LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: Utilizing coordination chemistry through formation of a Cu

Chatterjee, Sayantani / Jain, Chetan Kumar / Saha, Tanmoy / Roychoudhury, Susanta / Majumder, Hemanta Kumar / Das, Saurabh

Journal of inorganic biochemistry

2023 Volume 249, Page(s) 112369

Abstract: Quinalizarin, an analogue of anthracycline anticancer agents, is an anticancer agent itself. A ... ...

Abstract	Quinalizarin, an analogue of anthracycline anticancer agents, is an anticancer agent itself. A Cu
MeSH term(s)	Humans ; DNA Topoisomerases, Type I/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antibiotics, Antineoplastic ; Topoisomerase II Inhibitors/pharmacology ; Superoxides/metabolism ; Anthracyclines ; Free Radicals/metabolism ; Copper/chemistry ; Coordination Complexes/chemistry
Chemical Substances	1,2,5,8-tetrahydroxy anthraquinone (6D43C3LYSG) ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; Antineoplastic Agents ; Antibiotics, Antineoplastic ; Topoisomerase II Inhibitors ; Superoxides (11062-77-4) ; Anthracyclines ; Free Radicals ; Copper (789U1901C5) ; Coordination Complexes
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2023.112369
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1730: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.

Jain, Chetan Kumar / Majumder, Hemanta Kumar / Roychoudhury, Susanta

Current genomics

2017 Volume 18, Issue 1, Page(s) 75–92

Abstract: DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal ... ...

Abstract	DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal decatenation etc. These enzymes are important molecular drug targets and inhibitors of these enzymes are widely used as effective anticancer and antibacterial drugs. However, topoisomerase inhibitors have some therapeutic limitations and they exert serious side effects during cancer chemotherapy. Thus, development of novel anticancer topoisomerase inhibitors is necessary for improving cancer chemotherapy. Nature serves as a repertoire of structurally and chemically diverse molecules and in the recent years many DNA topoisomerase inhibitors have been identified from natural sources. The present review discusses anticancer properties and therapeutic importance of eighteen recently identified natural topoisomerase inhibitors (from the year 2009 to 2015). Structural characteristics of these novel inhibitors provide backbones for designing and developing new anticancer drugs.
Language	English
Publishing date	2017-04-28
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2033677-9
ISSN	1875-5488 ; 1389-2029
ISSN (online)	1875-5488
ISSN	1389-2029
DOI	10.2174/1389202917666160808125213
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5571: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor.

Jain, Chetan Kumar / Roychoudhury, Susanta / Majumder, Hemanta Kumar

Biochimica et biophysica acta

2015 Volume 1853, Issue 5, Page(s) 1195–1204

Abstract: Cancer cells with defective DNA decatenation checkpoint can be selectively targeted by the catalytic inhibitors of DNA topoisomerase IIα (topo IIα) enzyme. Upon treatment with catalytic topo IIα inhibitors, cells with defective decatenation checkpoint ... ...

Abstract	Cancer cells with defective DNA decatenation checkpoint can be selectively targeted by the catalytic inhibitors of DNA topoisomerase IIα (topo IIα) enzyme. Upon treatment with catalytic topo IIα inhibitors, cells with defective decatenation checkpoint fail to arrest their cell cycle in G2 phase and enter into M phase with catenated and under-condensed chromosomes resulting into impaired mitosis and eventually cell death. In the present work we analyzed decatenation checkpoint in five different colon cancer cell lines (HCT116, HT-29, Caco2, COLO 205 and SW480) and in one non-cancerous cell line (HEK293T). Four out of the five colon cancer cell lines i.e. HCT116, HT-29, Caco2, and COLO 205 were found to be compromised for the decatenation checkpoint function at different extents, whereas SW480 and HEK293T cell lines were found to be proficient for the checkpoint function. Upon treatment with ICRF193, decatenation checkpoint defective cell lines failed to arrest the cell cycle in G2 phase and entered into M phase without proper chromosomal decatenation, resulting into the formation of tangled mass of catenated and under-condensed chromosomes. Such cells underwent mitotic catastrophe and rapid apoptosis like cell death and showed higher sensitivity for ICRF193. Our study suggests that catalytic inhibitors of topoisomerase IIα are promising therapeutic agents for the treatment of colon cancers with defective DNA decatenation checkpoint.
MeSH term(s)	Biocatalysis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Chromosomes, Human/metabolism ; Colonic Neoplasms/pathology ; Etoposide/pharmacology ; G2 Phase/drug effects ; HEK293 Cells ; Humans ; Mitosis/drug effects ; Mitotic Index ; Piperazines/pharmacology ; Topoisomerase II Inhibitors/pharmacology ; Tumor Stem Cell Assay
Chemical Substances	Piperazines ; Topoisomerase II Inhibitors ; 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione (21416-68-2) ; Etoposide (6PLQ3CP4P3)
Language	English
Publishing date	2015-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2015.02.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Activity of Co

