LIVIVO - Search results -

Search results

Result 1 - 10 of total 355

Search options

Article ; Online: Use of 3D printing to integrate microchip electrophoresis with amperometric detection.

Selemani, Major A / Martin, R Scott

2024

Abstract: This paper describes the use of PolyJet 3D printing to fabricate microchip electrophoresis devices with integrated microwire electrodes for amperometric detection. The fabrication process involves 3D printing of two separate pieces, a channel layer and ... ...

Abstract	This paper describes the use of PolyJet 3D printing to fabricate microchip electrophoresis devices with integrated microwire electrodes for amperometric detection. The fabrication process involves 3D printing of two separate pieces, a channel layer and an electrode layer. The channel layer is created by 3D printing on a pre-fabricated mold with a T-intersection. For the electrode layer, a stencil design is printed directly on the printing tray and covered with a piece of transparent glass. Microwire electrodes are adhered over the glass piece (guided by underlaying stencil) and a CAD design of the electrode layer is then printed on top of the microwire electrode. After delamination from the glass after printing, the microwire is embedded in the printed piece, with the stencil design ensuring that alignment and positioning of the electrode is reproducible for each print. After a thermal bonding step between the channel layer and electrode layer, a complete electrophoresis device with integrated microelectrodes for amperometric detection results. It is shown that this approach enables different microwire electrodes (gold or platinum) and sizes (100 or 50 µm) to be integrated in an end-channel configuration with no gap between the electrode and the separation channel. These devices were used to separate a mixture of catecholamines and the effect of separation voltage on the potential voltage applied on the working electrode was also investigated. In addition, the effect of electrode size on the number of theoretical plates and limit of detection was studied. Finally, a device that contains different channel heights and a detection electrode was 3D-printed to integrate continuous flow sampling with microchip electrophoresis and amperometric detection.
Language	English
Publishing date	2024-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05260-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 69/97: Show issues
Archiv 3: Show issues
Z 9.4: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Selection of bispecific antibody therapies or CAR-T cell therapy in relapsed lymphomas.

Major, Ajay / Kamdar, Manali

Hematology. American Society of Hematology. Education Program

2023 Volume 2023, Issue 1, Page(s) 370–381

Abstract: Patients with relapsed and refractory (R/R) aggressive B-cell non-Hodgkin lymphomas have historically poor survival outcomes, with chimeric antigen receptor T-cell (CAR-T) therapy now presenting a curative option for a subset of those patients. However, ... ...

Abstract	Patients with relapsed and refractory (R/R) aggressive B-cell non-Hodgkin lymphomas have historically poor survival outcomes, with chimeric antigen receptor T-cell (CAR-T) therapy now presenting a curative option for a subset of those patients. However, with the approval of several novel bispecific monoclonal antibody (BsAb) therapies with considerable activity in R/R aggressive large B-cell lymphomas (LBCL), patients and oncologists will be faced with decisions regarding how to sequence CAR-T and BsAb therapies based on patient- and disease-related factors. In this review, we compare CAR-T and BsAb therapies for R/R LBCL, highlighting data on the efficacy and toxicity of each treatment paradigm, and provide a roadmap for sequencing these highly effective therapies.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen/therapeutic use ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse/pathology ; Antibodies, Bispecific/therapeutic use ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Antibodies, Bispecific
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2084287-9
ISSN	1520-4383 ; 1520-4391
ISSN (online)	1520-4383
ISSN	1520-4391
DOI	10.1182/hematology.2023000438
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Endotoxic kidney injury in Beagle dogs assessed by serum creatinine and symmetric dimethylarginine, and urinary neutrophil gelatinase-associated lipocalin and clusterin.

Steblaj, B / Kutter, A P N / Stirn, M / Daminet, S / Major, A / Zini, E

Research in veterinary science

2023 Volume 162, Page(s) 104966

Abstract: Sepsis of Gram negative bacterial origin results in lipopolysaccharide-induced endotoxemia. This often leads to acute kidney injury (AKI) and its recognition remains a challenge and delays treatment. As renal damage occurs before a rise in serum ... ...

