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  1. Book ; Online: Cancer and Bone Metastasis

    Mandal, Chandi C. / Sterling, Julie A.

    2020  

    Keywords Medicine ; Endocrinology ; cancer ; microenvironment ; bone metastases ; osteolysis ; stromal
    Size 1 electronic resource (116 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230600
    ISBN 9782889634088 ; 2889634086
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Novel Use of Lipids as Diagnostic Tools and Therapeutics in Cancer: Recent Insights and Challenges.

    Mandal, Chandi C

    Current drug targets

    2022  Volume 23, Issue 6, Page(s) 542–543

    MeSH term(s) Humans ; Lipids ; Neoplasms/diagnosis ; Neoplasms/drug therapy
    Chemical Substances Lipids
    Language English
    Publishing date 2022-05-15
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/138945012306220425130109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A Perspective on Bone Morphogenetic Proteins: Dilemma behind Cancer- related Responses.

    Kapoor, Anmol / Mandal, Chandi C

    Current drug targets

    2023  Volume 24, Issue 5, Page(s) 382–387

    Abstract: Bone morphogenetic proteins are a center of serious concern and are known to execute various cancer-related issues. The BMP signaling cascades have become more unpredictable as a result of their pleiotropic and risky characteristics, particularly when it ...

    Abstract Bone morphogenetic proteins are a center of serious concern and are known to execute various cancer-related issues. The BMP signaling cascades have become more unpredictable as a result of their pleiotropic and risky characteristics, particularly when it comes to cancer responses. This perspective discusses the current therapeutic implications, emphasizes different cellular aspects that impact the failures of the current drug treatments, and speculates on future research avenues that include novel strategies like metabolomic studies and bio-mimetic peptide therapeutics to mitigate cancerous outcomes.
    MeSH term(s) Humans ; Transforming Growth Factor beta/metabolism ; Bone Morphogenetic Proteins/metabolism ; Signal Transduction/physiology ; Neoplasms/drug therapy
    Chemical Substances Transforming Growth Factor beta ; Bone Morphogenetic Proteins
    Language English
    Publishing date 2023-01-29
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450124666230201144605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Osteolytic metastasis in breast cancer: effective prevention strategies.

    Mandal, Chandi C

    Expert review of anticancer therapy

    2020  Volume 20, Issue 9, Page(s) 797–811

    Abstract: Introduction: Breast cancer is the most common cancer in women throughout the world. Patients who are diagnosed early generally have better prognosis and survivability. Indeed, advanced stage breast cancer often develops osteolytic metastases, leading ... ...

    Abstract Introduction: Breast cancer is the most common cancer in women throughout the world. Patients who are diagnosed early generally have better prognosis and survivability. Indeed, advanced stage breast cancer often develops osteolytic metastases, leading to bone destruction. Although there are select drugs available to treat bone metastatic disease, these drugs have shown limited success.
    Area covered: This paper emphasizes updated mechanisms of bone remodeling and osteolytic bone metastases of breast cancer. This article also aims to explore the potential of novel natural and synthetic therapeutics in the effective prevention of breast cancer-induced osteolysis and osteolytic metastases of breast cancer.
    Expert opinion: Targeting TGFβ and BMP signaling pathways, along with osteoclast activity, appears to be a promising therapeutic strategy in the prevention of breast cancer-induced osteolytic bone destruction and metastatic growth at bone metastatic niches. Pilot studies in animal models suggest various natural and synthetic compounds and monoclonal antibodies as putative therapeutics in the prevention of breast cancer stimulated osteolytic activity. However, comprehensive pre-clinical studies demonstrating the PK/PD and in-depth understanding of molecular mechanism(s) by which these potential molecules exhibit anti-tumor growth and anti-osteolytic activity are still required to develop effective therapies against breast cancer-induced osteolytic bone disease.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Bone Neoplasms/prevention & control ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Humans ; Molecular Targeted Therapy ; Neoplasm Staging ; Osteoclasts/metabolism ; Osteolysis/etiology ; Osteolysis/prevention & control ; Prognosis ; Signal Transduction
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-08-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1807950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Editorial: Bone cell differentiation in health and disease.

    Tencerova, Michaela / Mandal, Chandi C

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 1115444

    MeSH term(s) Bone and Bones ; Osteoclasts ; Cell Differentiation
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1115444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Cancer and Bone Metastasis.

    Mandal, Chandi C

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 852

    Language English
    Publishing date 2019-12-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Metformin ameliorates BMP2 induced adipocyte-like property in breast cancer cells.

