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Book ; Online ; E-Book: Chronic Lung Diseases

Rayees, Sheikh / Din, Inshah / Singh, Gurdarshan / Malik, Fayaz A.

Pathophysiology and Therapeutics

2020

Abstract: Chronic lung diseases: pathophysiology and therapeutics provides a much-needed reference tool for pathologists, practicing pulmonologists and researchers who are currently working on lung related diseases. Each chapter addresses a specific lung disease, ... ...

Author's details	edited by Sheikh Rayees, Inshah Din, Gurdarshan Singh, Fayaz A Malik
Abstract	Chronic lung diseases: pathophysiology and therapeutics provides a much-needed reference tool for pathologists, practicing pulmonologists and researchers who are currently working on lung related diseases. Each chapter addresses a specific lung disease, which it introduces before turning to the disease’s pathophysiology, current treatment and future prospects. Various key lung diseases are covered, including chronic obstructive pulmonary disease, lung cancer, tuberculosis, chronic pneumonia, acute respiratory distress syndrome, asthma, cystic fibrosis and pulmonary hypertension. Medical students and researchers whose work involves pulmonary related disorders will find this work both instructive and informative.
Keywords	Medicine ; Biomedicine, general ; Malalties del pulmó ; Malalties cròniques
Subject code	780
Language	English
Size	1 online resource (VIII, 180 p. 6 illus., 4 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-3734-8 ; 981-15-3733-X ; 978-981-15-3734-9 ; 978-981-15-3733-2
DOI	10.1007/978-981-15-3734-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Unveiling the mechanisms and challenges of cancer drug resistance.

Khan, Sameer Ullah / Fatima, Kaneez / Aisha, Shariqa / Malik, Fayaz

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 109

Abstract: Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ... ...

Abstract	Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells to survive and progress under unfavorable conditions. Although the mechanism of drug resistance is being widely studied to generate new target-based drugs with better potency than existing ones. However, due to the broader flexibility in acquired drug resistance, advanced therapeutic options with better efficacy need to be explored. Combination therapy is an alternative with a better success rate though the risk of amplified side effects is commonplace. Moreover, recent groundbreaking precision immune therapy is one of the ways to overcome drug resistance and has revolutionized anticancer therapy to a greater extent with the only limitation of being individual-specific and needs further attention. This review will focus on the challenges and strategies opted by cancer cells to withstand the current therapies at the molecular level and also highlights the emerging therapeutic options -like immunological, and stem cell-based options that may prove to have better potential to challenge the existing problem of therapy resistance. Video Abstract.
MeSH term(s)	Humans ; Proteomics ; Drug Resistance, Neoplasm/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Review
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01302-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and Evaluation of Natural and Unnatural Tetrahydrocannabiorcol for Its Potential Use in Neuropathologies.

Anand, Radhika / Anand, Loveleena Kaur / Rashid, Nadia / Painuli, Ritu / Malik, Fayaz / Singh, Parvinder Pal

Journal of natural products

2024 Volume 87, Issue 2, Page(s) 167–175

Abstract: ...

Abstract	(-)-
MeSH term(s)	Humans ; Dronabinol/pharmacology ; Limonene ; Neuroblastoma/drug therapy ; Cannabinoids/chemistry ; Cannabinoids/pharmacology
Chemical Substances	Dronabinol (7J8897W37S) ; Limonene (9MC3I34447) ; Cannabinoids
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00172
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Article ; Online: Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis.

Khan, Sameer Ullah / Fatima, Kaneez / Malik, Fayaz

Clinical & experimental metastasis

2022 Volume 39, Issue 5, Page(s) 715–726

Abstract: Anchorage-independent survival of cancer cells is associated with metastasis as it enables cells to travel to secondary target sites. Tissue integrity is generally maintained by detachment-induced cell death called 'anoikis', but cancer cells undergoing ... ...

