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Article: An Exploration of the Effectiveness of Different Intensity Protocols of Modified Constraint-Induced Therapy in Stroke: A Systematic Review.

Psychouli, Pavlina / Mamais, Ioannis / Anastasiou, Charalambos

2023 Volume 2023, Page(s) 6636987

Abstract: Purpose: To examine the effectiveness of different modified Constraint-Inuced Therapy (mCIMT) protocol intensities on upper extremity motor function in adults with hemiplegia.: Methods: A search was conducted in PubMed, Scopus, EBSCO, and Cochrane ... ...

Abstract	Purpose: To examine the effectiveness of different modified Constraint-Inuced Therapy (mCIMT) protocol intensities on upper extremity motor function in adults with hemiplegia. Methods: A search was conducted in PubMed, Scopus, EBSCO, and Cochrane Library for articles published between April 2010 and December 2021. Only randomized controlled trials (RCTs) were included. Studies were excluded if they used a sample of less than five, mCIMT in combination with other therapy, and/or if they were not written in English. Methodologic quality was assessed using the Cochrane collaboration risk of bias tool-2. Results: Thirty-six RCTs with a total of 721 participants were included. Most researchers followed a moderate to low protocol intensity in terms of total treatment time and moderate to high intensity with regard to restriction time. Almost all of the upper limb motor function measures showed statistically significant improvements ( Conclusions: Low-intensity CIMT protocols may result in comparable improvements to more intensive ones but caution has to be taken when drawing conclusions due to high risk of bias studies.
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2587420-2
ISSN	2090-2875 ; 2090-2867
ISSN (online)	2090-2875
ISSN	2090-2867
DOI	10.1155/2023/6636987
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Article ; Online: Safety Profile of Niraparib as Maintenance Therapy for Ovarian Cancer: A Systematic Review and Meta-Analysis.

Pagkali, Antonia / Mamais, Ioannis / Michalinos, Adamantios / Agouridis, Aris P

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 1, Page(s) 321–336

Abstract: Background: Patients with epithelial ovarian cancer (EOC), treated with niraparib maintenance, present with haematological and gastrointestinal toxicities. Limited data exist on niraparib safety assessment.: Objective: To evaluate niraparib safety ... ...

Abstract	Background: Patients with epithelial ovarian cancer (EOC), treated with niraparib maintenance, present with haematological and gastrointestinal toxicities. Limited data exist on niraparib safety assessment. Objective: To evaluate niraparib safety profile, as maintenance therapy, in women with platinum-sensitive EOC. Methods: PubMed and Cochrane searches were carried out up to April 2021 for randomised controlled trials (RCTs) evaluating niraparib versus placebo in EOC patients with a response to platinum-based chemotherapy. Regarding the meta-analysis, for dichotomous data, the pooled risk ratio (RR) was calculated. Results: A total of 1539 patients from three RCTs revealed that niraparib-treated patients are associated with a significantly higher risk of any grade of nausea (RR, 2.15; 95% CI, 1.86 to 2.48), fatigue (RR, 1.26; 95% CI, 1.05 to 1.52, Conclusion: Niraparib is considered an effective and well-tolerated choice, with an improved safety profile, for the maintenance treatment of EOC patients.
MeSH term(s)	Carcinoma, Ovarian Epithelial/chemically induced ; Carcinoma, Ovarian Epithelial/drug therapy ; Female ; Humans ; Indazoles/adverse effects ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Piperidines
Chemical Substances	Indazoles ; Piperidines ; niraparib (HMC2H89N35)
Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29010029
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Zs.A 4305: Show issues

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Article ; Online: Comparing hip and knee focused exercises versus hip and knee focused exercises with the use of blood flow restriction training in adults with patellofemoral pain.

Constantinou, Antonis / Mamais, Ioannis / Papathanasiou, Giorgos / Lamnisos, Demetris / Stasinopoulos, Dimitrios

European journal of physical and rehabilitation medicine

2022 Volume 58, Issue 2, Page(s) 225–235

Abstract: Background: Hip and knee strengthening exercises are implemented in rehabilitation of patellofemoral pain patients, but typically use high loads (70% of 1 repetition maximum). This may lead to increased patellofemoral joint stress. Low load training (20- ...

