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Book: Amorphous solid dispersions

Shah, Navnit / Sandhu, Harpreet / Choi, Duk Soon / Chokshi, Hitesh / Malick, A. Waseem

theory and practice

(Advances in delivery science and technology ;)

2014

Institution	Controlled Release Society,
Author's details	Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick, editors
Series title	Advances in delivery science and technology ;
MeSH term(s)	Technology, Pharmaceutical/methods ; Solubility
Language	English
Size	xxii, 699 pages :, illustrations.
Document type	Book
ISBN	9781493915972 ; 1493915975 ; 9781493915989 ; 1493915983
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Online: Amorphous Solid Dispersions

Shah, Navnit / Choi, Duk Soon / Chokshi, Hitesh / Malick, A. Waseem / Sandhu, Harpreet

Theory and Practice

(Advances in Delivery Science and Technology)

2014

Abstract: This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of ... ...

Author's details	edited by Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick
Series title	Advances in Delivery Science and Technology
Abstract	This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Keywords	Medicine ; Pharmaceutical technology
Language	English
Size	Online-Ressource (XXII, 699 p. 206 illus., 141 illus. in color), online resource
Publisher	Springer New York
Publishing place	New York, NY ;s.l
Document type	Book ; Online
ISBN	9781493915972 ; 9781493915989 ; 1493915975 ; 1493915983
DOI	10.1007/978-1-4939-1598-9
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Ceftriaxone Absorption Enhancement for Noninvasive Administration as an Alternative to Injectable Solutions.

Ba, Boubakar / Gaudin, Karen / Désiré, Amélie / Phoeung, Thida / Langlois, Marie-Hélène / Behl, Charan R / Unowsky, Joel / Patel, Indravadan H / Malick, A Waseem / Gomes, Melba / White, Nicholas / Kauss, Tina

Antimicrobial agents and chemotherapy

2018 Volume 62, Issue 12

Abstract: Neonatal sepsis is a major cause of infant mortality in developing countries because of delayed injectable treatment, making it urgent to develop noninjectable formulations that can reduce treatment delays in resource-limited settings. Ceftriaxone, ... ...

Abstract	Neonatal sepsis is a major cause of infant mortality in developing countries because of delayed injectable treatment, making it urgent to develop noninjectable formulations that can reduce treatment delays in resource-limited settings. Ceftriaxone, available only for injection, needs absorption enhancers to achieve adequate bioavailability via nonparenteral administration. This article presents all available data on the nonparenteral absorption of ceftriaxone in humans and animals, including unpublished work carried out by F. Hoffmann-La Roche (Roche) in the 1980s and new data from preclinical studies with rabbits, and discusses the importance of these data for the development of noninjectable formulations for noninvasive treatment. The combined results indicate that the rectal absorption of ceftriaxone is feasible and likely to lead to a bioavailable formulation that can reduce treatment delays in neonatal sepsis. A bile salt, chenodeoxycholate sodium salt (Na-CDC), used as an absorption enhancer at a 125-mg dose, together with a 500-mg dose of ceftriaxone provided 24% rectal absorption of ceftriaxone and a maximal plasma concentration of 21 µg/ml with good tolerance in human subjects. The rabbit model developed can also be used to screen for the bioavailability of other formulations before assessment in humans.
MeSH term(s)	Administration, Rectal ; Adult ; Animals ; Anti-Bacterial Agents/blood ; Anti-Bacterial Agents/pharmacokinetics ; Biological Availability ; Ceftriaxone/blood ; Ceftriaxone/pharmacokinetics ; Chenodeoxycholic Acid/administration & dosage ; Drug Administration Schedule ; Drug Evaluation, Preclinical ; Female ; Healthy Volunteers ; Humans ; Infant, Newborn ; Intestinal Absorption/drug effects ; Male ; Neonatal Sepsis/drug therapy ; Neonatal Sepsis/prevention & control ; Papio ; Rabbits ; Triglycerides/administration & dosage
Chemical Substances	Anti-Bacterial Agents ; Triglycerides ; Chenodeoxycholic Acid (0GEI24LG0J) ; witepsol (12713-12-1) ; Ceftriaxone (75J73V1629)
Language	English
Publishing date	2018-11-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01170-18
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Article: Affinity purification and characterization of an anti-PEG IgM.

