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Article ; Online: Squaramide-Immobilized Carbon Nanoparticles for Rapid and High-Efficiency Elimination of Anthropogenic Mercury Ions from Aquatic Systems.

Mamidi, Narsimha / Delgadillo, Ramiro Manuel Velasco

ACS applied materials & interfaces

2022 Volume 14, Issue 31, Page(s) 35789–35801

Abstract: Water pollution due to environmental remediation and poor waste administration in certain areas of the globe signifies a serious problem in acquiring safe and clean drinking water. This problem is especially critical in rural areas, where advanced water ... ...

Abstract	Water pollution due to environmental remediation and poor waste administration in certain areas of the globe signifies a serious problem in acquiring safe and clean drinking water. This problem is especially critical in rural areas, where advanced water purification techniques are deficient, and it remains a daunting task for ecosystem and public health protection. This critical task can be addressed herein by developing scalable poly squaramide-phenyl methacrylamide (PSQ)-functionalized carbon nanoparticles (CNPs) (PSQ-CNPs) with densely populated chelating sites with strong Hg
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c09232
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Emerging Foodborne Pathogen Spotlight: A Bibliometric Analysis and Scholarly Review of

Jangid, Himanshu / Kumar, Deepak / Kumar, Gaurav / Kumar, Raj / Mamidi, Narsimha

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 1

Abstract: Foodborne infections pose a substantial global threat, causing an estimated 600 million illnesses and resulting in approximately 420,000 deaths annually. Among the diverse array of pathogens implicated in these infections, ...

Abstract	Foodborne infections pose a substantial global threat, causing an estimated 600 million illnesses and resulting in approximately 420,000 deaths annually. Among the diverse array of pathogens implicated in these infections,
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13010060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy.

Kim, DaWon / Javius-Jones, Kaila / Mamidi, Narsimha / Hong, Seungpyo

Nanoscale

2024

Abstract: Immune activation, whether occurring from direct immune checkpoint blockade or indirectly as a result of chemotherapy, is an approach that has drastically impacted the way we treat cancer. Utilizing patients' own immune systems for anti-tumor efficacy ... ...

Abstract	Immune activation, whether occurring from direct immune checkpoint blockade or indirectly as a result of chemotherapy, is an approach that has drastically impacted the way we treat cancer. Utilizing patients' own immune systems for anti-tumor efficacy has been translated to robust immunotherapies; however, clinically significant successes have been achieved in only a subset of patient populations. Dendrimers and dendritic polymers have recently emerged as a potential nanocarrier platform that significantly improves the therapeutic efficacy of current and next-generation cancer immunotherapies. In this paper, we highlight the recent progress in developing dendritic polymer-based therapeutics with immune-modulating properties. Specifically, dendrimers, dendrimer hybrids, and dendronized copolymers have demonstrated promising results and are currently in pre-clinical development. Despite their early stage of development, these nanocarriers hold immense potential to make profound impact on cancer immunotherapy and combination therapy. This overview provides insights into the potential impact of dendrimers and dendron-based polymers, offering a preview of their potential utilities for various aspects of cancer treatment.
Language	English
Publishing date	2024-05-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d4nr00635f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Leveraging the Recent Advancements in GelMA Scaffolds for Bone Tissue Engineering: An Assessment of Challenges and Opportunities.

Mamidi, Narsimha / Ijadi, Fatemeh / Norahan, Mohammad Hadi

Biomacromolecules

2023 Volume 25, Issue 4, Page(s) 2075–2113

Abstract: The field of bone tissue engineering has seen significant advancements in recent years. Each year, over two million bone transplants are performed globally, and conventional treatments, such as bone grafts and metallic implants, have their limitations. ... ...

Abstract	The field of bone tissue engineering has seen significant advancements in recent years. Each year, over two million bone transplants are performed globally, and conventional treatments, such as bone grafts and metallic implants, have their limitations. Tissue engineering offers a new level of treatment, allowing for the creation of living tissue within a biomaterial framework. Recent advances in biomaterials have provided innovative approaches to rebuilding bone tissue function after damage. Among them, gelatin methacryloyl (GelMA) hydrogel is emerging as a promising biomaterial for supporting cell proliferation and tissue regeneration, and GelMA has exhibited exceptional physicochemical and biological properties, making it a viable option for clinical translation. Various methods and classes of additives have been used in the application of GelMA for bone regeneration, with the incorporation of nanofillers or other polymers enhancing its resilience and functional performance. Despite promising results, the fabrication of complex structures that mimic the bone architecture and the provision of balanced physical properties for both cell and vasculature growth and proper stiffness for load bearing remain as challenges. In terms of utilizing osteogenic additives, the priority should be on versatile components that promote angiogenesis and osteogenesis while reinforcing the structure for bone tissue engineering applications. This review focuses on recent efforts and advantages of GelMA-based composite biomaterials for bone tissue engineering, covering the literature from the last five years.
MeSH term(s)	Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Biocompatible Materials/chemistry ; Gelatin/chemistry ; Bone and Bones ; Hydrogels/chemistry ; Methacrylates
Chemical Substances	gelatin methacryloyl ; Biocompatible Materials ; Gelatin (9000-70-8) ; Hydrogels ; Methacrylates
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c00279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.

