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  1. Article ; Online: Genomic associations with antibody response to an oral cholera vaccine.

    Roy, Vijay Laxmi / Majumder, Partha P

    Vaccine

    2023  Volume 41, Issue 42, Page(s) 6391–6400

    Abstract: Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst ... ...

    Abstract Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that were moderately (p < 5 × 10
    MeSH term(s) Humans ; Cholera Vaccines ; Antibody Formation ; Genome-Wide Association Study ; Cholera/prevention & control ; Genomics ; Antibodies, Bacterial ; Administration, Oral
    Chemical Substances Cholera Vaccines ; Antibodies, Bacterial
    Language English
    Publishing date 2023-09-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Lockdown Maths: Part 1: Why We Must Comply

    Majumder, Partha P.

    Resonance

    Abstract: The following article is reproduced with permission from The Telegraph, Kolkata (Guest Column, Published on 25 March 2020). ...

    Abstract The following article is reproduced with permission from The Telegraph, Kolkata (Guest Column, Published on 25 March 2020).
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610965
    Database COVID19

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  3. Article ; Online: Lockdown Maths: Part 2: Relaxation of Lockdown—Perilous

    Majumder, Partha P.

    Reson

    Abstract: The following article is reproduced with permission from The Telegraph, Kolkata (Guest Column, Published 30 March 2020). ...

    Abstract The following article is reproduced with permission from The Telegraph, Kolkata (Guest Column, Published 30 March 2020).
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/s12045-020-0966-2
    Database COVID19

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  4. Article: Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.

    Biswas, Nidhan K / Majumder, Partha P

    The Indian journal of medical research

    2020  Volume 151, Issue 5, Page(s) 450–458

    Abstract: Background & objectives: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) is evolving with the progression of the pandemic. This study was aimed to investigate the diversity and evolution of the coronavirus SARS-CoV-2 with progression of the ...

    Abstract Background & objectives: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) is evolving with the progression of the pandemic. This study was aimed to investigate the diversity and evolution of the coronavirus SARS-CoV-2 with progression of the pandemic over time and to identify similarities and differences of viral diversity and evolution across geographical regions (countries).
    Methods: Publicly available data on type definitions based on whole-genome sequences of the SARS-CoV-2 sampled during December and March 2020 from 3636 infected patients spread over 55 countries were collected. Phylodynamic analyses were performed and the temporal and spatial evolution of the virus was examined.
    Results: It was found that (i) temporal variation in frequencies of types of the coronavirus was significant; ancestral viruses of type O were replaced by evolved viruses belonging to type A2a; (ii) spatial variation was not significant; with the spread of SARS-CoV-2, the dominant virus was the A2a type virus in every geographical region; (iii) within a geographical region, there was significant micro-level variation in the frequencies of the different viral types, and (iv) the evolved coronavirus of type A2a swept rapidly across all continents.
    Interpretation & conclusions: SARS-CoV-2 belonging to the A2a type possesses a non-synomymous variant (D614G) that possibly eases the entry of the virus into the lung cells of the host. This may be the reason why the A2a type has an advantage to infect and survive and as a result has rapidly swept all geographical regions. Therefore, large-scale sequencing of coronavirus genomes and, as required, of host genomes should be undertaken in India to identify regional and ethnic variation in viral composition and its interaction with host genomes. Further, careful collection of clinical and immunological data of the host can provide deep learning in relation to infection and transmission of the types of coronavirus genomes.
    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Evolution, Molecular ; Humans ; India/epidemiology ; Internationality ; Molecular Typing ; Pandemics ; Phylogeography ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; RNA, Viral/analysis ; RNA, Viral/genetics ; SARS-CoV-2 ; Spatio-Temporal Analysis
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1125_20
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  5. Article ; Online: A Humanitarian and a Great Indian.

    Majumder, Partha P

    Genome biology and evolution

    2016  Volume 8, Issue 2, Page(s) 467–469

    MeSH term(s) Altruism ; Genetics/history ; History, 19th Century ; History, 20th Century ; India ; United Kingdom
    Language English
    Publishing date 2016-02-01
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ISSN 1759-6653
    ISSN (online) 1759-6653
    DOI 10.1093/gbe/evw012
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  6. Article: Multiple migrations from East Asia led to linguistic transformation in NorthEast India and mainland Southeast Asia.

    Tagore, Debashree / Majumder, Partha P / Chatterjee, Anupam / Basu, Analabha

    Frontiers in genetics

    2022  Volume 13, Page(s) 1023870

    Abstract: NorthEast India, with its unique geographic location in the midst of the Himalayas and Bay of Bengal, has served as a passage for the movement of modern humans across the Indian subcontinent and East/Southeast Asia. In this study we look into the ... ...

    Abstract NorthEast India, with its unique geographic location in the midst of the Himalayas and Bay of Bengal, has served as a passage for the movement of modern humans across the Indian subcontinent and East/Southeast Asia. In this study we look into the population genetics of a unique population called the Khasi, speaking a language (also known as the Khasi language) belonging to the Austroasiatic language family and residing amidst the Tibeto-Burman speakers as an isolated population. The Khasi language belongs to one of the three major broad classifications or phyla of the Austroasiatic language and the speakers of the three sub-groups are separated from each other by large geographical distances. The Khasi speakers are separated from their nearest Austroasiatic language-speaking sub-groups: the "Mundari" sub-family from East and peninsular India and the "Mon-Khmers" in Mainland Southeast Asia. We found the Khasi population to be genetically distinct from other Austroasiatic speakers, i.e. Mundaris and Mon-Khmers, but relatively similar to the geographically proximal Tibeto Burmans. The possible reasons for this genetic-linguistic discordance lie in the admixture history of different migration events that originated from East Asia and proceeded possibly towards Southeast Asia. We found at least two distinct migration events from East Asia. While the ancestors of today's Tibeto-Burman speakers were affected by both, the ancestors of Khasis were insulated from the second migration event. Correlating the linguistic similarity of Tibeto-Burman and Sino-Tibetan languages of today's East Asians, we infer that the second wave of migration resulted in a linguistic transition while the Khasis could preserve their linguistic identity.
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1023870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genomics of immune response to typhoid and cholera vaccines.

