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  1. Article ; Online: Comparison of Volatile Organic Compounds of

    Marić, Tihana / Friščić, Maja / Marijanović, Zvonimir / Maleš, Željan / Jerković, Igor

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 19

    Abstract: A study on the headspace volatile organic compounds (VOCs) profile of native populations ... ...

    Abstract A study on the headspace volatile organic compounds (VOCs) profile of native populations of
    MeSH term(s) Croatia ; Dimethylpolysiloxanes/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Monoterpenes/analysis ; Phytochemicals/analysis ; Polyvinyls/chemistry ; Principal Component Analysis ; Sesquiterpenes/analysis ; Sideritis/chemistry ; Solid Phase Microextraction/instrumentation ; Solid Phase Microextraction/methods ; Volatile Organic Compounds/analysis
    Chemical Substances Dimethylpolysiloxanes ; Monoterpenes ; Phytochemicals ; Polyvinyls ; Sesquiterpenes ; Volatile Organic Compounds ; poly(dimethylsiloxane-divinylbenzene)
    Language English
    Publishing date 2021-10-01
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26195968
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    Zs.MO 81: Show issues

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  2. Article ; Online: Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery.

    Peršec, Jasminka / Šribar, Andrej / Ilić, Monika / Mamić, Ivan / Kifer, Domagoj / Domijan, Ana-Marija / Maleš, Željan / Turčić, Petra

    Acta pharmaceutica (Zagreb, Croatia)

    2023  Volume 73, Issue 4, Page(s) 691–708

    Abstract: The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, ... ...

    Abstract The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (
    MeSH term(s) Humans ; Dexmedetomidine ; Thoracic Surgery ; Analgesics ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Dexamethasone ; Oxidative Stress ; Inflammation/drug therapy ; Inflammation/prevention & control
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Analgesics ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-12-26
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2023-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Screening of flavonoid aglycons' metabolism mediated by the human liver cytochromes P450.

    Benković, Goran / Bojić, Mirza / Maleš, Željan / Tomić, Siniša

    Acta pharmaceutica (Zagreb, Croatia)

    2019  Volume 69, Issue 4, Page(s) 541–562

    Abstract: Biological effects of flavonoids have been extensively studied in the last 80 years. As flavonoids represent a rather large group of compounds, data on metabolic biotransformations of these compounds is relatively limited to those well studied. The ... ...

    Abstract Biological effects of flavonoids have been extensively studied in the last 80 years. As flavonoids represent a rather large group of compounds, data on metabolic biotransformations of these compounds is relatively limited to those well studied. The objective of this study was to screen the metabolism of 30 selected flavonoid aglycons mediated by the most relevant metabolic enzymes, human liver cytochromes P450. For this purpose, in vitro experiments with human liver microsomes and recombinant enzymes were conducted. To evaluate flavonoid's metabolism and structure of the products, high-performance liquid chromatography coupled with high-resolution mass spectrometry was used. Out of 30 flavonoids, 15 were susceptible to oxidative metabolism mediated by cytochromes P450. Dominant reactions were aromatic hydroxylation and O-demethylation, or a combination of these reactions. The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree. These results, to some extent, contribute to the understanding of the metabolism of constituents found in antioxidant dietary supplements and their possible interactions with other xenobiotics, i.e., medicinal products.
    MeSH term(s) Antioxidants/metabolism ; Chromatography, High Pressure Liquid/methods ; Cytochrome P-450 Enzyme System/metabolism ; Dietary Supplements ; Flavonoids/metabolism ; Humans ; Liver/metabolism ; Microsomes, Liver/metabolism
    Chemical Substances Antioxidants ; Flavonoids ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2019-10-21
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2019-0039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nutrition - facts and myths.

    Verbanac, Donatella / Maleš, Željan / Barišić, Karmela

    Acta pharmaceutica (Zagreb, Croatia)

    2019  Volume 69, Issue 4, Page(s) 497–510

    Abstract: Taking responsibility for your life, among other factors, means also considering what to eat and which nutrition pattern to follow. Everyone needs to think about what they put on the plate and which ingredients should be avoided. Food, as such, will ... ...