Abstract	Anchorage-independent survival of cancer cells is associated with metastasis as it enables cells to travel to secondary target sites. Tissue integrity is generally maintained by detachment-induced cell death called 'anoikis', but cancer cells undergoing the multistep metastatic process show resistance to anoikis. Anoikis resistance enables these cells to survive through the extracellular matrix (ECM) deprived phase, which starts when cancer cells detach and move into the circulation till cells reach to the secondary target site. Comprehensive analysis of the molecular and functional biology of anoikis resistance in cancer cells will provide crucial details about cancer metastasis, enabling us to identify novel therapeutic targets against cancer cell dissemination and ultimately secondary tumor formation. This review broadly summarizes recent advances in the understanding of cellular and molecular events leading to anoikis and anoikis resistance. It further elaborates more about the signaling cross-talk in anoikis resistance and its regulation during metastasis.
MeSH term(s)	Anoikis ; Cell Line, Tumor ; Cell Survival ; Extracellular Matrix/metabolism ; Humans ; Neoplasm Metastasis ; Signal Transduction
Language	English
Publishing date	2022-07-13
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-022-10172-9
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Zs.A 1855: Show issues

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Article ; Online: Targeting redox regulation and autophagy systems in cancer stem cells.

Khan, Sameer Ullah / Rayees, Sheikh / Sharma, Pankaj / Malik, Fayaz

Clinical and experimental medicine

2022 Volume 23, Issue 5, Page(s) 1405–1423

Abstract: Cancer is a dysregulated cellular level pathological condition that results in tumor formation followed by metastasis. In the heterogeneous tumor architecture, cancer stem cells (CSCs) are essential to push forward the progression of tumors due to their ... ...

Abstract	Cancer is a dysregulated cellular level pathological condition that results in tumor formation followed by metastasis. In the heterogeneous tumor architecture, cancer stem cells (CSCs) are essential to push forward the progression of tumors due to their strong pro-tumor properties such as stemness, self-renewal, plasticity, metastasis, and being poorly responsive to radiotherapy and chemotherapeutic agents. Cancer stem cells have the ability to withstand various stress pressures by modulating transcriptional and translational mechanisms, and adaptable metabolic changes. Owing to CSCs heterogeneity and plasticity, these cells display varied metabolic and redox profiles across different types of cancers. It has been established that there is a disparity in the levels of Reactive Oxygen Species (ROS) generated in CSCs vs Non-CSC and these differential levels are detected across different tumors. CSCs have unique metabolic demands and are known to change plasticity during metastasis by passing through the interchangeable epithelial and mesenchymal-like phenotypes. During the metastatic process, tumor cells undergo epithelial to mesenchymal transition (EMT) thus attaining invasive properties while leaving the primary tumor site, similarly during the course of circulation and extravasation at a distant organ, these cells regain their epithelial characteristics through Mesenchymal to Epithelial Transition (MET) to initiate micrometastasis. It has been evidenced that levels of Reactive Oxygen Species (ROS) and associated metabolic activities vary between the epithelial and mesenchymal states of CSCs. Similarly, the levels of oxidative and metabolic states were observed to get altered in CSCs post-drug treatments. As oxidative and metabolic changes guide the onset of autophagy in cells, its role in self-renewal, quiescence, proliferation and response to drug treatment is well established. This review will highlight the molecular mechanisms useful for expanding therapeutic strategies based on modulating redox regulation and autophagy activation to targets. Specifically, we will account for the mounting data that focus on the role of ROS generated by different metabolic pathways and autophagy regulation in eradicating stem-like cells hereafter referred to as cancer stem cells (CSCs).
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Neoplasms/pathology ; Oxidation-Reduction ; Neoplastic Stem Cells/metabolism ; Autophagy
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2022-12-06
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00955-5
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Zs.A 5481: Show issues

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Article ; Online: Cancer metastasis: Molecular mechanisms and clinical perspectives.

Khan, Sameer Ullah / Fatima, Kaneez / Malik, Fayaz / Kalkavan, Halime / Wani, Abubakar

Pharmacology & therapeutics

2023 Volume 250, Page(s) 108522

Abstract: Metastatic progression combined with non-responsiveness towards systemic therapy often shapes the course of disease for cancer patients and commonly determines its lethal outcome. The complex molecular events that promote metastasis are a combination of ... ...