Abstract	Background: Hip and knee strengthening exercises are implemented in rehabilitation of patellofemoral pain patients, but typically use high loads (70% of 1 repetition maximum). This may lead to increased patellofemoral joint stress. Low load training (20-30% of 1 repetition maximum) with blood flow restriction could allow for exercise strength benefits to proximal and distal muscles with reduced joint stress and by promoting hypoalgesia. Aim: The aim of this study was to compare hip and knee focused exercises with and without blood flow restriction in adults with patellofemoral pain for short term effectiveness. Design: A randomized observed-blind controlled trial. Setting: Musculoskeletal laboratories of the European University Cyprus, Nicosia, Cyprus. Population: 60 volunteer patients, 18-40 years of age with patellofemoral pain. Methods: Participants were randomly assigned to (1 reference group) hip and knee strengthening at (70% of 1 repetition maximum) or (2 experimental group) Strengthening with blood flow restriction at (30% of 1 repetition maximum at 70% of limb occlution pressure). Treatments took place 3 times per week for 4weeks and outcomes were assessed at baseline, end of treatment and at 2-month follow-up. The primary outcome was the Kujala Anterior Knee Pain Scale and secondary outcomes were worst and usual pain, pain with Single leg Squats, the maximum pain free flexion angle, the Tampa Scale of kinesiophobia, the Pain Catastrophizing Scale and isometric strength of knee extensors, hip extensors and hip abductors. Results: No difference were found for the main outcome of this study between groups. There was a significant effect of time for all outcome measures in both groups. Between group differences showed a significant difference for isometric strength of Knee extensor values at 2 month follow-up F(1,58)=5.56, P=0.02, partial η2=0.09, 459.4 (412.13, 506.64) vs. 380.68 (333.42, 427.93) and in worst pain post-treatment F(1,58)=5.27, P=0.02, partial η Conclusions: Blood flow restriction exercises of the hip and knee musculature used in this study were as effective as usual exercises of Hip and knee musculature in reducing symptoms in the short term. They also indicated greater increases in strength and reduction of worst pain post-treatment. Clinical rehabilitation impact: Further research is needed to investigate the dose response relationship with longer follow-ups.
MeSH term(s)	Adult ; Blood Flow Restriction Therapy ; Exercise Therapy ; Humans ; Muscle Strength/physiology ; Pain ; Patellofemoral Pain Syndrome/rehabilitation ; Resistance Training
Language	English
Publishing date	2022-01-05
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2426908-6
ISSN	1973-9095 ; 1973-9087
ISSN (online)	1973-9095
ISSN	1973-9087
DOI	10.23736/S1973-9087.22.06691-6
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Article ; Online: Blood flow restriction training in patients with knee osteoarthritis: Systematic review of randomized controlled trials.

Pitsillides, Alexios / Stasinopoulos, Dimitrios / Mamais, Ioannis

Journal of bodywork and movement therapies

2021 Volume 27, Page(s) 477–486

Abstract: Introduction: Knee osteoarthritis (KOA) is one of the most common musculoskeletal disorders in the elderly. The patient experiences reduction in muscle strength, pain, joint stiffness and consequently a reduction in quality of life. Whereas high ... ...

