Article ; Online: Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation.
2024 Volume 13, Issue 5
Abstract: Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver. However, the precise mechanism underlying ... ...
Abstract | Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver. However, the precise mechanism underlying hepatic steatosis in the setting of obesity remains unclear. Here, we report studies that address this question. After 14 weeks on a high-fat diet (HFD) with high sucrose, C57BL/6 mice revealed a phenotype of liver steatosis. Transcriptional profiling analysis of the liver tissues was performed using RNA sequencing (RNA-seq). Our RNA-seq data revealed 692 differentially expressed genes involved in processes of lipid metabolism, oxidative stress, immune responses, and cell proliferation. Notably, the gene encoding neutral sphingomyelinase, |
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MeSH term(s) | Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Sphingomyelin Phosphodiesterase ; Mice, Inbred C57BL ; Inflammation ; Obesity/metabolism ; Esterases |
Chemical Substances | Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Esterases (EC 3.1.-) |
Language | English |
Publishing date | 2024-03-06 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2661518-6 |
ISSN | 2073-4409 ; 2073-4409 |
ISSN (online) | 2073-4409 |
ISSN | 2073-4409 |
DOI | 10.3390/cells13050463 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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