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  1. Article ; Online: Pancreatic cystic lesions and the role of contrast enhanced endoscopic ultrasound.

    Hickman, K / Sadler, T J / Zhang, T T / Boninsegna, E / Majcher, V / Godfrey, E

    Clinical radiology

    2022  Volume 77, Issue 6, Page(s) 418–427

    Abstract: An exponential rise in the use of cross-sectional imaging has led to an increase in the incidental identification of pancreatic cystic lesions (PCL); however, with many subtypes defined to date and heterogeneous morphology with often absent defining ... ...

    Abstract An exponential rise in the use of cross-sectional imaging has led to an increase in the incidental identification of pancreatic cystic lesions (PCL); however, with many subtypes defined to date and heterogeneous morphology with often absent defining radiological features, PCLs present a diagnostic challenge. Computed tomography (CT) and/or magnetic resonance imaging (MRI) alone are frequently not sufficient to provide accurate characterisation. Endoscopic ultrasound (EUS) has an important role in the evaluation and classification of PCLs through its ability to define the internal architecture, which is further enhanced by the use of contrast medium. It is also used widely for the surveillance of larger cysts (>2 cm), which are associated with a greater malignant potential. The aim of this review is to demonstrate the role of contrast-enhanced (CE)-EUS in the diagnosis and risk stratification of PCLs. The features of the main non-neoplastic and neoplastic PCLs observed on CE-EUS are provided. When used in combination with other imaging techniques and patient characteristics, CE-EUS offers a more accurate assessment of PCLs and aids risk stratification. Additionally, CE-EUS enables assessment of parenchymal perfusion improving the precision of cyst characterisation and targeted biopsy of worrisome components. The International Consensus Guidelines recommend regular follow up for patients with mucinous or indeterminate PCLs that are fit enough for surgery. With the growing range of tools available to assess PCLs including CE-EUS, it is hoped that patients can be steered towards surgery, surveillance, or discharge with increasing accuracy.
    MeSH term(s) Endosonography ; Humans ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2022.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.201: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Images of the month 2: Pulmonary artery pseudoaneurysm formation within uterine leiomyosarcoma metastases.

    Vaid, Divya / Majcher, Veronika / Heptonstall, Nicholas / Sadler, Timothy J / Winterbottom, Andrew P

    Clinical medicine (London, England)

    2021  Volume 21, Issue 5, Page(s) e533–e534

    Abstract: We present a rare case of pulmonary artery pseudoaneurysm formation in leiomyosarcoma metastases with evidence of acute bleeding and subsequent interventional radiological management. ...

    Abstract We present a rare case of pulmonary artery pseudoaneurysm formation in leiomyosarcoma metastases with evidence of acute bleeding and subsequent interventional radiological management.
    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Female ; Humans ; Leiomyosarcoma ; Middle Aged ; Pulmonary Artery/diagnostic imaging ; Uterine Neoplasms
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5439: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment.

    Gowrishankar, Shravan V / Bidaye, Rohan / Das, Tilak / Majcher, Veronika / Fish, Brian / Casey, Ruth / Masterson, Liam

    Head & neck

    2022  Volume 45, Issue 3, Page(s) 706–720

    Abstract: Intrathyroidal parathyroid adenomas (IPAs) are a rare cause of primary hyperparathyroidism. They are often difficult to localize preoperatively and intraoperatively, making diagnosis and treatment challenging. Current data on IPAs are sparse and ... ...

    Abstract Intrathyroidal parathyroid adenomas (IPAs) are a rare cause of primary hyperparathyroidism. They are often difficult to localize preoperatively and intraoperatively, making diagnosis and treatment challenging. Current data on IPAs are sparse and fragmented in the literature. This makes it difficult to compare the effectiveness of different imaging and surgical techniques. To address this issue, this scoping review maps the literature on IPAs, focusing on four domains: clinical presentation, current localization methods, different surgical techniques, and histopathological features. A search of MEDLINE, Embase, and the Cochrane Library was conducted, with 19 studies meeting the inclusion criteria. The characteristics of IPAs on ultrasound, fine-needle aspiration, CT, MRI, sestamibi-based techniques, and selective venous sampling are summarized. Emerging imaging modalities, including autofluorescence, are introduced. Surgical methods and intraoperative factors that correlate with high success rates for removal are highlighted. This review also identifies gaps in knowledge to guide further research into this area.
    MeSH term(s) Humans ; Parathyroid Neoplasms/diagnostic imaging ; Parathyroid Neoplasms/surgery ; Parathyroid Glands/pathology ; Diagnostic Imaging ; Radiopharmaceuticals ; Ultrasonography ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Adenoma/pathology ; Technetium Tc 99m Sestamibi
    Chemical Substances Radiopharmaceuticals ; Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1493: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Incidental coronary artery calcification on non-gated CT thorax correlates with risk of cardiovascular events and death.

    Wetscherek, Maria T A / McNaughton, Edwina / Majcher, Veronika / Wetscherek, Andreas / Sadler, Timothy J / Alsinbili, Ahmed / Teh, Wen Hui / Moore, Samuel D / Patel, Nirav / Smith, William P W / Krishnan, Unni

    European radiology

    2023  Volume 33, Issue 7, Page(s) 4723–4733

    Abstract: Objectives: To assess coronary artery calcification (CAC) on non-contrast non-ECG-gated CT thorax (NC-NECG-CTT) and to evaluate its correlation with short-term risk of cardiovascular disease (CVD) events and death.: Methods: Single-institution ... ...

