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  1. Article ; Online: The multidrug efflux pump regulator AcrR directly represses motility in

    Maldonado, Jessica / Czarnecka, Barbara / Harmon, Dana E / Ruiz, Cristian

    mSphere

    2023  Volume 8, Issue 5, Page(s) e0043023

    Abstract: Efflux and motility are two key biological functions in bacteria. Recent findings have shown that efflux impacts flagellum biosynthesis and motility ... ...

    Abstract Efflux and motility are two key biological functions in bacteria. Recent findings have shown that efflux impacts flagellum biosynthesis and motility in
    MeSH term(s) Escherichia coli ; Escherichia coli Proteins/metabolism ; Ethidium ; Ligands ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism
    Chemical Substances Escherichia coli Proteins ; Ethidium (EN464416SI) ; Ligands ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00430-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative analysis of the myoglobin gene in whales and humans reveals evolutionary changes in regulatory elements and expression levels.

    Sackerson, Charles / Garcia, Vivian / Medina, Nicole / Maldonado, Jessica / Daly, John / Cartwright, Rachel

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0284834

    Abstract: Cetacea and other diving mammals have undergone numerous adaptations to their aquatic environment, among them high levels of the oxygen-carrying intracellular hemoprotein myoglobin in skeletal muscles. Hypotheses regarding the mechanisms leading to these ...

    Abstract Cetacea and other diving mammals have undergone numerous adaptations to their aquatic environment, among them high levels of the oxygen-carrying intracellular hemoprotein myoglobin in skeletal muscles. Hypotheses regarding the mechanisms leading to these high myoglobin levels often invoke the induction of gene expression by exercise, hypoxia, and other physiological gene regulatory pathways. Here we explore an alternative hypothesis: that cetacean myoglobin genes have evolved high levels of transcription driven by the intrinsic developmental mechanisms that drive muscle cell differentiation. We have used luciferase assays in differentiated C2C12 cells to test this hypothesis. Contrary to our hypothesis, we find that the myoglobin gene from the minke whale, Balaenoptera acutorostrata, shows a low level of expression, only about 8% that of humans. This low expression level is broadly shared among cetaceans and artiodactylans. Previous work on regulation of the human gene has identified a core muscle-specific enhancer comprised of two regions, the "AT element" and a C-rich sequence 5' of the AT element termed the "CCAC-box". Analysis of the minke whale gene supports the importance of the AT element, but the minke whale CCAC-box ortholog has little effect. Instead, critical positive input has been identified in a G-rich region 3' of the AT element. Also, a conserved E-box in exon 1 positively affects expression, despite having been assigned a repressive role in the human gene. Last, a novel region 5' of the core enhancer has been identified, which we hypothesize may function as a boundary element. These results illustrate regulatory flexibility during evolution. We discuss the possibility that low transcription levels are actually beneficial, and that evolution of the myoglobin protein toward enhanced stability is a critical factor in the accumulation of high myoglobin levels in adult cetacean muscle tissue.
    MeSH term(s) Animals ; Humans ; Minke Whale ; Muscle, Skeletal ; Myoglobin/genetics ; Regulatory Sequences, Nucleic Acid ; Evolution, Molecular
    Chemical Substances Myoglobin
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Successful Pancreatic Cancer Screening Among Individuals at Elevated Risk Using Endoscopic Ultrasound and Magnetic Resonance Imaging: A Community Hospital Experience.

    Raff, Joshua Peter / Cook, Brennan / Jafri, Farrukh Nadeem / Boxer, Nicole / Maldonado, Jessica / Hopkins, Una / Roayaie, Sasan / Noyer, Charles

    Pancreas

    2023  Volume 51, Issue 10, Page(s) 1345–1351

    Abstract: Objectives: Guidelines for testing individuals at risk (IAR) for developing pancreatic duct adenocarcinoma (PC) are being advanced from university hospital populations. We implemented a screen-in criteria and protocol for IAR for PC in our community ... ...

    Abstract Objectives: Guidelines for testing individuals at risk (IAR) for developing pancreatic duct adenocarcinoma (PC) are being advanced from university hospital populations. We implemented a screen-in criteria and protocol for IAR for PC in our community hospital setting.
    Methods: Eligibility was based on germline status and/or family history of PC. Longitudinal testing continued, alternating between endoscopic ultrasound (EUS) and magnetic resonance imaging (MRI). The primary objective was to analyze pancreatic conditions and their associations with risk factors. The secondary objective was to evaluate the outcomes and complications resulting from testing.
    Results: Over 93 months, 102 individuals completed baseline EUS, and 26 (25%) met defined endpoints of any abnormal findings in the pancreas. Average enrollment was 40 months, and all participants with endpoints continued standard surveillance. Two participants (1.8%) had endpoint findings requiring surgery for premalignant lesions. Increasing age predicted for endpoint findings. Analysis of longitudinal testing suggested reliability between the EUS and MRI results.
    Conclusions: In our community hospital population, baseline EUS was effective in identifying the majority of findings; advancing age correlated with a greater chance of abnormalities. No differences were observed between EUS and MRI findings. Screening programs for PC among IAR can be successfully performed in the community setting.
    MeSH term(s) Humans ; Hospitals, Community ; Reproducibility of Results ; Early Detection of Cancer/methods ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/epidemiology ; Endosonography/methods ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Interventions to treat methicillin-susceptible Staphylococcus aureus bacteremia: many methodological concerns.

    García-Perdomo, Herney Andrés / Toro Maldonado, Jessica Fernanda

    BMC infectious diseases

    2019  Volume 19, Issue 1, Page(s) 892

    Abstract: The aim of this letter was to point out some methodological concerns about an article written by Shi et al. and published in the journal. There is an increasing trend in the isolation of Methicillin-susceptible Staphylococcus aureus bacteremia and a ... ...

