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Article ; Online: Characterization of three

Narayanan, Sai / Couger, Brian / Bates, Haley / Gupta, Sushim Kumar / Malayer, Jerry / Ramachandran, Akhilesh

Access microbiology

2023 Volume 5, Issue 6, Page(s) acmi000451

Abstract: Francisella ... ...

Abstract	Francisella tularensis
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000451
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development and evaluation of Microbe Finder (MiFi)

Narayanan, Sai / Espindola, Andres S / Malayer, Jerry / Cardwell, Kitty / Ramachandran, Akhilesh

Journal of medical microbiology

2023 Volume 72, Issue 6

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Animals ; Cattle ; Metagenome ; Metagenomics ; Genomics ; Algorithms ; Polymerase Chain Reaction
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001720
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 634: Show issues

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Article: LncRNA FENDRR Expression Correlates with Tumor Immunogenicity

Munteanu, Maria Cristina / Sethuraman, Sri Nandhini / Singh, Mohit Pratap / Malayer, Jerry / Ranjan, Ashish

Genes. 2021 June 10, v. 12, no. 6

2021

Abstract: FENDRR (Fetal-lethal non-coding developmental regulatory RNA, LncRNA FOXF1-AS1) is a recently identified tumor suppressor long non-coding (LncRNA) RNA, and its expression has been linked with epigenetic modulation of the target genes involved in tumor ... ...

Abstract	FENDRR (Fetal-lethal non-coding developmental regulatory RNA, LncRNA FOXF1-AS1) is a recently identified tumor suppressor long non-coding (LncRNA) RNA, and its expression has been linked with epigenetic modulation of the target genes involved in tumor immunity. In this study, we aimed to understand the role of FENDRR in predicting immune-responsiveness and the inflammatory tumor environment. Briefly, FENDRR expression and its relationship to immune activation signals were assessed in murine cell lines. Data suggested that tumor cells (e.g., C26 colon, 4T1 breast) that typically upregulate immune activation genes and the MHC class I molecule exhibited high FENDRR expression levels. Conversely, tumor cells with a generalized downregulation of immune-related gene expression (e.g., B16F10 melanoma) demonstrated low to undetectable FENDRR levels. Mechanistically, the modulation of FENDRR expression enhanced the inflammatory and WNT signaling pathways in tumors. Our early data suggest that FENDRR can play an important role in the development of immune-relevant phenotypes in tumors, and thereby improve cancer immunotherapy.
Keywords	RNA ; breasts ; colon ; epigenetics ; gene expression ; immunogenicity ; immunotherapy ; melanoma ; mice
Language	English
Dates of publication	2021-0610
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12060897
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors.

Singh, Mohit Pratap / Sethuraman, Sri Nandhini / Miller, Craig / Malayer, Jerry / Ranjan, Ashish

Theranostics

2021 Volume 11, Issue 2, Page(s) 540–554

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; CD40 Antigens/immunology ; CD8-Positive T-Lymphocytes/immunology ; Combined Modality Therapy ; High-Intensity Focused Ultrasound Ablation/methods ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology
Chemical Substances	CD40 Antigens ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-01-01
Publishing country	Australia
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.49517
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: LncRNA FENDRR Expression Correlates with Tumor Immunogenicity.

Munteanu, Maria Cristina / Sethuraman, Sri Nandhini / Singh, Mohit Pratap / Malayer, Jerry / Ranjan, Ashish

