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  1. Article ; Online: Sentinel lymph node biopsy in a resourcelimited setting: a retrospective comparison of sentinel lymph node biopsy before and after the introduction of Sentimag at an academic breast unit.

    Yousef, M / Roodt, L / Masu, A / Nel, D / Malherbe, F

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2023  Volume 61, Issue 2, Page(s) 91–95

    Abstract: Background: Sentinel lymph node biopsy (SLNB) is performed for staging and prognostication of breast cancer (BC) in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold ... ...

    Abstract Background: Sentinel lymph node biopsy (SLNB) is performed for staging and prognostication of breast cancer (BC) in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold standard for SLNB. This study aims to evaluate the SLNB outcomes before and after the introduction of Sentimag at an academic breast unit. Sentimag uses an injection of superparamagnetic iron oxide which is then detected in the sentinal lymph node using a magnetometer.
    Methods: A retrospective cohort study was performed comparing SLNBs done from 1 January 2017 to 31 December 2018. During 2017, a nuclear medicine technique was used for all SLNBs, while the Sentimag system was used in 2018.
    Results: There was no difference between the two groups comparing age, T-stage, size of tumour, and molecular status. The only statistically significant difference found was more higher-grade tumours in the group where a nuclear medicine technique was used in 2017 (
    Conclusion: This result demonstrates the feasibility of the magnetic technique for SLNB in a resource-limited setting. This new method shows promise as a safe and effective technique for SLNB - it is a valuable alternative in the absence of nuclear medicine (N.Med) facilities.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy ; Breast Neoplasms/surgery ; Mastectomy ; Retrospective Studies ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery
    Language English
    Publishing date 2023-06-28
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
    DOI 10.36303/SAJS.3962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 593: Show issues Location:
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  2. Article ; Online: The Supero-medial Pedicle in Patients with Macromastia Undergoing Nipple Sparing Mastectomy: A Better Option?

    Hudson, Don A / Malherbe, Francois

    Aesthetic plastic surgery

    2022  Volume 47, Issue Suppl 1, Page(s) 116–117

    MeSH term(s) Humans ; Female ; Nipples/surgery ; Mastectomy ; Breast Neoplasms/surgery ; Mastectomy, Subcutaneous ; Mammaplasty ; Retrospective Studies
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Letter
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-022-03052-w
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  3. Article ; Online: South African National Cancer Prevention Services.

    Goldberg, P A / Muchengeti, M / Buccimazza, I / Malherbe, F / Mbatani, N / van Wyk, A / Ramesar, R

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2024  Volume 62, Issue 1, Page(s) 2–6

    MeSH term(s) Humans ; South Africa/epidemiology ; Neoplasms/epidemiology ; Neoplasms/prevention & control
    Language English
    Publishing date 2024-04-03
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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  4. Article ; Online: Medical aids and breast reduction: an oxymoron.

    Hudson, D A / Lelala, B / Malherbe, F / Hudson, C N

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2021  Volume 59, Issue 4, Page(s) 193–194

    MeSH term(s) Humans ; Mammaplasty
    Language English
    Publishing date 2021-12-10
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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  5. Article ; Online: Impact of COVID-19 on breast cancer diagnostic and surgical services at a South African academic hospital.

    Van Wyngaard, T / Cairncross, L / Maswime, S / Roodt, L / Malherbe, F

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2022  Volume 60, Issue 2, Page(s) 119–123

    Abstract: Background: The purpose of the study was to describe the impact of the COVID-19 pandemic on diagnostic and surgical breast cancer services at Groote Schuur Hospital (GSH) and affiliated hospitals.: Methods: All patients, newly diagnosed, awaiting ... ...