    Abstract Taking responsibility for your life, among other factors, means also considering what to eat and which nutrition pattern to follow. Everyone needs to think about what they put on the plate and which ingredients should be avoided. Food, as such, will never be a drug or medication, like a painkilling tablet relieving pain in a short amount of time, for example. However, proper nutrition is our ally in the prevention of diseases, maintaining balance in our body and our mind. By following the main principles of a healthy diet, the physiological homeostasis can be managed, as well as faster recovery from disease achieved. This review is aimed at summarizing basic principles of nutrition recommendations and at empowering stakeholders (pharmacists, medical biochemists, physicians) to be able to communicate to their patients and customers healthy and sustainable nutrition choices through the personalized advice.
    MeSH term(s) Diet, Healthy/standards ; Food/standards ; Humans ; Nutrients/standards ; Nutrition Policy ; Primary Prevention/methods
    Language English
    Publishing date 2019-10-21
    Publishing country Croatia
    Document type Journal Article ; Review
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2019-0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Actualities in the phytochemical research on selected terpenes.

    Jerković, Igor / Maleš, Željan / Friščić, Maja

    Acta pharmaceutica (Zagreb, Croatia)

    2019  Volume 69, Issue 4, Page(s) 533–540

    Abstract: A short review of our recent research on the essential oil phytochemical composition of Petasites albus (L.) Gaertn. and Petasites hybridus (L.) G. Gaertn., B. Mey. & Scherb. (Asteraceae) as well as on the oils of Globularia cordifolia L., Globularia ... ...

    Abstract A short review of our recent research on the essential oil phytochemical composition of Petasites albus (L.) Gaertn. and Petasites hybridus (L.) G. Gaertn., B. Mey. & Scherb. (Asteraceae) as well as on the oils of Globularia cordifolia L., Globularia meridionalis (Podp.) O. Schwarz and Globularia punctata Lapeyr. (Plantaginaceae) is presented. All essential oils contained a variety of oxygenated sesquiterpenes among their major constituents, including a bakkane type sesquiterpene fukinanolid (bakkenolide A). The paper is focused on: i) a short overview of the abundance of major terpenes in the essential oils of Petasites and Globularia species from Croatia; ii) possible biosynthetic pathways of major identified sesquiterpenes; and iii) biological activities (literature data) of major sesquiterpenes from Petasites and Globularia species.
    MeSH term(s) Oils, Volatile/chemistry ; Petasites/chemistry ; Phytochemicals/chemistry ; Plant Oils/chemistry ; Plantaginaceae/chemistry ; Terpenes/chemistry
    Chemical Substances Oils, Volatile ; Phytochemicals ; Plant Oils ; Terpenes
    Language English
    Publishing date 2019-10-21
    Publishing country Croatia
    Document type Journal Article ; Review
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2019-0036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterization of the CYP3A4 Enzyme Inhibition Potential of Selected Flavonoids.

    Kondža, Martin / Bojić, Mirza / Tomić, Ivona / Maleš, Željan / Rezić, Valentina / Ćavar, Ivan

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 10

    Abstract: Acacetin, apigenin, chrysin, and pinocembrin are flavonoid aglycones found in foods such as parsley, honey, celery, and chamomile tea. Flavonoids can act as substrates and inhibitors of the CYP3A4 enzyme, a heme containing enzyme responsible for the ... ...

    Abstract Acacetin, apigenin, chrysin, and pinocembrin are flavonoid aglycones found in foods such as parsley, honey, celery, and chamomile tea. Flavonoids can act as substrates and inhibitors of the CYP3A4 enzyme, a heme containing enzyme responsible for the metabolism of one third of drugs on the market. The aim of this study was to investigate the inhibitory effect of selected flavonoids on the CYP3A4 enzyme, the kinetics of inhibition, the possible covalent binding of the inhibitor to the enzyme, and whether flavonoids can act as pseudo-irreversible inhibitors. For the determination of inhibition kinetics, nifedipine oxidation was used as a marker reaction. A hemochromopyridine test was used to assess the possible covalent binding to the heme, and incubation with dialysis was used in order to assess the reversibility of the inhibition. All the tested flavonoids inhibited the CYP3A4 enzyme activity. Chrysin was the most potent inhibitor:
    MeSH term(s) Cytochrome P-450 CYP3A/drug effects ; Cytochrome P-450 CYP3A/metabolism ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Kinetics ; Molecular Structure ; Nifedipine/metabolism ; Oxidation-Reduction
    Chemical Substances Flavonoids ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Nifedipine (I9ZF7L6G2L)
    Language English
    Publishing date 2021-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26103018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  7. Article: The Effect of Short-Toothed and Dalmatian
Sage Extracts on Platelet Aggregation.

