Article ; Online: Synthesis and amelioration of inflammatory paw edema by novel benzophenone appended oxadiazole derivatives by exhibiting cyclooxygenase-2 antagonist activity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2018 Volume 103, Page(s) 1446–1455
Abstract: Ten new 2(4-hydroxy-3-benzoyl) benzamide-5-phenyl-1,3,4-oxadiazole derivatives (10a-j) were synthesized by coupling 3-benzoyl-4-hydroxybenzoic acid (5) with 2-amino-5-phenyl-1,3,4-oxadiazoles (9a-j). The structures of these compounds were confirmed by IR, ...
| Abstract | Ten new 2(4-hydroxy-3-benzoyl) benzamide-5-phenyl-1,3,4-oxadiazole derivatives (10a-j) were synthesized by coupling 3-benzoyl-4-hydroxybenzoic acid (5) with 2-amino-5-phenyl-1,3,4-oxadiazoles (9a-j). The structures of these compounds were confirmed by IR, |
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| MeSH term(s) | Animals ; Benzophenones/chemical synthesis ; Benzophenones/chemistry ; Benzophenones/pharmacology ; Benzophenones/therapeutic use ; Chickens ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Edema/complications ; Edema/drug therapy ; Edema/enzymology ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/enzymology ; Male ; Neovascularization, Physiologic/drug effects ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Oxadiazoles/therapeutic use ; Rats | |||||
| Chemical Substances | Benzophenones ; Cyclooxygenase 2 Inhibitors ; Oxadiazoles ; benzophenone (701M4TTV9O) ; Cyclooxygenase 2 (EC 1.14.99.1) | |||||
| Language | English | |||||
| Publishing date | 2018-05-07 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392415-4 | |||||
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 | |||||
| ISSN (online) | 1950-6007 | |||||
| ISSN | 0753-3322 ; 0300-0893 | |||||
| DOI | 10.1016/j.biopha.2018.04.167 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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