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Article ; Online: Heterologous Prime-boost Vaccination Using Adenovirus and Albumin Nanoparticles as Carriers for Human Papillomavirus 16 E7 Epitope.

Ghanaat, Momeneh / Kaboosi, Hami / Negahdari, Babak / Fattahi, Esmail / Malekshahi, Ziba Veisi

2022 Volume 24, Issue 9, Page(s) 1195–1203

Abstract: Background: Nanocarriers are these days considered an attractive approach in cancer immunotherapy owing to their ability to deliver antigens to antigen-presenting cells (APCs) for stimulating robust immune cells against the tumor.: Objectives: The ... ...

Abstract	Background: Nanocarriers are these days considered an attractive approach in cancer immunotherapy owing to their ability to deliver antigens to antigen-presenting cells (APCs) for stimulating robust immune cells against the tumor. Objectives: The objective of this study was to construct nanocomplexes using two nanocarriers with negative surface charge, adenovirus (Ad) and human serum albumin nanoparticle (HSA-NP), and coat their surface with a modified and positively-charged HPV16 E7 MHC-I specific epitope to assess their anti-tumor effects in a TC-1 mouse model. Methods: After the construction of Ad and HSA-NP, their complexes with HPV16 E7 MHC-I specific epitope were characterized by zeta potential and dynamic light scattering. Then, the cellular immunity and CTL responses in immunized mice were assessed by measuring the levels of IL-10 and IFN-γ and the expression of CD107a, a marker of CTL response, as well as tumor inhibition. Results: The zeta potential and dynamic light scattering results showed that incubation of the oppositely- charged nanocarriers and MHC-I specific epitope led to the formation of nanocomplexes in which the surface charge of nanocarriers was changed from negative to positive with minimal changes in the particle size. We demonstrated that the nanocomplex platforms in heterologous primeboost regimens generate significantly higher E7-specific IL-10, IFN-γ, and CTL responses. Moreover, the heterologous nanocomplex regimens, Alb/Pep-Ad/Pep and Ad/Pep-Alb/Pep, significantly suppressed the growth of TC-1 tumors Conclusion: The heterologous nanocomplexes might serve as an effective vaccine strategy against HPV-induced cervical cancer.
MeSH term(s)	Female ; Humans ; Mice ; Animals ; Interleukin-10 ; Human Papillomavirus Viruses ; Adenoviridae/genetics ; Epitopes ; Human papillomavirus 16/genetics ; Vaccination ; Uterine Cervical Neoplasms ; Albumins ; Nanoparticles ; Mice, Inbred C57BL ; Cancer Vaccines
Chemical Substances	Interleukin-10 (130068-27-8) ; Epitopes ; Albumins ; Cancer Vaccines
Language	English
Publishing date	2022-09-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/1389201023666220922122531
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Zs.A 6212: Show issues

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Article ; Online: Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: a review.

Danaeifar, Mohsen / Negahdari, Babak / Eslam, Houra Mobaleghol / Zare, Hamed / Ghanaat, Momeneh / Koushali, Sekinehe Shokouhi / Malekshahi, Ziba Veisi

Biotechnology letters

2023 Volume 45, Issue 9, Page(s) 1053–1072

Abstract: Cancer is one of the leading causes of death and mortality in the world. There is an essential need to develop new drugs or therapeutic approaches to manage treatment-resistant cancers. Cancer immunotherapy is a type of cancer treatment that uses the ... ...

Abstract	Cancer is one of the leading causes of death and mortality in the world. There is an essential need to develop new drugs or therapeutic approaches to manage treatment-resistant cancers. Cancer immunotherapy is a type of cancer treatment that uses the power of the body's immune system to prevent, control, and eliminate cancer. One of the materials used as a vaccine in immunotherapy is DNA. The application of polymeric nanoparticles as carriers for DNA vaccines could be an effective therapeutic approach to activate immune responses and increase antigen presentation efficiency. Various materials have been used as polymeric nanoparticles, including: chitosan, poly (lactic-co-glycolic acid), Polyethylenimine, dendrimers, polypeptides, and polyesters. Application of these polymer nanoparticles has several advantages, including increased vaccine delivery, enhanced antigen presentation, adjuvant effects, and more sustainable induction of the immune system. Besides many clinical trials and commercial products that were developed based on polymer nanoparticles, there is still a need for more comprehensive studies to increase the DNA vaccine efficiency in cancer immunotherapy using this type of carrier.
MeSH term(s)	Humans ; Vaccines, DNA/therapeutic use ; Adjuvants, Immunologic ; Polymers ; Neoplasms/therapy ; Immunotherapy ; Nanoparticles/therapeutic use ; Cancer Vaccines/therapeutic use
Chemical Substances	Vaccines, DNA ; Adjuvants, Immunologic ; Polymers ; Cancer Vaccines
Language	English
Publishing date	2023-06-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-023-03383-x
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Zs.A 4564: Show issues

