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  1. Article ; Online: Reframing the Paradigm for Assessing Optimal Test Selection When Suspecting Chronic Coronary Disease.

    Mancini, G B John

    Journal of the American Heart Association

    2023  Volume 12, Issue 16, Page(s) e031027

    MeSH term(s) Humans ; Computed Tomography Angiography ; Syndrome ; Heart ; Tomography, X-Ray Computed/methods ; Coronary Disease
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of adaptive or fixed thresholds and different platforms on the assessment of plaque characteristics using coronary computed tomography angiography.

    Mancini, G B John / Kamimura, Craig / Yeoh, Eunice / Ryomoto, Arnold

    Journal of cardiovascular computed tomography

    2024  Volume 18, Issue 3, Page(s) 297–303

    Abstract: Background: Coronary computed tomography angiography (CCTA) is used to evaluate components of atherosclerosis. Either adaptive or diverse, fixed Hounsfield Units (HU) are used to define components such as low attenuation (LAP), mixed (MP) and calcified ... ...

    Abstract Background: Coronary computed tomography angiography (CCTA) is used to evaluate components of atherosclerosis. Either adaptive or diverse, fixed Hounsfield Units (HU) are used to define components such as low attenuation (LAP), mixed (MP) and calcified plaque (CP). Comparisons of different platforms and different thresholding approaches have not been extensively evaluated. We compare two fixed threshold options to an adaptive threshold option within a specific platform and to fixed threshold options measured with another platform.
    Methods: Coronary segments (n ​= ​24) of good image quality, with well-defined boundaries and representing a broad range of atheroma were analyzed for LAP, MP and CP. Thresholds for LAP vs MP and MP vs CP were either Fixed
    Results: Within a single platform, measures were highly correlated irrespective of use of Adaptive or Fixed
    Conclusion: Measures of plaque components are highly correlated irrespective of use of Adaptive or Fixed threshold approaches within a given platform. But measures are more affected by the specific proprietary algorithms employed than by specific thresholding options, especially for LAP.
    MeSH term(s) Humans ; Plaque, Atherosclerotic ; Coronary Angiography ; Computed Tomography Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/physiopathology ; Predictive Value of Tests ; Coronary Vessels/diagnostic imaging ; Vascular Calcification/diagnostic imaging ; Reproducibility of Results ; Radiographic Image Interpretation, Computer-Assisted ; Male ; Female ; Severity of Illness Index ; Middle Aged ; Aged ; Multidetector Computed Tomography
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article ; Comparative Study
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2024.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6761: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Thesis ; Online: Synthesis and Evaluation of Novel Inhibitors of the Non-Mevalonate Pathway (MEP)

    Mancini, Giulia

    2020  

    Abstract: The leading infectious disease threat in the world is tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis). Although TB is preventable and treatable, the emergence of multidrug-resistant (MDR) strains highlights the need ...

    Abstract The leading infectious disease threat in the world is tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis). Although TB is preventable and treatable, the emergence of multidrug-resistant (MDR) strains highlights the need for the development of new drugs with novel modes of action. A proposed target for fighting TB is the non-mevalonate pathway (MEP). MEP is absent in humans whereas, in M. tuberculosis and Escherichia coli (E. coli), it is responsible for the synthesis of isoprenoids, essential compounds for their life cycle. Fosmidomycin is a natural antibiotic that inhibits the MEP pathway through inhibition of the enzyme 1-deoxylulose-5-phosphate reductoisomerase (DXR). Even though fosmidomycin shows potent in vitro activity against DXR, its polar character renders it membrane impermeable. Nonetheless, in pathogens such as E. coli, the active uptake of fosmidomycin is mediated by the glycerol- 3-phosphate transporter (GlpT). Fosmidomycin effectively inhibits mycobacterial DXR, but it is not active against mycobacteria due to their highly hydrophobic cell wall and the absence of a corresponding GlpT transporter. The present work describes the development of fosmidomycin analogs to improve both passive membrane diffusion and dependency of fosmidomycin from GlpT. Through experimentation, the negatively charged phosphonate group in fosmidomycin was replaced with a fluorophosphonate moiety, a less polar chemically reactive isosteres. This modification leads to the development of covalent analogs of fosmidomycin introducing a novel strategy of inhibition for DXR. In addition, the current work describes the development of the γ-borono phosphonate compounds that are rationally designed analog of fosmidomycin. Despite their structural similarity, the γ- borono phosphonates exhibit an antimicrobial activity against E. coli with a unique mechanism of action, suggesting they may serve as lead compound to develop a novel antimicrobial class. Moreover, structure activity relationship studies indicate the importance of the boronic acid functionality, the phosphonate group, and the three-carbon backbone for antimicrobial activity. Cytotoxicity analysis also shows that the γ-borono phosphonates are not toxic to the mammalian cells. However, the mechanism of action is still unclear although we suggest that the γ-borono phosphonate class does not act as an anti-biofilm agent.
    Keywords Organic chemistry|Pharmacology
    Subject code 540
    Language ENG
    Publishing date 2020-01-01 00:00:01.0
    Publisher University of the Sciences in Philadelphia
    Publishing country us
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: The Canadian initiative - more emerging issues

    Mancini, G. B. John

    [fourth meeting in Charlevoix, Québec, in August 2000]

    (The Canadian journal of cardiology ; 17, Suppl. A)

    2001  

    Institution Vascular Biology Working Group
    Author's details Vascular Biology Working Group. Co-chairs GB John Mancini
    Series title The Canadian journal of cardiology ; 17, Suppl. A
    Collection
    Language English
    Size 40A S. : graph. Darst.
    Publisher Pulsus Group
    Publishing place Oakville, Ontario
    Publishing country Canada
    Document type Book
    HBZ-ID HT013073295
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2150 -17,Suppl.A- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Benchmark Structures and Conformational Landscapes of Amino Acids in the Gas Phase: A Joint Venture of Machine Learning, Quantum Chemistry, and Rotational Spectroscopy.

    Barone, Vincenzo / Fusè, Marco / Lazzari, Federico / Mancini, Giordano

    Journal of chemical theory and computation

    2023  Volume 19, Issue 4, Page(s) 1243–1260

    Abstract: The accurate characterization of prototypical bricks of life can strongly benefit from the integration of high resolution spectroscopy and quantum mechanical computations. We have selected a number of representative amino acids (glycine, alanine, serine, ...

    Abstract The accurate characterization of prototypical bricks of life can strongly benefit from the integration of high resolution spectroscopy and quantum mechanical computations. We have selected a number of representative amino acids (glycine, alanine, serine, cysteine, threonine, aspartic acid and asparagine) to validate a new computational setup rooted in quantum-chemical computations of increasing accuracy guided by machine learning tools. Together with low-lying energy minima, the barriers ruling their interconversion are evaluated in order to unravel possible fast relaxation paths. Vibrational and thermal effects are also included in order to estimate relative free energies at the temperature of interest in the experiment. The spectroscopic parameters of all the most stable conformers predicted by this computational strategy, which do not have low-energy relaxation paths available, closely match those of the species detected in microwave experiments. Together with their intrinsic interest, these accurate results represent ideal benchmarks for more approximate methods.
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.2c01143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: The Canadian initiative - issues of emerging interest

    Mancini, G. B. John

    [third meeting ... in Victoria, British Columbia, in August 1999]

    (The Canadian journal of cardiology ; 16, Suppl. E)

    2000  

    Institution Vascular Biology Working Group
    Author's details co-chairs GB John Mancini
    Series title The Canadian journal of cardiology ; 16, Suppl. E
    Collection
    Language English
    Size 48E S. : Ill., graph. Darst.
    Publisher Pulsus Group
    Publishing place Oakville, Ontario
    Publishing country Canada
    Document type Book
    HBZ-ID HT012826399
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2150 -16,Suppl.E- not available for loan Zeitschriften-Lesesaal

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  7. Book: Vascular Biology Working Group: the Canadian initiative - advances in risk intervention

    Mancini, G. B. John

    [second meeting ... in Banff, Alberta, in May 1998]

    (The Canadian journal of cardiology ; 15, Suppl. B)

    1999  

    Institution Vascular Biology Working Group
    Author's details co-chairs GB John Mancini
    Series title The Canadian journal of cardiology ; 15, Suppl. B
    Collection
    Language English
    Size 40B S. : Ill., graph. Darst.
    Publisher Pulsus Group
    Publishing place Oakville, Ontario
    Publishing country Canada
    Document type Book
    HBZ-ID HT010731617
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2150 -15,Suppl.B- not available for loan Zeitschriften-Lesesaal

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  8. Article: Transplantation on a Posidonia oceanica meadow to facilitate its recovery after the Concordia shipwrecking

    Mancini, G. / Ventura, D. / Casoli, E. / Belluscio, A. / Ardizzone, G.D.

    Marine pollution bulletin. 2022 June, v. 179

    2022  

    Abstract: Ecological restoration is an important tool to reverse habitat loss and recover ecosystem services. Here, for two years, we examine the dynamic of Posidonia oceanica following the restoration of a 1149 m² meadow damaged by the Concordia shipwreck. To ... ...

    Abstract Ecological restoration is an important tool to reverse habitat loss and recover ecosystem services. Here, for two years, we examine the dynamic of Posidonia oceanica following the restoration of a 1149 m² meadow damaged by the Concordia shipwreck. To evaluate the suitability of a recently employed seagrass restoration protocol, we assessed the patches' survival and development by high-spatial resolution photomosaics over the whole transplanted surface. To estimate recovery trajectories, we quantified the cuttings' survival, shoot density, and Daily Leaf Production within fixed monitoring squares. The outcomes confirmed that our protocol could be efficiently applied at larger scales, showing diminutions in cuttings' survival and shoot density over the first year (up to −20%), followed by stability in the number of living cuttings and increases of leaf bundles (up to +5%/year). Our insights demonstrate that the recovery of P. oceanica can be speeded up and underline the need for case-specific transplantation strategies.
    Keywords Posidonia oceanica ; ecological restoration ; ecosystems ; habitat conservation ; habitat destruction ; leaves ; marine pollution ; meadows
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2022.113683
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: FCC spent catalyst as an alternative reagent in Mo-contaminated hazardous waste enhanced stabilization

    Mancini, G. / Palmeri, F. / Benina, G. / Cacciola, S. / Luciano, A. / Fino, D.

    Sustainable chemistry and pharmacy. 2022 May 22,

    2022  

    Abstract: Hazardous waste containing heavy metals must be stabilized through the addition of appropriate and costly chemical reagents before they can be safely disposed in non-hazardous waste landfill. Although effective, this practice can also significantly ... ...

    Abstract Hazardous waste containing heavy metals must be stabilized through the addition of appropriate and costly chemical reagents before they can be safely disposed in non-hazardous waste landfill. Although effective, this practice can also significantly increase the waste final mass. This work focuses on the possibility of using another Mo contaminated waste, as an alternative reagent, to partially stabilise critical contaminant leaching trough chemical-physical interactions. Thanks to its unusual properties, spent fluid catalytic cracking (FCCSC) catalyst, classified as hazardous waste, was tested here as good candidate for Mo-contaminated waste partial stabilization. Results highlighted that FCCSC can be effective in drastically reducing the Molybdenum leaching below the legal limit for non-hazardous waste landfill disposal while significantly limiting the increase of the final mass of waste to be disposed with a substantial reduction of the industrial treatment cost, landfill volume requirement and overall environmental burden. By minimizing the waste to be landfilled, this research supports both the European directives and policies on sustainable waste management strategies and BAT (Best Available Techniques) for the treatment of industrial wastes within a circular economy framework.
    Keywords catalysts ; circular economy ; green chemistry ; hazardous waste ; landfills ; molybdenum ; waste management
    Language English
    Dates of publication 2022-0522
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 2352-5541
    DOI 10.1016/j.scp.2022.100733
    Database NAL-Catalogue (AGRICOLA)

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  10. Book ; Conference proceedings: Vascular Biology Working Group: the Canadian initiative - risk intervention

    Mancini, G. B. John

    [two-day symposium in August 1997]

    (The Canadian journal of cardiology ; 14, Suppl. D)

    1998  

    Institution Vascular Biology Working Group
    Author's details co-chairs GB John Mancini
    Series title The Canadian journal of cardiology ; 14, Suppl. D
    Collection
    Language English
    Size 36D S. : Ill., graph. Darst.
    Publisher Pulsus Group
    Publishing place Oakville, Ontario
    Publishing country Canada
    Document type Book ; Conference proceedings
    HBZ-ID HT009063076
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2150 -14,Suppl.D- not available for loan Zeitschriften-Lesesaal

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