Mamidi, Narsimha / Delgadillo, Ramiro Manuel Velasco

Colloids and surfaces. B, Biointerfaces

2021 Volume 204, Page(s) 111819

Abstract: Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms. However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging. ...

Abstract	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms. However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging. Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy. CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release. Under pH 7.4, CNPs exhibited the highest drug release at 55 °C in 15 days. The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion. The CNPs also displayed good cell viability against human fibroblast cells. Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
MeSH term(s)	Chitosan ; Drug Carriers ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hydrogels ; Hydrogen-Ion Concentration ; Nanoparticles
Chemical Substances	Drug Carriers ; Hydrogels ; Chitosan (9012-76-4)
Language	English
Publishing date	2021-05-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2021.111819
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment.

Saurav, Sushmita / Sharma, Prashish / Kumar, Anil / Tabassum, Zeba / Girdhar, Madhuri / Mamidi, Narsimha / Mohan, Anand

Current issues in molecular biology

2024 Volume 46, Issue 1, Page(s) 585–611

Abstract: Numerous surgeries are carried out to replace tissues that have been harmed by an illness or an accident. Due to various surgical interventions and the requirement of bone substitutes, the emerging field of bone tissue engineering attempts to repair ... ...

Abstract	Numerous surgeries are carried out to replace tissues that have been harmed by an illness or an accident. Due to various surgical interventions and the requirement of bone substitutes, the emerging field of bone tissue engineering attempts to repair damaged tissues with the help of scaffolds. These scaffolds act as template for bone regeneration by controlling the development of new cells. For the creation of functional tissues and organs, there are three elements of bone tissue engineering that play very crucial role: cells, signals and scaffolds. For the achievement of these aims, various types of natural polymers, like chitosan, chitin, cellulose, albumin and silk fibroin, have been used for the preparation of scaffolds. Scaffolds produced from natural polymers have many advantages: they are less immunogenic as well as being biodegradable, biocompatible, non-toxic and cost effective. The hierarchal structure of bone, from microscale to nanoscale, is mostly made up of organic and inorganic components like nanohydroxyapatite and collagen components. This review paper summarizes the knowledge and updates the information about the use of natural polymers for the preparation of scaffolds, with their application in recent research trends and development in the area of bone tissue engineering (BTE). The article extensively explores the related research to analyze the advancement of nanotechnology for the treatment of bone-related diseases and bone repair.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46010038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Squaramide-Immobilized Carbon Nanoparticles for Rapid and High-Efficiency Elimination of Anthropogenic Mercury Ions from Aquatic Systems