Ehrlich, George K / Michel, Hanspeter / Chokshi, Hitesh P / Malick, A Waseem

Journal of molecular recognition : JMR

2009 Volume 22, Issue 2, Page(s) 99–103

Abstract: Anti-PEG IgM was purified by affinity chromatography using variable length PEG chains (5, 10, 20 and 30 kDa) as affinity ligands. Maximal binding of anti-PEG IgM was observed using the 30 kDa PEG-derivatized NuGel (single passage). Purified anti-PEG IgM ... ...

Abstract	Anti-PEG IgM was purified by affinity chromatography using variable length PEG chains (5, 10, 20 and 30 kDa) as affinity ligands. Maximal binding of anti-PEG IgM was observed using the 30 kDa PEG-derivatized NuGel (single passage). Purified anti-PEG IgM was characterized for binding to PEG functionalized proteins/peptides by surface plasmon resonance, western blotting and ELISA. Anti-PEG IgM, in solution and adsorbed on 20 kDa PEG-derivatized NuGel, was subjected to pepsin digestion followed by affinity chromatography. SDS-PAGE analysis of eluates in both preparations yielded one fragment that was similar in size. However, an additional lower molecular weight band was observed in solution-digested affinity purified material that was not present in the eluate from the material subjected to pepsin digestion on the affinity matrix. The lower MW fragment could be eluted under milder conditions, suggesting loss of binding multiplicity. Analysis by mass spectrometry yielded molecular weights of 132 kDa (both) and 82 kDa (solution) for the respective fragments. N-terminal sequencing of both fragments resulted in primary sequences (heavy and light chains) that were not only identical to each other but also to those of native IgM. The anti-PEG IgM fragments were characterized for binding to pegylated interferon alfa-2a by ELISA. The results from these studies suggest that affinity purified anti-PEG IgM and fragments can be used as probes in detection assays for PEG functionalized biotherapeutics in pre-clinical and clinical studies.
MeSH term(s)	Animals ; Blotting, Western ; Chromatography, Affinity ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Immunoglobulin M/immunology ; Immunoglobulin M/isolation & purification ; Immunoglobulin M/metabolism ; Interferon-alpha/metabolism ; Mice ; Molecular Weight ; Polyethylene Glycols/metabolism ; Recombinant Proteins ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Surface Plasmon Resonance
Chemical Substances	Immunoglobulin M ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2a (47RRR83SK7) ; peginterferon alfa-2a (Q46947FE7K)
Language	English
Publishing date	2009-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1015084-5
ISSN	1099-1352 ; 0952-3499
ISSN (online)	1099-1352
ISSN	0952-3499
DOI	10.1002/jmr.920
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Article ; Online: Supersolubilization and amorphization of a model basic drug, haloperidol, by interaction with weak acids.

Singh, Saumya / Parikh, Tapan / Sandhu, Harpreet K / Shah, Navnit H / Malick, A Waseem / Singhal, Dharmendra / Serajuddin, Abu T M

Pharmaceutical research

2013 Volume 30, Issue 6, Page(s) 1561–1573

Abstract: Purpose: To present a novel approach of greatly enhancing aqueous solubility of a model weakly basic drug, haloperidol, by using weak acids that would not form salts with the drug and to attain physically stable form of amorphous drug by drying such ... ...

Abstract	Purpose: To present a novel approach of greatly enhancing aqueous solubility of a model weakly basic drug, haloperidol, by using weak acids that would not form salts with the drug and to attain physically stable form of amorphous drug by drying such aqueous solutions. Method: Aqueous solubility of haloperidol in presence of increasing concentrations of four different weak organic acids (malic, tartaric, citric, fumaric) were determined. Several concentrated aqueous solutions with differing drug-to-acid molar ratios were dried in vacuum oven, and dried materials were characterized by DSC, powder XRD, dissolution testing, and stability study. Result: Acids were selected such that they would not form salts with haloperidol. Haloperidol solubility increased greatly with increased concentrations of malic, tartaric and citric acids, reaching >300 mg/g of solution. In contrast to the haloperidol HCl aqueous solubility of 4 mg/g, this may be called supersolubilization. Fumaric acid did not cause such solubilization as it had low water solubility. Dried solids formed dispersions of amorphous haloperidol in acids that were either amorphous or partially crystalline. Amorphous haloperidol was physically stable and had better dissolution rate than HCl salt. Conclusion: A novel method of drug solubilization in aqueous media by acid-base interaction is presented. Physically stable amorphous systems of drugs may also be prepared by using this organic solvent-free approach.
MeSH term(s)	Acids/chemistry ; Drug Stability ; Haloperidol/chemistry ; Hydrogen-Ion Concentration ; Salts/chemistry ; Solubility ; Solutions/chemistry ; Water/chemistry
Chemical Substances	Acids ; Salts ; Solutions ; Water (059QF0KO0R) ; Haloperidol (J6292F8L3D)
Language	English
Publishing date	2013-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-013-0994-7
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Article ; Online: Influence of an acrylic polymer blend on the physical stability of film-coated theophylline pellets.

