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  1. Article ; Online: Protein Supplementation in a Prehabilitation Program in Patients Undergoing Surgery for Endometrial Cancer.

    Sole-Sedeno, Josep M / Miralpeix, Ester / Muns, Maria-Dolors / Rodriguez-Cosmen, Cristina / Fabrego, Berta / Kanjou, Nadwa / Medina, Francesc-Xavier / Mancebo, Gemma

    International journal of environmental research and public health

    2023  Volume 20, Issue 8

    Abstract: Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways to reduce stress response and improve perioperative outcomes, which also include nutritional interventions. The aim of this study is to assess the ... ...

    Abstract Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways to reduce stress response and improve perioperative outcomes, which also include nutritional interventions. The aim of this study is to assess the impact of protein supplementation with 20 mg per day before surgery in a prehabilitation program in postoperative serum albumin, prealbumin, and total proteins in endometrial cancer patients undergoing laparoscopic surgery.
    Methods: A prospective study including patients who underwent laparoscopy for endometrial cancer was conducted. Three groups were identified according to ERAS and prehabilitation implementation (preERAS, ERAS, and Prehab). The primary outcome was levels of serum albumin, prealbumin, and total protein 24-48 h after surgery.
    Results: A total of 185 patients were included: 57 in the preERAS group, 60 in the ERAS group, and 68 in the Prehab group. There were no basal differences in serum albumin, prealbumin, or total protein between the three groups. After surgery, regardless of the nutritional intervention, the decrease in the values was also similar. Moreover, values in the Prehab group just before surgery were lower than the initial ones, despite the protein supplementation.
    Conclusions: Supplementation with 20 mg of protein per day does not impact serum protein levels in a prehabilitation program. Supplementations with higher quantities should be studied.
    MeSH term(s) Humans ; Female ; Preoperative Exercise ; Prealbumin ; Prospective Studies ; Endometrial Neoplasms/surgery ; Dietary Supplements
    Chemical Substances Prealbumin
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20085502
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  2. Article ; Online: Prehabilitation in an ERAS program for endometrial cancer patients: impact on post-operative recovery.

    Miralpeix, Ester / Fabregó, Berta / Rodriguez-Cosmen, Cristina / Solé-Sedeño, Josep-Maria / Gayete, Sonia / Jara-Bogunya, David / Corcoy, Marta / Mancebo, Gemma

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 4, Page(s) 528–533

    Abstract: Objectives: Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways that aim to reduce stress response and improve perioperative outcomes. However, literature is limited regarding the impact of ERAS and ... ...

    Abstract Objectives: Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways that aim to reduce stress response and improve perioperative outcomes. However, literature is limited regarding the impact of ERAS and prehabilitation in gynecologic oncology surgery. The aim of this study was to assess the impact of implementing an ERAS and prehabilitation program on post-operative outcomes of endometrial cancer patients undergoing laparoscopic surgery.
    Methods: We evaluated consecutive patients undergoing laparoscopy for endometrial cancer that followed ERAS and the prehabilitation program at a single center. A pre-intervention cohort that followed the ERAS program alone was identified. The primary outcome was length of stay, and secondary outcomes were normal oral diet restart, post-operative complications and readmissions.
    Results: A total of 128 patients were included: 60 patients in the ERAS group and 68 patients in the prehabilitation group. The prehabilitation group had a shorter length of hospital stay of 1 day (p<0.001) and earlier normal oral diet restart of 3.6 hours (p=0.005) in comparison with the ERAS group. The rate of post-operative complications (5% in the ERAS group and 7.4% in the prehabilitation group, p=0.58) and readmissions (1.7% in the ERAS group and 2.9% in the prehabilitation group, p=0.63) were similar between groups.
    Conclusions: The integration of ERAS and a prehabilitation program in endometrial cancer patients undergoing laparoscopy significantly reduced hospital stay and time to first oral diet as compared with ERAS alone, without increasing overall complications or the readmissions rate.
    MeSH term(s) Humans ; Female ; Enhanced Recovery After Surgery ; Preoperative Exercise ; Postoperative Complications/prevention & control ; Gynecologic Surgical Procedures ; Length of Stay ; Endometrial Neoplasms/surgery
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-004130
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  3. Article ; Online: Impact of prehabilitation during neoadjuvant chemotherapy and interval cytoreductive surgery on ovarian cancer patients: a pilot study.