Abstract	Metastatic progression combined with non-responsiveness towards systemic therapy often shapes the course of disease for cancer patients and commonly determines its lethal outcome. The complex molecular events that promote metastasis are a combination of both, the acquired pro-metastatic properties of cancer cells and a metastasis-permissive or -supportive tumor micro-environment (TME). Yet, dissemination is a challenging process for cancer cells that requires a series of events to enable cancer cell survival and growth. Metastatic cancer cells have to initially detach themselves from primary tumors, overcome the challenges of their intravasal journey and colonize distant sites that are suited for their metastases. The implicated obstacles including anoikis and immune surveillance, can be overcome by intricate intra- and extracellular signaling pathways, which we will summarize and discuss in this review. Further, emerging modulators of metastasis, like the immune-microenvironment, microbiome, sublethal cell death engagement, or the nervous system will be integrated into the existing working model of metastasis.
MeSH term(s)	Humans ; Neoplasms/metabolism ; Signal Transduction ; Anoikis ; Neoplasm Metastasis ; Epithelial-Mesenchymal Transition ; Tumor Microenvironment
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2023.108522
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Zs.A 1183: Show issues

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Article ; Online: Lavender plant: Farming and Health benefits.

Khan, Sameer Ullah / Hamza, Baseerat / Mir, Reyaz Hassan / Fatima, Kaneez / Malik, Fayaz

Current molecular medicine

2023

Abstract: Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made a significant contribution to the treatment of many ailments. Lavender is a Mediterranean shrub from the Lamiaceae family. Lavender flowers ( ... ...

Abstract	Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made a significant contribution to the treatment of many ailments. Lavender is a Mediterranean shrub from the Lamiaceae family. Lavender flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars, phytosterols, minerals, and tannins and are majorly used for herbal applications. Lavender essential oil's descriptive and analytical composition varies depending on genotype, growing region, climatic circumstances, propagation, and morphological characteristics. There are around 300 chemical components in essential oil. Linalool, terpinen-4-ol, linalyl acetate, ocimene, acetate lavandulol, and cineole are the most prominent constituents. Lavender oil has antibacterial and antioxidant properties. The lavender extract helps to prevent dementia and may slow cancer cell growth, while lavender oil is used to treat skin problems. This review will cover the recent medical, economic and regional advancements in levander propagation and how the Council of Scientific & Industrial Research Indian Institute of Integrative (CSIR IIIM) aroma mission is actively acting as a bridge between farmers and their economic improvement by attracting them to the field of medicinal plant cultivation.
Language	English
Publishing date	2023-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/1566524023666230518114027
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Zs.A 5580: Show issues

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Article ; Online: Small molecule '4ab' induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions.

Khan, Sameer Ullah / Fatima, Kaneez / Singh, Umed / Singh, Parvinder Paul / Malik, Fayaz

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 4, Page(s) 121

Abstract: Metastasis is the leading cause of death in cancer patients and a major challenging aspect of cancer biology. Various adaptive molecular signaling pathways play a crucial role in cancer metastasis and later in the formation of secondary tumors. ... ...

