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  1. Article ; Online: MRI Vessel Wall Imaging and Treatment of an Aneurysm at the Atlanto-Axial Segment of an Aberrant Vertebral Artery

    Tsang Chun On Anderson / Yeung Wan Lung Ryo / Mak Ka Fung / Lui Wai Man

    Neurointervention, Vol 13, Iss 1, Pp 62-

    2018  Volume 65

    Abstract: We report a case of unique location of an aneurysm at the atlanto-axial extradural segment of a unilateral aberrant vertebral artery. The MRI vessel wall imaging findings and possible mechanism of aneurysm formation were discussed. A 5 mm extracranial ... ...

    Abstract We report a case of unique location of an aneurysm at the atlanto-axial extradural segment of a unilateral aberrant vertebral artery. The MRI vessel wall imaging findings and possible mechanism of aneurysm formation were discussed. A 5 mm extracranial vertebral artery aneurysm located at the interlaminar space between C1 and C2 was diagnosed in a woman presenting with occipital headache. The index vertebral artery ran an aberrant course at the V3 segment, where it entered the dura between C1 and C2 instead of the usual atlanto-occipital space. MR vessel wall imaging showed homogenous wall enhancement of the aneurysm sac. We surmise the anomalous course of the vertebral artery subjected the V3 segment to repeated shearing force secondary to the atlanto-axial rotational neck movement. This led to vessel wall trauma and inflammation, and subsequent aneurysm formation. The aneurysm was successfully treated with endovascular coiling with resolution of symptoms.
    Keywords vessel wall imaging ; aneurysm ; vertebral artery ; Medicine (General) ; R5-920 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Korean Society of Interventional Neuroradiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Author Correction: MRI Vessel Wall Imaging and Treatment of an Aneurysm at the Atlanto-Axial Segment of an Aberrant Vertebral Artery.

    Tsang, Chun On Anderson / Yeung, Wan Lung Ryo / Mak, Ka Fung / Lui, Wai Man

    Neurointervention

    2018  Volume 13, Issue 2, Page(s) 145

    Language English
    Publishing date 2018-05-30
    Publishing country Korea (South)
    Document type Journal Article ; Published Erratum
    ZDB-ID 2639823-0
    ISSN 2233-6273 ; 2093-9043
    ISSN (online) 2233-6273
    ISSN 2093-9043
    DOI 10.5469/neuroint.2018.13.1.62.e1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Super Slice Interpolation For Generating Thin-Slice Images From Multichannel Multislice MRI Data.

    Feng, Yanqiu / Lyu, Mengye / Liu, Yilong / Xie, Victor B / Mak, Ka-Fung Henry / Guo, Hua / Wu, Ed X

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2018  Volume 2018, Page(s) 1351–1355

    Abstract: This study aims to develop a super slice interpolation (SSI) method that generates thin-slice images from multichannel multislice images by exploiting the intra-slice coil sensitivity variations. SSI first calculates the thin-slice sensitivity maps by ... ...

    Abstract This study aims to develop a super slice interpolation (SSI) method that generates thin-slice images from multichannel multislice images by exploiting the intra-slice coil sensitivity variations. SSI first calculates the thin-slice sensitivity maps by through-plane interpolation of the sensitivity maps computed from the acquired multislice images. It then reconstructs multiple thin-slice images from each acquired image using a through-plane regularized sensitivity encoding (SENSE) like procedure that consists of an initial SENSE reconstruction and denoising to set the prior information image, and subsequent regularized SENSE reconstruction. We evaluated SSI using multislice brain and abdominal images with typical slice thickness. SSI successfully separated each acquired image into two thinner ones without magnitude bias. Compared with the original thick-slice images, SSI revealed more anatomical details that were consistent with those in the separately acquired thin-slice images. SSI presents a novel slice interpolation approach to obtain thin-slice images from the multichannel thick-slice images.
    MeSH term(s) Brain ; Magnetic Resonance Imaging ; Phantoms, Imaging
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2018.8512523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders.

    Cheng, Pak Wing Calvin / Chang, Wing Chung / Lo, Gladys G / Chan, Kit Wa Sherry / Lee, Ho Ming Edwin / Hui, Lai Ming Christy / Suen, Yi Nam / Leung, Yim Lung Eric / Au Yeung, Kai Ming Paul / Chen, Sirong / Mak, Ka Fung Henry / Sham, Pak Chung / Santangelo, Barbara / Veronese, Mattia / Ho, Chi-Lai / Chen, Yu Hai Eric / Howes, Oliver D

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2020  Volume 45, Issue 11, Page(s) 1870–1876

    Abstract: There have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and ... ...

