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Article: Oral Pyogenic Granuloma at Different Spots: A Series of Case Reports.

Phull, Tanvi / Dadhwal, Hima / Kaur, Rajpreet / Malhotra, Ritu / Jyoti, Divya / Kaur, Ravneet

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S999–S1001

Abstract: Pyogenic granuloma is an inflammatory non-neoplastic lesion of the oral cavity. Chronic, mild, local irritation, trauma, hormonal variables, and certain medications are typical causes of pyogenic granulomas. Women have a higher prevalence than men. The ... ...

Abstract	Pyogenic granuloma is an inflammatory non-neoplastic lesion of the oral cavity. Chronic, mild, local irritation, trauma, hormonal variables, and certain medications are typical causes of pyogenic granulomas. Women have a higher prevalence than men. The risk is greatest in the second to fifth decades of life. Clinically, the lesion appears smooth, with soft to firm consistency and nontender with a pedunculated or sessile base. Various modalities have been proposed for the treatment of lesion, which include the conventional approach, the use of laser, cryotherapy, and electrocauterization. This case series discusses three cases of pyogenic granuloma in female patients at different locations in the oral cavity. The lesion was subsequently treated with electrosurgery and surgical convention methods. No recurrence of the lesion has been seen in either of the cases.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Case Reports
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_703_23
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Article: Diagnosis and Treatment of a Rare Case of Tubercular Gingival Enlargement.

Phull, Tanvi / Sharma, Harmesh / Gandhi, Sunidhi / Jyoti, Divya / Malhotra, Ritu / Katha, Nandita

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S969–S971

Abstract: Granulomatous inflammation is a distinctive variant of the chronic inflammatory response. The orofacial tissues may be affected by a wide range of granulomatous diseases. The lesions range from infections, immunological, and reactive, to foreign body ... ...

Abstract	Granulomatous inflammation is a distinctive variant of the chronic inflammatory response. The orofacial tissues may be affected by a wide range of granulomatous diseases. The lesions range from infections, immunological, and reactive, to foreign body granulomas. As is common knowledge, tuberculosis (TB) is a chronic infectious disease that can affect any region of the body, including the mouth. It may involve the tongue in the mouth and have quite peculiar features and forms. Therefore, while uncommon, oral lesions are crucial for the early detection and treatment of primary TB. We discuss a possible instance of gingival TB that manifested as an enlarged gingiva. The patient received a test dose of antituberculous therapy for one month. The antituberculous therapy was completed for the following five months after one month of treatment showed progress. This case report for dentists emphasizes how crucial it is to consider TB in the differential diagnosis of various types of gingival enlargements.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Case Reports
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_706_23
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Article: Diagnosis and Management of Papillon-Lefevre Syndrome: A Rare Case Report and a Brief Review of Literature.

Phull, Tanvi / Jyoti, Divya / Malhotra, Ritu / Nayak, Shanteri / Modi, Himanshi / Singla, Ishu / P, Aishwarrya

Cureus

2023 Volume 15, Issue 8, Page(s) e43335

Abstract: Papillon-Lefevre syndrome (PLS) manifests as an autosomal recessive disorder caused by a mutation in the cathepsin C (CTSC) gene. This genetic alteration results in palmoplantar hyperkeratosis, rapid onset of periodontitis, and premature shedding of both ...

Abstract	Papillon-Lefevre syndrome (PLS) manifests as an autosomal recessive disorder caused by a mutation in the cathepsin C (CTSC) gene. This genetic alteration results in palmoplantar hyperkeratosis, rapid onset of periodontitis, and premature shedding of both primary and permanent teeth. The major etiological factor responsible for the development of this disorder appears to be variations in the CTSC gene, which is responsible for the production of the cathepsin C enzyme in the body. The multifactorial aetiology of the syndrome is influenced by immunologic, genetic, or microbial factors. This case report presents a clinical picture of a 21-year-old Indian male patient with oligodontia and mobile teeth accompanied by palmoplantar keratosis and a history of recurrent infection. The detailed family history of the patient revealed genetic relevance with PLS. This article will discuss in detail the diagnosis, evaluation and treatment modalities involved in the management of the case.
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43335
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Article: Management of Chronic Inflammatory Gingival Enlargement: A Short Review and Case Report.