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Article ; Online: Heterologous administration of HPV16 E7 epitope-loaded nanocomplexes inhibits tumor growth in mouse model.

Goradel, Nasser Hashemi / Negahdari, Babak / Mohajel, Nasir / Malekshahi, Ziba Veisi / Shirazi, Maryam Mashhadi Abolghasem / Arashkia, Arash

International immunopharmacology

2021 Volume 101, Issue Pt B, Page(s) 108298

Abstract: The nanostructured complexes can result in enhanced vaccine efficacy by facilitating the distribution and uptake of antigens by antigen-presenting cells (APCs), thereby stimulating immune responses. Here, we hypothesized that either directly coating of ... ...

Abstract	The nanostructured complexes can result in enhanced vaccine efficacy by facilitating the distribution and uptake of antigens by antigen-presenting cells (APCs), thereby stimulating immune responses. Here, we hypothesized that either directly coating of nanoadjuvants including aluminum phosphate (AlPO
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Alum Compounds ; Animals ; Antigens ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/immunology ; Disease Models, Animal ; Epitopes/immunology ; Immunization ; Mice ; Neoplasms ; Oligodeoxyribonucleotides ; Papillomavirus E7 Proteins ; T-Lymphocytes, Cytotoxic/immunology ; Vaccination ; Vaccine Efficacy
Chemical Substances	Adjuvants, Immunologic ; Alum Compounds ; Antigens ; CPG-oligonucleotide ; Cancer Vaccines ; Epitopes ; Oligodeoxyribonucleotides ; Papillomavirus E7 Proteins ; oncogene protein E7, Human papillomavirus type 16 ; aluminum sulfate (34S289N54E)
Language	English
Publishing date	2021-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108298
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Article ; Online: Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model.

Mobahat, Mahsa / Sadroddiny, Esmaeil / Nooshabadi, Vajihe Taghdiri / Ebrahimi-Barough, Somayeh / Goodarzi, Arash / Malekshahi, Ziba Veisi / Ai, Jafar

Cell and tissue banking

2022 Volume 24, Issue 1, Page(s) 75–91

Abstract: Parkinson disease (PD) is considered as one of the most worldwide neurodegenerative disorders. The major reasons associated to neurodegeneration process of PD pathogenesis are oxidative stress. Many studies reported that natural antioxidant molecules, ... ...

Abstract	Parkinson disease (PD) is considered as one of the most worldwide neurodegenerative disorders. The major reasons associated to neurodegeneration process of PD pathogenesis are oxidative stress. Many studies reported that natural antioxidant molecules, especially, curcumin can suppress inflammatory pathways and preserve dopaminergic neurons damage in PD. Further, the poor pharmacokinetics, instability of chemical structure because of fast hydrolytic degradation at physiologic condition and especially, the presence of the blood brain barrier (BBB) has regarded as a considerable restriction factor for transfer of neurotherapeutic molecules to the brain tissue. The present research aims to the fabrication of nanoformulated curcumin loaded human endometrial stem cells derived exosomes (hEnSCs EXOs-Cur) to study on enhancing curcumin penetration to the brain across BBB and to improve anti- Parkinsonism effects of curcumin against neural death and alpha-synuclein aggregation. hEnSCs EXOs-Cur characterization results demonstrated the accurate size and morphology of formulated curcumin loaded exosomes with a proper stability and sustained release profile. In vivo studies including behavioral, Immunohistochemical and molecular evaluations displayed that novel formulation of hEnSCs EXO-Cur is able to cross BBB, enhance motor uncoordinated movements, suppress the aggregation of αS protein and rescue neuronal cell death through elevation of BCL2 expression level as an anti-apoptotic protein and the expression level reduction of BAX and Caspase 3 as apoptotic markers.
MeSH term(s)	Mice ; Animals ; Humans ; Parkinson Disease/drug therapy ; alpha-Synuclein/metabolism ; alpha-Synuclein/therapeutic use ; Curcumin/pharmacology ; Curcumin/chemistry ; Curcumin/therapeutic use ; Exosomes/metabolism ; Disease Models, Animal
Chemical Substances	alpha-Synuclein ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-06-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170897-6
ISSN	1573-6814 ; 1389-9333
ISSN (online)	1573-6814
ISSN	1389-9333
DOI	10.1007/s10561-022-10008-6
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Zs.A 5972: Show issues

