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  1. Article ; Online: Rational design, molecular docking and synthesis of novel homopiperazine linked imidazo[1,2-a]pyrimidine derivatives as potent cytotoxic and antimicrobial agents.

    Mantipally, Manohar / Gangireddy, Madhusudhana Reddy / Gundla, Rambabu / Badavath, Vishnu Nayak / Mandha, Santhosh Reddy / Maddipati, Venkatanarayana Chowdary

    Bioorganic & medicinal chemistry letters

    2019  Volume 29, Issue 16, Page(s) 2248–2253

    Abstract: Designed and synthesized novel homopiperazine linked imidazo[1,2-a]pyrimidine derivatives (10a-i, 11a-g, 12), and evaluated them for their in vitro cytotoxicity against HeLa cells (cervical cancer), A549 cells (lung cancer) cells, by MTT assay. Compound ... ...

    Abstract Designed and synthesized novel homopiperazine linked imidazo[1,2-a]pyrimidine derivatives (10a-i, 11a-g, 12), and evaluated them for their in vitro cytotoxicity against HeLa cells (cervical cancer), A549 cells (lung cancer) cells, by MTT assay. Compound 12 (IC
    MeSH term(s) A549 Cells ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Fungi/drug effects ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; HeLa Cells ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Piperazine/chemical synthesis ; Piperazine/chemistry ; Piperazine/pharmacology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Antineoplastic Agents ; Pyrimidines ; imidazo(1,2-a)pyrimidine ; Piperazine (1RTM4PAL0V)
    Language English
    Publishing date 2019-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2019.06.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: "One-pot" access to dihydrofurans via tandem oxidative difunctionalization and ring contraction of aminopyrans.

    Mandha, Santhosh Reddy / Alla, Manjula / Nanubolu, Jagadeesh Babu

    Organic & biomolecular chemistry

    2014  Volume 12, Issue 25, Page(s) 4412–4420

    Abstract: An operationally simple and efficient protocol for the construction of dihydrofuran derivatives has been accomplished via a sequential addition of N-chlorosuccinimide and a base to 2-amino-4H-pyran derivatives in alcohol medium. The one-pot protocol ... ...

    Abstract An operationally simple and efficient protocol for the construction of dihydrofuran derivatives has been accomplished via a sequential addition of N-chlorosuccinimide and a base to 2-amino-4H-pyran derivatives in alcohol medium. The one-pot protocol proceeding via tandem oxidative difunctionalization and ring contraction provides an entirely new strategy for the construction of the dihydrofuran skeleton.
    MeSH term(s) Chemistry, Organic/methods ; Esterification ; Esters/chemistry ; Furans/chemical synthesis ; Furans/chemistry ; Hydrolysis ; Hydroxides/chemistry ; Methanol/chemistry ; Molecular Conformation ; Oxidation-Reduction ; Potassium Compounds/chemistry ; Proton Magnetic Resonance Spectroscopy ; Pyrans/chemistry
    Chemical Substances Esters ; Furans ; Hydroxides ; Potassium Compounds ; Pyrans ; potassium hydroxide (WZH3C48M4T) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2014-07-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c4ob00324a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles.

    Mandha, Santhosh Reddy / Siliveri, Sravanthi / Alla, Manjula / Bommena, Vittal Rao / Bommineni, Madhava Reddy / Balasubramanian, Sridhar

    Bioorganic & medicinal chemistry letters

    2012  Volume 22, Issue 16, Page(s) 5272–5278

    Abstract: An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for ... ...

    Abstract An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/toxicity ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Edema/chemically induced ; Edema/drug therapy ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; MCF-7 Cells ; Microbial Sensitivity Tests ; Molecular Conformation ; Pyrazoles/chemistry ; Pyrazoles/therapeutic use ; Pyrazoles/toxicity ; Rats
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Pyrazoles
    Language English
    Publishing date 2012-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2012.06.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Oxidative difunctionalization of 2-amino-4H-pyrans in iodobenzene diacetate and N-chlorosuccinimide: reactivity, mechanistic insights, and DFT calculations.