Sandhu, Avreet / Jyoti, Divya / Malhotra, Ritu / Phull, Tanvi / Sidhu, Haridarshan S / Nayak, Shanteri

Cureus

2023 Volume 15, Issue 10, Page(s) e46770

Abstract: Inflammatory gingival enlargement, sometimes referred to as gingival hyperplasia or gingival hypertrophy, is an abnormal proliferation of gingival tissues caused by underlying inflammation. It might also be related to long-term periodontitis. Herein, we ... ...

Abstract	Inflammatory gingival enlargement, sometimes referred to as gingival hyperplasia or gingival hypertrophy, is an abnormal proliferation of gingival tissues caused by underlying inflammation. It might also be related to long-term periodontitis. Herein, we discuss the case of a young, otherwise healthy male patient wherein the anterior regions of both the upper and lower arches were affected by long-standing gingival growth. The overgrowth was removed, and an excellent aesthetic outcome was achieved, using a surgical procedure termed gingivectomy. After a 15-day follow-up period, the healing process was satisfactory and no negative effects were found.
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46770
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Article ; Online: Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer.

Basak, Nandini Pal / Jaganathan, Kowshik / Das, Biswajit / Muthusamy, Oliyarasi / M, Rajashekar / Malhotra, Ritu / Samal, Amit / Nath, Moumita / Ms, Ganesh / Shankar, Amritha Prabha / Bv, Prakash / Pillai, Vijay / Bv, Manjula / C, Jayaprakash / K, Vasanth / K, Gowri Shankar / Govindan, Sindhu / V, Syamkumar / Juby /

R, Koushika / Bhowal, Chandan / Kumar, Upendra / K, Govindaraj / Malhotra, Mohit / Sankaran, Satish

Nature communications

2024 Volume 15, Issue 1, Page(s) 1585

Abstract: Dynamic interactions within the tumor micro-environment drive patient response to immune checkpoint inhibitors. Existing preclinical models lack true representation of this complexity. Using a Head and Neck cancer patient derived TruTumor histoculture ... ...

Abstract	Dynamic interactions within the tumor micro-environment drive patient response to immune checkpoint inhibitors. Existing preclinical models lack true representation of this complexity. Using a Head and Neck cancer patient derived TruTumor histoculture platform, the response spectrum of 70 patients to anti-PD1 treatment is investigated in this study. With a subset of 55 patient samples, multiple assays to characterize T-cell reinvigoration and tumor cytotoxicity are performed. Based on levels of these two response parameters, patients are stratified into five sub-cohorts, with the best responder and non-responder sub-cohorts falling at extreme ends of the spectrum. The responder sub-cohort exhibits high T-cell reinvigoration, high tumor cytotoxicity with T-cells homing into the tumor upon treatment whereas immune suppression and tumor progression pathways are pre-dominant in the non-responders. Some moderate responders benefit from combination of anti-CTLA4 with anti-PD1, which is evident from better cytotoxic T-cell: T-regulatory cell ratio and enhancement of tumor cytotoxicity. Baseline and on-treatment gene expression signatures from this study stratify responders and non-responders in unrelated clinical datasets.
MeSH term(s)	Humans ; Head and Neck Neoplasms/drug therapy ; Tumor Microenvironment
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45723-z
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Article ; Online: ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.

Murrow, Lyndsay / Malhotra, Ritu / Debnath, Jayanta

Nature cell biology

2015 Volume 17, Issue 3, Page(s) 300–310

Abstract: The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12- ... ...

