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  1. Article: Inositol Supplementation in the Prevention of Gestational Diabetes Mellitus.

    Tahir, Faryal / Majid, Zainab

    Cureus

    2019  Volume 11, Issue 9, Page(s) e5671

    Abstract: Inositol, an emerging novel therapy for the treatment of gestational diabetes mellitus (GDM), is a cyclic polyol that has insulin-like effects and plays an important role in glucose homeostasis. The conventional treatment of GDM with insulin and oral ... ...

    Abstract Inositol, an emerging novel therapy for the treatment of gestational diabetes mellitus (GDM), is a cyclic polyol that has insulin-like effects and plays an important role in glucose homeostasis. The conventional treatment of GDM with insulin and oral antihyperglycemic drugs usually comes with side effects, paving the way for and shedding spotlight on clinical trials involving inositol. This review analyzed a host of recent trials that involved inositol supplementation for preventing GDM and their positive outcomes in reducing the rate of GDM among obese and overweight pregnant women, as well as women with polycystic ovarian syndrome (PCOS) or a family history of type 2 diabetes mellitus.
    Language English
    Publishing date 2019-09-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.5671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Long-standing Sporadic Pancreatic Insulinoma: Report of a Rare Case.

    Majid, Zainab / Tahir, Faryal / Haider, Syed Ali

    Cureus

    2020  Volume 12, Issue 2, Page(s) e6947

    Abstract: Insulinomas are rare, functional pancreatic neuroendocrine tumors arising from the pancreatic multipotent stem cells or neuroendocrine islet, occurring with a higher proportion in females. Majority of insulinomas have a sporadic etiology; however, only 5% ...

    Abstract Insulinomas are rare, functional pancreatic neuroendocrine tumors arising from the pancreatic multipotent stem cells or neuroendocrine islet, occurring with a higher proportion in females. Majority of insulinomas have a sporadic etiology; however, only 5%-10% develop as a part of multiple endocrine neoplasm type 1 syndrome. They usually present with symptoms of hypoglycemia including disturbance in orientation, tremors, diaphoresis, altered mental state, seizures and visual changes among others. The diagnosis is based on appreciation of the classic Whipple triad, i.e. neuroglycopenic symptoms and sympathetic drive along with low serum glucose levels (<50 mg/dL) and a complete reversibility of these symptoms with prompt administration of glucose. The gold standard treatment for insulinoma involves complete surgical excision (i.e. enucleation), which is curative in 90% of the patients. Health care physicians should have a high index of suspicion for this tumor in patients presenting with neurological and sympathetic symptoms, particularly if they are resolved after eating. Here, we report the case of a 48-year-old female with the history of multiple episodes of hypoglycemic symptoms for the past two years which improved on glucose intake. Furthermore, we also summarized the discussion regarding diagnosis and management of pancreatic insulinoma.
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Anatomical variations in upper arm vasculature pertinent to haemodialysis access creation: Are surgeons aware sufficiently?

    Rehman, Zia Ur / Majid, Zainab / Qadar, Laila Tul / Majid, Aamina

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 70, Issue 12(A), Page(s) 2239–2243

    Abstract: There exist wide anatomical variations of upper limb. Their implication is perhaps greatest when it comes to failure of arteriovenous fistula (AVF) for chronic haemodialysis. Among arteries of forearm, brachial artery is of note, whose high bifurcation ... ...

    Abstract There exist wide anatomical variations of upper limb. Their implication is perhaps greatest when it comes to failure of arteriovenous fistula (AVF) for chronic haemodialysis. Among arteries of forearm, brachial artery is of note, whose high bifurcation is associated with increased risk of failure. The superficial and accessory variants also cause difficulty for the surgeon. The single unpaired brachial vein and stenosis of cephalic vein compound the difficulties associated with AVF among many others. A thorough understanding of surgeons regarding normal anatomy and diverse variants holds high importance in context of deciding an appropriate site for arteriovenous (AV) anastomosis. Negligence in creation of fistula not only pose a threat to patients of end stage renal disease (ESRD) but also contributes to numerous other complications involving nerves and drug administration.
    MeSH term(s) Arm ; Arteriovenous Shunt, Surgical ; Brachial Artery/surgery ; Humans ; Renal Dialysis ; Surgeons ; Treatment Outcome ; Vascular Patency
    Language English
    Publishing date 2021-01-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Investigating the impact of fluid status on the ultrasound assessment of muscle quantity and quality in the diagnosis of sarcopenia - a multidimensional cross-sectional study.

    Stanley, Benjamin / Greig, Carolyn / Jackson, Thomas / Lewis, Danielle / Moorey, Hannah / Majid, Zainab / Masud, Tahir / Pinkney, Thomas / Welch, Carly

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 493

    Abstract: Background: Sarcopenia is a clinical manifestation of adverse ageing, characterised by progressive loss of muscle mass and function. Diagnosis requires assessment of muscle quantity and quality; ultrasound represents an emerging tool for this. However, ... ...

