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  1. Article ; Online: The cancer stigma - the importance of nomenclature.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2021  Volume 56, Issue 1, Page(s) 19

    MeSH term(s) Humans ; Neoplasms ; Social Stigma
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Editorial
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2021.1990400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Editorial.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2021  Volume 54, Issue 6, Page(s) 455

    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Editorial
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2020.1847185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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  3. Article ; Online: Abandoning testing for asymptomatic microscopic haematuria in Sweden - a long-term follow-up.

    Malmström, Per-Uno / Truls, Gårdmark

    Scandinavian journal of urology

    2023  Volume 58, Page(s) 109–114

    Abstract: Objectives: To test the hypothesis that the Swedish national policy of abandoning testing for asymptomatic microscopic haematuria (AMH) introduced in 1999 did not adversely affect the prognosis of patients with urinary bladder cancer. Specific aims were ...

    Abstract Objectives: To test the hypothesis that the Swedish national policy of abandoning testing for asymptomatic microscopic haematuria (AMH) introduced in 1999 did not adversely affect the prognosis of patients with urinary bladder cancer. Specific aims were to investigate possible effects on (1) Diagnostic delay as represented by stage distribution at diagnosis, (2) Survival and mortality trends, also in comparison to other countries and (3) National health care costs.
    Material and methods: The design was an observational study using open sources on patients included in the Swedish National Bladder Cancer Registry 1997-2016. Outcome measures were: Changes in initial tumour presentation during 5 years after the change and long-term relative survival and mortality in comparison to the other Nordic countries. Costs related to investigations were estimated based on the national price lists.
    Results: The proportion of patients diagnosed with muscle-invasive bladder cancer decreased following the policy change. The long-term relative 5-year survival increased during the study period. Mortality has remained constant during the period. In comparison to the other Nordic countries, Sweden remains among those with the best outcome despite a more restrictive approach. Cost savings because of the policy change were estimated to be substantial.
    Conclusions: Based on open-source registry data, the new restrictive policy was not found to adversely affect the survival of patients with urinary bladder cancer in Sweden. These observations argue against a major negative impact of abandoning further work-up for patients with AMH and may be of use for other countries when revising guidelines. The reduced number of patients undergoing investigation may allow for increased focus and be a relief both for caregivers and the health budget.
    MeSH term(s) Humans ; Sweden ; Follow-Up Studies ; Hematuria/diagnosis ; Hematuria/etiology ; Delayed Diagnosis ; Survival Rate ; Urinary Bladder Neoplasms/diagnosis
    Language English
    Publishing date 2023-11-21
    Publishing country Sweden
    Document type Observational Study ; Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.2340/sju.v58.11142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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  4. Article ; Online: Cystoscopic surveillance of patients with non-muscle-invasive bladder cancer revisited.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2020  Volume 54, Issue 5, Page(s) 364–366

    MeSH term(s) Cystoscopy ; Humans ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Urinary Bladder Neoplasms/epidemiology
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2020.1788635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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  5. Article ; Online: The association between BCG treatment in patients with bladder cancer and subsequent risk of developing Alzheimer and other dementia.-A Swedish nationwide cohort study from 1997 to 2019.

    Wang, Eugen / Hagberg, Oskar / Malmström, Per-Uno

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0292174

    Abstract: Background: Alzheimer's disease (AD) affects 50 million people worldwide. The immune system plays a major role in the pathogenesis of AD. Several retrospective analyses have reported a decreased risk of AD and other dementias in bladder cancer patients ... ...

