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  1. Book: Congenital anomalies

    Malone, Fergal D.

    (Clinics in perinatology ; 27,4)

    2000  

    Author's details Fergal D. Malone ..., guest ed
    Series title Clinics in perinatology ; 27,4
    Collection
    Language English
    Size XV S., S. 761 - 1068 : Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a
    Publishing country United States
    Document type Book
    HBZ-ID HT012894881
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: What is New in the Management of Acute Preterm Labor?: Best Articles From the Past Year.

    Malone, Fergal D

    Obstetrics and gynecology

    2016  Volume 127, Issue 2, Page(s) 398–399

    Abstract: This month we focus on current research in the management of acute preterm labor. Dr. Malone discusses four recent publications, which are concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on ... ...

    Abstract This month we focus on current research in the management of acute preterm labor. Dr. Malone discusses four recent publications, which are concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts.
    MeSH term(s) Delivery, Obstetric/adverse effects ; Delivery, Obstetric/methods ; Evidence-Based Medicine ; Female ; Fetal Monitoring/methods ; Humans ; Obstetric Labor, Premature/diagnosis ; Obstetric Labor, Premature/therapy ; Obstetrics/standards ; Obstetrics/trends ; Patient Safety ; Periodicals as Topic ; Physician's Role ; Predictive Value of Tests ; Pregnancy ; Pregnancy Outcome
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000001284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rare chromosomal abnormalities: Can they be identified using conventional first trimester combined screening methods?

    Kane, Daniel / D'Alton, Mary E / Malone, Fergal D

    European journal of obstetrics & gynecology and reproductive biology: X

    2021  Volume 10, Page(s) 100123

    Abstract: Objective: To evaluate the performance of first trimester combined screening for the detection of rare chromosomal abnormalities, other than Trisomies 21, 18 or 13 or 45 × .: Study design: A database containing 36,254 pregnancies was analyzed. These ... ...

    Abstract Objective: To evaluate the performance of first trimester combined screening for the detection of rare chromosomal abnormalities, other than Trisomies 21, 18 or 13 or 45 × .
    Study design: A database containing 36,254 pregnancies was analyzed. These patients were recruited at 15 US centers and included singleton pregnancies from 10 3/7-13 6/7 weeks. All patients had a nuchal translucency (NT) scan and those without a cystic hygroma (N = 36,120) underwent a combined first trimester screening test ('FTS' - NT, PAPP-A and fbHCG). A risk cut-off of 1:300, which was used for defining high risk for Trisomy 21, was also used to evaluate the detection rate for rare chromosomal abnormalities using the combined FTS test.
    Results: 36,120 patients underwent combined FTS. Of these, 123 were found to have one of the following chromosomal abnormalities: Trisomy 21, Trisomy 18, Trisomy 13 or Turner syndrome. This study focuses on 40 additional patients who were found to have 'other' rare chromosomal abnormalities such as triploidy, structural chromosomal abnormalities, sex chromosome abnormalities or unusual chromosomal abnormalities (e.g. 47XX + 16), giving an incidence of 1.1 in 1000 for these rare chromosomal abnormalities. Of these 40 pregnancies, only 2 (5%) had an NT measurement of ≥3 mm. The detection rate for combined FTS, using a risk cut-off of ≥1:300, was 35 % (14 of 40 cases). Therefore, 65 % of cases of rarer fetal chromosomal abnormalities had a 'normal' combined FTS risk (<1:300) and 95 % had a 'normal' NT (<3 mm).
    Conclusion: Traditional FTS methods are unable to identify the vast majority of rare chromosomal abnormalities. Our data do not support the potential detection of rare fetal chromosomal abnormalities as a reason to favour nuchal translucency-based first trimester screening over NIPT.
    Language English
    Publishing date 2021-02-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1613
    ISSN (online) 2590-1613
    DOI 10.1016/j.eurox.2021.100123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What is new in obstetric antecedents of chronic disease? Best articles from the past year.

    Malone, Fergal D

    Obstetrics and gynecology

    2014  Volume 123, Issue 4, Page(s) 883–884

    Abstract: This month, we focus on current research in obstetric antecedents of chronic disease. Dr Malone discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in ... ...

