LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Myasthenia Gravis Induced by Immune Checkpoint Inhibitors.

    Becquart, Ondine / Lacotte, Julie / Malissart, Pauline / Nadal, Jeremy / Lesage, Candice / Guillot, Bernard / Du Thanh, Aurélie

    Journal of immunotherapy (Hagerstown, Md. : 1997)

    2019  Volume 42, Issue 8, Page(s) 309–312

    Abstract: Immune checkpoint inhibitors deeply improved the prognosis of metastatic melanoma or other types of cancer, but their related adverse effects (AEs) can be very severe, especially when the neurological system is touched, as in myasthenia gravis (MG). It ... ...

    Abstract Immune checkpoint inhibitors deeply improved the prognosis of metastatic melanoma or other types of cancer, but their related adverse effects (AEs) can be very severe, especially when the neurological system is touched, as in myasthenia gravis (MG). It is a rare immune AE that can be life-threatening and can be revealed by several symptoms. We report a case of our experience and review the current literature of MG exacerbated or occurring during immunotherapy to describe characteristics of this AE, warn the oncologist about this toxicity, and summarize the treatments conducted. Thirty-four cases of MG were reported, mostly with anti-programmed cell death protein 1 checkpoint inhibitor, and with melanoma. Onset was quick after the first or second infusion. Treatment comprised corticosteroids, prostigmine, and more or less plasmapheresis or immunoglobulins. Prognosis is poor, as 13 patients died after MG. MG is a rare immune-related AE that must be rapidly evoked and treated in case of neurological symptoms emerging after immunotherapy.
    MeSH term(s) Aged ; Antineoplastic Agents, Immunological/adverse effects ; Female ; Humans ; Melanoma/drug therapy ; Myasthenia Gravis/drug therapy ; Myasthenia Gravis/etiology ; Neostigmine/therapeutic use ; Nivolumab/adverse effects ; Programmed Cell Death 1 Receptor/antagonists & inhibitors
    Chemical Substances Antineoplastic Agents, Immunological ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Nivolumab (31YO63LBSN) ; Neostigmine (3982TWQ96G)
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1064067-8
    ISSN 1537-4513 ; 1053-8550 ; 1524-9557
    ISSN (online) 1537-4513
    ISSN 1053-8550 ; 1524-9557
    DOI 10.1097/CJI.0000000000000278
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Carotid paraganglioma mimicking a cluster headache.

    Malissart, Pauline / Ducros, Anne / Labauge, Pierre / De Champfleur, Nicolas Menjot / Carra-Dalliere, Clarisse

    Cephalalgia : an international journal of headache

    2014  Volume 34, Issue 13, Page(s) 1111

    MeSH term(s) Carotid Body Tumor/complications ; Carotid Body Tumor/diagnosis ; Cluster Headache/etiology ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102414530523
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A Regional Network Organization for Thrombectomy for Acute Ischemic Stroke in the Anterior Circulation; Timing, Safety, and Effectiveness.

    Mourand, Isabelle / Malissart, Pauline / Dargazanli, Cyril / Nogue, Erika / Bouly, Stephane / Gaillard, Nicolas / Boukriche, Yassine / Corti, Lucas / Picot, Marie-Christine / Beaufils, Olivier / Chbicheb, Mohamed / Sablot, Denis / Bonafe, Alain / Costalat, Vincent / Arquizan, Caroline

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2018  Volume 28, Issue 2, Page(s) 259–266

    Abstract: Background: Mechanical thrombectomy (MT) in association with intravenous thrombolysis is recommended for treatment of acute ischemic stroke (AIS), with large vessel occlusion (LVO) in the anterior circulation. Because MT is only available in ... ...