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Article: Hybrid PCL/chitosan-PEO nanofibrous scaffolds incorporated with A. euchroma extract for skin tissue engineering application

Asghari, Fatemeh / Rabiei Faradonbeh, Davood / Malekshahi, Ziba Veisi / Nekounam, Houra / Ghaemi, Behnaz / Yousefpoor, Yaser / Ghanbari, Hossein / Faridi-Majidi, Reza

Carbohydrate polymers. 2022 Feb. 15, v. 278

2022

Abstract: Skin tissue engineering is an advanced method to repair and regenerate skin injuries. Recent research is focused on the development of scaffolds that are safe, bioactive, and cytocompatible. In this work, a new hybrid nanofibrous scaffold composed of ... ...

Abstract	Skin tissue engineering is an advanced method to repair and regenerate skin injuries. Recent research is focused on the development of scaffolds that are safe, bioactive, and cytocompatible. In this work, a new hybrid nanofibrous scaffold composed of polycaprolactone/chitosan-polyethylene oxide (PCL/Cs-PEO) incorporated with Arnebia euchroma (A. euchroma) extract were synthesized by the two-nozzle electrospinning method. Then the synthesized scaffold was characterized for morphology, sustainability, chemical structure and properties. Moreover, to verify their potential in the burn wound healing process, biodegradation rate, contact angle, swelling properties, water vapor permeability, mechanical properties, antibacterial activity and drug release profile were measured. Furthermore, cytotoxicity and biocompatibility tests were performed on human dermal fibroblasts cell line via XTT and LDH assay. It is shown that the scaffold improved and increased proliferation during in-vitro studies. Thus, results confirm the efficacy and potential of the hybrid nanofibrous scaffold for skin tissue engineering.
Keywords	Arnebia euchroma ; antibacterial properties ; biocompatibility ; biodegradation ; carbohydrates ; chemical structure ; contact angle ; cytotoxicity ; drugs ; fibroblasts ; humans ; nanofibers ; permeability ; water vapor
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2021.118926
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bone tissue regeneration by 58S bioactive glass scaffolds containing exosome: an in vivo study.

Ranjbar, Faezeh Esmaeili / Ranjbar, Afsaneh Esmaeili / Malekshahi, Ziba Veisi / Taghdiri-Nooshabadi, Zahra / Faradonbeh, Davood Rabiei / Youseflee, Pouya / Ghasemi, Sahar / Vatanparast, Mahboubeh / Azim, Fazli / Nooshabadi, Vajihe Taghdiri

Cell and tissue banking

2023 Volume 25, Issue 1, Page(s) 389–400

Abstract: Exosomes, the naturally secreted nanocarriers of cells, have recently been demonstrated to have therapeutic benefits in a variety of disease models where parent cells are not present. However, the use of exosomes in bone defect regeneration has been ... ...

Abstract	Exosomes, the naturally secreted nanocarriers of cells, have recently been demonstrated to have therapeutic benefits in a variety of disease models where parent cells are not present. However, the use of exosomes in bone defect regeneration has been unusual, and little is documented about the underlying processes. In recent study we produced and characterized exosomes derived human endometrial mesenchymal stem stromal cells and 58S bioactive glass scaffolds; in following, in this research exosome loaded scaffolds synthetized and release of exosome, porosity and bioactivity of them were assessed. More over the effect of scaffolds on repair of critical-size bone defects in rat's calvaria was evaluated by histological examination and micro computed tomography (µ CT). The findings confirmed that constructed porous scaffolds consistently release exosomes; additionally, in vivo findings including Hematoxilin & Eosin staining, Immunohistochemistry, Masson's trichrome, histomorphometric analysis, and µ CT clarified that our implant has osteogenic properties. We discovered that Exo-treated scaffolds might promote osteogenesis especially compared to pure scaffolds, indicating that produced scaffolds containing exosomes could be a potential replacement in bone tissue engineering.
MeSH term(s)	Rats ; Humans ; Animals ; Tissue Scaffolds/chemistry ; Exosomes ; X-Ray Microtomography ; Cell Differentiation ; Bone Regeneration ; Osteogenesis ; Skull ; Porosity ; Glass
Chemical Substances	bioactive glass 58S
Language	English
Publishing date	2023-12-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170897-6
ISSN	1573-6814 ; 1389-9333
ISSN (online)	1573-6814
ISSN	1389-9333
DOI	10.1007/s10561-023-10120-1
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Article ; Online: Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer.