Genes

2021 Volume 12, Issue 6

Abstract	FENDRR (Fetal-lethal non-coding developmental regulatory RNA, LncRNA FOXF1-AS1) is a recently identified tumor suppressor long non-coding (LncRNA) RNA, and its expression has been linked with epigenetic modulation of the target genes involved in tumor immunity. In this study, we aimed to understand the role of FENDRR in predicting immune-responsiveness and the inflammatory tumor environment. Briefly, FENDRR expression and its relationship to immune activation signals were assessed in murine cell lines. Data suggested that tumor cells (e.g., C26 colon, 4T1 breast) that typically upregulate immune activation genes and the MHC class I molecule exhibited high FENDRR expression levels. Conversely, tumor cells with a generalized downregulation of immune-related gene expression (e.g., B16F10 melanoma) demonstrated low to undetectable FENDRR levels. Mechanistically, the modulation of FENDRR expression enhanced the inflammatory and WNT signaling pathways in tumors. Our early data suggest that FENDRR can play an important role in the development of immune-relevant phenotypes in tumors, and thereby improve cancer immunotherapy.
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12060897
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Intensity Focused Ultrasound (HIFU) Heating Improves Perfusion and Antimicrobial Efficacy in Mouse Staphylococcus Abscess.

Wardlow, Rachel / Sahoo, Kaustuv / Dugat, Danielle / Malayer, Jerry / Ranjan, Ashish

Ultrasound in medicine & biology

2018 Volume 44, Issue 4, Page(s) 909–914

Abstract: Chronic wounds typically require long-duration treatment with a combination of antibiotics administered systemically. This incurs adverse side effects and can require aversive surgical treatments and limb amputations. To improve non-invasive ... ...

Abstract	Chronic wounds typically require long-duration treatment with a combination of antibiotics administered systemically. This incurs adverse side effects and can require aversive surgical treatments and limb amputations. To improve non-invasive antimicrobial therapy, the objective of this study was to investigate antimicrobial chemotherapy combined with high-intensity focused ultrasound (HIFU) heating (HT). A Staphylococcus aureus abscess (80 ± 30 mm
MeSH term(s)	Abscess/drug therapy ; Animals ; Anti-Bacterial Agents/therapeutic use ; Ciprofloxacin/therapeutic use ; Combined Modality Therapy/methods ; Disease Models, Animal ; High-Intensity Focused Ultrasound Ablation/methods ; Hot Temperature ; Mice ; Mice, Inbred C57BL ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
Language	English
Publishing date	2018-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2017.12.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 963: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity.

Sethuraman, Sri Nandhini / Singh, Mohit Pratap / Patil, Girish / Li, Shitao / Fiering, Steven / Hoopes, P Jack / Guha, Chandan / Malayer, Jerry / Ranjan, Ashish

Theranostics

2020 Volume 10, Issue 8, Page(s) 3397–3412

Abstract: ... ...

Abstract	Rationale
MeSH term(s)	Adaptive Immunity/drug effects ; Animals ; B7-H1 Antigen/metabolism ; CD47 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; Calreticulin/therapeutic use ; Cell Membrane/metabolism ; Combined Modality Therapy ; Cytokines/immunology ; Humans ; Immunogenic Cell Death ; Lymph Nodes/immunology ; Melanoma, Experimental/immunology ; Melanoma, Experimental/therapy ; Mice ; Nanoparticles/therapeutic use ; Spleen/immunology ; Tumor-Associated Macrophages/immunology ; Ultrasonic Therapy/methods ; Xenograft Model Antitumor Assays
Chemical Substances	B7-H1 Antigen ; CALR protein, human ; CD274 protein, human ; CD47 Antigen ; Calreticulin ; Cytokines
Language	English
Publishing date	2020-02-10
Publishing country	Australia
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.42243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of

Pulavendran, Sivasami / Prasanthi, Maram / Ramachandran, Akhilesh / Grant, Rezabek / Snider, Timothy A / Chow, Vincent T K / Malayer, Jerry R / Teluguakula, Narasaraju

Frontiers in immunology

2020 Volume 11, Page(s) 679

Abstract: Francisella ... ...

Abstract	Francisella tularensis
MeSH term(s)	Alveolar Epithelial Cells/pathology ; Animals ; Cats ; Cells, Cultured ; Extracellular Traps/metabolism ; Francisella tularensis/immunology ; Hydrogen Peroxide/metabolism ; Lung/pathology ; Mice ; Neutrophils/immunology ; Peroxidase/metabolism ; Rabbits ; Tularemia/immunology
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2020-04-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.00679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chemo-immunotherapy of colon cancer with focused ultrasound and Salmonella-laden temperature sensitive liposomes (thermobots).