    Abstract This month, we focus on current research in obstetric antecedents of chronic disease. Dr Malone discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page along with direct links to the abstracts.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Diabetes Mellitus/epidemiology ; Diabetes, Gestational ; Female ; Homocysteine/blood ; Humans ; Hyperhomocysteinemia/epidemiology ; Hypertension, Pregnancy-Induced/epidemiology ; Kidney Diseases/epidemiology ; Obesity/epidemiology ; Pregnancy ; Premature Birth/epidemiology
    Chemical Substances Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000000180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The IRELAnD study-investigating the role of early low-dose aspirin in diabetes mellitus: a double-blinded, placebo-controlled, randomized trial.

    Finnegan, Catherine / Dicker, Patrick / Asandei, Denisa / Higgins, Mary / O'Gorman, Neil / O' Riordan, Mairead / Dunne, Fidelma / Gaffney, Geraldine / Newman, Christine / McAuliffe, Fionnuala / Ciprike, Vineta / Fernandez, Elena / Malone, Fergal D / Breathnach, Fionnuala M

    American journal of obstetrics & gynecology MFM

    2024  Volume 6, Issue 4, Page(s) 101297

    Abstract: Background: Although aspirin therapy is being increasingly advocated with the intention of risk modification for a wide range of pregnancy complications, women with prepregnancy diabetes mellitus are commonly excluded from clinical trials.: Objective!# ...

    Abstract Background: Although aspirin therapy is being increasingly advocated with the intention of risk modification for a wide range of pregnancy complications, women with prepregnancy diabetes mellitus are commonly excluded from clinical trials.
    Objective: The primary aim of this study was to examine the effect of aspirin therapy on a composite measure of adverse perinatal outcome in pregnancies complicated by pregestational diabetes mellitus.
    Study design: A double-blinded, placebo-controlled randomized trial was conducted at 6 university-affiliated perinatology centers. Women with type 1 diabetes mellitus or type 2 diabetes mellitus of at least 6 months' duration were randomly allocated to 150-mg daily aspirin or placebo from 11 to 14 weeks' gestation until 36 weeks. Established vascular complications of diabetes mellitus, including chronic hypertension or nephropathy, led to exclusion from the trial. The primary outcome was a composite measure of placental dysfunction (preeclampsia, fetal growth restriction, preterm birth <34 weeks' gestation, or perinatal mortality). The planned sample size was 566 participants to achieve a 35% reduction in the primary outcome, assuming 80% statistical power. Secondary end points included maternal and neonatal outcomes and determination of insulin requirements across gestation. Data were centrally managed using ClinInfo and analyzed using SAS 9.4. The 2 treatment groups were compared using t tests or chi-square tests, as required, and longitudinal data were compared using a repeated-measures analysis.
    Results: From February 2020 to September 2022, 191 patients were deemed eligible, 134 of whom were enrolled (67 randomized to aspirin and 67 to placebo) with a retrospective power of 64%. A total of 101 (80%) women had type 1 diabetes mellitus and 25 (20%) had type 2 diabetes mellitus. Reaching the target sample size was limited by the impact of the COVID-19 pandemic. Baseline characteristics were similar between the aspirin and placebo groups. Treatment compliance was very high and similar between groups (97% for aspirin, 94% for placebo). The risk of the composite measure of placental dysfunction did not differ between groups (25% aspirin vs 21% placebo; P=.796). Women in the aspirin group had significantly lower insulin requirements throughout pregnancy compared with the placebo group. Insulin requirements in the aspirin group increased on average from 0.7 units/kg at baseline to 1.1 units/kg by 36 weeks' gestation (an average 83% within-patient increase), and increased from 0.7 units/kg to 1.3 units/kg (a 181% within-patient increase) in the placebo group, over the same gestational period (P=.002). Serial hemoglobin A1c levels were lower in the aspirin group than in the placebo group, although this trend did not reach statistical significance.
    Conclusion: In this multicenter, double-blinded, placebo-controlled randomized trial, aspirin did not reduce the risk of adverse perinatal outcome in pregnancies complicated by prepregnancy diabetes mellitus. Compared with the placebo group, aspirin-treated patients required significantly less insulin throughout pregnancy, indicating a beneficial effect of aspirin on glycemic control. Aspirin may exert a plausible placenta-mediated effect on pregestational diabetes mellitus that is not limited to its antithrombotic properties.
    MeSH term(s) Humans ; Aspirin/administration & dosage ; Pregnancy ; Female ; Double-Blind Method ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/complications ; Adult ; Pregnancy in Diabetics/epidemiology ; Pregnancy in Diabetics/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Pre-Eclampsia/prevention & control ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/diagnosis ; Ireland/epidemiology ; Premature Birth/prevention & control ; Premature Birth/epidemiology ; Pregnancy Outcome/epidemiology ; Infant, Newborn ; Fetal Growth Retardation/epidemiology ; Fetal Growth Retardation/prevention & control ; Insulin/administration & dosage
    Chemical Substances Aspirin (R16CO5Y76E) ; Insulin
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Multicenter Study
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2024.101297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reducing the risk of venous thromboembolism in pregnancy--The safe motherhood initiative thromboembolism bundle.