    Antolić, Andrea / Maleš, Željan / Tomičić, Maja / Bojić, Mirza

    Food technology and biotechnology

    2018  Volume 56, Issue 2, Page(s) 265–269

    Abstract: Sage ( ...

    Abstract Sage (
    Language English
    Publishing date 2018-08-20
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1340467-2
    ISSN 1330-9862
    ISSN 1330-9862
    DOI 10.17113/ftb.56.02.18.5474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 7645: Show issues

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  8. Article: Globularia alypum

    Friščić, Maja / Petlevski, Roberta / Kosalec, Ivan / Madunić, Josip / Matulić, Maja / Bucar, Franz / Hazler Pilepić, Kroata / Maleš, Željan

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: Species from the ... ...

    Abstract Species from the genus
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15050506
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  9. Article ; Online: The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.

    Bojić, Mirza / Kondža, Martin / Rimac, Hrvoje / Benković, Goran / Maleš, Željan

    Molecules (Basel, Switzerland)

    2019  Volume 24, Issue 17

    Abstract: Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to ... ...

    Abstract Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to which humans are exposed through everyday diet. In the previous study, selected flavonoid aglycones showed inhibition of CYP3A4 enzyme. Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes. For this purpose, the
    MeSH term(s) Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Substrate Specificity/drug effects
    Chemical Substances Flavonoids ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2019-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24173174
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  10. Article: Quantitative Analysis of Phenolic Acids and Antiplatelet Activity of Melissa officinalis Leaf Extracts.

    Maleš, Željan / Antolić, Andrea / Babić, Ivana / Jurić, Sandra / Bojić, Mirza

    Natural product communications

    2019  Volume 12, Issue 1, Page(s) 93–94

    Abstract: The contents of total phenolic acids and rosmarinic acid were determined and the antiplatelet potential assessed of extracts of lemon balm (Melissa officinalis L., Lamiaceae) leaf samples collected during 2014 and 2015. The quantity of total phenolic ... ...

    Abstract The contents of total phenolic acids and rosmarinic acid were determined and the antiplatelet potential assessed of extracts of lemon balm (Melissa officinalis L., Lamiaceae) leaf samples collected during 2014 and 2015. The quantity of total phenolic acids ranged from 4.8 to 8.5%, while the rosmarinic acid content ranged from 1.78 to 4.35%. Results of statistical analysis showed that the undiluted extracts have antiplatelet activity in the ADP test (final concentration 31.25 mg/L). While there are reports on antiplatelet activity of lemon balm essential oil, to the best of our knowledge, this is the first report on antiplatelet activity of lemon balm leaf extracts.
    MeSH term(s) Adenosine Diphosphate/pharmacology ; Antioxidants ; Chromatography, High Pressure Liquid ; Cinnamates/chemistry ; Cinnamates/pharmacology ; Depsides/chemistry ; Depsides/pharmacology ; Healthy Volunteers ; Humans ; Hydroxybenzoates/analysis ; Hydroxybenzoates/pharmacology ; In Vitro Techniques ; Melissa/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Rosmarinic Acid
    Chemical Substances Antioxidants ; Cinnamates ; Depsides ; Hydroxybenzoates ; Plant Extracts ; Platelet Aggregation Inhibitors ; Adenosine Diphosphate (61D2G4IYVH) ; phenolic acid (I3P9R8317T)
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2430442-6
    ISSN 1555-9475 ; 1934-578X
    ISSN (online) 1555-9475
    ISSN 1934-578X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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