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  1. Article ; Online: Synthesis of Bi-heterocyclic Sulfonamides as Tyrosinase Inhibitors

    Muhammad Athar Abbasi / Zia Ur Rehman / Aziz Ur Rehman / Sabhat Zahra Siddiqui / Majid Nazir / Mubashir Hassan / Hussain Raza / Syed Adnan Ali Shah / sung-Yum Seo

    Acta Chimica Slovenica, Vol 67, Iss 2, Pp 403-

    Lineweaver–Burk Plot Evaluation and Computational Ascriptions

    2020  Volume 414

    Abstract: The designed bi-heterocyclic sulfonamides were synthesized through a two-step protocol and their structures were ascertained by spectral techniques including IR, 1H NMR and 13C NMR along with CHN analysis. The in vitro inhibitory effects of these ... ...

    Abstract The designed bi-heterocyclic sulfonamides were synthesized through a two-step protocol and their structures were ascertained by spectral techniques including IR, 1H NMR and 13C NMR along with CHN analysis. The in vitro inhibitory effects of these sulfonamides were evaluated against tyrosinase and kinetics mechanism was analyzed by Lineweaver–Burk plots. The binding modes of these molecules were ascribed through molecular docking studies. These synthesized bi-heterocyclic molecules were identified as potent inhibitors relative to the standard (kojic acid) and compound 5 inhibited the tyrosinase non-competitively by forming an enzyme-inhibitor complex. The inhibition constant Ki (0.09 µM) for compound 5 was calculated from Dixon plots. Computational results also displayed that all compounds possessed good binding profile against tyrosinase and interacted with core residues of target protein.
    Keywords bi-heterocycles ; 1-phenyl-piperazine ; sulfonamides ; tyrosinase ; chemical kinetics ; computational study ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Slovenian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Profile of Age related macular degeneration in a Kashmiri population-A hospital based study in Tertiary care hospital in Kashmir, India

    Tariq Qureshi / Majid Nazir / Nausheen Abdullah / Anjum Fazili / Rashid Maqbool / Rahila Ramzan

    Global Journal of Medicine and Public Health, Vol 02, Iss

    2013  Volume 02

    Abstract: Purpose To assess the profile of age related macular degeneration Material and Methods In a cross-sectional, prospective study 164 eyes of 100 ARMD patients were taken up for evaluation. Relevant clinical examination and FFA was done.Patients of wet ARMD ...

    Abstract Purpose To assess the profile of age related macular degeneration Material and Methods In a cross-sectional, prospective study 164 eyes of 100 ARMD patients were taken up for evaluation. Relevant clinical examination and FFA was done.Patients of wet ARMD were taken for OCT. Instruments used were Direct Ophthalmoscope (Heinz) slit lamp biomicroscope (Zeiss), Fundus camera (Zeiss) and spectral domain optical coherence tomography (Zeiss). Observation Out of 100 patients 63 were male and 37 were females. 64 patients had bilateral involvement while as 36 patients had unilateral involvement at presentation. 35 patients were in the age group of 61 to 65 yrs.95% of patients presented with the symptom of diminution of vision. 26% of patients had associated systemic ailments, 29.88% of patients had a visual acuity of < 6/60. On FFA, 82.32% (135 eyes) were having non exudative (dry) ARMD and 17.68 % (29 eyes) had exudative (wet) ARMD. In dry ARMD 95.55% had drusens and only 4.44% had geographic atrophy.Out of 29 eyes of wet ARMD,on FFA, 17 eyes 58.62% had classic CNV, Two eyes (6.9%) had occult CNV and 10 (34.48%) had serous PED. OCT findings suggested classic CNV in 17 eyes (58.62%), occult CNV in 4 eyes (13.79%) and serous PED in 8 eyes (27.58%) Conclusion ARMD is usually a bilateral condition affecting mostly in the early 5th decade. Dry ARMD is commoner than wet ARMD. FFA is the golden tool for screening wet ARMD. OCT is more specific in detecting early sub- retinal neo vascular membrane.
    Keywords ARMD (Age related macular degeneration) ; FFA (Fundus Fluorescein Angiography) ; OCT (Optical Coherence Tomography) ; CNV (Choroidal Neovascularsation ; PED (Pigment epithelial Detachment) ; Medicine ; R
    Language English
    Publishing date 2013-05-01T00:00:00Z
    Publisher Makhdoomi Printers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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