    Abstract Background: Alzheimer's disease (AD) affects 50 million people worldwide. The immune system plays a major role in the pathogenesis of AD. Several retrospective analyses have reported a decreased risk of AD and other dementias in bladder cancer patients treated with immunotherapy in the form of Bacillus Calmette-Guerin (BCG) bladder instillations. We tested this hypothesis in a Swedish population-based prospective cohort of patients with non-muscle invasive bladder cancer (NMIBC).
    Methods and findings: We utilized the BladderBaSe 2.0 database, which contains tumor-specific, health-related, and socio-demographic information for patients diagnosed with NMIBC between 1997 and 2019. The database also includes a matched comparison cohort sampled from the general population, consisting of individuals free from urinary tract cancer at the time of the index case's diagnosis. Five controls were randomly selected for each index case without replacement on the date of the index case's diagnosis. Our inclusion criteria identified participants diagnosed with NMIBC who had received BCG as primary treatment, along with their corresponding comparison cohort. We excluded those diagnosed with dementia before or within 6 months of NMIBC diagnosis. To compare the NMIBC cohort with their matched comparison cohort, we used a stratified Cox model, treating each case with its controls as a stratum. We identified 38,934 patients in the NMIBC cohort, with 6,496 receiving BCG after primary diagnosis (cases). AD/dementia was diagnosed during follow-up in 6.1% of cases and 7.4% of controls. Cases had a slightly lower risk of dementia than controls, with a hazard ratio (HR) of 0.88 (95% confidence interval [CI] 0.780-0.991), and a HR of 0.89 (CI 0.703-1.119) for AD. Subgroup analysis for dementia showed that age over 75 years had an HR of 0.73 (CI 0.616-0.863), and female gender had an HR of 0.73 (CI 0.552-0.971). The associations were similar for AD specifically, but not statistically significant. Similar to previous studies, we analyzed bladder cancer patients treated with and without BCG therapy. Multivariate Cox analysis indicated that those treated with BCG had a lower risk of dementia (HR 0.81, 95% CI 0.71-0.92), and an HR of 0.98 (95% CI 0.75-1.27) for AD specifically. High age was a significant risk modifier; the HR was 3.8 (CI 3.44-4.11) for dementia and 3.1 (CI 2.59-3.73) for AD. Even patients not receiving BCG had a significantly lower risk for AD than controls (HR 0.86, CI 0.77-0.96).
    Conclusions: This study observed a marginally decreased risk of developing AD/dementia associated with earlier intravesical BCG treatment in NMIBC patients. This small benefit was most pronounced in those with high age and female gender. The disparity from previous highly positive studies underscores the importance of using an appropriate control cohort.
    MeSH term(s) Humans ; Female ; Aged ; BCG Vaccine/therapeutic use ; Cohort Studies ; Sweden/epidemiology ; Retrospective Studies ; Prospective Studies ; Alzheimer Disease/drug therapy ; Alzheimer Disease/epidemiology ; Non-Muscle Invasive Bladder Neoplasms ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/pathology ; Administration, Intravesical ; Adjuvants, Immunologic ; Neoplasm Recurrence, Local/pathology ; Neoplasm Invasiveness
    Chemical Substances BCG Vaccine ; Adjuvants, Immunologic
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Scientific breakthrough or "fake news"?

    Malmström, Per-Uno

    Scandinavian journal of urology

    2017  Volume 51, Issue 3, Page(s) 177

    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2017.1329904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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  7. Article ; Online: Drugs and risk of cancer.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2017  Volume 51, Issue 3, Page(s) 212–218

    MeSH term(s) Analgesics/administration & dosage ; Analgesics/history ; Carcinoma, Transitional Cell/epidemiology ; Carcinoma, Transitional Cell/history ; Drug Misuse/history ; History, 20th Century ; Humans ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/history ; Kidney Pelvis ; Phenacetin/administration & dosage ; Phenacetin/history
    Chemical Substances Analgesics ; Phenacetin (ER0CTH01H9)
    Language English
    Publishing date 2017-06-28
    Publishing country England
    Document type Classical Article ; Historical Article ; Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2017.1329905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 601: Show issues Location:
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  8. Article ; Online: Half a decade of fluorescence in the bladder.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2017  Volume 51, Issue 3, Page(s) 219–227

    MeSH term(s) Carcinoma/diagnostic imaging ; Carcinoma/history ; Carcinoma/pathology ; Cystoscopy ; Fluorescence ; History, 20th Century ; Humans ; Optical Imaging/history ; Optical Imaging/methods ; Photosensitizing Agents ; Tetracycline ; Ultraviolet Rays ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/history ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Photosensitizing Agents ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2017-06-28
    Publishing country England
    Document type Classical Article ; Historical Article ; Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2017.1329903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How do we acquire high-level evidence in urology? A 30 year perspective.

    Malmström, Per-Uno

    Scandinavian journal of urology

    2016  Volume 50, Issue 1, Page(s) 1

    MeSH term(s) Biomedical Research ; Humans ; Randomized Controlled Trials as Topic ; Registries ; Urology
    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.3109/21681805.2016.1100846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Replik från Per-Uno Malmström angående mikroskopisk hematuri: - Trots allt ett fynd av klinisk betydelse?

    Malmström, Per-Uno

    Lakartidningen

    2016  Volume 113

    Title translation Reply by Per-Uno Malmström regarding microscopic hematuria: Despite all a finding of clinical significance?.
    MeSH term(s) Hematuria ; Humans
    Language Swedish
    Publishing date 2016--09
    Publishing country Sweden
    Document type Letter ; Comment
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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