Mukherjee Chatterjee, Sayantani / Jain, Chetan Kumar / Singha, Soumen / Das, Piyal / Roychoudhury, Susanta / Majumder, Hemanta Kumar / Das, Saurabh

ACS omega

2018 Volume 3, Issue 8, Page(s) 10255–10266

Abstract: Quinalizarin (THAQ), a hydroxy-9,10-anthraquinone analogue of the family of anthracycline anticancer drugs and an inhibitor of protein kinase, was observed for its anticancer activity. Because apart from showing anticancer activity, anthracyclines and ... ...

Abstract	Quinalizarin (THAQ), a hydroxy-9,10-anthraquinone analogue of the family of anthracycline anticancer drugs and an inhibitor of protein kinase, was observed for its anticancer activity. Because apart from showing anticancer activity, anthracyclines and their analogues also show cardiotoxic side effects, believed to be addressed through metal complex formation; an effort was made to realize this by preparing a Co
Language	English
Publishing date	2018-08-30
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.8b00706
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The biological in vitro effect and selectivity shown by a Coᴵᴵ complex of 2-(2-hydroxyphenylazo)-indole-3′-acetic acid on three distinctly different cancer cells [Erratum: Jan. 2017, v.7(6), p.3428]

Ganguly, Durba / Jain, Chetan Kumar / Chandra Santra, Ramesh / Roychoudhury, Susanta / Majumder, Hemanta Kumar / Das, Saurabh

RSC advances. 2016 Dec. 12, v. 6, no. 115

2016

Abstract: A major intention of this study was to use the modified toxicity of the azo moiety in [2-(2-hydroxyphenylazo)-1H-indol-3-yl]-acetic acid (HPIA), achieved through complex formation with Coᴵᴵ on some cancer cell lines. This is important because the azo ... ...

Abstract	A major intention of this study was to use the modified toxicity of the azo moiety in [2-(2-hydroxyphenylazo)-1H-indol-3-yl]-acetic acid (HPIA), achieved through complex formation with Coᴵᴵ on some cancer cell lines. This is important because the azo functional group has not been tried in cancer chemotherapy. Keeping in mind aspects of drug resistance of some of the common anticancer drugs, a serious problem and a major clinical challenge in cancer chemotherapy, it is essential that new molecules are identified with anticancer activity. Although cytotoxicity of azo compounds is established there are not many reports that utilize them in cancer treatment. Another important aspect is to prepare compounds having preferential activity on cancer cells over normal cells so that toxic side effects are a minimum. Enzyme assay on the reductive cleavage of the azo bond showed complex formation with Coᴵᴵ almost completely checked the generation of cytotoxic amines implying that the complex could be less cytotoxic which was actually observed in case of normal healthy cells. Even though the complex formed less cytotoxic amines and possessed an almost similar binding ability with DNA like that of HPIA surprisingly its activity on three cancer cell lines namely human colon carcinoma HCT116 cells, acute lymphoblastic leukemia MOLT-4 cells and MCF-7 breast cancer cells was much greater than HPIA. The difference in activity between HPIA and its Coᴵᴵ complex on cancer cells showed no correlation with DNA binding or amine formation like that observed for normal cells. The complex probably possesses multiple modes of action whereby it is able to inhibit one or more cellular processes or functioning of different enzymes involved in the cell cycle of cancer cells for which it was found more effective.
Keywords	DNA ; antineoplastic activity ; breast neoplasms ; cancer therapy ; cell cycle ; colorectal neoplasms ; cytotoxicity ; drug resistance ; drug therapy ; enzymes ; humans ; lymphocytic leukemia ; moieties ; neoplasm cells
Language	English
Dates of publication	2016-1212
Size	p. 114906-114915.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra23163b
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