    Abstract There have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and schizophrenia (SZ), antipsychotics are deemed equally effective pharmaceutical treatments for both conditions. In this context, dopamine dysregulation may be transdiagnostic of the pathophysiology of psychotic disorders such as DD and SZ. In this study, an examination is made of the dopamine synthesis capacity (DSC) of patients with SZ, DD, other psychotic disorders, and the DSC of healthy subjects. Fifty-four subjects were recruited to the study, comprising 35 subjects with first-episode psychosis (11 DD, 12 SZ, 12 other psychotic disorders) and 19 healthy controls. All received an
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Dopamine ; Humans ; Positron-Emission Tomography ; Psychotic Disorders/diagnostic imaging ; Psychotic Disorders/drug therapy ; Schizophrenia, Paranoid/diagnostic imaging ; Schizophrenia, Paranoid/drug therapy
    Chemical Substances Antipsychotic Agents ; Dopamine (VTD58H1Z2X)
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-020-0740-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis.

    Liu, Ju-Hua / Ng, Ming-Yen / Cheung, Tommy / Chung, Ho-Yin / Chen, Yan / Zhen, Zhe / Zou, Yuan / Mak, Ka-Fung / Khong, Pek-Lan / Lau, Chak-Sing / Tse, Hung-Fat / Yiu, Kai-Hang

    Clinical rheumatology

    2017  Volume 36, Issue 4, Page(s) 807–816

    Abstract: Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular ...

    Abstract Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (CS) and 10-year predicted coronary CS, based on the pattern of the general population, were compared. Calcification of the coronary and carotid artery and the aorta was assessed by multi-detector computed tomography. Significant CS progression was determined by the difference between the square root of baseline and square root of follow-up calcium score (i.e., SQRT method). The 10-year predicted coronary CS was based on the mathematical formula derived by the Heinz Nixdorf Recall Study. A total of 49 patients (54 ± 11 years, 90% female) had a follow-up scan after 10.0 ± 0.2 years. The CS in all vascular beds was significantly increased; 55% of the patients had a significant progression of CS in the coronary, 29% in the carotid, and 80% in the aorta. Age and systolic blood pressure (SBP) were independently associated with calcification progression in all vascular beds. Importantly, the absolute increase in 10-year actual coronary CS was significantly higher than that predicted. In patients with RA, calcification in all vascular beds significantly increased over 10 years and was independently associated with age and SBP. Importantly, the absolute increase in 10-year actual coronary CS progression was significantly higher than that predicted.
    MeSH term(s) Adult ; Aged ; Aorta, Thoracic/diagnostic imaging ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/pathology ; Atherosclerosis/diagnostic imaging ; Carotid Arteries/diagnostic imaging ; China ; Coronary Vessels/diagnostic imaging ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Tomography, X-Ray Computed ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/pathology
    Language English
    Publishing date 2017-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-016-3536-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition.

    Mok, Mo Yin / Lau, Chak Sing / Chiu, Sonny Sau Hin / Tso, Annette Wai Kwan / Lo, Yi / Law, Lawrence Siu Chun / Mak, Ka Fung / Wong, Woon Sing / Khong, Peh Lan / Lam, Karen Siu Ling

    Arthritis and rheumatism

    2011  Volume 63, Issue 5, Page(s) 1387–1395

    Abstract: Objective: Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary ... ...

    Abstract Objective: Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients.
    Methods: The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, high-sensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined.
    Results: We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ± SD age of 53.1 ± 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P = 0.001), high-density lipoprotein cholesterol levels (P = 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS ≥ 101) compared to those with lesser severity (CACS <100) (56.5% versus 29.4%; P = 0.01). Multiple logistic regression analysis revealed SSc to be an independent determinant for a CACS ≥ 101 (OR 10.89 [95% CI 2.21-53.75], P = 0.003) together with age and LDL cholesterol level after adjustment for other cardiovascular risk factors. Among disease-specific factors, only disease duration (OR 1.14 [95% CI 1.02-1.27], P = 0.02) was independently associated with more severe coronary calcification (CACS ≥ 101).
    Conclusion: Our findings indicate that SSc is an independent risk factor for coronary calcification, in addition to the conventional risk factors for coronary atherosclerosis, such as age and hypertension.
    MeSH term(s) Adult ; Aged ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Carotid Artery, Common/diagnostic imaging ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/etiology ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Radiography ; Risk Factors ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.30283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong.