Abstract	Sepsis of Gram negative bacterial origin results in lipopolysaccharide-induced endotoxemia. This often leads to acute kidney injury (AKI) and its recognition remains a challenge and delays treatment. As renal damage occurs before a rise in serum creatinine is detected, new early biomarkers of kidney injury need to be explored. The aim of this study was to determine changes in serum parameters of renal function and urine biomarkers of renal injury. This was a descriptive study. Endotoxemia was induced intravenously in six anaesthetized Beagles (T1). To achieve normotension, dogs received fluids (T2), followed by a continuous infusion of noradrenaline and dexmedetomidine or 0.9% NaCl (T3). Ten minutes later, the dogs received fluids (T4) and noradrenaline and dexmedetomidine or 0.9% NaCl in a crossover manner (T5). At each timepoint, blood and urine were collected for serum creatinine, urea, symmetric dimethylarginine, urine protein/creatinine (UPC) ratio, urine neutrophil-gelatinase-associated lipocalin (U-NGAL), U-NGAL/creatinine ratio, urine clusterin (U-clusterin) and U-clusterin/creatinine ratio. Data were analyzed using a mixed-effect model taking into account time and stage of veterinary AKI (VAKI). Three of six dogs had a VAKI stage ≥1; one with anuria and elevated creatinine. Serum creatinine (P < 0.001), U-NGAL/creatinine ratio (P = 0.01) and U-clusterin/creatinine ratio increased over time (P < 0.01). The UPC ratio (mean (range) 0.68 (0.35-2.3) versus 0.39 (0.15-0.71) P < 0.01) and U-NGAL (3164 pg/mL (100-147,555) versus 100 (100-14,524), P = 0.01) were higher in VAKI stage ≥1 versus stage 0, respectively. Endotoxemia induced VAKI stage ≥1 in half of the dogs. Repeated measurement of selected parameters could detect AKI early.
MeSH term(s)	Animals ; Dogs ; Lipocalin-2/urine ; Creatinine/urine ; Dexmedetomidine ; Endotoxins ; Clusterin ; Endotoxemia/veterinary ; Saline Solution ; Lipocalins/urine ; Proto-Oncogene Proteins/urine ; Acute-Phase Proteins/metabolism ; Kidney/metabolism ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/veterinary ; Biomarkers ; Dog Diseases/urine
Chemical Substances	Lipocalin-2 ; Creatinine (AYI8EX34EU) ; Dexmedetomidine (67VB76HONO) ; Endotoxins ; Clusterin ; symmetric dimethylarginine (49787G1ULV) ; Saline Solution ; Lipocalins ; Proto-Oncogene Proteins ; Acute-Phase Proteins ; Biomarkers
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2023.104966
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma.

Major, Ajay / Porcu, Pierluigi / Haverkos, Bradley M

Cancers

2023 Volume 15, Issue 5

Abstract: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next- ... ...

Abstract	Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next-generation and whole genome sequencing has revealed diverse genomic mutations in multiple signaling pathways, with the identification of multiple putative targets for novel therapeutic agents. In this review, we summarize the biological underpinnings of newly-understood therapeutic targets in ENKTL with a focus on translational implications, including epigenetic and histone regulatory aberrations, activation of cell proliferation signaling pathways, suppression of apoptosis and tumor suppressor genes, changes in the tumor microenvironment, and EBV-mediated oncogenesis. In addition, we highlight prognostic and predictive biomarkers which may enable a personalized medicine approach toward ENKTL therapy.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15051366
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Bourbon.

Major, Ajay

JAMA oncology

2017 Volume 3, Issue 10, Page(s) 1309

MeSH term(s)	Electronic Health Records ; Empathy ; Fatal Outcome ; Female ; Humans ; Narration ; Oncologists/psychology
Language	English
Publishing date	2017-05-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2017.1067
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Investigating manual performance when using push buttons following cold water hand immersion.

Major, Alexandria / Molyneux, David / Brown, Robert

Applied ergonomics

2023 Volume 114, Page(s) 104127

Abstract: The purpose of this study was to investigate manual performance of humans when using push buttons following cold water hand immersion. An experiment involving 29 human participants was carried out to measure the activation rate of twelve different shaped ...

Abstract	The purpose of this study was to investigate manual performance of humans when using push buttons following cold water hand immersion. An experiment involving 29 human participants was carried out to measure the activation rate of twelve different shaped push buttons mounted on a novel test apparatus after their dominant hand was immersed in cold (2 °C) and thermoneutral (34 °C) water for 2 min. A series of standardized hand dexterity tests were completed to assess the participants' baseline tactile sensitivity in a dry thermoneutral state. The mean baseline performance of participants indicates that they were representative of the general population. The button test apparatus was developed specifically for this experiment and was comprised of 12 different buttons at different locations on the panel which were varying in size, surface shape and texture. After the participants immersed their dominant hand in the assigned temperature condition, their index finger was guided to the centre of the panel, and they were instructed to find and press as many buttons as they could in a 2-min time period using only their index finger. For the button panel test, the participants' view was obstructed from seeing the buttons. The results of the study indicate that temperature does not influence the activation rate of the push buttons on the button test apparatus. In addition, button size (large) was the most significant factor, followed by shape (protruding), however button texture was not a significant parameter. Given that exposure to cold water reduces manual performance, along with anecdotal evidence from survival training centres that users sometimes struggle to activate PLBs, the motivation for this research was to understand how humans interact with these devices in cold water emergency situations. It is expected that the results of this research will be useful for designers of emergency signalling devices used for rescue at sea.
MeSH term(s)	Humans ; Water ; Immersion ; Hand/physiology ; Fingers/physiology ; Cold Temperature ; Skin Temperature
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2003513-5
ISSN	1872-9126 ; 0003-6870
ISSN (online)	1872-9126
ISSN	0003-6870
DOI	10.1016/j.apergo.2023.104127
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Reply.