    Walsh, Jennifer M / Malone, Fergal D

    Seminars in perinatology

    2016  Volume 40, Issue 2, Page(s) 93–95

    Abstract: Maternal mortality from venous thromboembolism (VTE) remains a significant cause of direct maternal death, and one that is largely preventable. The incidence of VTE in pregnancy and the postnatal period is, however, rising in the United States, likely ... ...

    Abstract Maternal mortality from venous thromboembolism (VTE) remains a significant cause of direct maternal death, and one that is largely preventable. The incidence of VTE in pregnancy and the postnatal period is, however, rising in the United States, likely reflecting increasing obesity and operative delivery rates. There is a clear need to establish and implement risk assessment tools and thromboprophylaxis guidelines in an effort to curb these rising rates and reverse this current trend. In this article, Friedman and D'Alton introduce a thromboembolism bundle of recommendations from the Safe Motherhood Initiative, which aim to do just that. In this article, we review the recommendations made, and compare to established guidelines, such as those from the Royal College of Obstetricians and Gynaecologists, which have successfully reduced maternal mortality from VTE following publication.
    MeSH term(s) Anticoagulants/therapeutic use ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/drug therapy ; Risk Assessment ; Risk Factors ; Thromboembolism ; United States ; Venous Thromboembolism/epidemiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1053/j.semperi.2015.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Do obstetrics trainees working hours affect caesarean section rates in normal risk women?

    Kane, Daniel / Shanahan, Ita / Geary, Michael / Malone, Fergal D / Kent, Etaoin / Burke, Naomi

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 258, Page(s) 358–361

    Abstract: Objectives: The rate of caesarean section (CS) is increasing globally. The nulliparous, term, singleton, vertex presentation, spontaneously labouring woman (Robson Group 1/RG1) is considered low risk for CS. It has been hypothesized that more CS occur ... ...

    Abstract Objectives: The rate of caesarean section (CS) is increasing globally. The nulliparous, term, singleton, vertex presentation, spontaneously labouring woman (Robson Group 1/RG1) is considered low risk for CS. It has been hypothesized that more CS occur at nighttime or at weekends due to doctor fatigue. The European Working Time Directive (EWTD) was implemented in our institution in 2013 to limit doctor working hours, which aimed at reducing fatigue but arguably fractures continuity of care. This study aimed to determine the effect of nocturnal hours and weekend on-call as well as the implementation of EWTD on our RG1 CS rates.
    Study design: This was a population-based study in a tertiary referral centre from 2008-2017. The inclusion criteria for our study were limited to RG1. Data were analysed from an established clinical database, including mode and time of delivery. Descriptive statistics are presented as number and percent for categorical variables. Relative frequencies were tested using chi-squared test. All statistical analyses were performed using SPSS Version 26. Statistical significance was defined as p < .05.
    Results: There were 86,473 deliveries over the 10-year study period. There were 18,761 women in RG1. Overall the RG1 CS rate was 12.9 % (n = 2415). Rates of CS in the RG1 were not statistically different between those delivering on weekdays (12.9 %, n = 1726/13,430) and weekends (12.9 %, n = 689/5,331, OR 0.99, 95 % CI = 0.90-1.09, p = .89). During daytime hours the CS rate was 12.1 % (n = 777/6411) and at nighttime was 13.3 % (n = 1638/12,350, OR 1.10, 95 % CI = 1.01-1.21, p = .03). Comparing the time periods pre and post EWTD implementation, there was a significant increase in CS rates (12.1 % n = 1319/10,873 V 13.9 % n = 1096/7,888, OR 1.17, 95 % CI = 1.07-1.27 p < .001). With respect to other modes of delivery in RG1 pre and post EWTD, there was a statistically significant decrease in operative vaginal delivery (OVD) rates (40.1%, n=4,360 V 37.7%, n=2,973, OR 0.90, 95% CI = 0.85-0.95, p = .001) CONCLUSION: This study shows an association between obstetric trainee working practices, RG1 CS and OVD rates; this is most pronounced at night and after the introduction of the EWTD. It is unlikely that obstetric trainee working practices are the only factor related to the increasing CS rate and reduced OVD rate. Consideration should be giving to addressing the needs of obstetric trainees in relation to achieving their competencies with now reduced labour ward exposure. Further study is required to see if alternate arrangements in relation to simulation training could increase the OVD rate and reduce the CS rate.
    MeSH term(s) Cesarean Section ; Delivery, Obstetric ; Female ; Humans ; Labor, Obstetric ; Obstetrics ; Pregnancy ; Risk
    Language English
    Publishing date 2021-01-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.01.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Application of a preeclampsia screening algorithm in a low-risk nulliparous population.

    Mone, Fionnuala / McAuliffe, Fionnuala M / Malone, Fergal D

    American journal of obstetrics and gynecology

    2018  Volume 219, Issue 5, Page(s) 506

    MeSH term(s) Algorithms ; Biomarkers ; Female ; Gestational Age ; Humans ; Placenta Growth Factor ; Pre-Eclampsia ; Pregnancy ; Risk Factors
    Chemical Substances Biomarkers ; Placenta Growth Factor (144589-93-5)
    Language English
    Publishing date 2018-06-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2018.05.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Outcomes of Uterine Rupture in the Setting of the Unscarred Compared With the Scarred Uterus.

    McEvoy, Aoife / Corbett, Gillian A / Nolan, Ciara / Daly, Ronan / Murnane, Megan / Higgins, Shane / Malone, Fergal D / O'Connell, Michael P / Hehir, Mark P / Walsh, Jennifer M

    Obstetrics and gynecology

    2023  Volume 141, Issue 4, Page(s) 854–856

    Abstract: Uterine rupture is a rare obstetric complication that is associated with maternal and neonatal morbidity and mortality. The aim of this study was to examine uterine rupture and its outcomes in the setting of the unscarred compared with the scarred uterus. ...

    Abstract Uterine rupture is a rare obstetric complication that is associated with maternal and neonatal morbidity and mortality. The aim of this study was to examine uterine rupture and its outcomes in the setting of the unscarred compared with the scarred uterus. A retrospective observational cohort study was performed examining all cases of uterine rupture in three tertiary care hospitals in Dublin, Ireland, over a 20-year period. The primary outcome was perinatal mortality rate with uterine rupture, which was 11.02% (95% CI 6.5-17.3). There was no significant difference in perinatal mortality between cases of scarred and unscarred uterine rupture. Unscarred uterine rupture was associated with higher maternal morbidity , defined as major obstetric hemorrhage or hysterectomy.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Uterine Rupture/etiology ; Uterine Rupture/surgery ; Pregnancy Outcome ; Retrospective Studies ; Uterus ; Hysterectomy/adverse effects ; Perinatal Death
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000005108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The dilemma of vaginal breech delivery worldwide.

    Hehir, Mark P / Malone, Fergal D

    Lancet (London, England)

    2014  Volume 384, Issue 9949, Page(s) 1184

    MeSH term(s) Breech Presentation/surgery ; Delivery, Obstetric/methods ; Female ; Global Health ; Humans ; Pregnancy
    Language English
    Publishing date 2014-09-27
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(14)61719-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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