Abstract	The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12-ATG3 have impaired basal autophagic flux, accumulation of perinuclear late endosomes, and impaired endolysosomal trafficking. Furthermore, we identify an interaction between ATG12-ATG3 and the ESCRT-associated protein Alix (also known as PDCD6IP) and demonstrate that ATG12-ATG3 controls multiple Alix-dependent processes including late endosome distribution, exosome biogenesis and viral budding. Similar to ATG12-ATG3, Alix is functionally required for efficient basal, but not starvation-induced, autophagy. Overall, these results identify a link between the core autophagy and ESCRT machineries and uncover a role for ATG12-ATG3 in late endosome function that is distinct from the canonical role of either ATG in autophagosome formation.
MeSH term(s)	Amino Acid Sequence ; Animals ; Autophagy/genetics ; Autophagy-Related Protein 12 ; Autophagy-Related Proteins ; Calcium Signaling ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Endosomes/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Deletion ; Gene Expression Regulation ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mice ; Molecular Sequence Data ; Proteins/genetics ; Proteins/metabolism ; Ubiquitin-Conjugating Enzymes/deficiency ; Ubiquitin-Conjugating Enzymes/genetics ; Red Fluorescent Protein
Chemical Substances	Atg12 protein, mouse ; Autophagy-Related Protein 12 ; Autophagy-Related Proteins ; Calcium-Binding Proteins ; Luminescent Proteins ; Pdcd6ip protein, mouse ; Proteins ; Green Fluorescent Proteins (147336-22-9) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Atg3 protein, mouse (EC 6.3.2.-)
Language	English
Publishing date	2015-02-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/ncb3112
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.

Malhotra, Ritu / Warne, James P / Salas, Eduardo / Xu, Allison W / Debnath, Jayanta

Autophagy

2015 Volume 11, Issue 1, Page(s) 145–154

Abstract: The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons. Upon high-fat diet (HFD) consumption, mice ... ...

Abstract	The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons. Upon high-fat diet (HFD) consumption, mice lacking Atg12 in POMC-positive neurons exhibit accelerated weight gain, adiposity, and glucose intolerance, which is associated with increased food intake, reduced ambulation, and decreased LEP/leptin sensitivity. Importantly, although genetic deletion of either Atg12 or Atg5 renders POMC neurons autophagy-deficient, mice lacking Atg5 in POMC neurons do not exhibit these phenotypes. Hence, we propose nonautophagic functions for ATG12 in POMC neurons that counteract excessive weight gain in response to HFD consumption.
MeSH term(s)	Adiposity ; Animals ; Animals, Newborn ; Autophagy-Related Protein 12 ; Autophagy-Related Protein 5 ; Body Weight ; Diet, High-Fat ; Energy Metabolism ; Feeding Behavior ; Gene Deletion ; Gene Targeting ; Integrases/metabolism ; Leptin/metabolism ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; Neurons/metabolism ; Obesity/metabolism ; Obesity/pathology ; Pro-Opiomelanocortin/metabolism ; Proteins/metabolism
Chemical Substances	Atg12 protein, mouse ; Atg5 protein, mouse ; Autophagy-Related Protein 12 ; Autophagy-Related Protein 5 ; Leptin ; Microtubule-Associated Proteins ; Proteins ; Pro-Opiomelanocortin (66796-54-1) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2014.998917
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Article: [No title information]

Gupta, Neeraj / Saxena, R. K. / Juneja and Malhotra, Ritu A. K.

Homœopathic Links

2013 Volume 26, Issue 04, Page(s) 256–261

Abstract: Autism spectrum disorder (ASD) is a neural developmental ailment and causes impaired social interaction and communication by restricted and repetitive behaviour in children. It develops due to unknown ... ...