    Chan, Kam Hoi / Chan, Chun Wing / Chow, Wai Hung / Kwan, Wai Keung / Kong, Chi Kwan / Mak, Ka Fung / Leung, Miu Yi / Lau, Lin Kiu

    World journal of gastroenterology

    2006  Volume 12, Issue 14, Page(s) 2223–2228

    Abstract: Aim: To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors (GISTs) in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence.: Methods: From the database of the Department of ... ...

    Abstract Aim: To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors (GISTs) in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence.
    Methods: From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model.
    Results: The patients included 26 males and 21 females, with a mean age of 66.6 years (SD 13.1, range 29-87 years). The estimated prevalence of GISTs was 13.4-15.6 per 100,000 people, with an annual incidence of 1.68-1.96 per 100,000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100,000 people and 2.1 per 100,000 people respectively. Stomach (34 patients, 72.3%) was the most common location for the tumor, followed by the small intestine (8 patients, 17.0%), esophagus (2 patients, 4.3%), omentum (2 patients, 4.3%) and colon (1 patient, 2.1%). Thirty-one patients (66%) had complete tumor resection. Eleven out of 16 deaths (23%) were tumor-related. The median survival time was 26 mo. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis.
    Conclusion: The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence.
    MeSH term(s) Adult ; Aged ; Cohort Studies ; Female ; Gastrointestinal Stromal Tumors/epidemiology ; Gastrointestinal Stromal Tumors/mortality ; Gastrointestinal Stromal Tumors/therapy ; Hong Kong/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Prognosis
    Language English
    Publishing date 2006-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v12.i14.2223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pattern of arterial calcification in patients with systemic lupus erythematosus.

    Yiu, Kai-Hang / Wang, Silun / Mok, Mo-Yin / Ooi, Gaik Cheng / Khong, Pek-Lan / Mak, Ka-Fung Henry / Lam, Kwok-Fai / Lau, Chak-Sing / Tse, Hung-Fat

    The Journal of rheumatology

    2009  Volume 36, Issue 10, Page(s) 2212–2217

    Abstract: Objective: To evaluate the prevalence and pattern of arterial calcification in patients with asymptomatic systemic lupus erythematosus (SLE) compared with control subjects. SLE patients are prone to adverse cardiovascular events; however, the underlying ...

    Abstract Objective: To evaluate the prevalence and pattern of arterial calcification in patients with asymptomatic systemic lupus erythematosus (SLE) compared with control subjects. SLE patients are prone to adverse cardiovascular events; however, the underlying atherosclerotic process is unknown. Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events.
    Methods: Fifty age and sex matched SLE patients and controls were enrolled. All subjects underwent 64 slice MDCT scan to evaluate CS in coronary, carotid arteries and the aorta.
    Results: As compared with controls, SLE patients had higher mean CS and prevalence of CS > 0 across all vascular beds. After adjustment for age and sex, SLE patient odds of having CS > 0 in any vascular bed was 33.6 (95% CI: 9.5-165.2) were higher versus patients in the control group, mainly due to more prevalent coronary calcification (OR 30.0, 95% CI: 6.7-203.8). In SLE patients, the most frequent vessel with CS > 0 was coronary (42%) followed by carotid artery (24%). Further, arterial calcification occurred early involving 40% of SLE patients at age < 40 years, with increasing prevalence as age advanced.
    Conclusion: Our study confirms that patients with SLE have significantly higher prevalence and extent of systemic arterial calcification compared with age and sex matched controls.
    MeSH term(s) Adult ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/pathology ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/epidemiology ; Atherosclerosis/physiopathology ; Calcinosis/diagnostic imaging ; Calcinosis/epidemiology ; Calcinosis/physiopathology ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/diagnostic imaging ; Cardiovascular System/pathology ; Cardiovascular System/physiopathology ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology ; Case-Control Studies ; Coronary Vessels/pathology ; Female ; Hong Kong ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Tomography, Spiral Computed
    Language English
    Publishing date 2009-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.090312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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