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  1. Article ; Online: Alzheimer's Disease in Diabetic Patients: A Lipidomic Prospect.

    Makki, Bassel Eldeen / Rahman, Sarah

    Neuroscience

    2023  Volume 530, Page(s) 79–94

    Abstract: Diabetes Mellitus (DM) and Alzheimer's disease (AD) have been two of the most common chronic diseases affecting people worldwide. Type 2 DM (T2DM) is a metabolic disease depicted by insulin resistance, dyslipidemia, and chronic hyperglycemia while AD is ... ...

    Abstract Diabetes Mellitus (DM) and Alzheimer's disease (AD) have been two of the most common chronic diseases affecting people worldwide. Type 2 DM (T2DM) is a metabolic disease depicted by insulin resistance, dyslipidemia, and chronic hyperglycemia while AD is a neurodegenerative disease marked by Amyloid β (Aβ) accumulation, neurofibrillary tangles aggregation, and tau phosphorylation. Various clinical, epidemiological, and lipidomics studies have linked those diseases claiming shared pathological pathways raising the assumption that diabetic patients are at an increased risk of developing AD later in their lives. Insulin resistance is the tipping point beyond where advanced glycation end (AGE) products and free radicals are produced leading to oxidative stress and lipid peroxidation. Additionally, different types of lipids are playing a crucial role in the development and the relationship between those diseases. Lipidomics, an analysis of lipid structure, formation, and interactions, evidently exhibits these lipid changes and their direct and indirect effect on Aβ synthesis, insulin resistance, oxidative stress, and neuroinflammation. In this review, we have discussed the pathophysiology of T2DM and AD, the interconnecting pathological pathways they share, and the lipidomics where different lipids such as cholesterol, phospholipids, sphingolipids, and sulfolipids contribute to the underlying features of both diseases. Understanding their role can be beneficial for diagnostic purposes or introducing new drugs to counter AD.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Insulin Resistance ; Neurodegenerative Diseases ; Lipidomics ; Diabetes Mellitus, Type 2/metabolism ; Lipids
    Chemical Substances Amyloid beta-Peptides ; Lipids
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2023.08.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Erratum to "Alzheimer's Disease in Diabetic Patients: A Lipidomic Prospect" [Neuroscience 530 (2023) 79-94].

    Makki, Bassel Eldeen / Rahman, Sarah

    Neuroscience

    2023  Volume 532, Page(s) 164–165

    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2023.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Clinicoradiological Outcomes and Complication Profiles of Bilateral Dual Sacral-Alar-Iliac Screws versus Bilateral Single Sacral-Alar-Iliac Screws in Patients with Spinal Deformity Who Underwent Grade 3 or 4 Spinal Osteotomies: A Retrospective Comparative Study.

    Kankam, Samuel Berchi / Zarei, Mohammad / Moghadam, Navid / Jouibari, Morteza Faghih / Bazzazi, Amir Mohammad / Yaseen Khan, Furqan Mohammed / Moosavi, Mersad / Shafizadeh, Milad / Roohollahi, Faramarz / Makki, Bassel Eldeen / Khadivi, Masoud / Rostami, Mohsen

    World neurosurgery

    2023  Volume 178, Page(s) e646–e656

    Abstract: Objective: To compare short-term clinical and radiological outcomes and complication profiles between bilateral dual sacral-2-alar-iliac (S2AI) screw and bilateral single S2AI screw fixation techniques in patients who underwent grade 3 or 4 spinal ... ...

    Abstract Objective: To compare short-term clinical and radiological outcomes and complication profiles between bilateral dual sacral-2-alar-iliac (S2AI) screw and bilateral single S2AI screw fixation techniques in patients who underwent grade 3 or 4 spinal osteotomies.
    Methods: A retrospective review of 83 patients treated with bilateral dual S2AI screws and 32 patients treated with bilateral single S2AI screws was conducted between 2018 and 2020 with a minimum 1-year follow-up. Clinical and radiological outcomes of patients and incidence of perioperative complications, including rod breakage, screw dislodgment, proximal junctional kyphosis, proximal junctional failure, need for reoperation, and systemic adverse effects, were collected and statistically compared between the groups.
    Results: With a mean follow-up of 18.2 months, rod fracture (6.0% vs. 18.7%, P = 0.03), screw dislodgment (0 vs. 12.5%, P < 0.01), and S2AI screw loosening (1.2% vs. 18.7%, P < 0.01) were significantly lower in the dual S2AI screws group than in the single S2AI screws group. However, the reoperation rate was similar between the 2 groups (24.1% vs. 34.3%, P = 0.26). No significant differences in clinical and radiological outcomes as well as proximal junctional kyphosis (10.8% vs. 18.7%, P = 0.25) and proximal junctional failure (9.6% vs. 18.7%, P = 0.18) were identified between the 2 groups.
    Conclusions: The dual S2AI screw fixation technique showed more advantages over the single S2AI screw fixation technique with reduced incidence of screw dislodgment, rod fractures, and sacral-alar-iliac screw loosening.
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.07.139
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    Zs.A 1159: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: An Epidemiological Study on COVID-19: A Rapidly Spreading Disease.

