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  1. Article ; Online: Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review.

    Malarz, Janusz / Michalska, Klaudia / Stojakowska, Anna

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 9

    Abstract: Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to plant-environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the ... ...

    Abstract Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to plant-environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from the subtribe (
    MeSH term(s) Polyphenols/chemistry ; Polyphenols/pharmacology ; Humans ; Plants, Medicinal/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Asteraceae/chemistry
    Chemical Substances Polyphenols ; Plant Extracts ; Phytochemicals
    Language English
    Publishing date 2024-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29092014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates.

    Malarz, Janusz / Yudina, Yulia V / Stojakowska, Anna

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses in both plants and humans. They are being used as food preservatives and additives or ingredients of cosmetics. ...

    Abstract Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses in both plants and humans. They are being used as food preservatives and additives or ingredients of cosmetics. For nearly forty years,
    MeSH term(s) Humans ; Plants, Genetically Modified/genetics ; Antioxidants/metabolism ; Agrobacterium/genetics ; Phenols/metabolism ; Plant Roots/metabolism ; Transformation, Genetic ; Rhizobium/genetics
    Chemical Substances Antioxidants ; Phenols ; phenolic acid (I3P9R8317T)
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24086920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chemical constituents from Lactuca plumieri (L.) Gren. & Godr. (Asteraceae)

    Michalska, Klaudia / Malarz, Janusz / Stojakowska, Anna

    Natural Product Research. 2022 Oct. 13, v. 36, no. 20 p.5337-5341

    2022  

    Abstract: This is the first report concerning the natural products of the hitherto unstudied Lactuca plumieri (L.) Gren. & Godr., a member of the tribe Cichorieae (Asteraceae). From aerial parts and roots of this plant, five sesquiterpene lactones and one coumarin ...

    Abstract This is the first report concerning the natural products of the hitherto unstudied Lactuca plumieri (L.) Gren. & Godr., a member of the tribe Cichorieae (Asteraceae). From aerial parts and roots of this plant, five sesquiterpene lactones and one coumarin were isolated. The compounds were identified as sonchuside A, 11β,13-dihydrolactucin-8-O-acetate, 11β,13-dihydrolactucin, cichorioside B, 11β,13-dihydrolactucin-8-O-acetate-15-O-β-glucopyranoside and coumarin – cichoriin. Their structures were established by ¹H NMR. Moreover, HPLC/PAD analysis of a hydroalcoholic extract from the aerial parts of the plant revealed the presence of caffeic acid derivatives, coumarins and flavonoids commonly found in lettuces.
    Keywords Lactuca ; caffeic acid ; coumarin ; flavonoids ; research ; sesquiterpenoid lactones ; Asteraceae ; Lactuca plumieri ; sesquiterpenoids ; caffeic acid derivatives
    Language English
    Dates of publication 2022-1013
    Size p. 5337-5341.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1920583
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Chemical Composition and Cytotoxic Activity of Extracts from

    Malarz, Janusz / Galanty, Agnieszka / Stojakowska, Anna

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 21

    Abstract: Carpesium divaricatum Sieb. & Zucc. is a plant species rich in terpenoids of anti-inflammatory and cytotoxic activity, especially germacranolides of potential medicinal value. The present study describes in vitro multiplication of C. divaricatum, ... ...

    Abstract Carpesium divaricatum Sieb. & Zucc. is a plant species rich in terpenoids of anti-inflammatory and cytotoxic activity, especially germacranolides of potential medicinal value. The present study describes in vitro multiplication of C. divaricatum, analysis of active constituents in the multiple shoots, and assessment of cytotoxic activities of extracts prepared from in vitro- and field-grown plants. The plant extracts were evaluated for cytotoxicity using two melanoma cell lines (HTB140 and A375); human keratinocytes (HaCaT); two colon cancer cell lines (Caco2 and HT29); human hepatocellular carcinoma cells (HepG2); two lines of prostate cancer cells (DU145 and PC3) and prostate epithelial cells (PNT2). Chemical compositions of the assayed extracts were analyzed by HPLC/DAD, in reference to isolated compounds. Maximum of 4.07 ± 1.61 shoots regenerated from a nodal explant of C. divaricatum, cultivated in a liquid MS medium supplemented with thidiazuron (1 μM). In vitro grown shoots and plantlets of C. divaricatum accumulated terpenoids that are known as active constituents of the intact plant. Cytotoxic activity of the extracts prepared from the in vitro cultured plants was like that demonstrated by the extracts prepared from field-grown plants and seemed to be more selective than cytotoxicities of the individual germacranolides.
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11212815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Constituents of