    Abstract Objectives: To assess coronary artery calcification (CAC) on non-contrast non-ECG-gated CT thorax (NC-NECG-CTT) and to evaluate its correlation with short-term risk of cardiovascular disease (CVD) events and death.
    Methods: Single-institution retrospective study including all patients 40-70 years old who underwent NC-NECG-CTT over a period of 6 months. Individuals with known CVD were excluded. The presence of CAC was assessed and quantified by the Agatston score (CACS). CAC severity was defined as mild (< 100), moderate (100-400), or severe (> 400). CVD events (including CVD death, myocardial infarction, revascularisation procedures, ischaemic stroke, acute peripheral atherosclerotic ischaemia), and all-cause mortality over a median of 3.5 years were recorded. Cox proportional-hazards regression modelling was performed including CACS, age, gender and CVD risk factors (smoking, hypertension, diabetes mellitus, dyslipidaemia, and family history of CVD).
    Results: Of the total 717 eligible cases, 325 (45%) had CAC. In patients without CAC, there was only one CVD event, compared to 26 CVD events including 5 deaths in patients with CAC. The presence and severity of CAC correlated with CVD events (p < 0.001). A CACS > 100 was significantly associated with both CVD events, hazard ratio (HR) 5.74, 95% confidence interval: 2.19-15.02; p < 0.001, and all-cause mortality, HR 1.7, 95% CI: 1.08-2.66; p = 0.02. Ever-smokers with CAC had a significantly higher risk for all-cause mortality compared to never-smokers (p = 0.03), but smoking status was not an independent predictor for CVD events in any subgroup category of CAC severity.
    Conclusions: The presence and severity of CAC assessed on NC-NECG-CTT correlates with short-term cardiovascular events and death.
    Key points: • Patients aged 40-70 years old without known CVD but with CAC on NC-NECG-CTT have a higher risk of CVD events compared to those without CAC. • CAC (Agatston) score above 100 confers a 5.7-fold increase in the risk of short-term CVD events in these patients. • The presence and severity of CAC on NC-NECG-CTT may have prognostic and therapeutic implications.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Coronary Vessels ; Brain Ischemia ; Coronary Angiography/methods ; Risk Factors ; Risk Assessment ; Stroke ; Coronary Artery Disease/diagnostic imaging ; Tomography, X-Ray Computed ; Thorax ; Vascular Calcification/diagnostic imaging ; Prognosis
    Language English
    Publishing date 2023-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09428-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3300: Show issues Location:
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  5. Article ; Online: Autophagy receptor defects and ALS-FTLD.

    Majcher, Veronika / Goode, Alice / James, Victoria / Layfield, Robert

    Molecular and cellular neurosciences

    2015  Volume 66, Issue Pt A, Page(s) 43–52

    Abstract: Various pathophysiological mechanisms have been implicated in the ALS-FTLD clinicopathological spectrum of neurodegenerative disorders. Here we focus on the role of autophagy, an intracellular catabolic pathway, in these conditions. Growing evidence ... ...

    Abstract Various pathophysiological mechanisms have been implicated in the ALS-FTLD clinicopathological spectrum of neurodegenerative disorders. Here we focus on the role of autophagy, an intracellular catabolic pathway, in these conditions. Growing evidence suggests that the autophagic process can be disturbed in ALS-FTLD, including by genetic mutations affecting autophagy receptor proteins (ubiquilin-2, optineurin, SQSTM1/p62) and regulators (VCP). Such mutations may impair clearance of autophagy substrates with pathological consequences. Recent studies have also uncovered a direct connection between autophagy and RNA processing, supporting an integrated model connecting several ALS-FTLD associated gene products. This article is part of a Special Issue entitled 'Neuronal Protein'.
    MeSH term(s) Amyotrophic Lateral Sclerosis/physiopathology ; Animals ; Autophagy/physiology ; Frontotemporal Lobar Degeneration/physiopathology ; Humans ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Signal Transduction/physiology
    Chemical Substances Nerve Tissue Proteins
    Language English
    Publishing date 2015-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1046640-x
    ISSN 1095-9327 ; 1044-7431
    ISSN (online) 1095-9327
    ISSN 1044-7431
    DOI 10.1016/j.mcn.2015.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3035: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

    Rea, Sarah L / Majcher, Veronika / Searle, Mark S / Layfield, Rob

    Experimental cell research

    2014  Volume 325, Issue 1, Page(s) 27–37

    Abstract: Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic element with mutations affecting the SQSTM1 gene, encoding the p62 protein, ... ...

    Abstract Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic element with mutations affecting the SQSTM1 gene, encoding the p62 protein, frequently identified. Recently SQSTM1 mutations have also been reported in a small number of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), neurodegenerative disorders in which significant coexistence with PDB has not been previously recognized. Although several SQSTM1 mutations are common to both ALS/FTLD and PDB, many are ALS/FTLD-specific. The p62 protein regulates various cellular processes including NF-κB signaling and autophagy pathways. Here we consider how knowledge of the impact of PDB-associated SQSTM1 mutations (several of which are now known to be relevant for ALS/FTLD) on these pathways, as well as the locations of the mutations within the p62 primary sequence, may provide new insights into ALS/FTLD disease mechanisms.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/physiology ; Amyotrophic Lateral Sclerosis/genetics ; Animals ; Autophagy ; Frontotemporal Lobar Degeneration/genetics ; Genetic Predisposition to Disease ; Humans ; NF-kappa B/metabolism ; Osteitis Deformans/genetics ; Sequestosome-1 Protein ; Signal Transduction
    Chemical Substances Adaptor Proteins, Signal Transducing ; NF-kappa B ; SQSTM1 protein, human ; Sequestosome-1 Protein
    Language English
    Publishing date 2014-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2014.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 563: Show issues Location:
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