Ektate, Kalyani / Munteanu, Maria Cristina / Ashar, Harshini / Malayer, Jerry / Ranjan, Ashish

Scientific reports

2018 Volume 8, Issue 1, Page(s) 13062

Abstract: Using attenuated Salmonella that efficiently homes in solid tumors, here we developed thermobots that actively transported membrane attached low-temperature sensitive liposome (LTSL) inside colon cancer cells for triggered doxorubicin release and ... ...

Abstract	Using attenuated Salmonella that efficiently homes in solid tumors, here we developed thermobots that actively transported membrane attached low-temperature sensitive liposome (LTSL) inside colon cancer cells for triggered doxorubicin release and simultaneous polarized macrophages to M1 phenotype with high intensity focused ultrasound (HIFU) heating (40-42 °C). Biocompatibility studies showed that the synthesized thermobots were highly efficient in LTSL loading without impacting its viability. Thermobots demonstrated efficient intracellular trafficking, high nuclear localization of doxorubicin, and induced pro-inflammatory cytokine expression in colon cancer cells in vitro. Combination of thermobots and HIFU heating (~30 min) in murine colon tumors significantly enhanced polarization of macrophages to M1 phenotype and therapeutic efficacy in vivo compared to control. Our data suggest that the thermobots and focused ultrasound treatments have the potential to improve colon cancer therapy.
MeSH term(s)	Animals ; Colonic Neoplasms/blood ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Colonic Neoplasms/therapy ; Cytokines/blood ; Female ; Gene Expression Regulation ; Immunotherapy ; Inflammation Mediators/metabolism ; Liposomes ; Mice ; Mice, Inbred BALB C ; Phenotype ; RAW 264.7 Cells ; Salmonella/metabolism ; T-Lymphocytes, Helper-Inducer/immunology ; Temperature ; Ultrasonics
Chemical Substances	Cytokines ; Inflammation Mediators ; Liposomes
Language	English
Publishing date	2018-08-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-30106-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 Genomes From Oklahoma, United States.

Narayanan, Sai / Ritchey, John C / Patil, Girish / Narasaraju, Teluguakula / More, Sunil / Malayer, Jerry / Saliki, Jeremiah / Kaul, Anil / Agarwal, Pratul K / Ramachandran, Akhilesh

Frontiers in genetics

2021 Volume 11, Page(s) 612571

Abstract: Genomic sequencing has played a major role in understanding the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the current pandemic, it is essential that SARS-CoV-2 viruses are sequenced regularly to determine ... ...

Abstract	Genomic sequencing has played a major role in understanding the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the current pandemic, it is essential that SARS-CoV-2 viruses are sequenced regularly to determine mutations and genomic modifications in different geographical locations. In this study, we sequenced SARS-CoV-2 from five clinical samples obtained in Oklahoma, United States during different time points of pandemic presence in the state. One sample from the initial days of the pandemic in the state and four during the peak in Oklahoma were sequenced. Previously reported mutations including D614G in S gene, P4715L in ORF1ab, S194L, R203K, and G204R in N gene were identified in the genomes sequenced in this study. Possible novel mutations were also detected in the S gene (G1167V), ORF1ab (A6269S and P3371S), ORF7b (T28I), and ORF8 (G96R). Phylogenetic analysis of the genomes showed similarity to other SARS-CoV-2 viruses reported from across the globe. Structural characterization indicates that the mutations in S gene possibly influences conformational flexibility and motion of the spike protein, and the mutations in N gene are associated with disordered linker region within the nucleocapsid protein.
Language	English
Publishing date	2021-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.612571
Database	MEDical Literature Analysis and Retrieval System OnLINE

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