Kucera, Shawn / Shah, Navnit H / Malick, A Waseem / Infeld, Martin H / McGinity, James W

AAPS PharmSciTech

2009 Volume 10, Issue 3, Page(s) 864–871

Abstract: The purpose of this study was to investigate the physical stability of a coating system consisting of a blend of two sustained release acrylic polymers and its influence on the drug release rate of theophylline from coated pellets. The properties of both ...

Abstract	The purpose of this study was to investigate the physical stability of a coating system consisting of a blend of two sustained release acrylic polymers and its influence on the drug release rate of theophylline from coated pellets. The properties of both free films and theophylline pellets coated with the polymer blend were investigated, and the miscibility was determined via differential scanning calorimetry. Eudragit RS 30 D was plasticized by the addition of Eudragit NE 30 D, and the predicted glass transition temperature (T(g)) of the blend was similar to the experimental values. Sprayed films composed of a blend of Eudragit NE 30 D/Eudragit RS 30 D (1:1) showed a water vapor permeability six times greater than films containing only Eudragit NE 30 D. The presence of quaternary ammonium functional groups from the RS 30 D polymer increased the swellability of the films. The films prepared from the blend exhibited stable permeability values when stored for 1 month at both 25 degrees C and 40 degrees C, while the films which were composed of only Eudragit NE 30 D showed a statistically significant decrease in this parameter when stored under the same conditions. Eudragit NE 30 D/Eudragit RS 30 D (1:1)-sprayed films decreased in elongation from 180% to 40% after storage at 40 degrees C for 1 month, while those stored at 25 degrees C showed no change in elongation. In coated pellets, the addition of Eudragit RS 30 D to the Eudragit NE 30 D increased the theophylline release rate, and the pellets were stable when stored at 25 degrees C for a period of up to 3 months due to maintenance of the physico-mechanical properties of the film. Pellets stored at 40 degrees C exhibited a decrease in drug release rate over time as a result of changes in film physico-mechanical properties which were attributed to further coalescence and densification of the polymer. When the storage temperature was above the T(g) of the composite, instabilities in both drug release rate and physical properties were evident. Stabilization in drug release rate from coated pellets could be correlated with the physico-mechanical stability of the film formulation when stored at temperatures below the T(g) of the polymer.
MeSH term(s)	Acrylates ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/chemistry ; Drug Stability ; Drug Storage ; Excipients ; Kinetics ; Permeability ; Polymers ; Polymethacrylic Acids ; Theophylline/administration & dosage ; Theophylline/chemistry ; Water/chemistry
Chemical Substances	Acrylates ; Bronchodilator Agents ; Excipients ; Polymers ; Polymethacrylic Acids ; Water (059QF0KO0R) ; methylmethacrylate-methacrylic acid copolymer (25086-15-1) ; Theophylline (C137DTR5RG)
Language	English
Publishing date	2009-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-009-9275-5
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Article ; Online: A method to predict the equilibrium solubility of drugs in solid polymers near room temperature using thermal analysis.

Bellantone, Robert A / Patel, Piyush / Sandhu, Harpreet / Choi, Duk Soon / Singhal, Dharmendra / Chokshi, H / Malick, A Waseem / Shah, Navnit

Journal of pharmaceutical sciences

2012 Volume 101, Issue 12, Page(s) 4549–4558

Abstract: A method is presented for determining the equilibrium solubility of a drug in a solid polymer at or near room temperature, which represents a typical storage temperature. The method is based on a thermodynamic model to calculate the Gibbs energy change ... ...