Mamidi, Narsimha / Delgadillo, Ramiro Manuel Velasco

ACS applied materials & interfaces. 2022 July 26, v. 14, no. 31

2022

Abstract	Water pollution due to environmental remediation and poor waste administration in certain areas of the globe signifies a serious problem in acquiring safe and clean drinking water. This problem is especially critical in rural areas, where advanced water purification techniques are deficient, and it remains a daunting task for ecosystem and public health protection. This critical task can be addressed herein by developing scalable poly squaramide-phenyl methacrylamide (PSQ)-functionalized carbon nanoparticles (CNPs) (PSQ-CNPs) with densely populated chelating sites with strong Hg²⁺-binding capacity. The PSQ-CNPs have shown high efficiency in removing Hg²⁺ from aqueous solution, providing a Hg²⁺ capacity of 2840 mg g–¹, surpassing all the amine and thiol-based adsorbents reported hitherto. More significantly, the adsorbent reveals the largest distribution coefficient value (Kd) of 9.09 × 10¹⁰ mL g–¹, which allows it to reduce Hg²⁺ content from 10 ppm to less than 0.011 ppb, well below the United States Environmental Protection Agency (EPA) limits for drinking water standards (2 ppb). The adsorption measurements of the adsorbent followed the Langmuir isotherm model and pseudo-second order. The practical applicability of PSQ-CNPs was verified with the real samples (the lake, river, and industrial wastewater) and has been proven to be excellent. The adsorbent could still retain its Hg²⁺ removal efficacy even after 12 sorption cycles. It is attributed that the remarkable performance of PSQ-CNPs arises from the high-density chelating sites and pores on the surface of CNPs. The present work shows a new benchmark for Hg²⁺-removal adsorbents and presents a novel practical approach for decontaminating Hg²⁺ and other heavy metal ions from wastewater.
Keywords	adsorbents ; adsorption ; aqueous solutions ; carbon nanoparticles ; ecosystems ; health promotion ; heavy metals ; industrial wastewater ; lakes ; mercury ; remediation ; rivers ; sorption isotherms ; water pollution ; water purification
Language	English
Dates of publication	2022-0726
Size	p. 35789-35801.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.2c09232
Database	NAL-Catalogue (AGRICOLA)

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Article: Bibliometric Examination of Global Scientific Research about Carbapenem-Resistant

Jangid, Himanshu / Kumar, Deepak / Kumar, Gaurav / Kumar, Raj / Mamidi, Narsimha

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 11

Abstract: This review paper presents a comprehensive bibliometric analysis of the global scientific research pertaining to carbapenem-resistant Acinetobacter baumannii (CRAB) from the years 1996 to 2023. The review employs a systematic approach to evaluate the ... ...

Abstract	This review paper presents a comprehensive bibliometric analysis of the global scientific research pertaining to carbapenem-resistant Acinetobacter baumannii (CRAB) from the years 1996 to 2023. The review employs a systematic approach to evaluate the trends, patterns, and collaborative networks within the CRAB research landscape, shedding light on its substantial global health implications. An analysis of the Scopus database reveals that the earliest publication within the CRAB research domain dates back to 1996. By conducting a meticulous examination of publication output, citation trends, author affiliations, and keyword distributions, this paper provides valuable insights into the evolution of research themes and the emergence of new areas of interest concerning CRAB. The findings of this bibliometric analysis prominently feature the most influential author within this field, namely, Higgins PG, who has contributed a remarkable 39 documents to CRAB research. It is noteworthy that China leads in terms of the quantity of published research articles in this domain, whereas the United States occupies the foremost position about citations within the CRAB research sphere. Furthermore, a more profound exploration of the data yields a heightened understanding of the current status of CRAB research, emphasizing potential avenues for future investigations and underscoring the imperative need for collaborative initiatives to address the challenges posed by this antibiotic-resistant pathogen.
Language	English
Publishing date	2023-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12111593
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of Heterocyclic PPAR Ligands for Potential Therapeutic Applications.

Virendra, Sharma Arvind / Kumar, Ankur / Chawla, Pooja A / Mamidi, Narsimha

Pharmaceutics

2022 Volume 14, Issue 10

Abstract: The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the body. Whereas activation of PPARα is known to reduce the levels of ... ...

Abstract	The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the body. Whereas activation of PPARα is known to reduce the levels of circulating triglycerides and regulate energy homeostasis, the activation of PPARγ brings about insulin sensitization and increases the metabolism of glucose. On the other hand, PPARβ when activated increases the metabolism of fatty acids. Further, these PPARs have been claimed to be utilized in various metabolic, neurological, and inflammatory diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity. A series of different heterocyclic scaffolds have been synthesized and evaluated for their ability to act as PPAR agonists. This review is a compilation of efforts on the part of medicinal chemists around the world to find novel compounds that may act as PPAR ligands along with patents in regards to PPAR ligands. The structure-activity relationship, as well as docking studies, have been documented to better understand the mechanistic investigations of various compounds, which will eventually aid in the design and development of new PPAR ligands. From the results of the structural activity relationship through the pharmacological and in silico evaluation the potency of heterocycles as PPAR ligands can be described in terms of their hydrogen bonding, hydrophobic interactions, and other interactions with PPAR.
Language	English
Publishing date	2022-10-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14102139
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Article: Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release.

Mamidi, Narsimha / Velasco Delgadillo, Ramiro Manuel / Barrera, Enrique V

Pharmaceuticals (Basel, Switzerland)

2021 Volume 14, Issue 4

Abstract: Herein, poly ( ...

Abstract	Herein, poly (
Language	English
Publishing date	2021-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph14040291
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