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  1. Article ; Online: Plasma cell dactylitis: a case report.

    Ye, L-R / Man, X-Y

    QJM : monthly journal of the Association of Physicians

    2023  Volume 116, Issue 12, Page(s) 1011–1012

    MeSH term(s) Humans ; Plasma Cells ; Arthritis, Psoriatic ; Fingers
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pirfenidone combined with corticosteroids in a patient with systemic lupus erythematosus-associated interstitial lung disease.

    Yang, B-B / Man, X-Y / Zheng, M

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2017  Volume 31, Issue 9, Page(s) e388–e389

    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Drug Therapy, Combination ; Female ; Glucocorticoids/administration & dosage ; Humans ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/etiology ; Lupus Erythematosus, Systemic/complications ; Middle Aged ; Prednisone/administration & dosage ; Pyridones/administration & dosage
    Chemical Substances Adrenal Cortex Hormones ; Anti-Inflammatory Agents, Non-Steroidal ; Glucocorticoids ; Pyridones ; pirfenidone (D7NLD2JX7U) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2017-04-12
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.14192
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 413: Show issues

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  3. Article ; Online: Expression of pigment epithelium-derived factor in human cutaneous appendages.

    Li, C-M / Li, W / Man, X-Y / Liu, Z-G / Zheng, M

    Clinical and experimental dermatology

    2013  Volume 38, Issue 6, Page(s) 652–658

    Abstract: Background: Pigment epithelium-derived factor (PEDF), a 50-kDa glycoprotein and a member of the serine protease inhibitor gene family, is well known as a potent endogenous inhibitor of angiogenesis. However, the expression of PEDF in human cutaneous ... ...

    Abstract Background: Pigment epithelium-derived factor (PEDF), a 50-kDa glycoprotein and a member of the serine protease inhibitor gene family, is well known as a potent endogenous inhibitor of angiogenesis. However, the expression of PEDF in human cutaneous appendages has not yet been determined.
    Aim: To investigate the expression of PEDF in human cutaneous appendages.
    Methods: Immunohistochemical staining was used to detect the expression of PEDF in human cutaneous appendages. Reverse transcriptase PCR, western blotting and indirect immunofluorescence were used to determine the mRNA and protein expression of PEDF on cells of the outer root sheath (ORS). A wound-healing assay was used to determine the effect of different concentrations of PEDF on the migration of ORS cells.
    Results: PEDF was expressed in the hair follicle (including epidermal matrix, inner root sheath, ORS and fibrous root sheath), sebaceous glands and eccrine sweat glands. Both protein and RNA expression of PEDF was detected, and expression was localized to both cytoplasm and nucleus of ORS cells. Both interleukin (IL)-4 and IL-17 at 25 ng/mL upregulated the expression of PEDF of ORS cells, with IL-4 having the greater effect. PEDF 50 ng/mL decreased migration of ORS cells.
    Conclusions: PEDF is expressed in human cutaneous appendages and may play a modulatory role in the physiology of ORS cells.
    MeSH term(s) Adult ; Blotting, Western ; Cell Movement/drug effects ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Eccrine Glands/metabolism ; Eye Proteins/metabolism ; Eye Proteins/pharmacology ; Female ; Hair Follicle/metabolism ; Humans ; Immunohistochemistry ; Interleukin-17/pharmacology ; Interleukin-4/pharmacology ; Male ; Nerve Growth Factors/metabolism ; Nerve Growth Factors/pharmacology ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sebaceous Glands/metabolism ; Serpins/metabolism ; Serpins/pharmacology ; Young Adult
    Chemical Substances Eye Proteins ; Interleukin-17 ; Nerve Growth Factors ; RNA, Messenger ; Serpins ; pigment epithelium-derived factor ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.12066
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1278: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Regulation of integrin α5 and β4 in normal and scleroderma epidermal keratinocytes.

    Zhou, J / Man, X-Y / Li, W / Chen, J-Q / Cai, S-Q / Zheng, M

    The British journal of dermatology

    2012  Volume 166, Issue 6, Page(s) 1369–1370

    MeSH term(s) Cytokines/metabolism ; Humans ; Immunohistochemistry ; Integrin alpha5/metabolism ; Integrin beta4/metabolism ; Keratinocytes/metabolism ; Scleroderma, Systemic/metabolism
    Chemical Substances Cytokines ; Integrin alpha5 ; Integrin beta4
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.2012.10795.x
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  5. Article ; Online: Role of endothelin-1 in the skin fibrosis of systemic sclerosis.

