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  1. AU="Mallett, Garry"
  2. AU=Lemos Pedro A
  3. AU="Bakris, George L."
  4. AU="Tun-Linn Thein"
  5. AU="Michelle Schinkel"
  6. AU="Scolieri, G"

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  1. Artikel ; Online: What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2.

    Hodgson, Susanne H / Mansatta, Kushal / Mallett, Garry / Harris, Victoria / Emary, Katherine R W / Pollard, Andrew J

    The Lancet. Infectious diseases

    2020  Band 21, Heft 2, Seite(n) e26–e35

    Abstract: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 1 million deaths in the first 6 months of the pandemic and huge economic and social upheaval internationally. An efficacious vaccine is essential to ...

    Abstract The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 1 million deaths in the first 6 months of the pandemic and huge economic and social upheaval internationally. An efficacious vaccine is essential to prevent further morbidity and mortality. Although some countries might deploy COVID-19 vaccines on the strength of safety and immunogenicity data alone, the goal of vaccine development is to gain direct evidence of vaccine efficacy in protecting humans against SARS-CoV-2 infection and COVID-19 so that manufacture of efficacious vaccines can be selectively upscaled. A candidate vaccine against SARS-CoV-2 might act against infection, disease, or transmission, and a vaccine capable of reducing any of these elements could contribute to disease control. However, the most important efficacy endpoint, protection against severe disease and death, is difficult to assess in phase 3 clinical trials. In this Review, we explore the challenges in assessing the efficacy of candidate SARS-CoV-2 vaccines, discuss the caveats needed to interpret reported efficacy endpoints, and provide insight into answering the seemingly simple question, "Does this COVID-19 vaccine work?"
    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Humans ; Immunogenicity, Vaccine ; Outcome Assessment, Health Care ; Research Design ; SARS-CoV-2/immunology ; Treatment Outcome ; Vaccination
    Chemische Substanzen COVID-19 Vaccines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30773-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Cross-sectional Survey of Medical student Attitudes to Research and Training pathways (SMART) in the UK: study protocol.

    Roche, Sophie / Bandyopadhyay, Soham / Grassam-Rowe, Alexander / Brown, Robin Andrew / Iveson, Poppy / Mallett, Garry / Eggington, Holly / Swales, Catherine

    BMJ open

    2021  Band 11, Heft 9, Seite(n) e050104

    Abstract: Background: An understanding and appreciation of scientific research is a key quality of the modern clinician. Yet the Medical Schools Council has previously reported a reduction in the number of clinicians performing research. To explore the reasons ... ...

    Abstract Background: An understanding and appreciation of scientific research is a key quality of the modern clinician. Yet the Medical Schools Council has previously reported a reduction in the number of clinicians performing research. To explore the reasons for this difficulty, this multicentre, cross-sectional study aims to determine the medical student involvement and perceptions of research and research-orientated careers. It will additionally identify perceived barriers and incentives to participating in research as a student.
    Methods and analysis: This cross-sectional study of medical students at UK medical schools recognised by the General Medical Council will be administered using an online questionnaire. This will be disseminated nationally over a 2-month period through collaborative university medical school and student networks. The primary outcome is to determine the extent to which medical students are currently involved in research. Secondary outcomes include identifying the personal and demographic factors involved in incentivising and deterring medical students from becoming involved in research during medical school. This will be achieved using a selection of Likert scale, multiple-choice and free text questions. Ordinal logistic regression analysis will be performed to understand the association between specific factors and student involvement in research. This study will also characterise the proportion of medical students who are currently interested in conducting research in the future.
    Ethics and dissemination: Ethics approval has been obtained from the Medical Sciences Interdivisional Research Ethics Committee, Oxford, England. The results will be disseminated via publication in a peer-reviewed medical journal and may be presented at local, regional, national and international conferences by medical student collaborators.
    Mesh-Begriff(e) Attitude ; Cross-Sectional Studies ; Humans ; Multicenter Studies as Topic ; Schools, Medical ; Students, Medical ; United Kingdom
    Sprache Englisch
    Erscheinungsdatum 2021-09-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-050104
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

    Hodgson, Susanne H / Mansatta, Kushal / Mallett, Garry / Harris, Victoria / Emary, Katherine R W / Pollard, Andrew J

    Lancet infect. dis

    Abstract: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 1 million deaths in the first 6 months of the pandemic and huge economic and social upheaval internationally. An efficacious vaccine is essential to ...