    Abstract Background: Sarcopenia is a clinical manifestation of adverse ageing, characterised by progressive loss of muscle mass and function. Diagnosis requires assessment of muscle quantity and quality; ultrasound represents an emerging tool for this. However, ultrasound muscle assessment may be impacted by fluid balance. This is particularly important when assessing for acute sarcopenia in hospitalised patients, where fluid disturbance often occurs. The primary aim of this study was to characterise the impact of fluid status on ultrasound muscle assessment, such that this may be accounted for in sarcopenia diagnostics.
    Methods: This Multidimensional Cross-sectional study involved 80 participants, who were inpatients at QEHB, a large UK tertiary centre. Fluid status was evaluated clinically and quantified using Bioelectrical Impedance Analysis (BIA). Muscle quantity was measured using Bilateral Anterior Thigh Thickness (BATT) with Rectus Femoris (RF) echogenicity used to assesses muscle adiposity and hence provide an inverse measure of muscle quality.
    Results: A significant positive correlation was found between fluid status, measured using BIA, and BATT as a measure of muscle quantity, in males (rs = 0.662, p < 0.001) and females (rs = 0.638, p < 0.001). A significant negative correlation was found between fluid status and RF echogenicity (rs=-0.448, p < 0.001).
    Conclusions: These findings demonstrate associations between fluid balance and ultrasound assessment of muscle quantity and quality. Given the emerging use of ultrasound muscle assessment in sarcopenia diagnosis, there is a need to account for this in clinical practice. Future research should focus on the development of a corrective equation allowing assessment of muscle quantity and quality which account for changes in fluid status, hence aiding accurate diagnosis of sarcopenia.
    MeSH term(s) Male ; Female ; Humans ; Sarcopenia/diagnostic imaging ; Muscle, Skeletal/physiology ; Cross-Sectional Studies ; Quadriceps Muscle/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04177-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute Myocardial Infarction as an Initial Presentation of Protein C and Protein S Deficiency Followed by Dilated Cardiomyopathy in a Young Male.

    Tahir, Faryal / Majid, Zainab / Majid, Bushra / Khan, Sherbano

    Cureus

    2019  Volume 11, Issue 4, Page(s) e4492

    Abstract: Protein C and protein S are vitamin K dependent anti-coagulant proteins required for the inhibition of activated protein V and VIII. In an inherited thrombophilia, hypercoagulability caused by the deficiency of protein C and protein S predisposes an ... ...

    Abstract Protein C and protein S are vitamin K dependent anti-coagulant proteins required for the inhibition of activated protein V and VIII. In an inherited thrombophilia, hypercoagulability caused by the deficiency of protein C and protein S predisposes an individual to increased risk of thromboembolism (TE) that could herald as a venous thromboemboilsm (VTE) in the leg, pulmonary embolism (PE), stroke, or Budd-Chiari syndrome. However, very rarely does inherited thrombophilia cause coronary artery thrombosis leading to the development of myocardial infarction (MI). We report a case of a young male with combined protein C and protein S deficiency who presented with acute MI, worsened ventricular systolic function, and progressive declination of ejection fraction (EF) secondary to dilated cardiomyopathy (DCM).
    Language English
    Publishing date 2019-04-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.4492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Female doctors; an easy target for violence?

    Majid, Zainab / Asghar, Sarrah Ali / Imtiaz, Fauzia

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 5, Page(s) 756

    MeSH term(s) Female ; Humans ; Physicians, Women ; Workplace Violence/prevention & control ; Workplace Violence/psychology
    Language English
    Publishing date 2019-05-20
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  7. Article: Zinc deficiency: An independent risk factor for high blood pressure.

    Tahir, Faryal / Majid, Zainab / Qadar, Laila Tul

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 10, Page(s) 1578

    MeSH term(s) Biological Availability ; Deficiency Diseases/metabolism ; Deficiency Diseases/prevention & control ; Humans ; Hypertension/metabolism ; Hypertension/prevention & control ; Nutritional Requirements ; Renal Reabsorption/physiology ; Risk Factors ; Zinc/deficiency ; Zinc/metabolism
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2019-10-17
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Chronic Traumatic Encephalopathy; a mere concern for athletes or single blow victims equally vulnerable?

    Majid, Bushra / Majid, Zainab / Tahir, Faryal

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 11, Page(s) 1762

    MeSH term(s) Athletes ; Brain Concussion ; Chronic Traumatic Encephalopathy ; Humans ; Motion Pictures ; Physicians
    Language English
    Publishing date 2019-11-18
    Publishing country Pakistan
    Document type Journal Article ; Comment
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.5455/JPMA.36521.
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  9. Article: Foot burn from Motorcycles, exacerbated by Polyneuropathy in Diabetics: A rising concern in Pakistan.

    Majid, Zainab / Qadar, Laila Tul / Haque, Ayema

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 9, Page(s) 1410

    MeSH term(s) Burns/etiology ; Diabetic Foot/complications ; Foot Injuries/etiology ; Humans ; Motorcycles ; Pakistan
    Language English
    Publishing date 2019-10-22
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  10. Article: Cerebral Infarction Followed by Myocardial Infarction in a Young Adult with Protein C and S Deficiency.

    Tahir, Faryal / Majid, Zainab / Bin Arif, Taha / Ahmed, Jawad

    Cureus

    2020  Volume 12, Issue 1, Page(s) e6665

    Abstract: Protein C (PC) and protein S (PS) are natural anticoagulants that protect the body against thrombosis, and their deficiency, either inherited or acquired, renders the body to a hypercoagulable state. This leads to venous thromboembolism manifesting as ... ...

    Abstract Protein C (PC) and protein S (PS) are natural anticoagulants that protect the body against thrombosis, and their deficiency, either inherited or acquired, renders the body to a hypercoagulable state. This leads to venous thromboembolism manifesting as thrombosis, pulmonary embolism and superficial thrombophlebitis among other causes. The involvement of arteries is rare and has been explained by only a few studies. Hence, the presentation of PC and PS deficiencies with stroke and myocardial infarction (MI) is rarely observed, especially in young patients. We report a case of a 33-year old male with a past medical history of stroke and MI for which no underlying cause was found. He presented now with shortness of breath and left-sided chest pain and after a series of workup, eventually diagnosed as a rare case of PC and PS deficiencies.
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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