Ghanaat, Momeneh / Goradel, Nasser Hashemi / Arashkia, Arash / Ebrahimi, Nasim / Ghorghanlu, Sajjad / Malekshahi, Ziba Veisi / Fattahi, Esmail / Negahdari, Babak / Kaboosi, Hami

Acta pharmacologica Sinica

2021 Volume 42, Issue 12, Page(s) 1981–1990

Abstract: Although most human papillomavirus (HPV) infections are harmless, persistent infection with high-risk types of HPV is known to be the leading cause of cervical cancer. Following the infection of the epithelium and integration into the host genome, the ... ...

Abstract	Although most human papillomavirus (HPV) infections are harmless, persistent infection with high-risk types of HPV is known to be the leading cause of cervical cancer. Following the infection of the epithelium and integration into the host genome, the oncogenic proteins E6 and E7 disrupt cell cycle control by inducing p53 and retinoblastoma (Rb) degradation. Despite the FDA approval of prophylactic vaccines, there are still issues with cervical cancer treatment; thus, many therapeutic approaches have been developed to date. Due to strong immunogenicity, a high capacity for packaging foreign DNA, safety, and the ability to infect a myriad of cells, adenoviruses have drawn attention of researchers. Adenovirus vectors have been used for different purposes, including as oncolytic agents to kill cancer cells, carrier for RNA interference to block oncoproteins expression, vaccines for eliciting immune responses, especially in cytotoxic T lymphocytes (CTLs), and gene therapy vehicles for restoring p53 and Rb function.
MeSH term(s)	Adenoviridae/genetics ; Alphapapillomavirus/pathogenicity ; Animals ; Female ; Genetic Therapy ; Genetic Vectors/therapeutic use ; Humans ; Oncolytic Virotherapy ; Papillomavirus Infections/complications ; Uterine Cervical Neoplasms/etiology ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Neoplasms/virology ; Viral Vaccines/therapeutic use
Chemical Substances	Viral Vaccines
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/s41401-021-00616-5
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Article ; Online: Hybrid PCL/chitosan-PEO nanofibrous scaffolds incorporated with A. euchroma extract for skin tissue engineering application.

Asghari, Fatemeh / Rabiei Faradonbeh, Davood / Malekshahi, Ziba Veisi / Nekounam, Houra / Ghaemi, Behnaz / Yousefpoor, Yaser / Ghanbari, Hossein / Faridi-Majidi, Reza

Carbohydrate polymers

2021 Volume 278, Page(s) 118926

Abstract	Skin tissue engineering is an advanced method to repair and regenerate skin injuries. Recent research is focused on the development of scaffolds that are safe, bioactive, and cytocompatible. In this work, a new hybrid nanofibrous scaffold composed of polycaprolactone/chitosan-polyethylene oxide (PCL/Cs-PEO) incorporated with Arnebia euchroma (A. euchroma) extract were synthesized by the two-nozzle electrospinning method. Then the synthesized scaffold was characterized for morphology, sustainability, chemical structure and properties. Moreover, to verify their potential in the burn wound healing process, biodegradation rate, contact angle, swelling properties, water vapor permeability, mechanical properties, antibacterial activity and drug release profile were measured. Furthermore, cytotoxicity and biocompatibility tests were performed on human dermal fibroblasts cell line via XTT and LDH assay. It is shown that the scaffold improved and increased proliferation during in-vitro studies. Thus, results confirm the efficacy and potential of the hybrid nanofibrous scaffold for skin tissue engineering.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Boraginaceae/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Chitosan/chemistry ; Chitosan/pharmacology ; Escherichia coli/drug effects ; Fibroblasts/drug effects ; Humans ; Microbial Sensitivity Tests ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyesters/chemistry ; Polyesters/pharmacology ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; Staphylococcus aureus/drug effects ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Anti-Bacterial Agents ; Biocompatible Materials ; Plant Extracts ; Polyesters ; polycaprolactone (24980-41-4) ; Polyethylene Glycols (3WJQ0SDW1A) ; Chitosan (9012-76-4)
Language	English
Publishing date	2021-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2021.118926
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Article ; Online: Targeting siRNA in colorectal cancer therapy: Nanotechnology comes into view.