    Abstract The aim of this letter was to point out some methodological concerns about an article written by Shi et al. and published in the journal. There is an increasing trend in the isolation of Methicillin-susceptible Staphylococcus aureus bacteremia and a variety of questions regarding the best therapy to treat this condition. These concerns might lead to selection, publication and information bias that prevent the generalization and application of these results in our clinical practice.
    MeSH term(s) Anti-Bacterial Agents ; Bacteremia ; Cefazolin ; Humans ; Methicillin ; Penicillins ; Staphylococcal Infections ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; Cefazolin (IHS69L0Y4T) ; Methicillin (Q91FH1328A)
    Language English
    Publishing date 2019-10-25
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-019-4520-3
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  5. Article ; Online: A practical synthesis of xylo- and arabinofuranoside precursors by diastereoselective reduction using Corey-Bakshi-Shibata catalyst.

    Utley, Lynn M / Maldonado, Jessica / Awad, Ahmed M

    Nucleosides, nucleotides & nucleic acids

    2018  Volume 37, Issue 1, Page(s) 20–34

    Abstract: The Corey-Bakshi-Shibata (CBS) catalyst provides an efficient mechanism to reduce ketones and achieve desired enantiopure alcohols. Herein, the diastereoselective reduction of C-2' and C-3'-keto ribofuranoside derivatives to the corresponding arabino- ... ...

    Abstract The Corey-Bakshi-Shibata (CBS) catalyst provides an efficient mechanism to reduce ketones and achieve desired enantiopure alcohols. Herein, the diastereoselective reduction of C-2' and C-3'-keto ribofuranoside derivatives to the corresponding arabino- and xylofuranosides in greater than 95% diastereomeric excess is reported. The stereo-directed substitution with an azido group as well as the synthesis of prodrugs cytarabine and vidarabine are also described. The reported strategy offers superior diastereoselectivity, shorter reaction times, and obviates cooling required with comparable protocols involving achiral reductants.
    MeSH term(s) Arabinonucleosides/chemical synthesis ; Catalysis ; Glucosides/chemical synthesis ; Molecular Structure ; Oxidation-Reduction ; Prodrugs/chemical synthesis ; Stereoisomerism ; Vidarabine/chemical synthesis
    Chemical Substances Arabinonucleosides ; Glucosides ; Prodrugs ; Vidarabine (FA2DM6879K)
    Language English
    Publishing date 2018-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2017.1414240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3870: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: Brote urbano de leishmaniasis en Colombia.

    Manotas-Berdugo, Hernán / Toro-Maldonado, Jessica / Rodríguez-Rodríguez, Jairo / Salgado-García, Doris

    Revista de salud publica (Bogota, Colombia)

    2018  Volume 20, Issue 1, Page(s) 89–93

    Abstract: Objectives: To describe the epidemiology, clinical characteristics and treatment of children with visceral Leishmaniasis in Neiva- Huila, from April to June 2012.: Methodology: We performed a descriptive study of an outbreak of visceral leshmaniasis ... ...

    Title translation Urban outbreak of leishmaniasis in Colombia.
    Abstract Objectives: To describe the epidemiology, clinical characteristics and treatment of children with visceral Leishmaniasis in Neiva- Huila, from April to June 2012.
    Methodology: We performed a descriptive study of an outbreak of visceral leshmaniasis in children from the urban area of Neiva.
    Results: There were seven cases in children younger than five years. All of them had prolonged fever, hepato-splenomegaly, severe anemia and leukopenia. Five were admitted with severe thrombocytopenia, without hemorrhagic manifestations. Six patients received first-line treatment with miltefosine, five of them had treatment failure requirirng therapy escalation to amphotericin B, two received liposomal amphotericin B and three deoxycholate amphotericin B. The main vector identified was the Lutzomyia gomezi and its main reservoir were canines.
    Conclusion: We describe the first visceral leishmaniasis outbreak in children living in an urban area, with no mortality. Most of the cases had a good response to amphotericin B.
    MeSH term(s) Antiprotozoal Agents/therapeutic use ; Child, Preschool ; Colombia/epidemiology ; Disease Outbreaks ; Female ; Humans ; Infant ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/epidemiology ; Male ; Treatment Outcome ; Urban Health/statistics & numerical data
    Chemical Substances Antiprotozoal Agents
    Language Spanish
    Publishing date 2018-09-03
    Publishing country Colombia
    Document type Journal Article
    ZDB-ID 2060572-9
    ISSN 0124-0064
    ISSN 0124-0064
    DOI 10.15446/rsap.V20n1.47135
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  7. Article: Casuística de gammapatía monoclonal de significado incierto y mieloma múltiple en el Hospital Naval Almirante Nef, Viña del Mar, Chile.

    Barría, Katherine / Maldonado, Jessica / Alvarez, Rocío / Rodríguez, María / Cortés, Magdalena

    Revista medica de Chile

    2010  Volume 138, Issue 6, Page(s) 788–790

    Title translation Case study of monoclonal gammopathy of undetermined significance and multiple myeloma at "Hospital Naval Almirante Nef" viña del Mar, Chile.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Chile ; Female ; Hospitals, Military ; Humans ; Male ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Multiple Myeloma/diagnosis ; Myeloma Proteins/analysis ; Retrospective Studies
    Chemical Substances Myeloma Proteins ; multiple myeloma M-proteins
    Language Spanish
    Publishing date 2010-09-28
    Publishing country Chile
    Document type Letter
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872010000600021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 402: Show issues Location:
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