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  1. Article ; Online: Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy.

    Ortona, Elena / Malorni, Walter

    The European respiratory journal

    2022  Volume 59, Issue 2

    MeSH term(s) COVID-19/complications ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02245-2021
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: The Role of Sex Differences in Bone Health and Healing.

    Ortona, Elena / Pagano, Maria Teresa / Capossela, Lavinia / Malorni, Walter

    Biology

    2023  Volume 12, Issue 7

    Abstract: Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present ... ...

    Abstract Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present review, we report the main findings, hypotheses and pitfalls that could lead to these differences. In particular, the role of sex hormones and inflammation has been reported to have a role in the observed less efficient bone healing in females in comparison with that observed in males. In addition, estrogen-induced cellular processes such as autophagic cell cycle impairment and molecular signals suppressing cell cycle progression seem also to play a role in female fracture healing delay. In conclusion, it seems conceivable that a complex framework of events could contribute to the female bias in bone healing, and we suggest that a reappraisal of the compelling factors could contribute to the mitigation of sex/gender disparity and improve bone healing outcomes.
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12070993
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  3. Article ; Online: The Role of Sex Differences in Bone Health and Healing

    Ortona, Elena / Pagano, Maria Teresa / Capossela, Lavinia / Malorni, Walter

    Biology (Basel). 2023 July 12, v. 12, no. 7

    2023  

    Abstract: Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present ... ...

    Abstract Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present review, we report the main findings, hypotheses and pitfalls that could lead to these differences. In particular, the role of sex hormones and inflammation has been reported to have a role in the observed less efficient bone healing in females in comparison with that observed in males. In addition, estrogen-induced cellular processes such as autophagic cell cycle impairment and molecular signals suppressing cell cycle progression seem also to play a role in female fracture healing delay. In conclusion, it seems conceivable that a complex framework of events could contribute to the female bias in bone healing, and we suggest that a reappraisal of the compelling factors could contribute to the mitigation of sex/gender disparity and improve bone healing outcomes.
    Keywords bone health ; cell cycle ; females ; inflammation
    Language English
    Dates of publication 2023-0712
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12070993
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Long COVID: an estrogen-associated autoimmune disease?

    Ortona, Elena / Buonsenso, Danilo / Carfi, Angelo / Malorni, Walter

    Cell death discovery

    2021  Volume 7, Issue 1, Page(s) 77

    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-021-00464-6
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  5. Article ; Online: Culture, religion and gender: considerations in facing migration related health inequalities in Italy.

    Giovannini, Claudio / Sisti, Leuconoe Grazia / Michieli, Raffaella / Angelucci, Maria Augusta / Ricciardi, Walter / Malorni, Walter

    Annali dell'Istituto superiore di sanita

    2023  Volume 59, Issue 3, Page(s) 199–203

    Abstract: Background: The presence in Italy of a significant foreign population (5-6 million including both formally residents and not officially registered ones) introduces significant transformations in the Italian demography with important challenges on ... ...

    Abstract Background: The presence in Italy of a significant foreign population (5-6 million including both formally residents and not officially registered ones) introduces significant transformations in the Italian demography with important challenges on ensuring fundamental rights including work, education and above all, health. Access to healthcare. Issues common to the entire migrant population concern the difficulty of accessing the health system of the host country due to the lack of knowledge of its rules and its functioning, the linguistic and cultural barriers and the distrust towards a system that is not recognized as his own, as well as the difficulties and misunderstandings encountered in the relationship with health professionals. Religion, culture and gender may even increase these difficulties. Conlusion and future perspective. Culture and religion should be taken into account when designing and implementing healthcare services and healthcare workers need to be trained in acknowledging these challenges. The National Health Service should become more sensitive to the increasing cultural and religious pluralism of patients starting with investing more in the training of health professionals.
    MeSH term(s) Humans ; State Medicine ; Italy ; Delivery of Health Care ; Religion ; Transients and Migrants ; Culture
    Language English
    Publishing date 2023-08-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 950344-4
    ISSN 2384-8553 ; 0021-2571
    ISSN (online) 2384-8553
    ISSN 0021-2571
    DOI 10.4415/ANN_23_03_05
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 231: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Role of Religions in the COVID-19 Pandemic: A Narrative Review.

    Sisti, Leuconoe Grazia / Buonsenso, Danilo / Moscato, Umberto / Costanzo, Gianfranco / Malorni, Walter

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Culture, religion and health are closely intertwined, profoundly affecting people's attitudes and behaviors as well as their conception and experience of illness and disease. In order to analyze the impact of religion in the current COVID-19 pandemic, we ...

    Abstract Culture, religion and health are closely intertwined, profoundly affecting people's attitudes and behaviors as well as their conception and experience of illness and disease. In order to analyze the impact of religion in the current COVID-19 pandemic, we performed a literature review investigating both the scientific and grey literature on the topic. COVID-19 outbreaks reported in pilgrimages and religious ceremonies around the world-especially in the first wave of the pandemic wave-and the role played by religion in conveying culturally sensitive information about COVID-19 are some of the evidence we reviewed. Our research highlights how religions have represented, on the one hand, a risk for the spread of the virus and, on the other, a precious opportunity to engage people, and in particular minorities, in fighting the pandemic. To overcome this pandemic and to be prepared for similar ones in the future, scientists, politicians and health professionals should acknowledge the role that culture and religion play in people's lives and how it can assist in tackling complex health challenges.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Religion ; Attitude
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20031691
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  7. Article: Gender differences in vitiligo: psychological symptoms and quality of life assessment description.

    Samela, Tonia / Malorni, Walter / Matarrese, Paola / Mattia, Gianfranco / Alfani, Stefania / Abeni, Damiano

    Frontiers in psychology

    2023  Volume 14, Page(s) 1234734

    Abstract: Objective: Assuming that the difference exist in the manifestation of psychological suffering among genders, the purpose of this review is to summarize the current knowledge on gender differences in vitiligo quality of life and psychological assessment.! ...

    Abstract Objective: Assuming that the difference exist in the manifestation of psychological suffering among genders, the purpose of this review is to summarize the current knowledge on gender differences in vitiligo quality of life and psychological assessment.
    Methods: We searched in PubMed, Scopus, and Web of Science databases for original articles in English language. Results were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist).
    Results: The study yielded 107 results; 12 articles have been evaluated as eligible. Each eligible study has been screened and analyzed. The study's qualitative evaluation revealed that 8 papers were classifiable as satisfactory, 4 were classifiable as unsatisfactory. The agreement between the coders was high (% agreement = 84.6%; Cohen's kappa = 0.79). All considered researches (100%) were cross-sectional studies, based on self-report questionnaires. From our analysis, women with vitiligo had a higher risk to experience lower quality of life, and worse mental health in a wide range of psychopathology symptoms than men. A wide heterogeneity of tools is used to investigate the quality of life and psychological symptoms among these patients.
    Conclusion: Unfortunately, there are few explanatory models proposed in the literature to rationalize these findings. It will be important to investigate in further researches the specific influence of known risk factors for psychopathology in this population to better explore these phenomena.
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1234734
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  8. Article ; Online: Adenosine A

    Abbracchio, Maria P / Ceruti, Stefania / Brambilla, Roberta / Barbieri, Daniela / Camurri, Alessandra / Franceschi, Claudio / Giammarioli, Anna Maria / Jacobson, Kenneth A / Cattabeni, Flaminio / Malorni, Walter

    Drug development research

    2024  Volume 45, Issue 3-4, Page(s) 379–386

    Abstract: We investigated the role of the ... ...

    Abstract We investigated the role of the A
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/(sici)1098-2299(199811/12)45:3/4<379::aid-ddr38>3.0.co;2-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2542: Show issues Location:
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  9. Article: Mitochondria and Sex-Specific Cardiac Function.

    Vona, Rosa / Ascione, Barbara / Malorni, Walter / Straface, Elisabetta

    Advances in experimental medicine and biology

    2018  Volume 1065, Page(s) 241–256

    Abstract: The focus of this chapter is the gender differences in mitochondria in cardiovascular disease. There is broad evidence suggesting that some of the gender differences in cardiovascular outcome may be partially related to differences in mitochondrial ... ...

    Abstract The focus of this chapter is the gender differences in mitochondria in cardiovascular disease. There is broad evidence suggesting that some of the gender differences in cardiovascular outcome may be partially related to differences in mitochondrial biology (Ventura-Clapier R, Moulin M, Piquereau J, Lemaire C, Mericskay M, Veksler V, Garnier A, Clin Sci (Lond) 131(9):803-822, 2017)). Mitochondrial disorders are causally affected by mutations in either nuclear or mitochondrial genes involved in the synthesis of respiratory chain subunits or in their posttranslational control. This can be due to mutations of the mtDNA which are transmitted by the mother or mutations in the nuclear DNA. Because natural selection on mitochondria operates only in females, mutations may have had more deleterious effects in males than in females (Ventura-Clapier R, Moulin M, Piquereau J, Lemaire C, Mericskay M, Veksler V, Garnier A, Clin Sci (Lond) 131(9):803-822, 2017; Camara AK, Lesnefsky EJ, Stowe DF. Antioxid Redox Signal 13(3):279-347, 2010). As mitochondrial mutations can affect all tissues, they are responsible for a large panel of pathologies including neuromuscular disorders, encephalopathies, metabolic disorders, cardiomyopathies, neuropathies, renal dysfunction, etc. Many of these pathologies present sex/gender specificity. Thus, alleviating or preventing mitochondrial dysfunction will contribute to mitigating the severity or progression of the development of diseases. Here, we present evidence for the involvement of mitochondria in the sex specificity of cardiovascular disorders.
    MeSH term(s) Animals ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/physiopathology ; Female ; Health Status Disparities ; Heart/physiopathology ; Humans ; Male ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Risk Factors ; Sex Characteristics ; Sex Factors ; Signal Transduction
    Language English
    Publishing date 2018-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-77932-4_16
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  10. Article ; Online: Hormones and Sex-Specific Medicine in Human Physiopathology.

    Tokatli, Maria Raza / Sisti, Leuconoe Grazia / Marziali, Eleonora / Nachira, Lorenza / Rossi, Maria Francesca / Amantea, Carlotta / Moscato, Umberto / Malorni, Walter

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: A prodigious increment of scientific evidence in both preclinical and clinical studies is narrowing a major gap in knowledge regarding sex-specific biological responses observed in numerous branches of clinical practices. Some paradigmatic examples ... ...

    Abstract A prodigious increment of scientific evidence in both preclinical and clinical studies is narrowing a major gap in knowledge regarding sex-specific biological responses observed in numerous branches of clinical practices. Some paradigmatic examples include neurodegenerative and mental disorders, immune-related disorders such as pathogenic infections and autoimmune diseases, oncologic conditions, and cardiovascular morbidities. The male-to-female proportion in a population is expressed as sex ratio and varies eminently with respect to the pathophysiology, natural history, incidence, prevalence, and mortality rates. The factors that determine this scenario incorporate both sex-associated biological differences and gender-dependent sociocultural issues. A broad narrative review focused on the current knowledge about the role of hormone regulation in gender medicine and gender peculiarities across key clinical areas is provided. Sex differences in immune response, cardiovascular diseases, neurological disorders, cancer, and COVID-19 are some of the hints reported. Moreover, gender implications in occupational health and health policy are offered to support the need for more personalized clinical medicine and public health approaches to achieve an ameliorated quality of life of patients and better outcomes in population health.
    MeSH term(s) COVID-19/epidemiology ; Female ; Hormones ; Humans ; Male ; Precision Medicine ; Quality of Life ; Sex Characteristics
    Chemical Substances Hormones
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030413
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