    Miralpeix, Ester / Sole-Sedeno, Josep-Maria / Rodriguez-Cosmen, Cristina / Taus, Alvaro / Muns, Maria-Dolors / Fabregó, Berta / Mancebo, Gemma

    World journal of surgical oncology

    2022  Volume 20, Issue 1, Page(s) 46

    Abstract: Background: Cytoreductive surgery followed by systemic chemotherapy is the standard of treatment in advanced ovarian cancer where feasible. Neoadjuvant chemotherapy (NACT) followed by surgery is applicable where upfront cytoreductive surgery is not ... ...

    Abstract Background: Cytoreductive surgery followed by systemic chemotherapy is the standard of treatment in advanced ovarian cancer where feasible. Neoadjuvant chemotherapy (NACT) followed by surgery is applicable where upfront cytoreductive surgery is not feasible because of few certain reasons. Nevertheless, surgical interventions and the chemotherapy itself may be associated with postoperative complications usually entailing slow postoperative recovery. Prehabilitation programs consist of the patient's preparation before surgery to improve the patient's functional capacity. The aim of this study was to evaluate the impact of a prehabilitation program during neoadjuvant treatment and interval cytoreductive surgery for ovarian cancer patients.
    Methods: A retrospective observational pilot study of patients with advanced ovarian cancer treated with NACT and interval cytoreductive surgery was conducted. The prehabilitation group received a structured intervention based on physical exercise, nutritional counseling, and psychological support. Nutritional parameters were assessed preoperatively and postoperatively, and functional parameters and perioperative and postoperative complications were also recorded.
    Results: A total of 29 patients were included in the study: 14 in the prehabilitation group and 15 in the control group. The patients in the prehabilitation program showed higher mean total protein levels in both preoperative (7.4 vs. 6.8, p = 0.004) and postoperative (4.9 vs. 4.3, p = 0.005) assessments. Up to 40% of controls showed intraoperative complications vs. 14.3% of patients in the prehabilitation group, and the requirement of intraoperative blood transfusion was significantly lower in the prehabilitation group (14.3% vs. 53.3%, p = 0.027). The day of the first ambulation, rate of postoperative complications, and length of hospital stay were similar between the groups. Finally, trends towards shorter time between diagnosis and interval cytoreductive surgery (p = 0.097) and earlier postoperative diet restart (p = 0.169) were observed in the prehabilitation group.
    Conclusion: Prehabilitation during NACT in women with ovarian cancer candidates to interval cytoreductive surgery may improve nutritional parameters and thereby increase postoperative recovery. Nevertheless, the results of this pilot study are preliminary, and further studies are needed to determine the clinical impact of prehabilitation programs.
    MeSH term(s) Chemotherapy, Adjuvant/methods ; Cytoreduction Surgical Procedures/methods ; Female ; Humans ; Neoadjuvant Therapy/methods ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery ; Pilot Projects ; Preoperative Exercise ; Retrospective Studies
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-022-02517-1
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  4. Article ; Online: Influence of age on treatment and prognosis of invasive cervical cancer.

    Mancebo, Gemma / Miralpeix, Ester / Solé-Sedeño, Josep-Maria / Tió, Gisela / Rodrigo-Calvo, Teresa / Lloveras, Belen / Alameda, Francesc

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 262, Page(s) 68–72

    Abstract: Objective: Invasive cervical cancer is considered a young women's disease, however up to 20 % of cases develop cervical cancer at advanced ages. The aim was to characterize invasive cervical cancer in women aged 65 and older assessing age-specific ... ...

