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  1. Article: The bidirectional relationship between endometriosis and microbiome.

    Uzuner, Cansu / Mak, Jason / El-Assaad, Fatima / Condous, George

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1110824

    Abstract: Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing ... ...

    Abstract Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis
    MeSH term(s) Endometriosis/genetics ; Endometriosis/pathology ; Gastrointestinal Microbiome ; Inflammation/complications ; Microbiota ; Humans ; Female ; Epigenomics
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1110824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Journal Watch.

    Mak, Jason Kc

    Annals of clinical biochemistry

    2017  Volume 54, Issue 2, Page(s) 304

    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/0004563216681362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 889: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: 'Seeing is believing': arguing for diagnostic laparoscopy as a diagnostic test for endometriosis.

    Mak, Jason / Leonardi, Mathew / Condous, George

    Reproduction & fertility

    2022  Volume 3, Issue 3, Page(s) C23–C28

    Abstract: Endometriosis is a benign disease that can cause pain and infertility in women. Debate exists over how endometriosis should best be diagnosed. On one hand, endometriosis can be diagnosed by directly examining pelvic anatomy via a surgical procedure known ...

    Abstract Endometriosis is a benign disease that can cause pain and infertility in women. Debate exists over how endometriosis should best be diagnosed. On one hand, endometriosis can be diagnosed by directly examining pelvic anatomy via a surgical procedure known as diagnostic laparoscopy. On the other hand, the disease can be diagnosed via non-surgical means such as using medical imaging, the symptoms described by the patient and whether the patient responds to non-surgical therapies such as medication. In this debate article, we argue in favour of diagnostic laparoscopy. We review the safety of the procedure, compare the ability of diagnostic laparoscopy vs medical imaging to detect endometriosis and consider the benefits of formally diagnosing or ruling out the condition.
    MeSH term(s) Animals ; Diagnostic Tests, Routine ; Endometriosis ; Female ; Humans ; Laparoscopy ; Pelvic Pain ; Pelvis ; Service Animals
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-21-0117
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  4. Article ; Online: Effectiveness of ultrasound for endometriosis diagnosis.

    Chen-Dixon, Katie / Uzuner, Cansu / Mak, Jason / Condous, George

    Current opinion in obstetrics & gynecology

    2022  Volume 34, Issue 5, Page(s) 324–331

    Abstract: Purpose of review: Endometriosis is a chronic benign gynaecological condition characterized by pelvic pain, subfertility and delay in diagnosis. There is an emerging philosophical shift from gold standard histopathological diagnosis through laparoscopy ... ...

    Abstract Purpose of review: Endometriosis is a chronic benign gynaecological condition characterized by pelvic pain, subfertility and delay in diagnosis. There is an emerging philosophical shift from gold standard histopathological diagnosis through laparoscopy to establishing diagnosis through noninvasive imaging.
    Recent findings: The ENZIAN classification system was updated in 2021 to be suitable for both diagnostic imaging and laparoscopy. The accuracy of transvaginal ultrasound (TVUS) in diagnosing endometriosis varies depending on location of the lesion. A recent international pilot study found that when ultrasound is performed in accordance with the IDEA consensus, a higher detection of deep endometriosis is seen, with an overall sensitivity of 88% and specificity of 79% compared with direct surgical visualization.
    Summary: Although ultrasound can detect adenomyosis, deep endometriosis and endometriomas, it is not possible to reliably detect superficial endometriosis. In the instance of a negative ultrasound with persistence of symptoms despite medical therapy, laparoscopy should be considered for diagnosis and treatment.
    MeSH term(s) Endometriosis ; Female ; Humans ; Pelvis ; Pilot Projects ; Sensitivity and Specificity ; Ultrasonography
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1049382-7
    ISSN 1473-656X ; 1040-872X
    ISSN (online) 1473-656X
    ISSN 1040-872X
    DOI 10.1097/GCO.0000000000000812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Vergissmeinnicht.

    Mak, Jason K C

    Medical humanities

    2017  Volume 43, Issue 2, Page(s) e19

    Language English
    Publishing date 2017-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018219-3
    ISSN 1473-4265 ; 1468-215X
    ISSN (online) 1473-4265
    ISSN 1468-215X
    DOI 10.1136/medhum-2017-011188
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    Zs.A 5257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6.