    Malarz, Janusz / Michalska, Klaudia / Galanty, Agnieszka / Kiss, Anna Karolina / Stojakowska, Anna

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 2

    Abstract: Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots ... ...

    Abstract Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots and aerial parts of P. inuloides were analyzed using the UHPLC-PAD-MSn technique and revealed the presence of six caffeoylquinic and eleven caffeoylhexaric conjugates together with hydroxykaempferol dimethyl ether and quercetagetin trimethyl ether. Moreover, constituents of chloroform extract from the whole P. inuloides plants were isolated and identified by spectroscopic methods. One new and four known caryophyllene derivatives, three thymol derivatives, and four polymethoxylated flavonols were found in the analyzed extract. The structure of the new compound was established by spectroscopic methods (HRESIMS, 1H NMR, 13C NMR, COSY, HSQC, HMBC, NOESY). The cytotoxicity of 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3’-trimethyl ether (chrysosplenol C), which are major flavonols isolated from the plant, were tested on prostate epithelial cells (PNT2), prostate cancer cells (DU145 and PC3), human keratinocytes (HaCaT), and melanoma cells (HTB140 and A375). Both flavonols demonstrated moderate cytotoxic activity against PC3 cells (IC50 = 59.5 µM and 46.6 µM, respectively). The remaining cell lines were less affected (IC50 > 150 µM).
    MeSH term(s) Humans ; Flavonols/pharmacology ; Pulicaria/chemistry ; Methyl Ethers ; Antineoplastic Agents ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
    Chemical Substances Flavonols ; dimethyl ether (AM13FS69BX) ; Methyl Ethers ; Antineoplastic Agents ; Plant Extracts
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Hairy Root Cultures as a Source of Polyphenolic Antioxidants: Flavonoids, Stilbenoids and Hydrolyzable Tannins.

    Malarz, Janusz / Michalska, Klaudia / Yudina, Yulia V / Stojakowska, Anna

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 15

    Abstract: Due to their chemical properties and biological activity, antioxidants of plant origin have gained interest as valuable components of the human diet, potential food preservatives and additives, ingredients of cosmetics and factors implicated in tolerance ...

    Abstract Due to their chemical properties and biological activity, antioxidants of plant origin have gained interest as valuable components of the human diet, potential food preservatives and additives, ingredients of cosmetics and factors implicated in tolerance mechanisms against environmental stress. Plant polyphenols are the most prominent and extensively studied, albeit not only group of, secondary plant (specialized) metabolites manifesting antioxidative activity. Because of their potential economic importance, the productive and renewable sources of the compounds are desirable. Over thirty years of research on hairy root cultures, as both producers of secondary plant metabolites and experimental systems to investigate plant biosynthetic pathways, brought about several spectacular achievements. The present review focuses on the
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11151950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chemical constituents from

    Michalska, Klaudia / Malarz, Janusz / Stojakowska, Anna

    Natural product research

    2021  Volume 36, Issue 20, Page(s) 5337–5341

    Abstract: This is the first report concerning the natural products of the hitherto ... ...

    Abstract This is the first report concerning the natural products of the hitherto unstudied
    MeSH term(s) Asteraceae/chemistry ; Coumarins ; Flavonoids ; Lactones/chemistry ; Phorbols ; Plant Extracts/chemistry ; Sesquiterpenes/chemistry
    Chemical Substances Coumarins ; Flavonoids ; Lactones ; Phorbols ; Plant Extracts ; Sesquiterpenes ; lactucin (R6E2918904)
    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1920583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hairy Root Cultures as a Source of Polyphenolic Antioxidants: Flavonoids, Stilbenoids and Hydrolyzable Tannins

    Malarz, Janusz / Michalska, Klaudia / Yudina, Yulia V. / Stojakowska, Anna

    Plants. 2022 July 27, v. 11, no. 15

    2022  

    Abstract: Due to their chemical properties and biological activity, antioxidants of plant origin have gained interest as valuable components of the human diet, potential food preservatives and additives, ingredients of cosmetics and factors implicated in tolerance ...