    Abstract Objective: Invasive cervical cancer is considered a young women's disease, however up to 20 % of cases develop cervical cancer at advanced ages. The aim was to characterize invasive cervical cancer in women aged 65 and older assessing age-specific survival differences.
    Study design: A retrospective study including cervical cancer patients was conducted at Hospital del Mar Barcelona from July-2007 to December-2016. Women were stratified: <65 or ≥65years. Clinical and pathological data were collected. Multivariate analysis was used to compare outcomes. Adjusted hazard ratios with 95 % confidence intervals for disease-free survival, and overall survival were estimated using Cox proportional hazards models.
    Results: 124 patients with invasive cervical cancer (n = 87 < 65years and n = 37 ≥ 65years) were included. At diagnosis, 48.3 % of <65years patients were diagnosed at advanced stages, while 64.9 % in ≥65years (p = 0.018). Standard treatment was given to 83.9 % of patients in <65years group compared to 62.2 % in ≥65years (p = 0.015). Disease-free survival and overall survival showed no significant differences between groups. Age ≥65 did not predict worse disease-free survival (HR: 0.3 95 %CI, 0.04-3.1, p = 0.347) or overall survival (HR: 0.82 95 %CI, 0.3-2.3, p = 0.729).
    Conclusion: Invasive cervical cancer was diagnosed at advanced stages and was treated less frequently with radical intention in patients ≥65years; overall survival and disease-free survival were similar to those cervical cancer diagnosed at younger ages.
    MeSH term(s) Disease-Free Survival ; Female ; Humans ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Uterine Cervical Neoplasms/pathology
    Language English
    Publishing date 2021-05-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.04.040
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    Zs.A 837: Show issues Location:
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  5. Article ; Online: Predictor factors for conservative management of cervical intraepithelial neoplasia grade 2: Cytology and HPV genotyping.

    Salvadó, Ariadna / Miralpeix, Ester / Solé-Sedeno, Josep M / Kanjou, Nadwa / Lloveras, Belen / Duran, Xavier / Mancebo, Gemma

    Gynecologic oncology

    2021  Volume 162, Issue 3, Page(s) 569–574

    Abstract: Objective: The purpose of this study was to evaluate the role of HPV genotyping and previous cytology result to predict the evolution of CIN2 histological lesions managed conservatively.: Methods: A prospective observational study was conducted at ... ...

    Abstract Objective: The purpose of this study was to evaluate the role of HPV genotyping and previous cytology result to predict the evolution of CIN2 histological lesions managed conservatively.
    Methods: A prospective observational study was conducted at Hospital del Mar in Barcelona from January 2012 to May 2017. Women with new diagnosis of CIN2 were invited to undergo conservative management for 24 months. Complete regression, partial regression, persistence and progression to CIN3 were defined as final outcomes. Univariate and multivariate analyses combining HPV genotyping and cytology were used to establish progression predictors of CIN2.
    Results: A total of 300 patients were included in the study, and 291 patients completed the 24-months follow-up. Of them, 214 patients (73.5%) showed regression; 43 (14.8%) persistence to CIN2, and 34 (11.7%) progression to CIN3. In multivariable analysis, HPV-16 infection (odds ratio [OR] 1.97, [95% confidence interval {CI} 1.13-3.43]) and previous HSIL cytology (OR 3.46, [95% CI 1.99-6.02]) significantly increased the risk of persistence or progression (CIN2+) of CIN2 lesions. In contrast, all HPV-negative lesions regressed (p < 0.001).
    Conclusions: The regression rate of CIN2 lesions supports conservative management in selected patients regardless of their age. Patients with a CIN2 biopsy and negative HPV test had a high rate of regression and should be offered follow-up without excisional treatment. In contrast, patients with HPV-16 and HSIL cytology had an increased risk of CIN2+, their treatment should be individualized and excisional treatment should be considered. The age may not be considered a criterion to decide the best management. New markers may help in the future to select the best management of CIN2.
    MeSH term(s) Adult ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/therapy ; Cervical Intraepithelial Neoplasia/virology ; Conservative Treatment ; Female ; Genotype ; Human papillomavirus 16/genetics ; Human papillomavirus 16/isolation & purification ; Humans ; Neoplasm Grading ; Papillomavirus Infections/pathology ; Papillomavirus Infections/therapy ; Papillomavirus Infections/virology ; Precancerous Conditions/pathology ; Precancerous Conditions/virology ; Predictive Value of Tests ; Prospective Studies ; Squamous Intraepithelial Lesions of the Cervix/pathology ; Squamous Intraepithelial Lesions of the Cervix/virology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Neoplasms/virology ; Young Adult
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2021.06.019
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    Zs.A 885: Show issues Location:
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  6. Article ; Online: The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification.

    Vrede, S W / Hulsman, A M C / Reijnen, C / Van de Vijver, K / Colas, E / Mancebo, G / Moiola, C P / Gil-Moreno, A / Huvila, J / Koskas, M / Weinberger, V / Minar, L / Jandakova, E / Santacana, M / Matias-Guiu, X / Amant, F / Snijders, M P L M / Küsters-Vandevelde, H V N / Bulten, J /
    Pijnenborg, J M A

    Gynecologic oncology

    2022  Volume 167, Issue 2, Page(s) 196–204

    Abstract: Objective: To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling ... ...

    Abstract Objective: To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome.
    Methods: A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1-2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC).
    Results: The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm
    Conclusion: The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.
    MeSH term(s) Female ; Humans ; Retrospective Studies ; Biopsy/methods ; Endometrial Neoplasms/pathology ; Endometrium/pathology ; Carcinoma, Endometrioid/surgery ; Carcinoma, Endometrioid/pathology
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2022.08.016
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  7. Article ; Online: Role and impact of multimodal prehabilitation for gynecologic oncology patients in an Enhanced Recovery After Surgery (ERAS) program.

    Miralpeix, Ester / Mancebo, Gemma / Gayete, Sonia / Corcoy, Marta / Solé-Sedeño, Josep-Maria

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2019  Volume 29, Issue 8, Page(s) 1235–1243

    Abstract: Patients undergoing major surgery are predisposed to a decrease in functional capacity as a response to surgical stress that can delay post-operative recovery. A prehabilitation program consists of patient preparation strategies before surgery, and ... ...

    Abstract Patients undergoing major surgery are predisposed to a decrease in functional capacity as a response to surgical stress that can delay post-operative recovery. A prehabilitation program consists of patient preparation strategies before surgery, and include pre-operative measures to improve functional capacity and enhance post-operative recovery. Multimodal prehabilitation may include exercise, nutritional counseling, psychological support, and optimization of underlying medical conditions, as well as cessation of unfavorable health behaviors such as smoking and drinking. Currently, there are no standardized guidelines for prehabilitation, and the existent studies are heterogeneous; however, multimodal approaches are likely to have a greater impact on functional outcomes than single management programs. We have reviewed the literature on prehabilitation in general, and in gynecologic surgery in particular, to identify tools to establish an optimal prehabilitation program within an Enhanced Recovery After Surgery (ERAS) protocol for gynecologic oncology patients. We suggest a safe, reproducible, functional, and easy-to-apply multimodal prehabilitation program for gynecologic oncology practice based on patient-tailored pre-operative medical optimization, physical training, nutritional counseling, and psychological support. The analysis of the prehabilitation program implementation in an ERAS protocol should undergo further research in order to test the efficacy on surgical outcome and recovery after surgery.
    MeSH term(s) Enhanced Recovery After Surgery ; Female ; Genital Neoplasms, Female/rehabilitation ; Genital Neoplasms, Female/surgery ; Gynecologic Surgical Procedures/methods ; Gynecologic Surgical Procedures/standards ; Humans ; Observational Studies as Topic ; Preoperative Care/methods ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2019-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2019-000597
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    Zs.A 3198: Show issues Location:
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  8. Article ; Online: Procalcitonin and C-reactive protein as early markers of anastomotic leakage in intestinal resections for advanced ovarian cancer (EDMOCS).

    Sánchez-Iglesias, José Luis / Morales-Coma, Clara / Minig, Lucas / Lago, Víctor / Domingo, Santiago / Mancebo, Gemma / Siegrist, Jaime / Fidalgo García, María Soledad / Llueca, Antoni / Serra, Anna / Cobas Lozano, Paloma / Lekuona Artola, Arantza / Gómez-Hidalgo, Natalia R / Acosta, Úrsula / Ferrer-Costa, Roser / Bradbury, Melissa / Pérez-Benavente, Assumpció / Gil-Moreno, Antonio

    Acta obstetricia et gynecologica Scandinavica

    2024  

    Abstract: Introduction: Serum levels of procalcitonin and C-reactive protein (CRP) have been used to predict anastomotic leakage after colorectal surgery, but information is scarce in advanced ovarian cancer (AOC) surgery with bowel resection. This study aimed to ...

    Abstract Introduction: Serum levels of procalcitonin and C-reactive protein (CRP) have been used to predict anastomotic leakage after colorectal surgery, but information is scarce in advanced ovarian cancer (AOC) surgery with bowel resection. This study aimed to assess the predictive value of procalcitonin and CRP in detecting anastomotic leakage after AOC surgery with bowel resection. The study also aimed to determine the optimal postoperative reference values and the best day for evaluating these markers.
    Material and methods: This prospective, observational and multicentric trial included 92 patients with AOC undergoing debulking surgery with bowel resection between 2017 and 2020 in 10 reference hospitals in Spain. Procalcitonin and CRP levels were measured at baseline and on postoperative days 1-6. Receiver operating characteristic analysis was performed to evaluate the predictive value of procalcitonin and CRP at each postoperative day. Sensitivity, specificity, positive and negative predictive values were calculated.
    Results: Anastomotic leakage was detected in six patients (6.5%). Procalcitonin and CRP values were consistently higher in patients with anastomotic leakage at all postoperative days. The maximum area under the curve (AUC) for procalcitonin was observed at postoperative day 1 (AUC = 0.823) with a cutoff value of 3.8 ng/mL (83.3% sensitivity, 81.3% specificity). For CRP, the maximum AUC was found at postoperative day 3 (AUC = 0.833) with a cutoff level of 30.5 mg/dL (100% sensitivity, 80.4% specificity).
    Conclusions: Procalcitonin and C-reactive protein are potential biomarkers for early detection of anastomotic leakage after ovarian cancer surgery with bowel resection. Further prospective studies with a larger sample size are needed to confirm these findings.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14834
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  9. Article ; Online: Psychological impact of COVID-19 lockdown on a population with serious mental illness. A prospective cohort study.

    Pedruzo, Borja / Catalan, Ana / Aymerich, Claudia / Bordenave, Marta / Estevez, Olatz / Gómez, Diego Aurofio / Herrero, Jon / Laborda, María / Mancebo, Gonzalo / Martínez, Ania / Pacho, Malein / Paniagua, Ana / Pérez, José Luis / González-Torres, Miguel Ángel

    Revista de psiquiatria y salud mental

    2022  Volume 16, Page(s) 59–67

    Abstract: Introduction: COVID-19 has spread worldwide since its appearance at the end of 2019. In Spain, 99-day long home confinement was set from March 15th 2020. Previous studies about events requiring situations of isolation suggested that mental health ... ...

    Abstract Introduction: COVID-19 has spread worldwide since its appearance at the end of 2019. In Spain, 99-day long home confinement was set from March 15th 2020. Previous studies about events requiring situations of isolation suggested that mental health problems may occur among the general population and, more specifically, vulnerable groups such as individuals with serious mental illness (SMI). This study aims to assess the psychological effect of confinement in patients with mental illness admitted to an inpatient psychiatric unit.
    Method: In this longitudinal study, IDER (State-Trait Depression Inventory) and STAI (State-Trait Anxiety Inventory) questionnaires were used at two different times (at the beginning and after the lockdown) of the pandemic to evaluate the depression and anxiety symptoms, respectively, in a population of patients who had been previously admitted to the Psychiatry Unit of the Basurto University Hospital.
    Results: 95 participants completed the IDER questionnaire in the first measurement, with a mean score of 24.56 (SD = 8.18) for state and 23.57 (SD = 8.14) for trait. In the case of STAI, the mean score was 27.86 (SD = 15.19) for the state and 30.49 (SD = 14.71) for the trait. No differences between the first and the second time were found in anxiety and depression levels. People with personality disorders presented high levels of anxiety.
    Conclusions: Individuals with a personality disorder showed the highest scores in anxiety and depression. Nevertheless, strict confinement did not affect this population, despite the literature that evidences that the pandemic has worsened people's mental health with SMI.
    Language English
    Publishing date 2022-06-17
    Publishing country Spain
    Document type Journal Article
    ISSN 1989-4600
    ISSN (online) 1989-4600
    DOI 10.1016/j.rpsm.2022.04.004
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  10. Article ; Online: COVID-19 pandemic effects on health worker's mental health: Systematic review and meta-analysis.

    Aymerich, Claudia / Pedruzo, Borja / Pérez, Jose Luís / Laborda, Maria / Herrero, Jon / Blanco, Jorge / Mancebo, Gonzalo / Andrés, Lucía / Estévez, Olatz / Fernandez, Maitane / Salazar de Pablo, Gonzalo / Catalan, Ana / González-Torres, Miguel Ángel

    European psychiatry : the journal of the Association of European Psychiatrists

    2022  Volume 65, Issue 1, Page(s) e10

    Abstract: Background: Healthcare workers (HCWs) exposed to coronavirus 19 (COVID-19) are at high risk of developing mental health concerns across several domains. The aim of this study is to determine the updated, global frequency of these outcomes.: Methods: ... ...

    Abstract Background: Healthcare workers (HCWs) exposed to coronavirus 19 (COVID-19) are at high risk of developing mental health concerns across several domains. The aim of this study is to determine the updated, global frequency of these outcomes.
    Methods: A multistep literature search was performed from database inception until March 1, 2021. PRISMA/MOOSE-compliant systematic review and PROSPERO protocol were used to identify studies reporting on depression, anxiety, acute stress, post-traumatic symptoms, insomnia, and burnout in HCWs exposed to COVID-19. A quantitative meta-analysis with random effects was conducted to analyze the proportion rate of the mental health disorders. Sensitivity analyses were performed to investigate the effect of the different continents and scales. Meta-regression analyses were conducted to examine the effect of gender, age, and work position.
    Results: 239 articles were included (n = 271,319 HCWs, mean age = 36.08 ± 8.33 (66.99% female). 33% HCWs exposed to COVID-19 reported depressive symptoms (95% confidence intervals [CI] = 28-38%), 42% anxiety features (95% CI = 35-48), 40% acute stress (95% CI = 32-47), 32% post-traumatic symptoms (95% CI = 26-37%), 42% insomnia (95% CI = 36-48), 37% burnout (95% CI = 31-42). Sensitivity analyses did not show statistically significant differences. Meta-regressions found a statistically significant lower prevalence of post-traumatic symptoms in Asia.
    Conclusions: HCWs exposed to COVID-19 were found to have a significant prevalence of mental health concerns in all domains analyzed. The effects of COVID-19 on HCWs' mental health could be underestimated and the future consequences dismissed.
    MeSH term(s) COVID-19 ; Depression/epidemiology ; Female ; Humans ; Male ; Mental Health ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 1074337-6
    ISSN 1778-3585 ; 0767-399X ; 0924-9338
    ISSN (online) 1778-3585
    ISSN 0767-399X ; 0924-9338
    DOI 10.1192/j.eurpsy.2022.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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