    Mandha, Santhosh Reddy / Alla, Manjula / Bommena, Vittal Rao / Nanubolu, Jagadeesh Babu / Lingala, Santosh Kumar / Yarasi, Soujanya

    The Journal of organic chemistry

    2012  Volume 77, Issue 23, Page(s) 10648–10654

    Abstract: Oxidative difunctionalization of 2-amino-4H-pyrans was accomplished with iodobenzene diacetate (IBD) and N-chlorosuccinimide (NCS) reagents in alcoholic medium. 2-Amino-4H-pyrans undergo geminal dialkoxylation with the migration of an amino group (1a,b, ... ...

    Abstract Oxidative difunctionalization of 2-amino-4H-pyrans was accomplished with iodobenzene diacetate (IBD) and N-chlorosuccinimide (NCS) reagents in alcoholic medium. 2-Amino-4H-pyrans undergo geminal dialkoxylation with the migration of an amino group (1a,b, 2a-i, 3a,b, and 4) in IBD, whereas with NCS addition of both chlorine and alkoxy groups takes place across the chromene double bond (6a-i).
    MeSH term(s) Iodobenzenes/chemistry ; Molecular Structure ; Oxidation-Reduction ; Pyrans/chemistry ; Quantum Theory ; Succinimides/chemistry
    Chemical Substances Iodobenzenes ; Pyrans ; Succinimides ; N-chlorosuccinimide (0FWP306H7X) ; iodobenzene (9HK5L7YBBR)
    Language English
    Publishing date 2012-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo301801b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Oxidative Difunctionalization of 2-Amino-4H-pyrans in Iodobenzene Diacetate and N-Chlorosuccinimide: Reactivity, Mechanistic Insights, and DFT Calculations

    Mandha, Santhosh Reddy / Alla Manjula / Bommena Vittal Rao / Lingala Santosh Kumar / Nanubolu Jagadeesh Babu / Yarasi Soujanya

    Journal of organic chemistry. 2012 Dec. 07, v. 77, no. 23

    2012  

    Abstract: Oxidative difunctionalization of 2-amino-4H-pyrans was accomplished with iodobenzene diacetate (IBD) and N-chlorosuccinimide (NCS) reagents in alcoholic medium. 2-Amino-4H-pyrans undergo geminal dialkoxylation with the migration of an amino group (1a,b, ... ...

    Abstract Oxidative difunctionalization of 2-amino-4H-pyrans was accomplished with iodobenzene diacetate (IBD) and N-chlorosuccinimide (NCS) reagents in alcoholic medium. 2-Amino-4H-pyrans undergo geminal dialkoxylation with the migration of an amino group (1a,b, 2a–i, 3a,b, and 4) in IBD, whereas with NCS addition of both chlorine and alkoxy groups takes place across the chromene double bond (6a–i).
    Keywords chemical reactions ; chemical structure ; chlorine ; organic chemistry ; organic compounds
    Language English
    Dates of publication 2012-1207
    Size p. 10648-10654.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Fjo301801b
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/42: Show issues
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  6. Article: Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

    Mandha, Santhosh Reddy / Siliveri, Sravanthi / Alla, Manjula / Bommena, Vittal Rao / Bommineni, Madhava Reddy / Balasubramanian, Sridhar

    Bioorganic & medicinal chemistry letters. 2012 Aug. 15, v. 22, no. 16

    2012  

    Abstract: An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for ... ...

    Abstract An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.
    Keywords chemistry ; cytotoxicity ; ethanol ; pyrazoles
    Language English
    Dates of publication 2012-0815
    Size p. 5272-5278.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2012.06.055
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
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  7. Article: Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

    Mandha, Santhosh Reddy / Siliveri, Sravanthi / Alla, Manjula / Bommena, Vittal Rao / Bommineni, Madhava Reddy / Balasubramanian, Sridhar

    Bioorganic & medicinal chemistry letters

    Volume v. 22,, Issue no. 1

    Abstract: An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for ... ...

    Abstract An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.
    Keywords ethanol ; chemistry ; cytotoxicity ; pyrazoles
    Language English
    Document type Article
    ISSN 0960-894X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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