    Jing, J / Dou, T T / Yang, J Q / Chen, X B / Cao, H L / Min, M / Cai, S Q / Zheng, M / Man, X Y

    European cytokine network

    2015  Volume 26, Issue 1, Page(s) 10–14

    Abstract: Endothelin-1 (ET-1) acts as a key regulator of vasoconstriction and fibrosis. Many previous studies have focused on the role of ET-1 in scleroderma (systemic sclerosis, SSc). We investigated the effects of ET-1 on the production of extracellular matrix ... ...

    Abstract Endothelin-1 (ET-1) acts as a key regulator of vasoconstriction and fibrosis. Many previous studies have focused on the role of ET-1 in scleroderma (systemic sclerosis, SSc). We investigated the effects of ET-1 on the production of extracellular matrix in SSc and normal skin fibroblasts. Primary cultured dermal fibroblasts from SSc patients and healthy controls were treated with ET-1 (25 ng/mL) for 0 min, 15 min, 1 h, 24 h, 48 h and 72 h, respectively. Our results showed that, in SSc fibroblasts, ET-1 upregulated collagen type I, connective tissue growth factor (CTGF), type I plasminogen activator inhibitor (PAI-1) and pAkt in a time-dependent manner within 72 h; in normal fibroblasts, 25 ng/mL ET-1 stimulation correlated with high levels of CTGF, PAI-1 and pAkt. The secretion of fibronectin (FN), collagen type I, and PAI-1 is markedly increased in the supernatant of both SSc fibroblasts and normal fibroblasts. Furthermore, ET-1 phosphorylates Smad2 and Smad3 in normal fibroblasts, but not in SSc fibroblasts. In conclusion, our results demonstrated that ET-1 may induce fibrosis in dermal fibroblasts through Akt signals.
    MeSH term(s) Adult ; Case-Control Studies ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Connective Tissue Growth Factor/genetics ; Connective Tissue Growth Factor/metabolism ; Endothelin-1/metabolism ; Endothelin-1/pharmacology ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibronectins/biosynthesis ; Fibronectins/metabolism ; Fibrosis ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Phosphorylation ; Plasminogen Activator Inhibitor 1/genetics ; Plasminogen Activator Inhibitor 1/metabolism ; Primary Cell Culture ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/metabolism ; Scleroderma, Systemic/pathology ; Signal Transduction ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Smad2 Protein/genetics ; Smad2 Protein/metabolism ; Smad3 Protein/genetics ; Smad3 Protein/metabolism
    Chemical Substances CCN2 protein, human ; Collagen Type I ; Endothelin-1 ; Fibronectins ; Plasminogen Activator Inhibitor 1 ; Recombinant Proteins ; SERPINE1 protein, human ; SMAD2 protein, human ; SMAD3 protein, human ; Smad2 Protein ; Smad3 Protein ; Connective Tissue Growth Factor (139568-91-5) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2015-05-14
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2015.0360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3447: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Expression and localization of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 in human epidermal appendages: a comparison study by immunofluorescence.

    Man, X-Y / Yang, X-H / Cai, S-Q / Bu, Z-Y / Wu, X-J / Lu, Z-F / Zheng, M

    Clinical and experimental dermatology

    2009  Volume 34, Issue 3, Page(s) 396–401

    Abstract: Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis and plays important roles in neovascularization and development of tissues. VEGF receptors (VEGFRs) are high-affinity receptors for VEGF and are originally considered specific ... ...