Abstract	Introduction: Knee osteoarthritis (KOA) is one of the most common musculoskeletal disorders in the elderly. The patient experiences reduction in muscle strength, pain, joint stiffness and consequently a reduction in quality of life. Whereas high intensity training (HI-TR) is the most effective in the general elderly population, in KOA patients, painless alternatives might be more suitable, since pain can be a deterrent for exercising. Research interest has increased in blood flow restriction training (BFR-TR) due to the observation that, in this specific population, BFR-TR results in equal muscular adaptions to HI-TR but with less join discomfort/pain. Objective: We aimed to: (1) determine the value of BFR-TR in patients with KOA and (2) examine which exercise guidelines applied to healthy elderly populations can be adopted for patients suffering from this knee pathology. Methodology: We searched the literature from the database inception to 2019 through PubMed, Cochrane, and Medline (EBSCO). The inclusion criteria were determined using PICOS principles. We assessed methodology using the Risk of Bias 2 tool and the Pedro scale. Conclusions were extracted with the use of best evidence synthesis. Results: The literature search yielded 45 articles. After screening, three studies matched the inclusion criteria. The included studies were analyzed and discussed. All the included studies reported within group improvements for BFR-TR regarding pain and strength. Conclusion: Although the evidence of BFR-TR efficacy on KOA remains scarce, the results favor its use for muscle strengthening and pain reduction in KOA. Further high-quality studies with larger samples are required.
MeSH term(s)	Aged ; Humans ; Knee Joint ; Muscle Strength ; Osteoarthritis, Knee ; Quality of Life ; Randomized Controlled Trials as Topic ; Regional Blood Flow ; Resistance Training
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2029441-4
ISSN	1532-9283 ; 1360-8592
ISSN (online)	1532-9283
ISSN	1360-8592
DOI	10.1016/j.jbmt.2021.04.015
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Zs.A 5620: Show issues

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Article: Effectiveness of surgical versus conservative treatment for carpal tunnel syndrome: A systematic review, meta-analysis and qualitative analysis.

Klokkari, Diony / Mamais, Ioannis

Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao

2018 Volume 38, Issue 2, Page(s) 91–114

Abstract: Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper limb. Treatment options include physiotherapy, splinting, steroid injections or surgery.: Objective: To compare the effectiveness of surgical versus ... ...

Abstract	Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper limb. Treatment options include physiotherapy, splinting, steroid injections or surgery. Objective: To compare the effectiveness of surgical versus conservative treatment for CTS for symptom and functional improvement and improvement of neurophysiological parameters. Methods: Systematic searches of PubMed and EBSCO host were conducted to identify the studies published between 1990 and 2016, comparing any surgical treatment to any conservative treatment. Participants were adults with a diagnosis of CTS, with symptom duration ranging from 8 months to 3 years. A meta-analysis and a qualitative analysis were conducted to summarize the results of the included studies and establish any agreement between the two. Results: A total of 15 studies were included in the study and 10 were included in the meta-analysis, involving 1787 wrists. The qualitative and quantitative analyses were consistent with the results of both indicating that surgical treatment leads to a greater improvement of symptoms at six months (mean difference: 0.52, 95%CI 0.27 to 0.78) and a greater improvement of neurophysiological parameters [distal motor latency (mean difference: 0.31, 95%CI 0.06 to 0.56), sensory nerve conduction velocity (mean difference: 3.71 m/s, 95%CI 1.94 to 5.49)]. At 3 months and 12 months, the results were not significant in favor of surgery or conservative treatment. Conclusion: Conservative treatment for CTS should be preferred for mild and short-term CTS. Surgery is more effective than conservative in CTS, and should be considered in persisting symptoms, taking into account the complications, which are more severe after surgery. Further research should focus on the field of manual therapy and compare it to surgical treatment for CTS.
Language	English
Publishing date	2018-07-02
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2202255-7
ISSN	1876-441X ; 1013-7025
ISSN (online)	1876-441X
ISSN	1013-7025
DOI	10.1142/S1013702518500087
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Article: Effectiveness of Low Level Laser Therapy (LLLT) in the treatment of Lateral elbow tendinopathy (LET): an umbrella review.

Mamais, Ioannis / Papadopoulos, Konstantinos / Lamnisos, Demetris / Stasinopoulos, Demetrios

Laser therapy

2020 Volume 27, Issue 3, Page(s) 174–186

Abstract: Purpose: The aim of this umbrella review is to determine the effectiveness of LLLT in the treatment of LET and to provide recommendations based on this evidence.: Methods: A comprehensive and systematic review was undertaken using Medline, EBSCO and ... ...