    Khachfe, Hussein H / Chahrour, Mohamad / Sammouri, Julie / Salhab, Hamza / Makki, Bassel Eldeen / Fares, Mohamad

    Cureus

    2020  Volume 12, Issue 3, Page(s) e7313

    Abstract: Background The outbreak of the novel coronavirus disease in 2019 (COVID-19) caused a major public health crisis worldwide and challenged healthcare systems across the six continents. The high infectivity of the disease led many governments to adopt ... ...

    Abstract Background The outbreak of the novel coronavirus disease in 2019 (COVID-19) caused a major public health crisis worldwide and challenged healthcare systems across the six continents. The high infectivity of the disease led many governments to adopt strict regulations and measures with the aim of containing its spread. The purpose of this study is to assess the incidence, severity, and territorial expansion of COVID-19. Methods Data from the World Health Organization was screened, and COVID-19 situation reports were extracted from January 21 up till March 14 (inclusive). Our data included the total number of cases, total number of new cases, total number of cured cases, and total number of related deaths. Percentage change of cases over the days of our study were calculated using the Joinpoint regression, with a significance level set at greater than 0.05. Results The total number of COVID-19 cases reached 156,622, with 5,845 subsequent deaths. China, Italy, and Iran have the highest number of cases worldwide. During the first 22 days, the incidence rate of COVID-19 increased significantly to reach 1.81 cases per million persons (p<0.001). That was followed by a significant decrease over the next 11 days (p<0.001) to reach 0.071 cases per million persons. A steady rise then followed, which saw a significant increase in incidence rate to 1.429 cases per million persons (p<0.001). Percentages of death and cured cases varied across the different countries; nevertheless, death percentages have generally been decreasing since the start of the crisis. Conclusion Adopting precautionary regulations such as social isolation, increasing sanitation, and employing strict quarantine measures have proved to be beneficial in containing the virus. Further research needs to be conducted to help discover therapeutic modalities and improve outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.7313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An Epidemiological Study on COVID-19: A Rapidly Spreading Disease

    Khachfe, Hussein H. / Chahrour, Mohamad / Sammouri, Julie / Salhab, Hamza / Makki, Bassel Eldeen / Fares, Mohamad

    Cureus

    Abstract: Background The outbreak of the novel coronavirus disease in 2019 (COVID-19) caused a major public health crisis worldwide and challenged healthcare systems across the six continents The high infectivity of the disease led many governments to adopt strict ...

    Abstract Background The outbreak of the novel coronavirus disease in 2019 (COVID-19) caused a major public health crisis worldwide and challenged healthcare systems across the six continents The high infectivity of the disease led many governments to adopt strict regulations and measures with the aim of containing its spread The purpose of this study is to assess the incidence, severity, and territorial expansion of COVID-19 Methods Data from the World Health Organization was screened, and COVID-19 situation reports were extracted from January 21 up till March 14 (inclusive) Our data included the total number of cases, total number of new cases, total number of cured cases, and total number of related deaths Percentage change of cases over the days of our study were calculated using the Joinpoint regression, with a significance level set at greater than 0 05 Results The total number of COVID-19 cases reached 156,622, with 5,845 subsequent deaths China, Italy, and Iran have the highest number of cases worldwide During the first 22 days, the incidence rate of COVID-19 increased significantly to reach 1 81 cases per million persons (p<0 001) That was followed by a significant decrease over the next 11 days (p<0 001) to reach 0 071 cases per million persons A steady rise then followed, which saw a significant increase in incidence rate to 1 429 cases per million persons (p<0 001) Percentages of death and cured cases varied across the different countries;nevertheless, death percentages have generally been decreasing since the start of the crisis Conclusion Adopting precautionary regulations such as social isolation, increasing sanitation, and employing strict quarantine measures have proved to be beneficial in containing the virus Further research needs to be conducted to help discover therapeutic modalities and improve outcomes
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #105926
    Database COVID19

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