    Abstract Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis and plays important roles in neovascularization and development of tissues. VEGF receptors (VEGFRs) are high-affinity receptors for VEGF and are originally considered specific to endothelial cells. We have previously shown that keratinocytes from human normal skin express VEGFRs. This poses the question of whether these receptors are also expressed by epidermal appendages, as epidermal appendages are lined with epithelial cells.
    Objective: To investigate the expression of VEGFR-2 compare with VEGF in epidermal appendages, including hair follicles, eccrine sweat glands and sebaceous glands.
    Methods: Monoclonal antibodies to VEGF and VEGFR-2 were used for immunohistochemical examination of cryostat-cut sections of normal human skin specimens from 11 donors undergoing cosmetic surgery.
    Results: Immunoreactivities for VEGF and VEGFR-2 principally showed parallel intense expression in anagen hair follicle (including outer root sheat, inner root sheath, dermal papillae epidermal matrix), sebaceous glands (ductal and secretory portions) and eccrine sweat glands (ductal and secretory portions), respectively. In particular, abundant expression of VEGF was found in the follicular basement membrane zone surrounding the bulb matrix and in the ductal and secretory portions of eccrine sweat glands.
    Conclusion: A potential VEGF/VEGFR-2 autocrine pathway may be defined by the coexpression of VEGF and VEGFR-2 in human skin epidermal appendages.
    MeSH term(s) Adolescent ; Adult ; Aged ; Basement Membrane/metabolism ; Child ; Eccrine Glands/metabolism ; Epidermis/metabolism ; Female ; Fluorescent Antibody Technique, Indirect ; Hair Follicle/metabolism ; Humans ; Male ; Middle Aged ; Sebaceous Glands/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Young Adult
    Chemical Substances VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2009-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/j.1365-2230.2008.03104.x
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    Zs.A 1278: Show issues Location:
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  7. Article: Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

    Man, X-Y / Luo, H-R / Li, X-P / Yao, Y-G / Mao, C-Z / Zhang, Y-P

    Annals of the rheumatic diseases

    2003  Volume 62, Issue 1, Page(s) 71–73

    Abstract: Objective: To investigate the association of complement C4 null genes (C4Q0, including C4AQ0 and C4BQ0) and C2 gene with systemic lupus erythematosus (SLE) in southwest Han Chinese; 136 patients with SLE and 174 matched controls were genotyped.: ... ...

    Abstract Objective: To investigate the association of complement C4 null genes (C4Q0, including C4AQ0 and C4BQ0) and C2 gene with systemic lupus erythematosus (SLE) in southwest Han Chinese; 136 patients with SLE and 174 matched controls were genotyped.
    Methods: C4 null genes were determined by a polymerase chain reaction (PCR) procedure with sequence specific primers (PCR-SSP). The 2 bp insertion in exon 29, which was previously identified in non-Chinese populations and caused defective C4A genes, was directly typed by sequencing the whole exon 29 using exon specific primers. The exon 6 of complement C2 was also sequenced in both the patients and controls.
    Results: The frequency of homozygous C4AQ0 allele was 12.5% (17/136) in patients with SLE compared with 1.1% (2/174) in controls (p<0.001, odds ratio (OR)=12.286, 95% confidence interval (95% CI) 2.786 to 54.170). There was no significant difference for homozygous C4BQ0 allele between patients with SLE and controls (p=0.699). Patients with the C4AQ0 gene had an increased risk of acquiring renal disorder, serositis, and anti-dsDNA antibodies compared with those without C4AQ0 (for renal disorder, p=0.018, OR=8.951, 95% CI 1.132 to 70.804; for serositis, p=0.011, OR 4.891, 95% CI 1.574 to 15.198; for anti-dsDNA, p=0.004, OR 7.630, 95%CI 1.636 to 35.584). None of the patients or controls had the 2 bp insertion in exon 29 of the C4 gene. The type I C2 deficiency was not detected in the 310 samples.
    Conclusion: It is suggested that deficiency of C4A (not due to a 2 bp insertion in exon 29), but not C4B or C2, may be a risk factor for acquiring SLE in south west Han Chinese; this results in increased risk of renal disorder, serositis, and anti-dsDNA antibodies in patients with SLE. Racial differences seem to be relevant in susceptibility to SLE
    MeSH term(s) Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; China/ethnology ; Complement C2/genetics ; Complement C4/genetics ; Complement C4a/genetics ; Complement C4b/genetics ; Female ; Gene Deletion ; Gene Frequency ; Genotype ; Homozygote ; Humans ; Lupus Erythematosus, Systemic/ethnology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/pathology ; Male ; Middle Aged ; Phenotype ; Polymerase Chain Reaction/methods
    Chemical Substances Complement C2 ; Complement C4 ; Complement C4a (80295-49-4) ; Complement C4b (80295-50-7)
    Language English
    Publishing date 2003-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard.62.1.71
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 167: Show issues

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