    Abstract Background: The purpose of the study was to describe the impact of the COVID-19 pandemic on diagnostic and surgical breast cancer services at Groote Schuur Hospital (GSH) and affiliated hospitals.
    Methods: All patients, newly diagnosed, awaiting surgery, and listed for neoadjuvant chemotherapy (NACT) by the breast surgical service from 23 March - 23 June 2020 were included. A historic control was used where appropriate consisting of patients presenting in the same period in 2019. Clinic attendance records and surgical waiting lists were used to identify patients in the three months and data were extracted from hospital records including hospital admission records and surgical operative notes.
    Results: The number of patients who presented with a new breast symptom to the diagnostic breast clinic decreased from 1 094 in 2019 to 299 in 2020, representing a 72.6% decrease. Telemedicine use as a function of the total follow-ups increased from 53% (n = 1 350) in 2019 to 75% (
    Conclusion: The impact of COVID-19 on breast cancer services has been both at the diagnostic level and in delays to surgery. A new online referral system improved referral efficacy translating to more cancers being diagnosed as a function of total referrals. The drop in absolute numbers of cancer diagnoses, however, represents an unmet health need. An expansion of our telemedicine service mitigated COVID risk in the outpatient setting. The greatest impact on our treatment decisions was seen in the cohort of patients placed on neo-adjuvant endocrine therapy (NET). We saw a global decrease in breast surgeries performed, with the greatest decrease being in reconstructions.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/surgery ; COVID-19/epidemiology ; Female ; Hospitals ; Humans ; Pandemics ; South Africa/epidemiology
    Language English
    Publishing date 2022-07-18
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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    Zs.B 593: Show issues Location:
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  6. Article ; Online: Surgery for Pheochromocytoma: A Single-Center Review of 60 Cases from South Africa.

    Nel, D / Panieri, E / Malherbe, F / Steyn, R / Cairncross, L

    World journal of surgery

    2020  Volume 44, Issue 6, Page(s) 1918–1924

    Abstract: Background: There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa.: Methods: This study was a retrospective review, which included all patients managed by the Groote ... ...

    Abstract Background: There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa.
    Methods: This study was a retrospective review, which included all patients managed by the Groote Schuur Hospital/University of Cape Town Endocrine Surgery unit for pheochromocytoma and abdominal paragangliomas, from January 2002 to June 2019.
    Results: Sixty patients were included in the study, of which 33% were male and 67% female. The mean age was 47 years (range 14-81). The median tumor size was 6 cm, with 45% larger than 6 cm. 92% were located in the adrenal gland (87% unilateral, 5% bilateral), and 8% were extra-adrenal. The conversion rate for laparoscopic cases was 20%, with 55% of cases overall completed laparoscopically. Eleven patients with tumors > 6 cm were initially attempted laparoscopically, of which 3 were converted to open, without any associated increased morbidity. A major adverse event was recorded for 5 cases (8%), including 1 mortality. Overall morbidity, blood loss, operating time and hospital stay were all significantly reduced in the laparoscopic group. There were 5 patients with malignant disease (8%).
    Conclusion: This large series, from an established academic endocrine surgery unit in Africa, can serve as a benchmark for units with similar settings and resource limitations, to compare their surgical management and perioperative outcomes.
    MeSH term(s) Adolescent ; Adrenal Gland Neoplasms/pathology ; Adrenal Gland Neoplasms/surgery ; Adrenal Glands/pathology ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Laparoscopy ; Length of Stay ; Male ; Middle Aged ; Pheochromocytoma/pathology ; Pheochromocytoma/surgery ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05420-6
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    Zs.A 1336: Show issues Location:
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  7. Article ; Online: Magseed placement before neoadjuvant chemotherapy to facilitate subsequent breastconserving surgery - a single-centre audit.

    Malherbe, F / Roodt, L / Noor, F / Gamieldien, R / Chetty, D / Anderson, D / Thebe, T / Cairncross, L

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2022  Volume 60, Issue 2, Page(s) 109–114

    Abstract: Background: A radio-opaque clip is placed in all patients planned for breast-conserving surgery (BCS) receiving neoadjuvant chemotherapy (NACT) to localise the tumour bed in case response to chemotherapy makes later localisation impossible. A tumour ... ...