    Abstract Due to their chemical properties and biological activity, antioxidants of plant origin have gained interest as valuable components of the human diet, potential food preservatives and additives, ingredients of cosmetics and factors implicated in tolerance mechanisms against environmental stress. Plant polyphenols are the most prominent and extensively studied, albeit not only group of, secondary plant (specialized) metabolites manifesting antioxidative activity. Because of their potential economic importance, the productive and renewable sources of the compounds are desirable. Over thirty years of research on hairy root cultures, as both producers of secondary plant metabolites and experimental systems to investigate plant biosynthetic pathways, brought about several spectacular achievements. The present review focuses on the Rhizobium rhizogenes-transformed roots that either may be efficient sources of plant-derived antioxidants or were used to elucidate some regulatory mechanisms responsible for the enhanced accumulation of antioxidants in plant tissues.
    Keywords antioxidant activity ; biosynthesis ; cosmetics ; flavonoids ; human nutrition ; metabolites ; polyphenols ; stilbenoids
    Language English
    Dates of publication 2022-0727
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11151950
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Stem Lettuce and Its Metabolites: Does the Variety Make Any Difference?

    Malarz, Janusz / Michalska, Klaudia / Stojakowska, Anna

    Foods. 2020 Dec. 29, v. 10, no. 1

    2020  

    Abstract: The objective of the present study was to characterize chemical composition of hitherto unexamined aerial parts of Lactuca sativa var. angustana cv. Grüner Stern. In contrast to leafy and head varieties of the lettuces, asparagus lettuce grown in Europe ... ...

    Abstract The objective of the present study was to characterize chemical composition of hitherto unexamined aerial parts of Lactuca sativa var. angustana cv. Grüner Stern. In contrast to leafy and head varieties of the lettuces, asparagus lettuce grown in Europe is much less studied. Fractionation of a methanolic extract from leaves of L. sativa cv. Grüner Stern, supported with HPLC/DAD and ¹H NMR analysis, led to the isolation and/or identification of numerous terpenoid and phenolic compounds, including five apocarotenoids—(-)-loliolide, (+)-dehydrovomifoliol, blumenol A, (6S,9S)-vomifoliol, and corchoionoside C; three sesquiterpene lactones; two lignans—((+)-syringaresinol and its 4-O-β-glucoside); five caffeic acid derivatives; and three flavonoids. Some of the compounds, to the best of our knowledge, have never been isolated from L. sativa before. Moreover, monolignols, phenolic acids and a tryptophan-derived alkaloid were found in the analyzed plant material. Stems, leaves and shoot tips of the asparagus lettuce were examined to assess their phenolics and sesquiterpene lactone content as well as DPPH scavenging activity. Another stem lettuce—L. sativa var. angustana cv. Karola, two cultivars of leafy lettuces and one species of wild lettuce—L. serriola, were also examined as a reference material using HPLC/DAD. The results have been discussed regarding our previous studies and the literature data available.
    Keywords Lactuca sativa var. angustana ; aerial parts ; alkaloids ; caffeic acid ; chemical composition ; cultivars ; flavonoids ; foods ; fractionation ; head ; knowledge ; leaf extracts ; leaves ; lettuce ; literature ; metabolites ; sesquiterpenoid lactones ; shoot tips ; stems ; Europe
    Language English
    Dates of publication 2020-1229
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10010059
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Stem Lettuce and Its Metabolites: Does the Variety Make Any Difference?

    Malarz, Janusz / Michalska, Klaudia / Stojakowska, Anna

    Foods (Basel, Switzerland)

    2020  Volume 10, Issue 1

    Abstract: The objective of the present study was to characterize chemical composition of hitherto unexamined aerial parts ... ...

    Abstract The objective of the present study was to characterize chemical composition of hitherto unexamined aerial parts of
    Language English
    Publishing date 2020-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10010059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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