    Abstract The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 1 million deaths in the first 6 months of the pandemic and huge economic and social upheaval internationally. An efficacious vaccine is essential to prevent further morbidity and mortality. Although some countries might deploy COVID-19 vaccines on the strength of safety and immunogenicity data alone, the goal of vaccine development is to gain direct evidence of vaccine efficacy in protecting humans against SARS-CoV-2 infection and COVID-19 so that manufacture of efficacious vaccines can be selectively upscaled. A candidate vaccine against SARS-CoV-2 might act against infection, disease, or transmission, and a vaccine capable of reducing any of these elements could contribute to disease control. However, the most important efficacy endpoint, protection against severe disease and death, is difficult to assess in phase 3 clinical trials. In this Review, we explore the challenges in assessing the efficacy of candidate SARS-CoV-2 vaccines, discuss the caveats needed to interpret reported efficacy endpoints, and provide insight into answering the seemingly simple question, "Does this COVID-19 vaccine work?"
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #894296
    Datenquelle COVID19

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  4. Artikel ; Online: What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

    Hodgson, Susanne H / Mansatta, Kushal / Mallett, Garry / Harris, Victoria / Emary, Katherine R W / Pollard, Andrew J

    The Lancet Infectious Diseases ; ISSN 1473-3099

    2020  

    Schlagwörter Infectious Diseases ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1016/s1473-3099(20)30773-8
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Impaired antibody response to COVID-19 vaccination in patients with chronic myeloid neoplasms.

    Chowdhury, Onima / Bruguier, Hannah / Mallett, Garry / Sousos, Nikolaos / Crozier, Kirsty / Allman, Caroline / Eyre, David / Lumley, Sheila / Strickland, Marie / Karali, Christina S / Murphy, Lauren / Sternberg, Alex / Jeffery, Katie / Mead, Adam J / Peniket, Andy / Psaila, Bethan

    British journal of haematology

    2021  Band 194, Heft 6, Seite(n) 1010–1015

    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Antibody Formation/drug effects ; BNT162 Vaccine ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; ChAdOx1 nCoV-19 ; Female ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/virology ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Vaccination
    Chemische Substanzen COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; BNT162 Vaccine (N38TVC63NU)
    Sprache Englisch
    Erscheinungsdatum 2021-06-24
    Erscheinungsland England
    Dokumenttyp Clinical Trial ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17644
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor-initiating cells.

    Artibani, Mara / Masuda, Kenta / Hu, Zhiyuan / Rauher, Pascal C / Mallett, Garry / Wietek, Nina / Morotti, Matteo / Chong, Kay / KaramiNejadRanjbar, Mohammad / Zois, Christos E / Dhar, Sunanda / El-Sahhar, Salma / Campo, Leticia / Blagden, Sarah P / Damato, Stephen / Pathiraja, Pubudu N / Nicum, Shibani / Gleeson, Fergus / Laios, Alexandros /
    Alsaadi, Abdulkhaliq / Santana Gonzalez, Laura / Motohara, Takeshi / Albukhari, Ashwag / Lu, Zhen / Bast, Robert C / Harris, Adrian L / Ejsing, Christer S / Klemm, Robin W / Yau, Christopher / Sauka-Spengler, Tatjana / Ahmed, Ahmed Ashour

    JCI insight

    2021  Band 6, Heft 11

    Abstract: Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here ... ...

    Abstract Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multiregion transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized by an adipocyte-like gene expression signature and a portion of them had undergone epithelial-mesenchymal transition (EMT). In a cell culture MRD model, MRD-mimic cells showed the same phenotype and were dependent on fatty acid oxidation (FAO) for survival and resistance to cytotoxic agents. These findings identify EMT and FAO as attractive targets to eradicate MRD in ovarian cancer and make a compelling case for the further testing of FAO inhibitors in treating MRD.
    Mesh-Begriff(e) Adipocytes/metabolism ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carboplatin/administration & dosage ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/metabolism ; Cell Line, Tumor ; Cytoreduction Surgical Procedures ; Epithelial-Mesenchymal Transition/genetics ; Fatty Acids/metabolism ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm, Residual/genetics ; Neoplasm, Residual/metabolism ; Neoplastic Stem Cells/metabolism ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Oxidation-Reduction ; Paclitaxel/administration & dosage ; Transcriptome
    Chemische Substanzen Fatty Acids ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
    Sprache Englisch
    Erscheinungsdatum 2021-06-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.147929
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.