Abstract	Autism spectrum disorder (ASD) is a neural developmental ailment and causes impaired social interaction and communication by restricted and repetitive behaviour in children. It develops due to unknown causative agents. It has an immense impact on parents and society. There is supposedly no permanent cure for the various symptoms of ASD. However, several remedial measures are available to control the various behavioural symptoms of autism disorder. The homeopathic therapeutic system has been found to be very effective in controlling the behavioural and other related abnormal conditions of ASD. This paper presents four cases of autistic children, having undergone regular homeopathic treatment. The results of the clinical study found quite meaningful improvement in autistic and other behavioural symptoms in all four subjects studied. This study suggests that a homeopathic medicinal regimen does produce positive improvement and modification of autistic symptoms, if followed dutifully.
Keywords	Autism Spectrum Disorder ; Bufo rana ; Calcarea carbonica ; Calcarea phosphorica ; Hyoscyamus niger ; Natrum muriaticum ; Phosphorus ; Santoninum ; Silicea ; Sulphur ; Tarantula ; Thuja occidentalis ; Tuberculinum ; Veratrum album
Language	English
Publishing date	2013-12-01
Publisher	Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1199312-1
ISSN	1860-3149 ; 1019-2050
ISSN (online)	1860-3149
ISSN	1019-2050
DOI	10.1055/s-0033-1350941
Database	Thieme publisher's database

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Article ; Online: FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Warr, Matthew R / Binnewies, Mikhail / Flach, Johanna / Reynaud, Damien / Garg, Trit / Malhotra, Ritu / Debnath, Jayanta / Passegué, Emmanuelle

Nature

2013 Volume 494, Issue 7437, Page(s) 323–327

Abstract: Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here we identify autophagy as an essential mechanism ... ...

Abstract	Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that mouse HSCs, in contrast to their short-lived myeloid progeny, robustly induce autophagy after ex vivo cytokine withdrawal and in vivo calorie restriction. We demonstrate that FOXO3A is critical to maintain a gene expression program that poises HSCs for rapid induction of autophagy upon starvation. Notably, we find that old HSCs retain an intact FOXO3A-driven pro-autophagy gene program, and that ongoing autophagy is needed to mitigate an energy crisis and allow their survival. Our results demonstrate that autophagy is essential for the life-long maintenance of the HSC compartment and for supporting an old, failing blood system.
MeSH term(s)	Aging ; Animals ; Apoptosis ; Autophagy/genetics ; Caloric Restriction ; Cell Survival/genetics ; Cellular Senescence ; Cytokines/deficiency ; Cytokines/metabolism ; Energy Metabolism/genetics ; Food Deprivation ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Homeostasis ; Mice ; Mice, Inbred C57BL ; Stress, Physiological/genetics
Chemical Substances	Cytokines ; Forkhead Box Protein O3 ; Forkhead Transcription Factors ; FoxO3 protein, mouse
Language	English
Publishing date	2013-02-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature11895
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Quality control of integral membrane proteins.

Krebs, Mark P / Noorwez, Syed M / Malhotra, Ritu / Kaushal, Shalesh

Trends in biochemical sciences

2004 Volume 29, Issue 12, Page(s) 648–655

Abstract: Integral membrane proteins (IMPs) are essential components of the plasma and organellar membranes of the eukaryotic cell. Non-native IMPs, which can arise as a result of mutations, errors during biosynthesis or cellular stress, can disrupt these ... ...

Abstract	Integral membrane proteins (IMPs) are essential components of the plasma and organellar membranes of the eukaryotic cell. Non-native IMPs, which can arise as a result of mutations, errors during biosynthesis or cellular stress, can disrupt these membranes and potentially lead to cell death. To protect against this outcome, the cell possesses quality control (QC) systems that detect and dispose of non-native IMPs from cellular membranes. Recent studies suggest that recognition of non-native IMPs by the QC machinery is correlated with the thermodynamic stability of these proteins. Consistent with this, small molecules known as chemical and pharmacological chaperones have been identified that stabilize non-native IMPs and enable them to evade QC. These findings have far-reaching implications for treating human diseases caused by defective IMPs.
MeSH term(s)	Cell Membrane/physiology ; Membrane Proteins/physiology ; Models, Biological ; Molecular Chaperones ; Protein Folding ; Quality Control
Chemical Substances	Membrane Proteins ; Molecular Chaperones
Language	English
Publishing date	2004-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2004.10.009
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