Das, Piyal / Chowdhury, Abhishek Dutta / Das, Saurabh / Dey, Sanjoy K / Jain, Chetan Kumar / Kumar, Sanjay / Majumder, Hemanta Kumar / Roychoudhury, Susanta / Saha, Rajat

RSC advances. 2014 Nov. 07, v. 4, no. 103

2014

Abstract: Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic. Metal–anthracyclines that generate relatively fewer ROS are however, effective antitumor ... ...

Abstract	Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic. Metal–anthracyclines that generate relatively fewer ROS are however, effective antitumor agents. Purpurin (LH3), a hydroxy-9,10-anthraquinone, closely resembles doxorubicin, an established anthracycline drug. This molecule was chosen to study the extent to which simpler analogues are effective. A Cu(ii) complex of LH3 [Cu(II)–(LH2)2] was synthesized to mimic the metal–anthracycline complexes. The crystal structure of [Cu(II)–(LH2)2] was determined by Rietveld refinement of PXRD data using an appropriate structural model developed on the basis of spectroscopic data. This is the first report on the crystal structure of any hydroxy-9,10-anthraquinone with a 3d-transition metal ion. The bond lengths and bond angles obtained by structural refinement corroborate those calculated by the DFT method. DNA binding of the complex was slightly better than purpurin. However, more importantly, unlike purpurin, binding constant values did not decrease with increasing pH of the medium. DNA relaxation assays show Cu(II)–(LH2)2 as a novel potent dual inhibitor of human DNA topoisomerase I and topoisomerase II enzymes. Cu(II)–(LH2)2 stabilizes covalent topoisomerase–DNA adducts both in vitro and within cancer cells. The cleavage assay keeps the complex well ahead of LH3 with regard to efficacy. These results paralleled those of cell growth inhibition and showed that the complex was more effective in killing ALL MOLT-4 cells than LH3, suggesting it targets topoisomerase enzymes within cells. The NADH dehydrogenase assay revealed further that the generation of superoxide was less in the case of the complex as compared to LH3.
Keywords	antineoplastic activity ; cell growth ; copper ; crystal structure ; DNA ; DNA topoisomerase ; DNA topoisomerase (ATP-hydrolysing) ; doxorubicin ; growth retardation ; humans ; models ; NAD (coenzyme) ; NADH dehydrogenase ; neoplasm cells ; neoplasms ; pH ; quinones ; reactive oxygen species ; spectral analysis
Language	English
Dates of publication	2014-1107
Size	p. 59344-59357.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c4ra07127a
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The molecular characterization of clinical isolates from Indian Kala-azar patients by MLEE and RAPD-PCR.

Manna, Madhumita / Majumder, Hemanta Kumar / Sundar, Shyam / Bhaduri, Amar Nath

Medical science monitor : international medical journal of experimental and clinical research

2005 Volume 11, Issue 7, Page(s) BR220–7

Abstract: Background: Kala-azar is a serious health problem in India. The situation has worsened further due to the occurrence of cases unresponsive to antimonials. About 30-50% patients do not respond to the prevailing regimen of antimonials. The etiological ... ...

