Article ; Online: The time interval between injection of nicotine and tremor initiation: a new index for evaluating nicotine efficacy in rodents.
Toxicology mechanisms and methods
2023 Volume 34, Issue 4, Page(s) 408–412
Abstract: Tremor is one of the effects of nicotine as a toxic substance, especially in animal models. The intensity and duration of tremors were used to evaluate the effect of nicotine on locomotor activity in laboratory animals. In our observations, the time ... ...
| Abstract | Tremor is one of the effects of nicotine as a toxic substance, especially in animal models. The intensity and duration of tremors were used to evaluate the effect of nicotine on locomotor activity in laboratory animals. In our observations, the time interval between nicotine injection and the onset of tremor changed depending on the dose. Therefore, by increasing the dose of nicotine in rats, the time interval of tremor onset was also shortened. These results suggest that the time interval between nicotine injection and the onset of tremors can be used as a complementary index for better evaluation of nicotine-derived motor disturbances. |
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| MeSH term(s) | Rats ; Animals ; Nicotine ; Tremor/chemically induced ; Rodentia | |||||
| Chemical Substances | Nicotine (6M3C89ZY6R) | |||||
| Language | English | |||||
| Publishing date | 2023-12-19 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2081252-8 | |||||
| ISSN | 1537-6524 ; 1537-6516 ; 1051-7235 | |||||
| ISSN (online) | 1537-6524 | |||||
| ISSN | 1537-6516 ; 1051-7235 | |||||
| DOI | 10.1080/15376516.2023.2294822 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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