Abstract	A method is presented for determining the equilibrium solubility of a drug in a solid polymer at or near room temperature, which represents a typical storage temperature. The method is based on a thermodynamic model to calculate the Gibbs energy change ΔG(SS) associated with forming a binary drug-polymer solid solution from the unmixed polymer and solid drug. The model includes contributions from heat capacity differences between the solid solution and the corresponding unmixed components, breaking up of the solid drug structure, and drug-polymer mixing. Calculation of ΔG(SS) from thermal analysis data is demonstrated, and it is shown that minima of plots of ΔG(SS) versus the dissolved drug concentration represent the equilibrium drug solubility in the polymer. Solid solutions were produced for drug-polymer systems (griseofulvin, indomethacin, itraconazole; PVP K30, Eudragit L100, Eudragit E100) in drug weight fractions up to ∼25%. At 25°C, it was seen that heat capacity effects were important in determining the drug solubility. It was concluded that drug solubilities in solid polymers can be determined using thermal analysis, and must include heat capacity effects when evaluated near room temperature.
MeSH term(s)	Acrylates/chemistry ; Calorimetry, Differential Scanning ; Griseofulvin/chemistry ; Indomethacin/chemistry ; Itraconazole/chemistry ; Models, Chemical ; Pharmaceutical Preparations/chemistry ; Polymers/chemistry ; Povidone/chemistry ; Solubility ; Temperature ; Thermodynamics
Chemical Substances	Acrylates ; Eudragit E100 ; Pharmaceutical Preparations ; Polymers ; Itraconazole (304NUG5GF4) ; Griseofulvin (32HRV3E3D5) ; Povidone (FZ989GH94E) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1002/jps.23319
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Article: In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles.

Forrest, M Laird / Won, Chee-Youb / Malick, A Waseem / Kwon, Glen S

Journal of controlled release : official journal of the Controlled Release Society

2005 Volume 110, Issue 2, Page(s) 370–377

Abstract: An injectable formulation of rapamycin was prepared using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL). Drug-loaded PEG-PCL micelles were prepared by a co-solvent extraction technique. Resulting ... ...

Abstract	An injectable formulation of rapamycin was prepared using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL). Drug-loaded PEG-PCL micelles were prepared by a co-solvent extraction technique. Resulting PEG-PCL micelles were less than 100 nm in diameter and contained rapamycin at 7% to 10% weight and >1 mg/mL. PEG-PCL micelles released rapamycin over several days, t50% 31 h, with no burst release; however, physiological concentrations of serum albumin increased the release rate 3-fold. Alpha-tocopherol, vitamin E, was co-incorporated into PEG-PCL micelles and increased the efficiency of rapamycin encapsulation. The addition of alpha-tocopherol also slowed the release of rapamycin from PEG-PCL micelles in the presence of serum albumin, t50% 39 h.
MeSH term(s)	Algorithms ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Calorimetry, Differential Scanning ; Ethylene Glycols ; Excipients ; Kinetics ; Micelles ; Particle Size ; Polyesters ; Protein Kinases/drug effects ; Sirolimus/administration & dosage ; Sirolimus/pharmacokinetics ; TOR Serine-Threonine Kinases ; Viscosity ; X-Ray Diffraction ; alpha-Tocopherol/chemistry
Chemical Substances	Anti-Bacterial Agents ; Ethylene Glycols ; Excipients ; Micelles ; Polyesters ; poly(epsilon-caprolactone)-b-poly(ethylene glycol) ; Protein Kinases (EC 2.7.-) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; alpha-Tocopherol (H4N855PNZ1) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2005-11-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2005.10.008
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Article: Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.

Schilling, Sandra U / Bruce, Caroline D / Shah, Navnit H / Malick, A Waseem / McGinity, James W

International journal of pharmaceutics

2008 Volume 361, Issue 1-2, Page(s) 158–168

Abstract: Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance ... ...