Aghamiri, Shahin / Jafarpour, Ali / Malekshahi, Ziba Veisi / Mahmoudi Gomari, Mohammad / Negahdari, Babak

Journal of cellular physiology

2019 Volume 234, Issue 9, Page(s) 14818–14827

Abstract: Colorectal cancer (CRC) is known as one of the most important causes of death and mortality worldwide. Although several efforts have been made for finding new therapies, no achievements have been made in this area. Multidrug resistance (MDR) mechanisms ... ...

Abstract	Colorectal cancer (CRC) is known as one of the most important causes of death and mortality worldwide. Although several efforts have been made for finding new therapies, no achievements have been made in this area. Multidrug resistance (MDR) mechanisms are one of the key factors that could lead to the failure of chemotherapy. Moreover, it has been shown that various chemotherapy drugs are associated with several side effects. Hence, it seems that finding new drugs or new therapeutic platforms is required. Among different therapeutic approaches, utilization of nanoparticles (NPs) for targeting a variety of molecules such as siRNAs are associated with good results for the treatment of CRC. Targeting siRNA-mediated NPs could turn off the effects of oncogenes and MDR-related genes. In the current study, we summarized various siRNAs targeted by NPs which could be used for the treatment of CRC. Moreover, we highlighted other routes such as liposome for targeting siRNAs in CRC therapy.
Language	English
Publishing date	2019-03-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.28281
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Article ; Online: An innovative systematic approach introduced the involved lncRNA-miR-mRNA network in cell cycle and proliferation after conventional treatments in breast cancer patients.

Mohsenikia, Maryam / Khalighfard, Solmaz / Alizadeh, Ali Mohammad / Khori, Vahid / Ghandian Zanjan, Maziar / Zare, Mohammadreza / Omranipour, Ramesh / Patrad, Elham / Razavi, Hengamesadat / Malekshahi, Ziba Veisi / Bagheri-Hosseinabadi, Zahra

Cell cycle (Georgetown, Tex.)

2022 Volume 21, Issue 16, Page(s) 1753–1774

Abstract: The present study aimed to explore the involved lncRNA-miRNA-mRNA network in the cell cycle and proliferation after conventional treatments in Luminal A breast cancer patients.The candidate miRNAs (miRs), lncRNAs, and mRNAs were first taken from the Gene ...

Abstract	The present study aimed to explore the involved lncRNA-miRNA-mRNA network in the cell cycle and proliferation after conventional treatments in Luminal A breast cancer patients.The candidate miRNAs (miRs), lncRNAs, and mRNAs were first taken from the Gene Expression Omnibus and TCGA databases. The lncRNA-miR-mRNA network was then constructed using the high-throughput sequencing data. The expression levels of selected targets were measured in the breast cancer and healthy samples by the Real-Time PCR technique and compared with the clinical outcomes by the Kaplan-Meier method.Our analysis revealed a group of differentially expressed 3 lncRNAs, 9 miRs, and 14 mRNAs in breast cancer patients. A significant expression decrease of the selected tumor suppressor lncRNAs, miRs, and genes and a substantial expression increase of the selected onco-lncRNAs, oncomiRs, and oncogenes were obtained in the patients compared to the healthy group. The plasma levels of the lncRNAs, miRs, and mRNAs were more significant after the operation, chemotherapy, and radiotherapy than the pre-treatment. The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer.
MeSH term(s)	Apoptosis Regulatory Proteins/genetics ; Breast Neoplasms/genetics ; Cell Cycle/genetics ; Cell Proliferation/genetics ; Female ; Gene Regulatory Networks ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics
Chemical Substances	Apoptosis Regulatory Proteins ; MicroRNAs ; PDCD4 protein, human ; RNA, Long Noncoding ; RNA, Messenger ; RNA-Binding Proteins
Language	English
Publishing date	2022-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2022.2070104
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