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  1. Article ; Conference proceedings: Small intestinal villus vascularization is driven via an epithelial-to-endothelial PAR1 signaling axis

    Mimmler, M. / Dremova, O. / Mann, A. / Malinarich, F. / Vergnolle, N. / Motta, J.-P. / Kalte, I. / Mammadova, K. / Pontarollo, G. / Reinhardt, C.

    Hämostaseologie

    2024  Volume 44, Issue S 01

    Event/congress GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0044-1779238
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Microbial Bioconversion: A Regio-specific Method for Novel Drug Design and Toxicological Study of Metabolites.

    Yousuf, Maria / Jamil, Waqas / Mammadova, Khayala

    Current pharmaceutical biotechnology

    2019  Volume 20, Issue 14, Page(s) 1156–1162

    Abstract: The methods of chemical structural alteration of small organic molecules by using microbes (fungi, bacteria, yeast, etc.) are gaining tremendous attention to obtain structurally novel and therapeutically potential leads. The regiospecific mild ... ...

    Abstract The methods of chemical structural alteration of small organic molecules by using microbes (fungi, bacteria, yeast, etc.) are gaining tremendous attention to obtain structurally novel and therapeutically potential leads. The regiospecific mild environmental friendly reaction conditions with the ability of novel chemical structural modification in compounds categorize this technique; a distinguished and unique way to obtain medicinally important drugs and their in vivo mimic metabolites with costeffective and timely manner. This review article shortly addresses the immense pharmaceutical importance of microbial transformation methods in drug designing and development as well as the role of CYP450 enzymes in fungi to obtain in vivo drug metabolites for toxicological studies.
    MeSH term(s) Bacteria/metabolism ; Biotransformation ; Drug Design ; Fungi/metabolism ; Molecular Structure ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Stereoisomerism ; Substrate Specificity
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2019-07-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201020666190618115821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.

    Bayer, Franziska / Dremova, Olga / Khuu, My Phung / Mammadova, Könül / Pontarollo, Giulia / Kiouptsi, Klytaimnistra / Soshnikova, Natalia / May-Simera, Helen Louise / Endres, Kristina / Reinhardt, Christoph

    Nutrients

    2021  Volume 13, Issue 7

    Abstract: The gastrointestinal tract is a functionally and anatomically segmented organ that is colonized by microbial communities from birth. While the genetics of mouse gut development is increasingly understood, how nutritional factors and the commensal gut ... ...

    Abstract The gastrointestinal tract is a functionally and anatomically segmented organ that is colonized by microbial communities from birth. While the genetics of mouse gut development is increasingly understood, how nutritional factors and the commensal gut microbiota act in concert to shape tissue organization and morphology of this rapidly renewing organ remains enigmatic. Here, we provide an overview of embryonic mouse gut development, with a focus on the intestinal vasculature and the enteric nervous system. We review how nutrition and the gut microbiota affect the adaptation of cellular and morphologic properties of the intestine, and how these processes are interconnected with innate immunity. Furthermore, we discuss how nutritional and microbial factors impact the renewal and differentiation of the epithelial lineage, influence the adaptation of capillary networks organized in villus structures, and shape the enteric nervous system and the intestinal smooth muscle layers. Intriguingly, the anatomy of the gut shows remarkable flexibility to nutritional and microbial challenges in the adult organism.
    MeSH term(s) Animals ; Diet, High-Fat ; Endothelium/immunology ; Enteric Nervous System ; Epithelial Cells/immunology ; Gastrointestinal Microbiome/immunology ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Homeostasis ; Humans ; Immunity, Innate ; Intestinal Mucosa/immunology ; Mice ; Morphogenesis/physiology ; Nutritional Status ; Symbiosis/physiology
    Language English
    Publishing date 2021-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13072198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emotional well-being and pain could be a greater determinant of quality of life compared to motor severity in cervical dystonia.

    Klingelhoefer, Lisa / Kaiser, Maximilian / Sauerbier, Anna / Untucht, Robert / Wienecke, Miriam / Mammadova, Könül / Falkenburger, Björn / Gregor, Olaf / Chaudhuri, K Ray / Reichmann, Heinz

    Journal of neural transmission (Vienna, Austria : 1996)

    2020  Volume 128, Issue 3, Page(s) 305–314

    Abstract: Non-motor symptoms (NMS) occur in patients with cervical dystonia (CD) but with variable frequencies and impact on health-related quality of life (HRQoL). To define non-motor and motor profiles and their respective impact on HRQoL in CD patients using ... ...

    Abstract Non-motor symptoms (NMS) occur in patients with cervical dystonia (CD) but with variable frequencies and impact on health-related quality of life (HRQoL). To define non-motor and motor profiles and their respective impact on HRQoL in CD patients using the newly validated Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest). In an observational prospective multicentre case-control study, we enrolled 61 patients with CD and 61 age- and sex-matched healthy controls (HC) comparing demographic data, motor and non-motor symptoms and HRQoL measurements. 95% CD patients reported at least one NMS. Mean total NMS score was significantly higher in CD patients (5.62 ± 3.33) than in HC (1.74 ± 1.52; p < 0.001). Pain, insomnia and stigma were the most prevalent NMS and HRQoL was significantly impaired in CD patients compared to HC. There was strong correlation of NMS burden with HRQoL (CDQ-24: r = 0.72, EQ-5D: r = - 0.59; p < 0.001) in CD patients. Regression analysis between HRQoL and NMS suggested that emotional well-being (standardized beta = - 0.352) and pain (standardized beta = - 0.291) had a major impact on HRQoL while, in contrast motor severity had no significant impact in this model. Most NMS with the exception of pain, stigma and ADL did not correlate with motor severity. NMS are highly prevalent in CD patients and occur independent of age, sex, disease duration, duration of botulinum neurotoxin therapy and socio-economic status. Specific NMS such as emotional well-being and pain have a major impact on HRQoL and are more relevant than motor severity.
    MeSH term(s) Case-Control Studies ; Humans ; Pain ; Prospective Studies ; Quality of Life ; Torticollis
    Language English
    Publishing date 2020-11-04
    Publishing country Austria
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-020-02274-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.150: Show issues Location:
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