    Majumder, Partha P

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2015  Volume 370, Issue 1671

    Abstract: Considerable variation in antibody response (AR) was observed among recipients of an injectable typhoid vaccine and an oral cholera vaccine. We sought to find whether polymorphisms in genes of the immune system, both innate and adaptive, were associated ... ...

    Abstract Considerable variation in antibody response (AR) was observed among recipients of an injectable typhoid vaccine and an oral cholera vaccine. We sought to find whether polymorphisms in genes of the immune system, both innate and adaptive, were associated with the observed variation in response. For both vaccines, we were able to discover and validate several polymorphisms that were significantly associated with immune response. For the typhoid vaccines, these polymorphisms were on genes that belonged to pathways of polysaccharide recognition, signal transduction, inhibition of T-cell proliferation, pro-inflammatory signalling and eventual production of antimicrobial peptides. For the cholera vaccine, the pathways included epithelial barrier integrity, intestinal homeostasis and leucocyte recruitment. Even though traditional wisdom indicates that both vaccines should act as T-cell-independent antigens, our findings reveal that the vaccines induce AR using different pathways.
    MeSH term(s) Antibodies, Bacterial/blood ; Antibody Formation/genetics ; Cholera/immunology ; Cholera/prevention & control ; Cholera Vaccines/immunology ; Gene Expression Regulation/immunology ; Genome, Human ; Genomics ; Humans ; Polymorphism, Genetic ; Typhoid Fever/immunology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines/immunology
    Chemical Substances Antibodies, Bacterial ; Cholera Vaccines ; Typhoid-Paratyphoid Vaccines
    Language English
    Publishing date 2015-05-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2014.0142
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  8. Article: Mutational landscape of gingivo-buccal oral cancer: new cancer genes and molecular subgroups identified.

    Majumder, Partha P

    Molecular cytogenetics

    2014  Volume 7, Issue Suppl 1 Proceedings of the International Conference on Human, Page(s) I8

    Language English
    Publishing date 2014-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2420849-8
    ISSN 1755-8166
    ISSN 1755-8166
    DOI 10.1186/1755-8166-7-S1-I8
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  9. Article ; Online: The Human Cell Atlas and equity: lessons learned.

    Majumder, Partha P / Mhlanga, Musa M / Shalek, Alex K

    Nature medicine

    2020  Volume 26, Issue 10, Page(s) 1509–1511

    MeSH term(s) Atlases as Topic ; Biomedical Research/ethics ; Biomedical Research/organization & administration ; Biomedical Research/trends ; Career Choice ; Career Mobility ; Cell Physiological Phenomena ; Cross-Cultural Comparison ; Female ; Health Equity/organization & administration ; Health Equity/trends ; Humans ; Male ; Patient Advocacy ; Patient Selection/ethics ; Racism/prevention & control ; Racism/trends ; Research Subjects ; Science/ethics ; Science/organization & administration ; Science/trends ; Socioeconomic Factors ; Whites
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-1100-4
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  10. Article: Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type

    Biswas, Nidhan K / Majumder, Partha P

    Indian journal of medical research

    Abstract: Background & objectives: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) is evolving with the progression of the pandemic. This study was aimed to investigate the diversity and evolution of the coronavirus SARS-CoV-2 with progression of the ... ...

    Abstract Background & objectives: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) is evolving with the progression of the pandemic. This study was aimed to investigate the diversity and evolution of the coronavirus SARS-CoV-2 with progression of the pandemic over time and to identify similarities and differences of viral diversity and evolution across geographical regions (countries). Methods: Publicly available data on type definitions based on whole-genome sequences of the SARS-CoV-2 sampled during December and March 2020 from 3636 infected patients spread over 55 countries were collected. Phylodynamic analyses were performed and the temporal and spatial evolution of the virus was examined. Results: It was found that (i) temporal variation in frequencies of types of the coronavirus was significant; ancestral viruses of type O were replaced by evolved viruses belonging to type A2a; (ii) spatial variation was not significant; with the spread of SARS-CoV-2, the dominant virus was the A2a type virus in every geographical region; (iii) within a geographical region, there was significant micro-level variation in the frequencies of the different viral types, and (iv) the evolved coronavirus of type A2a swept rapidly across all continents. Interpretation & conclusions: SARS-CoV-2 belonging to the A2a type possesses a non-synomymous variant (D614G) that possibly eases the entry of the virus into the lung cells of the host. This may be the reason why the A2a type has an advantage to infect and survive and as a result has rapidly swept all geographical regions. Therefore, large-scale sequencing of coronavirus genomes and, as required, of host genomes should be undertaken in India to identify regional and ethnic variation in viral composition and its interaction with host genomes. Further, careful collection of clinical and immunological data of the host can provide deep learning in relation to infection and transmission of the types of coronavirus genomes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32474553
    Database COVID19

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