    Howie, Jacqueline / Tulloch, Lindsay B / Brown, Elaine / Reilly, Louise / Ashford, Fiona B / Kennedy, Jennifer / Wypijewski, Krzysztof J / Aughton, Karen L / Mak, Jason K C / Shattock, Michael J / Fraser, Niall J / Fuller, William

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113679

    Abstract: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoylates PLM in ... ...

    Abstract Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoylates PLM in a glutathione-dependent manner. Glutathione loading cells acutely reduce PLM palmitoylation; glutathione depletion significantly increases PLM palmitoylation. Prdx6 silencing abolishes these effects, suggesting that PLM can be depalmitoylated by reduced Prdx6. In vitro, only recombinant Prdx6, among several peroxiredoxin isoforms tested, removes palmitic acid from recombinant palmitoylated PLM. The broad-spectrum depalmitoylase inhibitor palmostatin B prevents Prdx6-dependent PLM depalmitoylation in cells and in vitro. Our data suggest that Prdx6 is a thioesterase that can depalmitoylate proteins by nucleophilic attack via its reactive thiol, linking PLM palmitoylation and hence sodium pump activity to cellular glutathione status. We show that protein depalmitoylation can occur via a catalytic cysteine in which substrate specificity is determined by a protein-protein interaction.
    MeSH term(s) Peroxiredoxin VI ; Sodium-Potassium-Exchanging ATPase ; Membrane Proteins ; Glutathione ; Phosphoproteins
    Chemical Substances phospholemman (135541-82-1) ; Peroxiredoxin VI (EC 1.11.1.15) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Membrane Proteins ; Glutathione (GAN16C9B8O) ; Phosphoproteins
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113679
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  7. Article ; Online: Carotid body tumour associated with cyanotic heart disease.

    Mak, Jason K C / Kay, Mark

    BMJ case reports

    2016  Volume 2016

    MeSH term(s) Carotid Body Tumor/diagnostic imaging ; Carotid Body Tumor/etiology ; Carotid Body Tumor/surgery ; Cyanosis/complications ; Female ; Heart Diseases/complications ; Humans ; Middle Aged ; Organ Sparing Treatments/methods ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2016-03-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-214728
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  8. Article ; Online: An Ultrasound-based Prediction Model to Predict Ureterolysis during Laparoscopic Endometriosis Surgery.

    Zanardi, José Vitor C / Rocha, Rodrigo M / Leonardi, Mathew / Wood, Demi L / Lu, Chuan / Uzuner, Cansu / Mak, Jason / Condous, George

    Journal of minimally invasive gynecology

    2022  Volume 29, Issue 10, Page(s) 1170–1177

    Abstract: Study objective: To develop a model, including clinical features and ultrasound findings, to predict the need for ureterolysis (i.e., dissection of the ureter) during laparoscopy for endometriosis.: Design: A retrospective observational study of ... ...

    Abstract Study objective: To develop a model, including clinical features and ultrasound findings, to predict the need for ureterolysis (i.e., dissection of the ureter) during laparoscopy for endometriosis.
    Design: A retrospective observational study of patients who had undergone transvaginal ultrasound (TVS) according to the International Deep Endometriosis Analysis consensus and subsequent laparoscopy ± excision of endometriosis between January 2017 and February 2021 was conducted.
    Setting: Sydney Medical School Nepean, University of Sydney, Nepean Hospital, and Blue Mountains Hospital, New South Wales, Australia.
    Patients/participant: 177 patients.
    Intervention: The demographic, clinical, TVS, and intraoperative data were extracted through electronic clinical records.
    Measurements and main results: Multicategorical decision-tree and baseline models were built to choose the variables most correlated to the outcome under study. Receiver operating characteristic analysis was performed on the binary classification. Based on our results, we selected the variables performing with significant statistical differences (p <.05). During the study period, 177 consecutive patients were recruited and divided into 2 subgroups, ureterolysis (51.4%) and nonureterolysis (48.6%). Ureterolysis was noted in 87.5% of patients in which the left ovary was immobile (p <.001) and in 82.5% in which the right ovary was fixed (p <.001). For patients with right uterosacral ligament (USL) deep endometriosis (DE), ureterolysis was performed in 96.2% patients (p <.001) and 64.6% (p = .043) for left USL DE. Among patients with bowel DE, the proportion of patients undergoing ureterolysis was 95.5% (p <.001). The prognostic variables used in the final model to predict ureterolysis included dyschezia, absence of ovarian mobility, presence of right or left USL DE, and presence of bowel DE on TVS. According to the developed model, the baseline risk for performing ureterolysis is 20% in our sample. The overall model performance demonstrated an area under the receiver operating characteristic curve 0.82.
    Conclusion: Our study demonstrates that it is possible to predict the need for ureterolysis with clinical and sonographic data. Furthermore, patients presenting with a combination of the variables of our model (dyschezia, ovarian immobility, USL, and bowel DE lesions) have a high risk of ureterolysis. In contrast, patients without these features have a low risk (approximately 20%) of needing ureterolysis.
    MeSH term(s) Constipation/surgery ; Endometriosis/diagnostic imaging ; Endometriosis/pathology ; Endometriosis/surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Sensitivity and Specificity ; Ultrasonography/methods ; Ureter/diagnostic imaging ; Ureter/pathology ; Ureter/surgery
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2022.07.002
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    Zs.A 4205: Show issues Location:
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  9. Article ; Online: Back-side-on-BOX heterogeneously integrated III-V-on-silicon O-band discrete-mode lasers.

