Pirker, Luka / Opačić, Marko / Milosavljević, Ana / Lazarević, Nenad / Majaron, Boris / Remškar, Maja

    Nanotechnology

    2022  Volume 33, Issue 27

    Abstract: Four distinct tungsten suboxide ( ... ...

    Abstract Four distinct tungsten suboxide (WO
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac6316
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  7. Article: Physiological and structural characterization of human skin in vivo using combined photothermal radiometry and diffuse reflectance spectroscopy.

    Verdel, Nina / Marin, Ana / Milanič, Matija / Majaron, Boris

    Biomedical optics express

    2019  Volume 10, Issue 2, Page(s) 944–960

    Abstract: In this proof-of-concept study we combine two optical techniques to enable assessment of structure and composition of human skin in vivo: Pulsed photothermal radiometry (PPTR), which involves measurements of transient dynamics in mid-infrared emission ... ...

    Abstract In this proof-of-concept study we combine two optical techniques to enable assessment of structure and composition of human skin in vivo: Pulsed photothermal radiometry (PPTR), which involves measurements of transient dynamics in mid-infrared emission from sample surface after exposure to a light pulse, and diffuse reflectance spectroscopy (DRS) in visible part of the spectrum. The analysis involves simultaneous fitting of measured PPTR signals and DRS with corresponding predictions of a Monte Carlo model of light-tissue interaction. By using a four-layer optical model of skin we obtain a good match between the experimental and model data when scattering properties of the epidermis and dermis are also optimized on an individual basis. The assessed parameter values correlate well with literature data and demonstrate the expected trends in controlled tests involving temporary obstruction of peripheral blood circulation using a pressure cuff, and acute as well as seasonal sun tanning.
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.10.000944
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  8. Article ; Online: Deep tissue localization and sensing using optical microcavity probes.

    Kavčič, Aljaž / Garvas, Maja / Marinčič, Matevž / Unger, Katrin / Coclite, Anna Maria / Majaron, Boris / Humar, Matjaž

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1269

    Abstract: Optical microcavities and microlasers were recently introduced as probes inside living cells and tissues. Their main advantages are spectrally narrow emission lines and high sensitivity to the environment. Despite numerous novel methods for optical ... ...

    Abstract Optical microcavities and microlasers were recently introduced as probes inside living cells and tissues. Their main advantages are spectrally narrow emission lines and high sensitivity to the environment. Despite numerous novel methods for optical imaging in strongly scattering biological tissues, imaging at single-cell resolution beyond the ballistic light transport regime remains very challenging. Here, we show that optical microcavity probes embedded inside cells enable three-dimensional localization and tracking of individual cells over extended time periods, as well as sensing of their environment, at depths well beyond the light transport length. This is achieved by utilizing unique spectral features of the whispering-gallery modes, which are unaffected by tissue scattering, absorption, and autofluorescence. In addition, microcavities can be functionalized for simultaneous sensing of various parameters, such as temperature or pH value, which extends their versatility beyond the capabilities of standard fluorescent labels.
    MeSH term(s) Optical Imaging
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28904-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Elimination of single-beam substitution error in diffuse reflectance measurements using an integrating sphere.

    Vidovic, Luka / Majaron, Boris

    Journal of biomedical optics

    2014  Volume 19, Issue 2, Page(s) 27006

    Abstract: Diffuse reflectance spectra (DRS) of biological samples are commonly measured using an integrating sphere (IS). To account for the incident light spectrum, measurement begins by placing a highly reflective white standard against the IS sample opening and ...

    Abstract Diffuse reflectance spectra (DRS) of biological samples are commonly measured using an integrating sphere (IS). To account for the incident light spectrum, measurement begins by placing a highly reflective white standard against the IS sample opening and collecting the reflected light. After replacing the white standard with the test sample of interest, DRS of the latter is determined as the ratio of the two values at each involved wavelength. However, such a substitution may alter the fluence rate inside the IS. This leads to distortion of measured DRS, which is known as single-beam substitution error (SBSE). Barring the use of more complex experimental setups, the literature states that only approximate corrections of the SBSE are possible, e.g., by using look-up tables generated with calibrated low-reflectivity standards. We present a practical method for elimination of SBSE when using IS equipped with an additional reference port. Two additional measurements performed at this port enable a rigorous elimination of SBSE. Our experimental characterization of SBSE is replicated by theoretical derivation. This offers an alternative possibility of computational removal of SBSE based on advance characterization of a specific DRS setup. The influence of SBSE on quantitative analysis of DRS is illustrated in one application example.
    MeSH term(s) Humans ; Light ; Models, Theoretical ; Oxygen/blood ; Signal Processing, Computer-Assisted ; Skin/blood supply ; Skin/chemistry ; Spectrum Analysis/methods
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2014-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.19.2.027006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4699: Show issues Location:
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  10. Article ; Online: NaYF

    Lisjak, Darja / Vozlič, Maša / Kostiv, Uliana / Horák, Daniel / Majaron, Boris / Kralj, Slavko / Zajc, Irena / Žiberna, Lovro / Ponikvar-Svet, Maja

    Methods and applications in fluorescence

    2021  Volume 10, Issue 1

    Abstract: The increasing interest in upconverting nanoparticles (UCNPs) in biodiagnostics and therapy fuels the development of biocompatible UCNPs platforms. UCNPs are typically nanocrystallites of rare-earth fluorides codoped with ... ...

    Abstract The increasing interest in upconverting nanoparticles (UCNPs) in biodiagnostics and therapy fuels the development of biocompatible UCNPs platforms. UCNPs are typically nanocrystallites of rare-earth fluorides codoped with Yb
    MeSH term(s) Endothelial Cells ; Fluorides ; Humans ; Nanoparticles ; Organophosphonates/pharmacology ; Yttrium
    Chemical Substances Organophosphonates ; Yttrium (58784XQC3Y) ; Fluorides (Q80VPU408O)
    Language English
    Publishing date 2021-12-22
    Publishing country England
    Document type Journal Article
    ISSN 2050-6120
    ISSN (online) 2050-6120
    DOI 10.1088/2050-6120/ac41ba
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