Abstract	Metastasis is the leading cause of death in cancer patients and a major challenging aspect of cancer biology. Various adaptive molecular signaling pathways play a crucial role in cancer metastasis and later in the formation of secondary tumors. Aggressive cancer cells like triple negative breast cancer (TNBCs) are more inclined to undergo metastasis hence having a high recurrence rate and potential of micro-metastasis. Tumor cells in circulation known as circulating tumor cells (CTCs) offer an attractive drug target to treat metastatic disease. Cell cycle regulation and stress response of CTCs in blood has a crucial role in their survival and progression and thus may be considered therapeutically active hotspots. The cyclin D/cyclin-dependent kinase (CDK) pathway regulates cell cycle checkpoints, a process that is frequently dysregulated in cancer cells. Selective CDK inhibitors can limit the phosphorylation of cell cycle regulatory proteins by inducing cell cycle phase arrest, and thus may be an effective therapeutic strategy for aggressive cancer cells in their dividing phase at the primary or secondary site. However, during the floating condition, cancer cells halt their multiplication process and proceed through the various steps of metastasis. Current study showed that a novel CDK inhibitor 4ab induced autophagy and endoplasmic reticulum (ER) stress in agressive cancer cells grown under adherent and floating conditions resulting in paraptosis. Further, our results showed that 4ab efficiently induced cell death in aggressive cancer cells through ER stress-mediated activation of JNK signaling. Additionally, was observed that treatment of 4ab in tumor-bearing mice displayed a significant reduction in tumor burden and micro-metastasis. The outcome of these studies showed that 4ab can be a potential anti-tumor and anti-metastatic agent. Graphical representation of 4ab: image representing the effect of 4ab on death-inducing pathways in aggressive cancer cells. 4ab induces ER stress and activates autophagy leading to vacuolation of there by causing apoptosis in aggressive cancer cells.
MeSH term(s)	Animals ; Mice ; Apoptosis ; Endoplasmic Reticulum Stress ; Signal Transduction ; Cell Line, Tumor ; Autophagy ; Cell Proliferation ; Neoplasms
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-01963-5
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Article ; Online: Design, synthesis and neuroprotective evaluation of nitrogen heterocyclic and triazole derivatives of sarracinic acid.

Jameel, Salman / Kaur, Loveleena / Amin, Henna / Bhat, Showkat Ahmad / Malik, Fayaz A / Bhat, Khursheed Ahmad

Natural product research

2023 , Page(s) 1–10

Abstract: Novel sarracinic acid derivatives bearing triazole or N-heterocyclic moiety were ... ...

Abstract	Novel sarracinic acid derivatives bearing triazole or N-heterocyclic moiety were prepared
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2269464
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Article ; Online: Isolation and characterisation of pharmaceutically versatile molecules from Rumex dentatus and evaluation of their cytotoxic activity against human cancer cell lines

Khaliq, Tahirah / Waseem, Malik A. / Mir, Sameer A. / Sultan, Phalisteen / Malik, Fayaz A. / Hassan, Qazi Parvaiz

Natural Product Research. 2023 Mar. 4, v. 37, no. 5 p.857-862

2023

Abstract: The disclosed study reveals isolation, characterization and anticancer evaluation of Rumex dentatus. The extracts and isolated compounds were used for cytotoxic activity against (lung (A549), pancreatic (MIAPaCa), colon (HCT-116), breast (MDA-MB-231) and ...

Abstract	The disclosed study reveals isolation, characterization and anticancer evaluation of Rumex dentatus. The extracts and isolated compounds were used for cytotoxic activity against (lung (A549), pancreatic (MIAPaCa), colon (HCT-116), breast (MDA-MB-231) and breast (MDA-MB-468) cell lines. The extracts were screened for cytotoxicity using MTT colorimetric assay. Out of all extracts, methanolic (30) %: chloroform fraction (TAW6) with 75.01% inhibition at a concentration 100 µg/mL was observed. The selected extracts were further processed for column chromatography and led to isolation of seven compounds (A to G). The structural determination of isolated compounds was carried out using ¹HNMR, ¹³CNMR, IR and HRMS. All the isolates were tested for cytotoxic activity and compound B was found most active with IC₅₀ values 11.29 µg against HCT-116 (Colon). The compound B was then used for detailed study via transwell invasion assay and wound healing assay. Thus the significant anticancer activity particularly against colon cancerous cell lines recommends that the (Rumex dentatus) could act as a potential drug candidate for cancer, more particularly for colon cancer.
Keywords	Rumex dentatus ; antineoplastic activity ; breasts ; chloroform ; chromatography ; colon ; colorectal neoplasms ; colorimetry ; cytotoxicity ; humans ; lungs ; neoplasm cells ; research ; anticancer activity ; HCT-116 (Colon) ; compound B (Emodin) ; transwell invasion ; wound healing assay
Language	English
Dates of publication	2023-0304
Size	p. 857-862.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2092864
Database	NAL-Catalogue (AGRICOLA)

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