Abstract	Purpose: The aim of this umbrella review is to determine the effectiveness of LLLT in the treatment of LET and to provide recommendations based on this evidence. Methods: A comprehensive and systematic review was undertaken using Medline, EBSCO and EMBASE. Systematic reviews or meta-analysis were included if they compared Laser with at least one of the following: (i) placebo, (ii) no treatment, (iii) another treatment, conservative (physical therapy intervention or medical) or operative of LET. Principal outcomes included the assessment of short and long-term effect on functional status, pain, grip strength (pain-free or maximum) and a global measure (overall improvement). Results: Seven papers met the inclusion criteria for the umbrella review, Five papers were of moderate and two of low methodological quality. All reviews reported benefits associated with laser therapy Vs other intervention or placebo, however the significance of the identified benefits differed between studies and reviews. No review reported negative effects of laser therapy or harm to patients. All reviews noted significant variance between included studies with 2 reviews citing statistically significant heterogeneity. It is essential to consider this in the interpretation of these data. Conclusion: This umbrella review found poor results for the effectiveness of LLLT in the management of LET. Therefore, further research with well-designed RCTs is required to provide meaningful evidence on the effectiveness (absolute and relative) of LLLT for the management of LET.
Language	English
Publishing date	2020-02-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1036369-5
ISSN	0898-5901
ISSN	0898-5901
DOI	10.5978/islsm.27_18-OR-16
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Article ; Online: Reliability and validity of the Greek shoulder pain and disability index in patients with shoulder pain.

Spanou, Alexia / Mamais, Ioannis / Lamnisos, Dimitrios / Stasinopoulos, Dimitrios

Disability and rehabilitation

2019 Volume 42, Issue 9, Page(s) 1299–1304

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Adult ; Aged ; Ambulatory Care Facilities ; Disability Evaluation ; Female ; Greece ; Humans ; Male ; Middle Aged ; Pain Measurement ; Psychometrics ; Reproducibility of Results ; Rotator Cuff Injuries/classification ; Rotator Cuff Injuries/physiopathology ; Rotator Cuff Injuries/therapy ; Shoulder Pain/diagnosis ; Surveys and Questionnaires/standards ; Translating
Language	English
Publishing date	2019-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2018.1519728
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Zs.A 1569: Show issues

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Article: Association Between Aggressive Clinicopathologic Features of Papillary Thyroid Carcinoma and Body Mass Index: A Systematic Review and Meta-Analysis.

Economides, Aliki / Giannakou, Konstantinos / Mamais, Ioannis / Economides, Panayiotis A / Papageorgis, Panagiotis

Frontiers in endocrinology

2021 Volume 12, Page(s) 692879

Abstract: Background: The association between adiposity and papillary thyroid carcinoma (PTC) has been reported in several studies, but its association with aggressive clinicopathologic features is not well-recognized. Our aim is to systematically review the ... ...

Abstract	Background: The association between adiposity and papillary thyroid carcinoma (PTC) has been reported in several studies, but its association with aggressive clinicopathologic features is not well-recognized. Our aim is to systematically review the literature to identify whether adiposity, expressed through Body Mass Index (BMI), is related to aggressive clinicopathologic features such as tumor-node-metastasis (TNM) stage, extrathyroidal extension (ETE), lymph node (LN) metastasis and multifocality in patients with PTC. Methods: A systematic search for articles was performed using the PubMed, EBSCO, and Cochrane Library for all articles published in English until December 2020. Specific keywords such as "papillary thyroid carcinoma", "Body Mass Index", "clinicopathologic features" were used in the search strategy. Two independent reviewers screened all retrieved articles based on predefined inclusion and exclusion criteria. Meta-analysis was performed in the studies that reported crude and adjusted odds ratios (OR). The methodological quality was assessed using the Newcastle-Ottawa Scale. Results: A total of 11 retrospective cohort studies involving 26,196 participants included. Our findings showed that elevated BMI was significantly associated with ETE in both overweight (OR 1.26, 95% CI: 1.09-1.44) and obesity group (OR 1.45, 95% CI:1.26-1.64). Elevated BMI was also significantly associated with multifocality in overweight patients (OR 1.17, 95% CI:1.10-1.24) and obese patients (OR 1.45, 95% CI:1.29-1.62). Also, obesity was significantly associated with increased tumor size (OR 1.77, 95% CI:1.52-2.03) and with LN metastasis (OR 1.28, 95% CI: 1.12-1.44), whereas being overweight was significantly associated with advanced TNM stage (OR 1.55, 95% CI:1.27-1.83). Conclusion: Our results provide strong evidence for the association between higher BMI and ETE, multifocality, and tumor size. Further studies with a larger number of participants are required to elucidate further the association of increased BMI with advanced TNM stage and LN metastasis.
MeSH term(s)	Body Mass Index ; Humans ; Lymphatic Metastasis ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/pathology ; Tumor Burden
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.692879
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Article ; Online: Effect of public health interventions during the first epidemic wave of COVID-19 in Cyprus: a modelling study.