    Abstract Background: A radio-opaque clip is placed in all patients planned for breast-conserving surgery (BCS) receiving neoadjuvant chemotherapy (NACT) to localise the tumour bed in case response to chemotherapy makes later localisation impossible. A tumour that was localised with a radio-opaque clip before NACT will then need a second localisation procedure, after the completion of NACT to aid BCS. The two most commonly used methods are hookwire and radioguided occult lesion localisation. Magseed
    Methods: A retrospective cohort study was performed, collecting data on patients who had a Magseed placed before or during NACT from December 2018 to February 2020.
    Results: Twenty-one Magseed devices were placed into the breasts of 20 patients, 18 under ultrasound guidance, and three under stereotactic guidance. The average breast volume of individuals who had seeds placed was 1 532 g ± 869 g. The duration that the seeds were in situ was 138 days ± 45 days. All preoperatively placed seeds were retrieved at the surgery with no observed migration outside the tumour bed.
    Conclusion: Magseed placement before NACT is a safe and technically simple technique that can be done under ultrasound guidance in the majority of cases. It has the advantage of being a single procedure with an associated reduction in time off work and travel cost to the patient, as well as flexibility in terms of the time of placement.
    MeSH term(s) Breast ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy, Segmental/methods ; Neoadjuvant Therapy ; Retrospective Studies ; Ultrasonography
    Language English
    Publishing date 2022-07-18
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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    Zs.B 593: Show issues Location:
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  8. Article ; Online: Palpable breast lumps: An age-based approach to evaluation and diagnosis.

    Malherbe, Francois / Nel, Daniel / Molabe, Hunadi / Cairncross, Lydia / Roodt, Liana

    South African family practice : official journal of the South African Academy of Family Practice/Primary Care

    2022  Volume 64, Issue 1, Page(s) e1–e5

    Abstract: A palpable breast lump is a common presentation of breast disease to a general practitioner. Fortunately, investigation of most of these lumps will lead to a benign diagnosis. It is essential to have a clear and systematic approach when investigating a ... ...

    Abstract A palpable breast lump is a common presentation of breast disease to a general practitioner. Fortunately, investigation of most of these lumps will lead to a benign diagnosis. It is essential to have a clear and systematic approach when investigating a palpable breast lump to avoid over investigation with the resultant increase in healthcare cost and anxiety. This article will discuss an approach to evaluating and diagnosing a palpable breast lump in the primary care setting.
    MeSH term(s) Breast/diagnostic imaging ; Breast Diseases/diagnosis ; Female ; Humans ; Mammography ; Palpation ; Ultrasonography, Mammary
    Language English
    Publishing date 2022-09-23
    Publishing country South Africa
    Document type Journal Article
    ISSN 2078-6204
    ISSN (online) 2078-6204
    DOI 10.4102/safp.v64i1.5571
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  9. Book ; Online: Optimal capital requirements over the business and financial cycles

    Malherbe, Frederic

    (Working paper series / European Central Bank ; 1830)

    2015  

    Author's details Frederic Malherbe
    Series title Working paper series / European Central Bank ; 1830
    Keywords Basler Akkord ; Konjunktur ; Spekulationsblase ; Finanzkrise ; Finanzmarktregulierung ; Stabilisierungspolitik ; Theorie
    Language English
    Size Online-Ressource (44 S.), graph. Darst.
    Publisher Europ. Central Bank
    Publishing place Frankfurt am Main
    Document type Book ; Online
    ISBN 9789289916431 ; 9289916435
    Database ECONomics Information System

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  10. Article: Self-fulfilling liquidity dry-ups

    Malherbe, Frederic

    The journal of finance : the journal of the American Finance Association Vol. 69, No. 2 , p. 947-970

    2014  Volume 69, Issue 2, Page(s) 947–970

    Author's details Frederic Malherbe
    Keywords Portfolio-Management ; Marktliquidität ; Schock ; Adverse Selektion ; Finanzkrise ; Anlegerschutz ; Second Best ; Theorie
    Language English
    Size graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ [u.a.]
    Document type Article
    ZDB-ID 218191-5 ; 2010241-0
    ISSN 1540-6261 ; 0022-1082
    ISSN (online) 1540-6261
    ISSN 0022-1082
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