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  1. Book ; Online: Gynaecological Cancers Risk : Breast Cancer, Ovarian Cancer and Endometrial Cancer

    Manchanda, Ranjit

    2022  

    Keywords Public health & preventive medicine ; breast cancer ; galectins ; galectin-7 ; galectin-8 ; prognostic markers ; tumor infiltrating macrophages ; screening ; mammography ; incidence-based mortality ; population genetic testing ; ovarian cancer risk ; risk stratification ; BRCA1 ; BRCA2 ; RAD51C ; RAD51D ; BRIP1 ; SNP ; risk modelling ; BRCA ; population testing ; cost-effectiveness ; ovarian cancer ; cancer prevention ; CA125 ; HE4 ; UKCTOCS ; MMT ; postmenopausal women ; rare germline variants ; susceptibility genes ; genomics ; questionnaires ; attitudes ; symptoms ; early detection ; risk assessment ; diagnostic prediction model ; triage tool ; ovarian cancer symptoms ; family history ; risk ; genes ; prevention ; dyskerin ; DKC1 ; endometrial cancer ; telomerase ; proliferation ; telomeres ; obesity ; metabolomics ; liquid biopsy ; mass spectrometry ; plasma biomarkers ; artificial intelligence ; ultrasound ; TVS ; trial ; randomised controlled trial ; genomic sequencing ; tumor mutational signatures ; hereditary cancer genes ; mismatch repair ; familial cancer ; menopausal hormone therapy ; breast cancer risk ; BMI ; early BMI ; age of pregnancy ; mammographic density ; body mass index ; weight loss ; breast cancer prevention ; premenopausal ; genetic testing ; germline ; somatic ; n/a
    Size 1 electronic resource (338 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291828
    ISBN 9783036529820 ; 3036529829
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Special Issue "Gynaecological Cancers Risk: Breast Cancer, Ovarian Cancer and Endometrial Cancer".

    Manchanda, Ranjit

    Cancers

    2022  Volume 14, Issue 2

    Abstract: Over the last decade there have been significant advances and developments in our understanding of factors affecting women's cancer risk, our ability to identify individuals at increased risk and risk stratify populations, as well as implement and ... ...

    Abstract Over the last decade there have been significant advances and developments in our understanding of factors affecting women's cancer risk, our ability to identify individuals at increased risk and risk stratify populations, as well as implement and evaluate strategies for screening and prevention [...].
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14020319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advances in the screening and prevention of Women's cancers.

    Manchanda, Ranjit

    Best practice & research. Clinical obstetrics & gynaecology

    2020  Volume 65, Page(s) 1–2

    Language English
    Publishing date 2020-03-16
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2020.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ovarian cancer: identifying and managing familial and genetic risk-summary of new NICE guidance.

    Slade, Eric / Berg, Laura / Dworzynski, Katharina / Manchanda, Ranjit

    BMJ (Clinical research ed.)

    2024  Volume 385, Page(s) q807

    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/therapy ; Genetic Predisposition to Disease ; Genetic Testing ; Practice Guidelines as Topic ; Risk Assessment ; Risk Factors ; United Kingdom
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Screening and prevention of ovarian cancer.

    Sideris, Michail / Menon, Usha / Manchanda, Ranjit

    The Medical journal of Australia

    2024  Volume 220, Issue 5, Page(s) 264–274

    Abstract: Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and 207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to increase in Australia by 42% and 55% respectively by 2040. Earlier detection and ... ...

    Abstract Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and 207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to increase in Australia by 42% and 55% respectively by 2040. Earlier detection and significant downstaging of ovarian cancer have been demonstrated with multimodal screening in the largest randomised controlled trial of ovarian cancer screening in women at average population risk. However, none of the randomised trials have demonstrated a mortality benefit. Therefore, ovarian cancer screening is not currently recommended in women at average population risk. More frequent surveillance for ovarian cancer every three to four months in women at high risk has shown good performance characteristics and significant downstaging, but there is no available information on a survival benefit. Population testing offers an emerging novel strategy to identify women at high risk who can benefit from ovarian cancer prevention. Novel multicancer early detection biomarker, longitudinal multiple marker strategies, and new biomarkers are being investigated and evaluated for ovarian cancer screening. Risk-reducing salpingo-oophorectomy (RRSO) decreases ovarian cancer incidence and mortality and is recommended for women at over a 4-5% lifetime risk of ovarian cancer. Pre-menopausal women without contraindications to hormone replacement therapy (HRT) undergoing RRSO should be offered HRT until 51 years of age to minimise the detrimental consequences of premature menopause. Currently risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) should only be offered to women at increased risk of ovarian cancer within the context of a research trial. Pre-menopausal early salpingectomy is associated with fewer menopausal symptoms and better sexual function than bilateral salpingo-oophorectomy. A Sectioning and Extensively Examining the Fimbria (SEE-FIM) protocol should be used for histopathological assessment in women at high risk of ovarian cancer who are undergoing surgical prevention. Opportunistic salpingectomy may be offered at routine gynaecological surgery to all women who have completed their family. Long term prospective opportunistic salpingectomy studies are needed to determine the effect size of ovarian cancer risk reduction and the impact on menopause.
    MeSH term(s) Female ; Humans ; Prospective Studies ; Early Detection of Cancer ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/prevention & control ; Ovariectomy/adverse effects ; Ovariectomy/methods ; Salpingectomy/adverse effects ; Salpingectomy/methods
    Language English
    Publishing date 2024-02-14
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.52227
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  6. Article ; Online: Population-based genetic testing for cancer susceptibility genes: quo vadis?

    Manchanda, Ranjit / Sideris, Michail

    BJOG : an international journal of obstetrics and gynaecology

    2022  Volume 130, Issue 2, Page(s) 125–130

    MeSH term(s) Humans ; Genetic Testing ; Neoplasms/diagnosis ; Neoplasms/genetics
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.17283
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  7. Article ; Online: Prioritizing the detection of rare pathogenic variants in population screening.

    Lacaze, Paul / Manchanda, Ranjit / Green, Robert C

    Nature reviews. Genetics

    2023  Volume 24, Issue 4, Page(s) 205–206

    MeSH term(s) Humans ; Mutation ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-022-00571-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Patient-reported quality of life following prophylactic surgery for breast and ovarian cancer prevention: response.

    Wei, Xia / Oxley, Samuel / Sideris, Michail / Legood, Rosa / Manchanda, Ranjit

    American journal of obstetrics and gynecology

    2023  Volume 230, Issue 2, Page(s) 274–275

    MeSH term(s) Female ; Humans ; Quality of Life ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Breast ; Patient Reported Outcome Measures ; Breast Neoplasms/prevention & control ; Breast Neoplasms/surgery ; Ovariectomy ; Mutation
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.08.028
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  9. Article ; Online: Population-based Genetic Testing for Precision Prevention.

    Evans, Olivia / Manchanda, Ranjit

    Cancer prevention research (Philadelphia, Pa.)

    2020  Volume 13, Issue 8, Page(s) 643–648

    Abstract: Global interest in genetic testing for cancer susceptibility genes (CSG) has surged with falling costs, increasing awareness, and celebrity endorsement. Current access to genetic testing is based on clinical criteria/risk model assessment which uses ... ...

    Abstract Global interest in genetic testing for cancer susceptibility genes (CSG) has surged with falling costs, increasing awareness, and celebrity endorsement. Current access to genetic testing is based on clinical criteria/risk model assessment which uses family history as a surrogate. However, this approach is fraught with inequality, massive underutilization, and misses 50% CSG carriers. This reflects huge missed opportunities for precision prevention. Early CSG identification enables uptake of risk-reducing strategies in unaffected individuals to reduce cancer risk. Population-based genetic testing (PGT) can overcome limitations of clinical criteria/family history-based testing. Jewish population studies show population-based
    MeSH term(s) Biomarkers, Tumor/genetics ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/prevention & control ; Cost-Benefit Analysis ; Counseling/economics ; Counseling/methods ; DNA Mutational Analysis/economics ; DNA Mutational Analysis/methods ; Early Detection of Cancer/economics ; Early Detection of Cancer/methods ; Female ; Genetic Predisposition to Disease ; Genetic Testing/economics ; Genetic Testing/methods ; Heterozygote ; Humans ; Jews/genetics ; Mutation ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/prevention & control ; Patient Education as Topic/economics ; Patient Education as Topic/methods ; Precision Medicine/economics ; Precision Medicine/methods ; Prevalence ; Risk Assessment/economics ; Risk Assessment/methods
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-20-0002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic review of acceptability, cardiovascular, neurological, bone health and HRT outcomes following risk reducing surgery in BRCA carriers.

    Gaba, Faiza / Manchanda, Ranjit

    Best practice & research. Clinical obstetrics & gynaecology

    2020  Volume 65, Page(s) 46–65

    Abstract: Primary surgical prevention in the form of risk-reducing salpingo-oophorectomy (RRSO) is the most effective option and the gold standard for ovarian cancer (OC) risk-reduction, particularly given the absence of an effective national OC screening ... ...

    Abstract Primary surgical prevention in the form of risk-reducing salpingo-oophorectomy (RRSO) is the most effective option and the gold standard for ovarian cancer (OC) risk-reduction, particularly given the absence of an effective national OC screening programme. However, premenopausal RRSO leads to premature surgical menopause with detrimental long-term health sequelae particularly in women who do not/are unable to take hormone replacement therapy (HRT). HRT uptake in women undergoing pre-menopausal oophorectomy appears low and is dependent on informed counselling, the safety of HRT and efficacy in mitigating the health sequelae of premature menopause. Acceptance of a central role for the fallopian tube in OC etiopathogenesis, coupled with the detrimental consequences of premature menopause, has led to the attractive proposal of early-salpingectomy with delayed oophorectomy as an alternative OC surgical prevention strategy in premenopausal women who have completed childbearing but decline or wish to delay RRSO. The successful implementation of risk reducing surgery for OC prevention depends on the acceptability of surgery to both, recipients (e.g. BRCA1/BRCA2 carriers) and intervention deliverers (healthcare professionals/researchers). Acceptability is also informed by an understanding of health outcomes following risk reducing surgery and the safety of HRT. It is therefore vital to understand the effects of surgery on important health outcomes such as cardiovascular health, neurological function and bone health. We present a comprehensive review of acceptability, the selected health outcomes mentioned above and HRT safety following risk reducing surgery.
    MeSH term(s) BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; BRCA2 Protein/genetics ; BRCA2 Protein/metabolism ; Bone Density/physiology ; Female ; Genetic Predisposition to Disease ; Heterozygote ; Hormone Replacement Therapy ; Humans ; Mutation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Ovariectomy/adverse effects ; Ovariectomy/methods ; Salpingectomy/adverse effects ; Salpingectomy/methods ; Salpingo-oophorectomy/adverse effects ; Salpingo-oophorectomy/methods
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
    Language English
    Publishing date 2020-02-04
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2020.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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