Abstract	Background: Kala-azar is a serious health problem in India. The situation has worsened further due to the occurrence of cases unresponsive to antimonials. About 30-50% patients do not respond to the prevailing regimen of antimonials. The etiological agent for Indian kala-azar has long been known to be Leishmania donovani. Recently, in a somewhat startling report, it was claimed that L. Tropica causes nearly 25% of current kala-azar cases in India. It was also suggested that this might be in some way related to the unresponsiveness to pentavalent antimonials in the field. Material/methods: Two independent molecular characterization techniques, multilocus enzyme electrophoresis (MLEE) and RAPD-PCR, were employed to analyze 15 clinical isolates from confirmed Indian kala-azar patients collected from the eastern part of the country over a period of nearly 20 years. The collection included six Sb5+-unresponsive and one PKDL case. Results: Our observations strongly suggest that all the clinical isolates, including the antimony Sb5+-unresponsive and PKDL ones, we studied were identical to the WHO reference strain (DD8) for Leishmania donovani by both the above methods and no strain variation might have occurred in two major epidemic and inter-epidemic periods. We also observed that none of the Sb5+-unresponsive stains we analyzed was related to L. Tropica. Conclusions: We conclude that L. Donovani may be the causal agent for Indian kala-azar and that L. Tropica is most likely not an etiological agent for Indian Kala-azar cases that are unresponsive to antimonials.
MeSH term(s)	Animals ; Bone Marrow/parasitology ; DNA Primers ; Drug Resistance ; Electrophoresis, Cellulose Acetate ; Humans ; India ; Isoenzymes/genetics ; Leishmania donovani/enzymology ; Leishmania donovani/genetics ; Leishmania donovani/isolation & purification ; Leishmania tropica/enzymology ; Leishmania tropica/genetics ; Leishmania tropica/isolation & purification ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/genetics ; Leishmaniasis, Visceral/parasitology ; Random Amplified Polymorphic DNA Technique ; Spleen/parasitology
Chemical Substances	DNA Primers ; Isoenzymes
Language	English
Publishing date	2005-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4924: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.

Jain, Chetan Kumar / Pradhan, Bhola Shankar / Banerjee, Sukdeb / Mondal, Nirup Bikash / Majumder, Subeer S / Bhattacharyya, Madhumita / Chakrabarti, Saikat / Roychoudhury, Susanta / Majumder, Hemanta Kumar

Scientific reports

2015 Volume 5, Page(s) 12082

Abstract: DNA topoisomerase II inhibitors e.g. doxorubicin and etoposide are currently used in the chemotherapy for acute lymphoblastic leukemia (ALL). These inhibitors have serious side effects during the chemotherapy e.g. cardiotoxicity and secondary ... ...

Abstract	DNA topoisomerase II inhibitors e.g. doxorubicin and etoposide are currently used in the chemotherapy for acute lymphoblastic leukemia (ALL). These inhibitors have serious side effects during the chemotherapy e.g. cardiotoxicity and secondary malignancies. In this study we show that sulfonoquinovosyl diacylglyceride (SQDG) isolated from Azadirachta indica exerts potent anti-ALL activity both in vitro and in vivo in nude mice and it synergizes with doxorubicin and etoposide. SQDG selectively targets ALL MOLT-4 cells by inhibiting catalytic activity of topoisomerase I enzyme and inducing p53 dependent apoptotic pathway. SQDG treatment induces recruitment of ATR at chromatin and arrests the cells in S-phase. Down-regulation of topoisomerase I or p53 renders the cells less sensitive for SQDG, while ectopic expression of wild type p53 protein in p53 deficient K562 cells results in chemosensitization of the cells for SQDG. We also show that constant ratio combinations of SQDG and etoposide or SDQG and doxorubicin exert synergistic effects on MOLT-4 cell killing. This study suggests that doses of etoposide/doxorubicin can be substantially reduced by combining SQDG with these agents during ALL chemotherapy and side effects caused can be minimized. Thus dual targeting of topoisomerase I and II enzymes is a promising strategy for improving ALL chemotherapy.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Replication/drug effects ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Drug Synergism ; Etoposide/pharmacology ; Glycolipids/pharmacology ; Mice ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Signal Transduction/drug effects ; Topoisomerase I Inhibitors/pharmacology ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Antineoplastic Agents ; Glycolipids ; Topoisomerase I Inhibitors ; Tumor Suppressor Protein p53 ; sulfoquinovosyl diglyceride ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2015-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep12082
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito