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  1. Article ; Online: An In-depth Guide to the Ultrastructural Expansion Microscopy (U-ExM) of

    Klena, Nikolai / Maltinti, Giovanni / Batman, Umut / Pigino, Gaia / Guichard, Paul / Hamel, Virginie

    Bio-protocol

    2023  Volume 13, Issue 17, Page(s) e4792

    Abstract: Expansion microscopy is an innovative method that enables super-resolution imaging of biological materials using a simple confocal microscope. The principle of this method relies on the physical isotropic expansion of a biological specimen cross-linked ... ...

    Abstract Expansion microscopy is an innovative method that enables super-resolution imaging of biological materials using a simple confocal microscope. The principle of this method relies on the physical isotropic expansion of a biological specimen cross-linked to a swellable polymer, stained with antibodies, and imaged. Since its first development, several improved versions of expansion microscopy and adaptations for different types of samples have been produced. Here, we show the application of ultrastructure expansion microscopy (U-ExM) to investigate the 3D organization of the green algae
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4792
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  2. Article ; Online: A novel "salvage" indication to intestinal derotation procedure: reconstruction after duodenopancreatectomy.

    Bechi, Paolo / Maltinti, Gherardo

    The American journal of case reports

    2014  Volume 15, Page(s) 322–325

    Abstract: Patient: Male, 77.: Final diagnosis: Pancreatic tumor.: Symptoms: Jaundice.: Medication: -.: Clinical procedure: Intestinal derotation procedure.: Specialty: General surgery.: Objective: Rare disease.: Background: The purpose of the ...

    Abstract Patient: Male, 77.
    Final diagnosis: Pancreatic tumor.
    Symptoms: Jaundice.
    Medication: -.
    Clinical procedure: Intestinal derotation procedure.
    Specialty: General surgery.
    Objective: Rare disease.
    Background: The purpose of the present paper is to stress the relevance for surgeons of being familiar with the procedure of intestinal derotation. This procedure is usually ignored by atlases of surgical technique and only few dedicated papers have been published since its first descriptions both in the U.S. and Europe more than 50 yrs ago.
    Case report: The occasion for this message has been provided by a recent application of this procedure, which has also provided a brand new indication to it. In the case which is reported in the paper the reconstruction, after the resection phase of Whipple procedure, appeared impossible. As a matter of fact, a lipomatosis of the jejunal mesentery reaching up the vasa recta made impossible to raise up the jejunum in order to perform anastomoses with the remaining pancreas and the bile duct. After a minute in which we felt lost, intestinal derotation solved the problem.
    Conclusions: In conclusion, intestinal derotation represents a valuable technical tool, which in very selected cases may be helpful in solving otherwise insoluble surgical problems. Therefore, it seems to be a necessary part of the armamentarium of any good surgeon.
    MeSH term(s) Aged, 80 and over ; Anastomosis, Surgical ; Duodenum/surgery ; Humans ; Jejunum/surgery ; Male ; Pancreas/surgery ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy ; Postoperative Complications/surgery ; Plastic Surgery Procedures/methods ; Salvage Therapy/methods
    Language English
    Publishing date 2014-07-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.889793
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  3. Article ; Online: Transverse loop colostomy and colonic motility.

    Pucciani, F / Ringressi, M N / Maltinti, G / Bechi, P

    Techniques in coloproctology

    2014  Volume 18, Issue 11, Page(s) 1029–1034

    Abstract: Background: The motility of the defunctionalized colon, distal to transverse loop colostomy, has never been studied "in vivo." The aim of our study was to evaluate the influence of transverse loop colostomy on colonic motility.: Methods: Thirteen ... ...

    Abstract Background: The motility of the defunctionalized colon, distal to transverse loop colostomy, has never been studied "in vivo." The aim of our study was to evaluate the influence of transverse loop colostomy on colonic motility.
    Methods: Thirteen patients were examined before stoma closure by means of clinical evaluation and colonic manometry; we studied both the right and distal colon in both fasting and fed patients in order to detect motor activity.
    Results: Quantitative and qualitative manometric analyses showed that the diverted colon had motor activity even if no regular colonic motor pattern was observed. The spreading of aboral propagated contractions (PCs) was sometimes recorded from the right colon to the distal colon. The response of the proximal and distal colon to a standard meal, when compared to fasting values, increased more than 40 and 35 %, respectively. Stool and gas ejections from the colostomy were never related to a particular type of colonic motility: Motor quiescence such as PCs was chaotically related to stool escape.
    Conclusions: In conclusion, motility of the defunctionalized colon is preserved in patients with transverse loop colostomy.
    MeSH term(s) Aged ; Aged, 80 and over ; Colon, Transverse/physiopathology ; Colon, Transverse/surgery ; Colostomy/methods ; Female ; Follow-Up Studies ; Gastrointestinal Motility/physiology ; Humans ; Male ; Manometry ; Middle Aged ; Pressure ; Rectal Neoplasms/physiopathology ; Rectal Neoplasms/surgery ; Retrospective Studies ; Time Factors
    Language English
    Publishing date 2014-06-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-014-1173-5
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  4. Article ; Online: Obstructive left side colon cancer: time for a tailored operative approach?

    Bergamini, Carlo / Giordano, Alessio / Maltinti, Gherardo / Alemanno, Giovanni / Cianchi, Fabio / Coratti, Andrea / Manetti, Roberto / Valeri, Andrea / Prosperi, Paolo

    Minerva chirurgica

    2020  Volume 75, Issue 4, Page(s) 244–254

    Abstract: Background: Colorectal cancer (CRC) obstruction is frequent but doubts remain on the best treatment. The aim of this study is to analyze the different operative approach used for CRC treatment and evaluate the outcomes for the different cases.: ... ...

    Abstract Background: Colorectal cancer (CRC) obstruction is frequent but doubts remain on the best treatment. The aim of this study is to analyze the different operative approach used for CRC treatment and evaluate the outcomes for the different cases.
    Methods: Patients were collected from January 2014 to December 2019 and divided in four groups: two "P" groups, namely the Hartmann's procedure (PH) group and the primary anastomosis (PA) group, and two "S" groups, namely the deviating stoma (SD) group and the self-expanding metallic stent (SS) group. The main endpoints were the quality of life and the oncologic safety.
    Results: One hundred and eight patients were enrolled. The mean follow-up time was 39 months. The stomas were performed less frequently in SS but lasted more in that group. Only 45% underwent reversal surgery. Cumulative operating time was greater in S versus P groups. The rate of major complications was similar. PA had greater overall survival and disease-free survival rates than PH.
    Conclusions: The various options of treatment should have different indications: primary anastomosis in stable patients, Hartmann in critical cases, SEMS for palliative intent and stoma when neo-adjuvant therapy is needed.
    MeSH term(s) Aged ; Anastomosis, Surgical/methods ; Colon, Descending ; Colonic Neoplasms/complications ; Colonic Neoplasms/mortality ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Critical Care/methods ; Female ; Follow-Up Studies ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Kaplan-Meier Estimate ; Male ; Neoadjuvant Therapy/instrumentation ; Neoadjuvant Therapy/methods ; Operative Time ; Palliative Care ; Patient Dropouts/statistics & numerical data ; Postoperative Complications/epidemiology ; Quality of Life ; Retrospective Studies ; Self Expandable Metallic Stents/statistics & numerical data ; Surgical Stomas/statistics & numerical data ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-05-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123603-9
    ISSN 1827-1626 ; 0026-4733
    ISSN (online) 1827-1626
    ISSN 0026-4733
    DOI 10.23736/S0026-4733.20.08299-1
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  5. Article ; Online: The Role of DAMPS in Burns and Hemorrhagic Shock Immune Response: Pathophysiology and Clinical Issues. Review.

    Pantalone, Desirè / Bergamini, Carlo / Martellucci, Jacopo / Alemanno, Giovanni / Bruscino, Alessandro / Maltinti, Gherardo / Sheiterle, Maximilian / Viligiardi, Riccardo / Panconesi, Roberto / Guagni, Tommaso / Prosperi, Paolo

    International journal of molecular sciences

    2021  Volume 22, Issue 13

    Abstract: Severe or major burns induce a pathophysiological, immune, and inflammatory response that can persist for a long time and affect morbidity and mortality. Severe burns are followed by a "hypermetabolic response", an inflammatory process that can be ... ...

    Abstract Severe or major burns induce a pathophysiological, immune, and inflammatory response that can persist for a long time and affect morbidity and mortality. Severe burns are followed by a "hypermetabolic response", an inflammatory process that can be extensive and become uncontrolled, leading to a generalized catabolic state and delayed healing. Catabolism causes the upregulation of inflammatory cells and innate immune markers in various organs, which may lead to multiorgan failure and death. Burns activate immune cells and cytokine production regulated by damage-associated molecular patterns (DAMPs). Trauma has similar injury-related immune responses, whereby DAMPs are massively released in musculoskeletal injuries and elicit widespread systemic inflammation. Hemorrhagic shock is the main cause of death in trauma. It is hypovolemic, and the consequence of volume loss and the speed of blood loss manifest immediately after injury. In burns, the shock becomes evident within the first 24 h and is hypovolemic-distributive due to the severely compromised regulation of tissue perfusion and oxygen delivery caused by capillary leakage, whereby fluids shift from the intravascular to the interstitial space. In this review, we compare the pathophysiological responses to burns and trauma including their associated clinical patterns.
    MeSH term(s) Alarmins/metabolism ; Burns/immunology ; Cytokines/metabolism ; Gene Expression Regulation ; Humans ; Mitochondria/metabolism ; Shock, Hemorrhagic/immunology
    Chemical Substances Alarmins ; Cytokines
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22137020
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  6. Article: Combination of diagnostic laparoscopy and intraoperative indocyanine green fluorescence angiography for the early detection of intestinal ischemia not detectable at CT scan.

    Alemanno, Giovanni / Somigli, Riccardo / Prosperi, Paolo / Bergamini, Carlo / Maltinti, Gherardo / Giordano, Alessio / Valeri, Andrea

    International journal of surgery case reports

    2016  Volume 26, Page(s) 77–80

    Abstract: Introduction: Acute mesenteric ischemia is the most severe gastrointestinal complication of acute aortic dissection. The timing of diagnosis is of major importance, in fact the recognition of acute mesenteric ischemia often occurs too late due to the ... ...

    Abstract Introduction: Acute mesenteric ischemia is the most severe gastrointestinal complication of acute aortic dissection. The timing of diagnosis is of major importance, in fact the recognition of acute mesenteric ischemia often occurs too late due to the presence of unspecific symptoms and lack of reliable exams. Recently, indocyanine green fluorescence angiography has been adopted in order to measure blood perfusion and microcirculation.
    Presentation of case: We decided to perform a diagnostic laparoscopy with the support of intra-operative near-infrared indocyanine green fluorescence angiography, in order to detect an initial intestinal ischemia in a 68-year-old patient previously treated with a TEVAR procedure for a type-B aortic dissection. The fluorescence system demonstrated an hypoperfused area in the ascending colon, therefore an ileocholic resection was thus performed. Opening the operatory specimen, the mucosa of the colon appeared totally ischemic, whilst the serosa was normal.
    Discussion: When ischemia occurs, the oxygen supply is interrupted, hence the necrosis of the enteral mucosa occurs within 3h, whilst the necrosis of the full thickness of the bowel wall occurs within 6h. A diagnosis during these "golden hours" is of major importance for a successful treatment.
    Conclusion: The combination of laparoscopy and UV light and fluorescein dye should be considered as an invaluable diagnostic procedure for the diagnosis of early stage acute bowel ischemia which is not visible at instrumental examinations nor with diagnostic laparoscopy.
    Language English
    Publishing date 2016-07-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2016.07.016
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  7. Article ; Online: A minimally invasive approach with a 3d imaging system for the treatment of esophageal perforation due to Boerhaave syndrome.

    Prosperi, Paolo / Alemanno, Giovanni / Di Bella, Annamaria / Ardu, Massimiliano / Maltinti, Gherardo / Iacopini, Veronica / Bergamini, Carlo / Valeri, Andrea

    Annali italiani di chirurgia

    2018  Volume 7

    Abstract: Boerhaave's syndrome is a rare life-threatening condition that requires urgent surgical management. There are various methods of managing it, with the main principles of limiting sepsis, draining the area and maintaining nutrition. Although the gold ... ...

    Abstract Boerhaave's syndrome is a rare life-threatening condition that requires urgent surgical management. There are various methods of managing it, with the main principles of limiting sepsis, draining the area and maintaining nutrition. Although the gold standard is open thoracotomy and/or laparotomy, mostly in patients with sepsis, we present a case of a 53-year-old man treated with a combination of laparoscopic suture (3D imaging system) of the oesophageal perforation site, decompressive percutaneous endoscopic gastrostomy and feeding jejunostomy. We conclude that this approach is a safe and a viable option in the management of Boerhaave syndrome in a septic patient presenting early. KEY WORDS: Boerhaave's syndrome, Laparoscopy, Minimally invasive surgery, Oesophageal Rupture, Surgery, 3D-laparoscopy.
    MeSH term(s) Emergencies ; Esophageal Perforation/diagnostic imaging ; Esophageal Perforation/surgery ; Gastroscopy ; Gastrostomy ; Humans ; Imaging, Three-Dimensional/instrumentation ; Imaging, Three-Dimensional/methods ; Jejunostomy ; Male ; Mediastinal Diseases/diagnostic imaging ; Mediastinal Diseases/surgery ; Middle Aged ; Minimally Invasive Surgical Procedures ; Surgery, Computer-Assisted ; Suture Techniques ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-12-19
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
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    Zs.B 50: Show issues Location:
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  8. Article ; Online: Chevrel technique for ventral incisional hernia. Is it still an effective procedure?

    Alemanno, Giovanni / Bruscino, Alessandro / Martellucci, Jacopo / Bergamini, Carlo / Maltinti, Gherardo / Di Bella, Annamaria / Iacopini, Veronica / Giordano, Alessio / Valeri, Andrea / Prosperi, Paolo

    Minerva chirurgica

    2020  Volume 75, Issue 5, Page(s) 286–291

    Abstract: Background: Incisional hernia still represents the most frequent late complication of abdominal surgery. After a direct repair, in literature is reported a recurrence rate ranging from 31 to 49%, meanwhile after a prosthetic repair such values were much ...

    Abstract Background: Incisional hernia still represents the most frequent late complication of abdominal surgery. After a direct repair, in literature is reported a recurrence rate ranging from 31 to 49%, meanwhile after a prosthetic repair such values were much lower, with a recurrence rate up to 10%. The sites of prosthetic placement in the abdominal wall are premusculo-aponeurotic (onlay, or Chevrel technique), retromuscular-prefascial and preperitoneal (Rives technique, Stoppa technique), whereas intraperitoneal insertion can be done with open or laparoscopic surgery. The aim of this study was to evaluate the immediate and late postoperative results in patients treated with a Chevrel technique for ventral incisional hernia.
    Methods: A retrospective review was conducted on the medical records of patients undergoing ventral hernia repair between January 2008 and December 2018 at the Emergency Surgery Unit of the Careggi University Hospital in Florence.
    Results: Between January 2008 and December 2018 at the Emergency Surgery Unit of the Careggi University Hospital in Florence, 461 patients (245 male, 216 female) with a mean age of 61,52 years were submitted to ventral incisional hernia repair with a Chevrel technique. The mean operatory time was 95.29 min (±50.48) and in 72 patients (15.61%) human fibrin glue was vaporized under the mesh using a spray device. Mean postoperative hospital stay was 5 days and all drain tubes were removed after 7.1 days as mean (±4.3). No intraoperative mortality nor postoperative mortality was reported. In our experience the Chevrel technique for ventral incisional hernia show a recurrence rate (3.2%). Parietal complications observed were seroma in 7.1% of patients, hematoma in 4.7%, localized skin necrosis in 5.2%, surgical site infection in 6.7%, data comparable with the results reported in the other studies.
    Conclusions: Most of the objections to the Chevrel procedure focus on the parietal complications and risk of infection. Chevrel procedure cannot be considered an obsolete intervention, in our series, results were very satisfactory in both immediate and late follow-up; moreover this technique is safe and easy to perform.
    MeSH term(s) Female ; Fibrin Tissue Adhesive/administration & dosage ; Hematoma/epidemiology ; Hernia, Ventral/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Humans ; Incisional Hernia/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Operative Time ; Postoperative Cognitive Complications ; Recurrence ; Retrospective Studies ; Seroma/epidemiology ; Surgical Mesh ; Surgical Wound Infection/epidemiology ; Tissue Adhesives/administration & dosage ; Treatment Outcome
    Chemical Substances Fibrin Tissue Adhesive ; Tissue Adhesives
    Language English
    Publishing date 2020-11-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123603-9
    ISSN 1827-1626 ; 0026-4733
    ISSN (online) 1827-1626
    ISSN 0026-4733
    DOI 10.23736/S0026-4733.20.08463-1
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  9. Article: DIURNAL RHYTHM IN THE ADRENAL CORTICAL SECRETION AND IN THE RATE OF METABOLISM OF CORTICOSTERONE IN THE RAT. 3. IN BLIND ANIMALS.

    SABA, P / CARNICELLI, A / SABA, G C / MALTINTI, G / MARESCOTTI, V

    Acta endocrinologica

    2002  Volume 49, Page(s) 289–292

    MeSH term(s) Adrenal Cortex ; Adrenal Glands ; Animals ; Blindness ; Blood ; Circadian Rhythm ; Corticosterone ; Metabolism ; Periodicity ; Physiology ; Rats ; Research
    Chemical Substances Corticosterone (W980KJ009P)
    Language English
    Publishing date 2002-11-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 68-1
    ISSN 0001-5598
    ISSN 0001-5598
    DOI 10.1530/acta.0.0490289
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  10. Article: Thrombocytopenic purpura: an unusual complication of eradication therapy for Helicobacter pylori.

    Marchi, S / Bellini, M / Costa, F / De Bortoli, N / Petrini, M / Maltinti, G

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2002  Volume 34, Issue 9, Page(s) 665–667

    Abstract: A case of severe thrombocytopenic purpura is described in a 56-year-old female following Helicobacter pylori eradication therapy consisting of omeprazole, clarithromycin and amoxycillin. The pathogenesis of this patient's thrombocytopenia appears to be ... ...

    Abstract A case of severe thrombocytopenic purpura is described in a 56-year-old female following Helicobacter pylori eradication therapy consisting of omeprazole, clarithromycin and amoxycillin. The pathogenesis of this patient's thrombocytopenia appears to be quite complex. Whilst it was clearly triggered by antibiotic treatment, a direct toxic mechanism does not provide an adequate explanation for the severity and lack of responsiveness to drug treatment. It is tempting to suggest that an immunological mechanism and splenomegaly were also involved.
    MeSH term(s) Amoxicillin/adverse effects ; Anti-Bacterial Agents/adverse effects ; Anti-Ulcer Agents/adverse effects ; Clarithromycin/adverse effects ; Drug Therapy, Combination ; Female ; Helicobacter Infections/drug therapy ; Humans ; Methylprednisolone/therapeutic use ; Middle Aged ; Omeprazole/adverse effects ; Penicillins/adverse effects ; Platelet Count ; Purpura, Thrombocytopenic/chemically induced ; Purpura, Thrombocytopenic/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Anti-Ulcer Agents ; Penicillins ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A) ; Omeprazole (KG60484QX9) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2002-10-31
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1459373-7
    ISSN 1590-8658 ; 1125-8055
    ISSN 1590-8658 ; 1125-8055
    DOI 10.1016/s1590-8658(02)80211-0
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