    Hu, Zhiyuan / Artibani, Mara / Alsaadi, Abdulkhaliq / Wietek, Nina / Morotti, Matteo / Shi, Tingyan / Zhong, Zhe / Santana Gonzalez, Laura / El-Sahhar, Salma / Carrami, Eli M / Mallett, Garry / Feng, Yun / Masuda, Kenta / Zheng, Yiyan / Chong, Kay / Damato, Stephen / Dhar, Sunanda / Campo, Leticia / Garruto Campanile, Riccardo /
    Soleymani Majd, Hooman / Rai, Vikram / Maldonado-Perez, David / Jones, Stephanie / Cerundolo, Vincenzo / Sauka-Spengler, Tatjana / Yau, Christopher / Ahmed, Ahmed Ashour

    Cancer cell

    2020  Band 37, Heft 2, Seite(n) 226–242.e7

    Abstract: The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here ... ...

    Abstract The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FTE cells, predominantly from non-ovarian cancer patients, identified 6 FTE subtypes. We used subtype signatures to deconvolute SOC expression data and found substantial intra-tumor NGH. Importantly, NGH-based stratification of ∼1,700 tumors robustly correlated with survival. Our findings lay the foundation for accurate prognostic and therapeutic stratification of SOC.
    Mesh-Begriff(e) Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/metabolism ; Cystadenocarcinoma, Serous/pathology ; Epithelial Cells/pathology ; Epithelium/metabolism ; Epithelium/pathology ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/metabolism ; Fallopian Tube Neoplasms/pathology ; Fallopian Tubes/metabolism ; Fallopian Tubes/pathology ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Heterogeneity ; Humans ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2020-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.01.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2

    Folegatti, Pedro M / Ewer, Katie J / Aley, Parvinder K / Angus, Brian / Becker, Stephan / Belij-Rammerstorfer, Sandra / Bellamy, Duncan / Bibi, Sagida / Bittaye, Mustapha / Clutterbuck, Elizabeth A / Dold, Christina / Faust, Saul N / Finn, Adam / Flaxman, Amy L / Hallis, Bassam / Heath, Paul / Jenkin, Daniel / Lazarus, Rajeka / Makinson, Rebecca /
    Minassian, Angela M / Pollock, Katrina M / Ramasamy, Maheshi / Robinson, Hannah / Snape, Matthew / Tarrant, Richard / Voysey, Merryn / Green, Catherine / Douglas, Alexander D / Hill, Adrian V S / Lambe, Teresa / Gilbert, Sarah C / Pollard, Andrew J / Aboagye, Jeremy / Adams, Kelly / Ali, Aabidah / Allen, Elizabeth / Allison, Jennifer L. / Anslow, Rachel / Arbe-Barnes, Edward H. / Babbage, Gavin / Baillie, Kenneth / Baker, Megan / Baker, Natalie / Baker, Philip / Baleanu, Ioana / Ballaminut, Juliana / Barnes, Eleanor / Barrett, Jordan / Bates, Louise / Batten, Alexander / Beadon, Kirsten / Beckley, Rebecca / Berrie, Eleanor / Berry, Lisa / Beveridge, Amy / Bewley, Kevin R. / Bijker, Else Margreet / Bingham, Tracey / Blackwell, Luke / Blundell, Caitlin L. / Bolam, Emma / Boland, Elena / Borthwick, Nicola / Bower, Thomas / Boyd, Amy / Brenner, Tanja / Bright, Philip D. / Brown-O'Sullivan, Charlie / Brunt, Emily / Burbage, Jamie / Burge, Sharon / Buttigieg, Karen R. / Byard, Nicholas / 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    The Lancet

    a preliminary report of a phase 1/2, single-blind, randomised controlled trial

    2020  Band 396, Heft 10249, Seite(n) 467–478

    Schlagwörter General Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31604-4
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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