    Abstract Background: Mechanical thrombectomy (MT) in association with intravenous thrombolysis is recommended for treatment of acute ischemic stroke (AIS), with large vessel occlusion (LVO) in the anterior circulation. Because MT is only available in comprehensive stroke centers (CSC), the challenge of stroke organization is to ensure equitable access to the fastest endovascular suite. Our aim was to evaluate the feasibility, efficacy, and safety of MT in patients initially managed in 1 CSC (mothership), compared with patients first managed in primary stroke center (PSC), and then transferred to the CSC for MT (drip-and-ship).
    Methods: We retrospectively analyzed 179 consecutive patients (93 in the mothership group and 86 in the drip-and-ship group), with AIS secondary to LVO in the anterior cerebral circulation and a clinical-radiological mismatch (NIHSS ≥ 8 and DWI-ASPECT score ≥5), up to 6 hours after symptoms onset. We evaluated 3-month functional modified Rankin scale (mRS), periprocedural time management, mortality, and symptomatic intracranial haemorrhage (sICH).
    Results: Despite significant longer process time in the drip-and-ship group, mRS ≤ 2 at 3 months (39.8% versus 44.1%, P = .562), Thrombolysis in cerebral infarction 2b-3 (85% versus 78%, P = .256), and sICH (7.0% versus 9.7%, P = .515) were similar in both group regardless of baseline clinical or radiological characteristics. After multivariate logistic regression, the predictive factors for favorable outcome were age (odds ratio [OR]
    Conclusions: Our study showed encouraging results from a regional protocol of MT comparing patients transferred from PSC or brought directly in CSC.
    MeSH term(s) Aged ; Brain Infarction/diagnosis ; Brain Infarction/mortality ; Brain Infarction/physiopathology ; Brain Infarction/surgery ; Delivery of Health Care, Integrated/organization & administration ; Disability Evaluation ; Feasibility Studies ; Female ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/adverse effects ; Humans ; Infusions, Intravenous ; Male ; Mechanical Thrombolysis/adverse effects ; Mechanical Thrombolysis/mortality ; Middle Aged ; Patient Transfer/organization & administration ; Recovery of Function ; Regional Health Planning/organization & administration ; Retrospective Studies ; Risk Factors ; Thrombectomy/adverse effects ; Thrombectomy/mortality ; Time Factors ; Time-to-Treatment/organization & administration ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2018.09.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy.

    Delmont, Emilien / Manso, Constance / Querol, Luis / Cortese, Andrea / Berardinelli, Angela / Lozza, Alessandro / Belghazi, Maya / Malissart, Pauline / Labauge, Pierre / Taieb, Guillaume / Yuki, Nobuhiro / Illa, Isabel / Attarian, Shahram / Devaux, Jérôme J

    Brain : a journal of neurology

    2017  Volume 140, Issue 7, Page(s) 1851–1858

    Abstract: Chronic inflammatory demyelination polyneuropathy is a heterogeneous and treatable immune-mediated disorder that lacks biomarkers to support diagnosis. Recent evidence indicates that paranodal proteins (contactin 1, contactin-associated protein 1, and ... ...

    Abstract Chronic inflammatory demyelination polyneuropathy is a heterogeneous and treatable immune-mediated disorder that lacks biomarkers to support diagnosis. Recent evidence indicates that paranodal proteins (contactin 1, contactin-associated protein 1, and neurofascin-155) are the targets of autoantibodies in subsets of patients showing distinct clinical presentations. Here, we identified neurofascin-186 and neurofascin-140 as the main targets of autoantibodies in five patients presenting IgG reactivity against the nodes of Ranvier. Four patients displayed predominantly IgG4 antibodies, and one patient presented IgG3 antibodies that activated the complement pathway in vitro. These patients present distinct clinical features compared to those with anti-neurofascin-155 IgG4. Most patients had a severe phenotype associated with conduction block or decreased distal motor amplitude. Four patients had a subacute-onset and sensory ataxia. Two patients presented with nephrotic syndromes and one patient with an IgG4-related retroperitoneal fibrosis. Intravenous immunoglobulin and corticosteroids were effective in three patients, and one patient remitted following rituximab treatment. Clinical remission was associated with autoantibody depletion and with recovery of conduction block and distal motor amplitude suggesting a nodo-paranodopathy. Our data demonstrate that the pathogenic mechanisms responsible for chronic inflammatory demyelination polyneuropathy are broad and may include dysfunctions at the nodes of Ranvier in a subgroup of patients.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Autoantibodies/blood ; Autoantibodies/immunology ; Case-Control Studies ; Cell Adhesion Molecules/immunology ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Middle Aged ; Nerve Growth Factors/immunology ; Neural Conduction/physiology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/blood ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/drug therapy ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology ; Protein Isoforms/immunology ; Ranvier's Nodes/immunology ; Rituximab/therapeutic use ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Autoantibodies ; Cell Adhesion Molecules ; Immunoglobulins, Intravenous ; NFASC protein, human ; Nerve Growth Factors ; Protein Isoforms ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2017-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awx124
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top