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  1. AU="Maleki, Mobina"
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  1. Article: A Comprehensive Study on the Correlation of Treatment, Diagnosis and Epidemiology of Tuberculosis and Lung Cancer.

    Sheikhpour, Mojgan / Mirbahari, Seyedeh Nasim / Sadr, Makan / Maleki, Mobina / Arabi, Mohadeseh / Abolfathi, Hanie

    Tanaffos

    2023  Volume 22, Issue 1, Page(s) 7–18

    Abstract: The correlation between tuberculosis (TB) and lung cancer (LC) in diagnosis, epidemiology, and treatment is still unclear. Based on different cohort and retrospective studies, this correlation could be justified by immune weakness because of exposure to ... ...

    Abstract The correlation between tuberculosis (TB) and lung cancer (LC) in diagnosis, epidemiology, and treatment is still unclear. Based on different cohort and retrospective studies, this correlation could be justified by immune weakness because of exposure to TB which may increase the risk of LC. In this study, we tried to exhibit a prominent connection between TB and LC. The diagnosis and treatment of patients with concomitant TB and LC differ from patients with only one of the diseases. In this review, it was well clarified that the most practical diagnostic method for LC is chest tomography, biopsy, and histopathology, and for pulmonary TB sputum microscopic examination, Autofluorescence bronchoscopy (AFB), culture, and PCR. Also, immunological methods can be a good alternative for differential diagnosis. Most epidemiological studies were about concomitant TB and LC in TB-endemic areas, especially in the Middle East. The most suggested methods for definite treatment of LC are chemotherapy, radiotherapy, and surgery while for TB, a long course of anti-TB therapy can be used. Moreover, immunotherapy is considered a good treatment for lung cancer if the interferon-gamma release assay (IGRA) is negative.
    Language English
    Publishing date 2023-10-17
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A review of epigenetic changes in asthma: methylation and acetylation.

    Sheikhpour, Mojgan / Maleki, Mobina / Ebrahimi Vargoorani, Maryam / Amiri, Vahid

    Clinical epigenetics

    2021  Volume 13, Issue 1, Page(s) 65

    Abstract: Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most ... ...

    Abstract Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most common epigenetic alternations consist of DNA methylation and histone modifications. How these changes lead to asthmatic phenotype or promote the asthma features, in particular by immune pathways regulation, is an understudied topic. Since external effects, like exposure to tobacco smoke, air pollution, and drugs, influence both asthma development and the epigenome, elucidating the role of epigenetic changes in asthma is of great importance. This review presents available evidence on the epigenetic process that drives asthma genes and pathways, with a particular focus on DNA methylation, histone methylation, and acetylation. We gathered and assessed studies conducted in this field over the past two decades. Our study examined asthma in different aspects and also shed light on the limitations and the important factors involved in the outcomes of the studies. To date, most of the studies in this area have been carried out on DNA methylation. Therefore, the need for diagnostic and therapeutic applications through this molecular process calls for more research on the histone modifications in this disease.
    MeSH term(s) Acetylation ; Asthma/genetics ; Asthma/physiopathology ; DNA Methylation/genetics ; Epigenomics ; Gene Expression ; Humans
    Language English
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-021-01049-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An effective nano drug delivery and combination therapy for the treatment of Tuberculosis.

    Sheikhpour, Mojgan / Delorme, Vincent / Kasaeian, Alibakhsh / Amiri, Vahid / Masoumi, Morteza / Sadeghinia, Mohammad / Ebrahimzadeh, Nayereh / Maleki, Mobina / Pourazar, Shahin

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9591

    Abstract: Drug resistance in tuberculosis is exacerbating the threat this disease is posing to human beings. Antibiotics that were once effective against the causative agent, Mycobacterium tuberculosis (Mtb), are now no longer usable against multi- and extensively ...

    Abstract Drug resistance in tuberculosis is exacerbating the threat this disease is posing to human beings. Antibiotics that were once effective against the causative agent, Mycobacterium tuberculosis (Mtb), are now no longer usable against multi- and extensively drug-resistant strains of this pathogen. To address this issue, new drug combinations and novel methods for targeted drug delivery could be of considerable value. In addition, studies have shown that the use of the antidepressant drug fluoxetine, a serotonin reuptake inhibitor, can be useful in the treatment of infectious diseases, including bacterial infections. In this study, an isoniazid and fluoxetine-conjugated multi-walled carbon nanotube nanofluid were designed to increase drug delivery efficiency alongside eliminating drug resistance in vitro. The prepared nanofluid was tested against Mtb. Expression levels of inhA and katG mRNAs were detected by Real-time PCR. ELISA was applied to measure levels of cytokine secretion (TNF-α, and IL-6) from infected macrophages treated with the nano delivery system. The results showed that these nano-drug delivery systems are effective for fluoxetine at far lower doses than for free drugs. Fluoxetine also has an additive effect on the effect of isoniazid, and their concomitant use in the delivery system can have significant effects in treating infection of all clinical strains of Mtb. In addition, it was found that the expression of isoniazid resistance genes, including inhA, katG, and the secretion of cytokines TNFα and IL6 under the influence of this drug delivery system is well regulated. It was shown that the drug conjugation can improve the antibacterial activity of them in all strains and these two drugs have an additive effect on each other both in free and conjugated forms. This nano-drug delivery method combined with host targeted molecules could be a game-changer in the development of a new generation of antibiotics that have high therapeutic efficiencies, low side effects, and the potential to overcome the problem of drug resistance.
    MeSH term(s) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Bacterial Proteins/metabolism ; Drug Resistance, Bacterial/genetics ; Fluoxetine/pharmacology ; Humans ; Isoniazid/pharmacology ; Isoniazid/therapeutic use ; Microbial Sensitivity Tests ; Mutation ; Mycobacterium tuberculosis ; Nanoparticles/therapeutic use ; Tuberculosis/drug therapy ; Tuberculosis/microbiology ; Tuberculosis, Multidrug-Resistant/microbiology
    Chemical Substances Antitubercular Agents ; Bacterial Proteins ; Fluoxetine (01K63SUP8D) ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-13682-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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