Ornoff, Douglas M / Berry, Andrew / Major, Ajay

The American journal of medicine

2023 Volume 136, Issue 3, Page(s) e52

Language	English
Publishing date	2023-01-29
Publishing country	United States
Document type	Letter
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.11.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.289: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: DA-R-EPOCH vs R-CHOP in DLBCL: How do we choose?

Major, Ajay / Smith, Sonali M

Clinical advances in hematology & oncology : H&O

2021 Volume 19, Issue 11, Page(s) 698–709

Abstract: The emerging molecular and prognostic characterization of diffuse large B-cell lymphoma (DLBCL) has challenged the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment paradigm in recent years, with the identification ... ...

Abstract	The emerging molecular and prognostic characterization of diffuse large B-cell lymphoma (DLBCL) has challenged the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment paradigm in recent years, with the identification of several DLBCL subtypes associated with significantly inferior survival after standard R-CHOP therapy. Efforts to improve upon the R-CHOP backbone have included dose intensification as well as the addition of new agents; the infusional dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) regimen has been identified as a potential replacement for R-CHOP in high-risk DLBCL. In this review, we provide a historical perspective on the R-CHOP and DA-R-EPOCH regimens and summarize the clinical trial literature regarding the efficacy of each regimen in various risk groups of DLBCL. Further, we propose clinical management scenarios in which DA-R-EPOCH may be preferred, including some for patient populations in which the use of R-CHOP vs DA-R-EPOCH is controversial.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Etoposide/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Prednisone/therapeutic use ; Rituximab/therapeutic use ; Treatment Outcome ; Vincristine/therapeutic use
Chemical Substances	Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2271951-9
ISSN	1543-0790
ISSN	1543-0790
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6505: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mixed-Methods Study of End-of-Life Experiences of Patients With Hematologic Malignancies in Social Hospice Residential Home Care Settings.

Weisse, Carol S / Melekis, Kelly / Cheng, Alice / Konda, Anuja Keerthi / Major, Ajay

JCO oncology practice

2024 , Page(s) OP2300534

Abstract: Purpose: Hospice is underutilized by patients with hematologic malignancies (HM), and when patients are referred, they are typically more ill, hospitalized, and with shorter length of stay (LOS) than patients with solid tumors (ST), limiting research ... ...

Abstract	Purpose: Hospice is underutilized by patients with hematologic malignancies (HM), and when patients are referred, they are typically more ill, hospitalized, and with shorter length of stay (LOS) than patients with solid tumors (ST), limiting research about home hospice care experiences of patients with HM. In this mixed-methods study, we examined the hospice experiences of patients with HM who died at residential care homes (RCHs), home-based settings in which volunteer caregivers and hospice staff provide end-of-life (EOL) care under the social hospice model. Methods: We queried a registry of 535 hospice patients who died at RCHs between 2005 and 2020 that included quantitative medication administration data as well as qualitative data from hospice intake forms and written volunteer caregiver narratives. Qualitative data were analyzed by collective case study methodology. Quantitative comparisons of LOS and liquid morphine use were performed with matched patients with ST. Results: The registry yielded 29 patients with HM, of whom qualitative data were available for 18 patients. Patients with HM exhibited common EOL symptoms (pain, dyspnea, and agitation). Instances of bleeding were low (22%), and notable HM-specific care concerns were described regarding bone fractures, skin integrity, and delirium. Most (78%) experienced good symptom management and peaceful or comfortable deaths. In only one case were symptoms described as severe and poorly managed. Patients with HM had comparable LOS on hospice and at the RCHs to patients with ST, with no group differences in liquid morphine use. Conclusion: In this registry cohort, most patients with HM achieved good symptom management in home care settings with volunteer caregivers and hospice support. Caregivers may require additional counseling and palliative medications for HM-specific EOL symptoms.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.23.00534
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perspectives on geriatric oncology research presented at the 2023 American Society of Hematology Annual Meeting: Young International Society of Geriatric Oncology report.

Abdallah, Maya / Akhtar, Othman Salim / Major, Ajay / Mian, Hira / Tsang, Mazie / Torka, Pallawi

Journal of geriatric oncology

2024 , Page(s) 101762

Language	English
Publishing date	2024-04-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2024.101762
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito