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  1. Article ; Online: Bio-based matrix photocatalysts for photodegradation of antibiotics.

    Maldonado-Carmona, Nidia / Piccirillo, Giusi / Godard, Jérémy / Heuzé, Karine / Genin, Emilie / Villandier, Nicolas / Calvete, Mário J F / Leroy-Lhez, Stéphanie

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  Volume 23, Issue 3, Page(s) 587–627

    Abstract: Antibiotics development during the last century permitted unprecedent medical advances. However, it is undeniable that there has been an abuse and misuse of antimicrobials in medicine and cosmetics, food production and food processing, in the last ... ...

    Abstract Antibiotics development during the last century permitted unprecedent medical advances. However, it is undeniable that there has been an abuse and misuse of antimicrobials in medicine and cosmetics, food production and food processing, in the last decades. The pay toll for human development and consumism is the emergence of extended antimicrobial resistance and omnipresent contamination of the biosphere. The One Health concept recognizes the interconnection of human, environmental and animal health, being impossible alter one without affecting the others. In this context, antibiotic decontamination from water-sources is of upmost importance, with new and more efficient strategies needed. In this framework, light-driven antibiotic degradation has gained interest in the last few years, strongly relying in semiconductor photocatalysts. To improve the semiconductor properties (i.e., efficiency, recovery, bandgap width, dispersibility, wavelength excitation, etc.), bio-based supporting material as photocatalysts matrices have been thoroughly studied, exploring synergetic effects as operating parameters that could improve the photodegradation of antibiotics. The present work describes some of the most relevant advances of the last 5 years on photodegradation of antibiotics and other antimicrobial molecules. It presents the conjugation of semiconductor photocatalysts to different organic scaffolds (biochar and biopolymers), then to describe hybrid systems based on g-C
    MeSH term(s) Animals ; Humans ; Anti-Bacterial Agents ; Photolysis ; Catalysis ; Anti-Infective Agents
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00536-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer's structure and delivery systems.

    Maldonado-Carmona, Nidia / Ouk, Tan-Sothea / Leroy-Lhez, Stéphanie

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2021  Volume 21, Issue 1, Page(s) 113–145

    Abstract: Antimicrobial resistance is threatening to overshadow last century's medical advances. Etiological agents of previously eradicated infectious diseases are now resurgent as multidrug-resistant strains, especially for Gram-negative strains. Finding new ... ...

    Abstract Antimicrobial resistance is threatening to overshadow last century's medical advances. Etiological agents of previously eradicated infectious diseases are now resurgent as multidrug-resistant strains, especially for Gram-negative strains. Finding new therapeutic solutions is a real challenge for our society. In this framework, Photodynamic Antimicrobial ChemoTherapy relies on the generation of toxic reactive oxygen species in the presence of light, oxygen, and a photosensitizer molecule. The use of reactive oxygen species is common for disinfection processes, using chemical agents, such as chlorine and hydrogen peroxide, and as they do not have a specific molecular target, it decreases the potential of tolerance to the antimicrobial treatment. However, light-driven generated reactive species result in an interesting alternative, as reactive species generation can be easily tuned with light irradiation and several PSs are known for their low environmental impact. Over the past few years, this topic has been thoroughly studied, exploring strategies based on single-molecule PSs (tetrapyrrolic compounds, dipyrrinate derivatives, metal complexes, etc.) or on conjunction with delivery systems. The present work describes some of the most relevant advances of the last 6 years, focusing on photosensitizers design, formulation, and potentiation, aiming for the disinfection of Gram-negative bacteria.
    MeSH term(s) Anti-Bacterial Agents ; Disinfection ; Gram-Negative Bacteria ; Photochemotherapy ; Photosensitizing Agents/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Photosensitizing Agents
    Language English
    Publishing date 2021-11-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-021-00128-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acetylated lignin nanoparticles as a possible vehicle for photosensitizing molecules.

    Marchand, Guillaume / Fabre, Gabin / Maldonado-Carmona, Nidia / Villandier, Nicolas / Leroy-Lhez, Stéphanie

    Nanoscale advances

    2020  Volume 2, Issue 12, Page(s) 5648–5658

    Abstract: Lignins are underused and abundant bio-sourced polymers with various potential applications. An attractive one is the development of nanoparticles for bioactive compound delivery. Here, we optimized the synthesis of hydrodispersible nanoparticles of ... ...

    Abstract Lignins are underused and abundant bio-sourced polymers with various potential applications. An attractive one is the development of nanoparticles for bioactive compound delivery. Here, we optimized the synthesis of hydrodispersible nanoparticles of acetylated lignin by comparing different lignin sources, degrees of acetylation and preparation methods. The formation of acetylated lignin nanoparticles in various solvents was probed by both experiments and, for the first time, a molecular dynamics simulation. We showed that dialysis is more suitable to obtain these nanoparticles than anti-solvent addition. The encapsulation of hydrophobic photosensitizing porphyrin in these nanoparticles was also demonstrated and rationalized at the molecular level, together with experiments, docking and molecular dynamics simulations. As acetylated lignin has been demonstrated to exhibit photosensitizing activity, the encapsulation of bioactive compounds in lignin nanoparticles opens the doors to a broad range of potential applications.
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d0na00615g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles.

    Maldonado-Carmona, Nidia / Ouk, Tan-Sothea / Villandier, Nicolas / Calliste, Claude Alain / Calvete, Mário J F / Pereira, Mariette M / Leroy-Lhez, Stéphanie

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: Lignin has recently attracted the attention of the scientific community, as a suitable raw material for biomedical applications. In this work, acetylated lignin was used to encapsulate five different porphyrins, aiming to preserve their photophysical ... ...

    Abstract Lignin has recently attracted the attention of the scientific community, as a suitable raw material for biomedical applications. In this work, acetylated lignin was used to encapsulate five different porphyrins, aiming to preserve their photophysical properties, and for further use as antibacterial treatment. The obtained nanoparticles were physically characterized, through dynamic light scattering size measurement, polydispersity index and zeta potential values. Additionally, the photophysical properties of the nanoparticles, namely UV-vis absorption, fluorescence emission, singlet oxygen production and photobleaching, were compared with those of the free porphyrins. It was found that all the porphyrins were susceptible to encapsulation, with an observed decrease in their fluorescence quantum yield and singlet oxygen production. These nanoparticles were able to exert an effective photodynamic bactericide effect (blue-LED light, 450-460 nm, 15 J/cm
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10050513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Conjugating biomaterials with photosensitizers: advances and perspectives for photodynamic antimicrobial chemotherapy.

    Maldonado-Carmona, Nidia / Ouk, Tan-Sothea / Calvete, Mário J F / Pereira, Mariette M / Villandier, Nicolas / Leroy-Lhez, Stephanie

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2020  Volume 19, Issue 4, Page(s) 445–461

    Abstract: Antimicrobial resistance is threatening to overshadow last century's medical advances. Previously eradicated infectious diseases are now resurgent as multi-drug resistant strains, leading to expensive, toxic and, in some cases, ineffective antimicrobial ... ...

    Abstract Antimicrobial resistance is threatening to overshadow last century's medical advances. Previously eradicated infectious diseases are now resurgent as multi-drug resistant strains, leading to expensive, toxic and, in some cases, ineffective antimicrobial treatments. Given this outlook, researchers are willing to investigate novel antimicrobial treatments that may be able to deal with antimicrobial resistance, namely photodynamic therapy (PDT). PDT relies on the generation of toxic reactive oxygen species (ROS) in the presence of light and a photosensitizer (PS) molecule. PDT has been known for almost a century, but most of its applications have been directed towards the treatment of cancer and topical diseases. Unlike classical antimicrobial chemotherapy treatments, photodynamic antimicrobial chemotherapy (PACT) has a non-target specific mechanism of action, based on the generation of ROS, working against cellular membranes, walls, proteins, lipids and nucleic acids. This non-specific mechanism diminishes the chances of bacteria developing resistance. However, PSs usually are large molecules, prone to aggregation, diminishing their efficiency. This review will report the development of materials obtained from natural sources, as delivery systems for photosensitizing molecules against microorganisms. The present work emphasizes on the biological results rather than on the synthesis routes to prepare the conjugates. Also, it discusses the current state of the art, providing our perspective on the field.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Reactive Oxygen Species/metabolism
    Chemical Substances Anti-Bacterial Agents ; Biocompatible Materials ; Photosensitizing Agents ; Reactive Oxygen Species
    Language English
    Publishing date 2020-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1039/c9pp00398c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interplay between carbon, nitrogen and phosphate utilization in the control of secondary metabolite production in Streptomyces.

    Romero-Rodríguez, Alba / Maldonado-Carmona, Nidia / Ruiz-Villafán, Beatriz / Koirala, Niranjan / Rocha, Diana / Sánchez, Sergio

    Antonie van Leeuwenhoek

    2018  Volume 111, Issue 5, Page(s) 761–781

    Abstract: Streptomyces species are a wide and diverse source of many therapeutic agents (antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important source of compounds with potential applications in medicine. The effect of nitrogen, ...