    Soni, Sneha / Yadav, Pooja / Mandal, Chandi C

    Biochemical and biophysical research communications

    2023  Volume 672, Page(s) 201–208

    Abstract: Neighboring adipocytes of tumor cells/cancer associated adipocytes supply many factors and fatty acids as fuel to cancer cells for inducing cancer progression and development. Epithelial breast cancer cells also differentiate into several cell types to ... ...

    Abstract Neighboring adipocytes of tumor cells/cancer associated adipocytes supply many factors and fatty acids as fuel to cancer cells for inducing cancer progression and development. Epithelial breast cancer cells also differentiate into several cell types to meet various demands. This study reports that breast cancer cells exhibit inherent adipocyte-like property which is further enhanced in presence of BMP2. Antidiabetic metformin inhibits BMP2 induced adipocyte-like potential in breast cancer cells. Interestingly, breast cancer cells not only show lipid accumulation but also have ability to release lipid content. Thus, this study centers around the presence of the adipocyte cell-like property in breast cancer cells, the significance of BMP2 and metformin that may be explored in designing therapeutics against breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Metformin/pharmacology ; Fatty Acids/metabolism ; Adipocytes/metabolism ; Bone Morphogenetic Protein 2/metabolism
    Chemical Substances Metformin (9100L32L2N) ; Fatty Acids ; BMP2 protein, human ; Bone Morphogenetic Protein 2
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  8. Article: Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis.

    Kumar, Navneet / Mandal, Chandi C

    Frontiers in genetics

    2021  Volume 12, Page(s) 724149

    Abstract: Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and ... ...

    Abstract Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. Since its involvement in several signaling pathways, its dysregulation is commonly reported in several cancers. Thus, targeting Akt could be an effective approach for cancer prevention and therapy. Cholesterol-lowering drugs have been found to affect the expression of Akt, and its activation in the cancer cells and thus have shown anticancer activity in different type of cancers. These drugs act on various signaling pathways such as PTEN/Akt, PI3k/Akt, Akt/NF-κB, Akt/FOXO1, Akt/mTOR, etc., which will be discussed in this article. This review article will discuss the significance of cholesterol in cancer cells, cholesterol-lowering drugs, the role of Akt in cancer cells, and the effects of cholesterol-lowering drugs on Akt in the prevention of therapy resistance and metastasis.
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.724149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Anti-Obesity Medications in Cancer Therapy: A Comprehensive Insight.

    Shekhawat, Rajveer / Mandal, Chandi C

    Current cancer drug targets

    2021  Volume 21, Issue 6, Page(s) 476–494

    Abstract: The interplay between cancer and obesity is multifactorial and complex with the increased risk of cancer development in obese individuals posing a significant threat. Obesity leads to the upregulation or hyperactivation of several oncogenic pathways in ... ...

    Abstract The interplay between cancer and obesity is multifactorial and complex with the increased risk of cancer development in obese individuals posing a significant threat. Obesity leads to the upregulation or hyperactivation of several oncogenic pathways in cancer cells, which drives them towards a deleterious phenotype. The cross-talk between cancer and obesity is considered a large contributing factor in the development of chemotherapeutic drug resistance and the resistance to radiotherapy. The link between obesity and the development of cancer is so strong that a medication that demonstrates effectiveness against both conditions would serve as an essential step. In this context, anti-obesity medications provide a worthy list of candidates based on their chemo-preventive potential and chemotherapeutic properties. The current study focuses on exploring the potential of anti-obesity medicines as dual anticancer drugs. These medications target several key signaling pathways (e.g., AMPK, PI3K/Akt/mTOR, MAPK, NF-κB, JNK/ERK), which prove to be crucial for both cancer growth and metastases. Some of these drugs also play an important role in attenuating the signaling and cellular events which incite cancer-obesity cross-talk and demonstrate efficient counteraction of neoplastic transformation. Thus, this review highlights a comprehensive view of the potential use of anti-obesity medicines to treat both cancer and obesity for patients exhibiting both comorbities.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Neoplasms/drug therapy ; Oncogenes ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
    Chemical Substances NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-07-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/1568009621666210322122829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5589: Show issues Location:
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  10. Article: Editorial: Cancer and bone metastasis, volume II.

    Mandal, Chandi C / Rhoades Sterling, Julie A

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 971240

    MeSH term(s) Bone Neoplasms/secondary ; Humans
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.971240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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