Abstract	Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem hydrochloride from melt extruded Eudragit RS PO tablets and to eliminate drug particle size effects. Preformulation studies demonstrated the thermal stability of all components, drug insolubility in the polymer but miscibility with the CA MH. Tablets with either constant polymer levels or constant drug-to-polymer ratios and containing different drug particle size fractions and increasing amounts of CA MH were manufactured by melt extrusion and characterized by dissolution testing, powder X-ray diffraction and scanning electron microscopy. The addition of CA MH to the formulation promoted the thermal processibility and matrix integrity by plasticization of the polymer. The drug release from systems with constant drug-to-polymer ratio was significantly increased when CA MH was added as a result of enhanced pore formation. Particle size effects were eliminated when large amounts of CA MH were used due to the loss of drug crystallinity. Matrix tablets with CA MH furthermore showed a faster and more complete drug release compared to systems with drug only or alternative pore formers (sucrose, NaCl, or PEG 3350). The enhanced drug release was attributed to the amorphous character of the soluble components, improved drug dispersion in the plasticized polymer along with increased polymer permeability. In summary, CA MH promoted the miscibility between the drug and Eudragit RS PO during hot-melt extrusion, resulting in the extrusion of an amorphous system with improved dissolution characteristics.
MeSH term(s)	Calcium Channel Blockers/chemistry ; Chemistry, Pharmaceutical ; Citric Acid/chemistry ; Crystallization ; Delayed-Action Preparations ; Diltiazem/chemistry ; Drug Carriers/chemistry ; Drug Stability ; Excipients/chemistry ; Hot Temperature ; Microscopy, Electron, Scanning ; Particle Size ; Polymethacrylic Acids/chemistry ; Powder Diffraction ; Solubility ; Tablets
Chemical Substances	Calcium Channel Blockers ; Delayed-Action Preparations ; Drug Carriers ; Eudragit RSPO ; Excipients ; Polymethacrylic Acids ; Tablets ; Citric Acid (2968PHW8QP) ; Diltiazem (EE92BBP03H)
Language	English
Publishing date	2008-09-01
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2008.05.035
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Article: Effect of formulation and processing variables on the granulation kinetics of hot melt granulation (HMG) process.

Sandhu, Harpreet K / Chatterji, Ashish / Shah, Navnit H / Malick, A Waseem / Desai, Dipen / Zia, Hossein

Pharmaceutical development and technology

2007 Volume 12, Issue 2, Page(s) 145–151

Abstract: The objective of the study was to evaluate the effect of formulation factors, such as type of drug and particulate properties of a drug, and processing variables, i.e. jacket temperature, impeller speed, and scale, on granulation kinetics the of hot-melt ...

Abstract	The objective of the study was to evaluate the effect of formulation factors, such as type of drug and particulate properties of a drug, and processing variables, i.e. jacket temperature, impeller speed, and scale, on granulation kinetics the of hot-melt granulation (HMG) process. Two model active pharmaceutical ingredients (API) Ro-A and indomethacin were selected for this evaluation using poloxamer 188 as a meltable binder. The effect of solid-state properties of API was investigated for Ro-A, whereas the binder properties were maintained constant. General factorial design was used to investigate the effect of independent process variables, impeller speed and jacket temperature using impeller motor power consumption as response variable. Consistent granulation could be developed for Ro-A by optimizing the binder level and impeller speed, however, the addition of third excipient was necessary for indomethacin. The granulation rate was related to the bulk density and the surface area of the drug. The jacket temperature affected overall granulation time but had no significant effect on the granulation kinetics, suggesting that faster heating rate is desirable for optimal productivity. A significant increase in the granulation rate was observed with increase in impeller speed. The effect of impeller speed was further confirmed at 5 L and 25 L scale. From the formulation prospective, the critical factors were the level of binder, inherent binding properties of the API, the solid-state properties of API and binder. From processing perspectives, the impeller speed had a significant effect on the granulation kinetics.
MeSH term(s)	Chemistry, Pharmaceutical/methods ; Excipients/chemistry ; Hot Temperature ; Indomethacin/chemistry ; Lactose/chemistry ; Particle Size ; Poloxamer/chemistry ; Povidone/chemistry ; Surface Properties ; Technology, Pharmaceutical/methods ; Temperature
Chemical Substances	Excipients ; Poloxamer (106392-12-5) ; Povidone (FZ989GH94E) ; Lactose (J2B2A4N98G) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2007-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1331774-x
ISSN	1097-9867 ; 1083-7450
ISSN (online)	1097-9867
ISSN	1083-7450
DOI	10.1080/10837450701212495
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