Gountas, Ilias / Quattrocchi, Annalisa / Mamais, Ioannis / Tsioutis, Constantinos / Christaki, Eirini / Fokianos, Konstantinos / Nikolopoulos, Georgios

BMC public health

2021 Volume 21, Issue 1, Page(s) 1898

Abstract: Background: Cyprus addressed the first wave of SARS CoV-2 (COVID-19) by implementing non-pharmaceutical interventions (NPIs). The aims of this study were: a) to estimate epidemiological parameters of this wave including infection attack ratio, infection ...

Abstract	Background: Cyprus addressed the first wave of SARS CoV-2 (COVID-19) by implementing non-pharmaceutical interventions (NPIs). The aims of this study were: a) to estimate epidemiological parameters of this wave including infection attack ratio, infection fatality ratio, and case ascertainment ratio, b) to assess the impact of public health interventions and examine what would have happened if those interventions had not been implemented. Methods: A dynamic, stochastic, individual-based Susceptible-Exposed-Infected-Recovered (SEIR) model was developed to simulate COVID-19 transmission and progression in the population of the Republic of Cyprus. The model was fitted to the observed trends in COVID-19 deaths and intensive care unit (ICU) bed use. Results: By May 8th, 2020, the infection attack ratio was 0.31% (95% Credible Interval [CrI]: 0.15, 0.54%), the infection fatality ratio was 0.71% (95% CrI: 0.44, 1.61%), and the case ascertainment ratio was 33.2% (95% CrI: 19.7, 68.7%). If Cyprus had not implemented any public health measure, the healthcare system would have been overwhelmed by April 14th. The interventions averted 715 (95% CrI: 339, 1235) deaths. If Cyprus had only increased ICU beds, without any social distancing measure, the healthcare system would have been overwhelmed by April 19th. Conclusions: The decision of the Cypriot authorities to launch early NPIs limited the burden of the first wave of COVID-19. The findings of these analyses could help address the next waves of COVID-19 in Cyprus and other similar settings.
MeSH term(s)	COVID-19 ; Cyprus/epidemiology ; Epidemics ; Humans ; Public Health ; SARS-CoV-2
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-021-11945-9
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Article ; Online: Microcirculation-mediated preconditioning and intracellular hypothermia.

Chalkias, Athanasios / Mamais, Ioannis / Xanthos, Theodoros

Medical hypotheses

2018 Volume 115, Page(s) 8–12

Abstract: Microcirculation is a network of perfused capillaries that connects macrocirculation with the cells. Although research has provided insight into microcirculatory blood flow, our knowledge remains limited. In this article, we propose a new role of ... ...

Abstract	Microcirculation is a network of perfused capillaries that connects macrocirculation with the cells. Although research has provided insight into microcirculatory blood flow, our knowledge remains limited. In this article, we propose a new role of microcirculation in physiological and shock states. In healthy individuals, microcirculation maintains cellular homeostasis via preconditioning. When blood volume decreases, the ensuing microcirculatory changes result in heterogeneity of perfusion and tissue oxygenation. Initially, this is partly compensated by the preserved autoregulation and the increase in the metabolism rate of cells, but at later stages, the loss of autoregulation activates the cascade of intracellular hypothermia.
MeSH term(s)	Blood Volume ; Body Temperature ; Hemodynamics ; Homeostasis ; Humans ; Hypothermia/physiopathology ; Intracellular Space/physiology ; Ischemic Preconditioning ; Microcirculation/physiology ; Models, Cardiovascular ; Shock, Hemorrhagic/physiopathology
Language	English
Publishing date	2018-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2018.03.006
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