    Thiessen, Torrey / Menezo, Sylvie / Jany, Christophe / Mak, Jason C C / Poon, Joyce K S

    Optics express

    2020  Volume 28, Issue 26, Page(s) 38579–38591

    Abstract: We demonstrate foundry-fabricated O-band III-V-on-silicon discrete-mode lasers. The laser fabrication follows the back-side-on-buried-oxide laser integration process and is compatible with complex, multilayer, silicon-on-insulator based platforms. A ... ...

    Abstract We demonstrate foundry-fabricated O-band III-V-on-silicon discrete-mode lasers. The laser fabrication follows the back-side-on-buried-oxide laser integration process and is compatible with complex, multilayer, silicon-on-insulator based platforms. A series of devices were characterized, with the best devices producing on-chip powers of nearly 20 mW with Lorentzian linewidths below 20 kHz and a side mode suppression ratio of at least 60 dB.
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.412839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: "Lessons from the extremes: Epigenetic and genetic regulation in point monocentromere and holocentromere establishment on artificial chromosomes".

    Wong, Charmaine Yan Yu / Ling, Yick Hin / Mak, Jason Ka Ho / Zhu, Jing / Yuen, Karen Wing Yee

    Experimental cell research

    2020  Volume 390, Issue 2, Page(s) 111974

    Abstract: The formation of de novo centromeres on artificial chromosomes in humans (HACs) and fission yeast (SpYACs) has provided much insights to the epigenetic and genetic control on regional centromere establishment and maintenance. Similarly, the use of ... ...

    Abstract The formation of de novo centromeres on artificial chromosomes in humans (HACs) and fission yeast (SpYACs) has provided much insights to the epigenetic and genetic control on regional centromere establishment and maintenance. Similarly, the use of artificial chromosomes in point centromeric budding yeast Saccharomyces cerevisiae (ScYACs) and holocentric Caenorhabditis elegans (WACs) has revealed epigenetic regulation in the originally thought purely genetically-determined point centromeres and some centromeric DNA sequence features in holocentromeres, respectively. These relatively extreme and less characterized centromere organizations, on the endogenous chromosomes and artificial chromosomes, will be discussed and compared to the more well-studied regional centromere systems. This review will highlight some of the common epigenetic and genetic features in different centromere architectures, including the presence of the centromeric histone H3 variant, CENP-A or CenH3, centromeric and pericentric transcription, AT-richness and repetitiveness of centromeric DNA sequences.
    MeSH term(s) Animals ; Bombyx/genetics ; Bombyx/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Candida albicans/genetics ; Candida albicans/metabolism ; Centromere/metabolism ; Centromere/ultrastructure ; Centromere Protein A/genetics ; Centromere Protein A/metabolism ; Chromatin/chemistry ; Chromatin/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosomes, Artificial/chemistry ; Chromosomes, Artificial/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Epigenesis, Genetic ; Histones/genetics ; Histones/metabolism ; Humans ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Zea mays/genetics ; Zea mays/metabolism
    Chemical Substances Centromere Protein A ; Chromatin ; Chromosomal Proteins, Non-Histone ; Histones
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2020.111974
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    Zs.A 563: Show issues Location:
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