    Abstract Streptomyces species are a wide and diverse source of many therapeutic agents (antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important source of compounds with potential applications in medicine. The effect of nitrogen, phosphate and carbon on the production of secondary metabolites has long been observed, but it was not until recently that the molecular mechanisms on which these effects rely were ascertained. In addition to the specific macronutrient regulatory mechanisms, there is a complex network of interactions between these mechanisms influencing secondary metabolism. In this article, we review the recent advances in our understanding of the molecular mechanisms of regulation exerted by nitrogen, phosphate and carbon sources, as well as the effects of their interconnections, on the synthesis of secondary metabolites by members of the genus Streptomyces.
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Carbon/metabolism ; Gene Expression Regulation, Bacterial ; Models, Biological ; Nitrogen/metabolism ; Phosphates/metabolism ; Receptor Cross-Talk ; Secondary Metabolism/genetics ; Secondary Metabolism/physiology ; Streptomyces/metabolism
    Chemical Substances Anti-Bacterial Agents ; Phosphates ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2018-03-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 214861-4
    ISSN 1572-9699 ; 0003-6072
    ISSN (online) 1572-9699
    ISSN 0003-6072
    DOI 10.1007/s10482-018-1073-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Correction to: Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production

    Tierrafría, Víctor H / Licona-Cassani, Cuauhtemoc / Maldonado-Carmona, Nidia / Romero-Rodríguez, Alba / Centeno-Leija, Sara / Marcellin, Esteban / Rodríguez-Sanoja, Romina / Ruiz-Villafán, Beatriz / Nielsen, Lars K / Sánchez, Sergio

    Applied microbiology and biotechnology. 2020 Apr., v. 104, no. 8

    2020  

    Abstract: The published online version of this paper contains mistake. The authors first and last names have been interchanged. The correct version is given above. ...

    Abstract The published online version of this paper contains mistake. The authors first and last names have been interchanged. The correct version is given above.
    Keywords Streptomyces coelicolor ; acetyl-CoA carboxylase ; anthraquinones ; bacterial proteins ; glycolysis
    Language English
    Dates of publication 2020-04
    Size p. 3687.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Published Erratum
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-020-10499-x
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Porphyrin-Loaded Lignin Nanoparticles Against Bacteria: A Photodynamic Antimicrobial Chemotherapy Application.

    Maldonado-Carmona, Nidia / Marchand, Guillaume / Villandier, Nicolas / Ouk, Tan-Sothea / Pereira, Mariette M / Calvete, Mário J F / Calliste, Claude Alain / Żak, Andrzej / Piksa, Marta / Pawlik, Krzysztof J / Matczyszyn, Katarzyna / Leroy-Lhez, Stéphanie

    Frontiers in microbiology

    2020  Volume 11, Page(s) 606185

    Abstract: The need for alternative strategies to fight bacteria is evident from the emergence of antimicrobial resistance. To that respect, photodynamic antimicrobial chemotherapy steadily rises in bacterial eradication by using light, a photosensitizer and oxygen, ...

    Abstract The need for alternative strategies to fight bacteria is evident from the emergence of antimicrobial resistance. To that respect, photodynamic antimicrobial chemotherapy steadily rises in bacterial eradication by using light, a photosensitizer and oxygen, which generates reactive oxygen species that may kill bacteria. Herein, we report the encapsulation of 5,10,15,20-tetrakis(4-hydroxyphenyl)-21H,23H-porphyrin into acetylated lignin water-dispersible nanoparticles (
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.606185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction to: Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production.

    Tierrafría, Víctor H / Licona-Cassani, Cuauhtemoc / Maldonado-Carmona, Nidia / Romero-Rodríguez, Alba / Centeno-Leija, Sara / Marcellin, Esteban / Rodríguez-Sanoja, Romina / Ruiz-Villafán, Beatriz / Nielsen, Lars K / Sánchez, Sergio

    Applied microbiology and biotechnology

    2020  Volume 104, Issue 8, Page(s) 3687

    Abstract: The published online version of this paper contains mistake. The authors first and last names have been interchanged. The correct version is given above. ...

    Abstract The published online version of this paper contains mistake. The authors first and last names have been interchanged. The correct version is given above.
    Language English
    Publishing date 2020-03-23
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-020-10499-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of ∼omics in the detection and validation of potential anti-infective drugs.

    Maldonado-Carmona, Nidia / Vázquez-Hernández, Melissa / Patiño Chávez, Osiris Jair / Rodríguez-Luna, Stefany Daniela / Jiménez Rodríguez, Omar / Sanchez, Sergio / Ceapă, Corina Diana

    Current opinion in pharmacology

    2019  Volume 48, Page(s) 1–7

    Abstract: New anti-infective drugs are an unmet necessity of modern medicine. The use of ∼omics technologies has exponentially increased the knowledge on active anti-infective structures, where to search for them and their mechanisms of action. Research involving ... ...

    Abstract New anti-infective drugs are an unmet necessity of modern medicine. The use of ∼omics technologies has exponentially increased the knowledge on active anti-infective structures, where to search for them and their mechanisms of action. Research involving extreme and unique environments (such as endophytes) revealed their potential for many yet unknown active molecules. This work intends to review a recent research involving discovery of secondary metabolites with an established anti-infective action which was mediated by one of the ∼omics sciences: genomics, proteomics, transcriptomics, metabolomics, glycomics or their combinations, as well as the software at the base of these discoveries.
    MeSH term(s) Anti-Infective Agents ; Databases, Factual ; Drug Discovery ; Genomics ; Humans ; Metabolomics ; Software
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2019-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2019.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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