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  1. Article ; Online: Through-The-Needle Biopsy: Shifting From Cytology to Histology for Preoperative Assessment of Pancreatic Cystic Lesions.

    Crinò, Stefano Francesco / Manfrin, Erminia

    Archives of pathology & laboratory medicine

    2021  Volume 145, Issue 10, Page(s) 1193b–1193

    MeSH term(s) Biopsy, Needle ; Cytodiagnosis ; Humans ; Pancreas/pathology ; Pancreatic Cyst/diagnosis ; Pancreatic Cyst/pathology
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2021-0207-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Secretory carcinoma of salivary glands with NTRK3 break-apart molecular rearrangement: Potential misdiagnosis with mucoepidermoid carcinoma.

    Nocini, Riccardo / Sanna, Giangiacomo / Trotolo, Alessandro / Fior, Andrea / Brunelli, Matteo / Manfrin, Erminia / Favero, Vittorio

    Journal of stomatology, oral and maxillofacial surgery

    2023  Volume 124, Issue 6S, Page(s) 101635

    Abstract: A woman presented a right submandibular gland lesion with cytologic diagnosis of mucoepidermoid carcinoma. Patient underwent sialoadenectomy en bloc with supraomohyoid neck dissection. Positivity for ETV6-NTRK3 genes fusion on surgical sample led to ... ...

    Abstract A woman presented a right submandibular gland lesion with cytologic diagnosis of mucoepidermoid carcinoma. Patient underwent sialoadenectomy en bloc with supraomohyoid neck dissection. Positivity for ETV6-NTRK3 genes fusion on surgical sample led to final diagnosis of secretory carcinoma (SC). Secretory carcinoma has been renamed by WHO in 2017 from mammary-analogue-secretory carcinoma (MASC). Only 649 have been reported until 2019. While cytologic alteration are shared with other neoplasms as the acinic cell and mucoepidermoid carcinomas, ETV6-NTRK3 rearrangement is pathognomonic of SC. Although usually indolent and with low-stage presentation, SC has higher rate of local recurrences and nodal involvement than ACC. Surgical treatment represent the gold standard. Real prevalence of SC is probably underestimated due to the recent WHO 2017 reclassification. While cytologic analysis does not allow to discriminate SC from other malignancies, chromosomal examination is recommended. When low-grade SC is diagnosed, complete surgical resection assures good prognosis.
    MeSH term(s) Female ; Humans ; Carcinoma, Mucoepidermoid/diagnosis ; Carcinoma, Mucoepidermoid/genetics ; Carcinoma, Mucoepidermoid/surgery ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/surgery ; Oncogene Proteins, Fusion/genetics ; Immunohistochemistry ; Salivary Glands/pathology ; Carcinoma ; Diagnostic Errors
    Chemical Substances Oncogene Proteins, Fusion
    Language English
    Publishing date 2023-09-12
    Publishing country France
    Document type Case Reports
    ZDB-ID 2916276-2
    ISSN 2468-7855 ; 2468-8509
    ISSN (online) 2468-7855
    ISSN 2468-8509
    DOI 10.1016/j.jormas.2023.101635
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  3. Article ; Online: Response.

    Crinò, Stefano Francesco / Gabbrielli, Armando / Manfrin, Erminia

    Gastrointestinal endoscopy

    2020  Volume 92, Issue 1, Page(s) 236–237

    MeSH term(s) Biopsy ; Humans ; Pancreatic Cyst/diagnosis
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.03.010
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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 519: Show issues

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  4. Article ; Online: EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases.

    Pop, Ruxandra Mihaela / Diaconu, Claudia Irina / Rimbaş, Mihai / Mateescu, Radu Bogdan / Rouhani, Farid / Popp, Cristiana / Manfrin, Erminia / Crinò, Stefano Francesco / Cauni, Victor

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2023  Volume 61, Issue 2, Page(s) 116–124

    Abstract: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often ... ...

    Abstract Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.
    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnostic imaging ; Adenocarcinoma ; Osteoclasts/pathology ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Carcinoma/pathology ; Giant Cells/pathology ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-05-08
    Publishing country Germany
    Document type Review ; Case Reports
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2023-0008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 738: Show issues Location:
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  5. Article ; Online: A Pancreatic Lymphoepithelial Cyst With Floating Balls.

    Crinò, Stefano Francesco / Gabbrielli, Armando / Manfrin, Erminia

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2019  Volume 18, Issue 4, Page(s) A32

    MeSH term(s) Diagnosis, Differential ; Humans ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2019.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Time to standardize through-the-needle biopsy specimen handling.

    Crinò, Stefano Francesco / Ammendola, Serena / Gabbrielli, Armando / Manfrin, Erminia

    Gastrointestinal endoscopy

    2020  Volume 92, Issue 4, Page(s) 981–983

    MeSH term(s) Biopsy, Needle ; Humans ; Pancreas ; Pancreatic Cyst ; Pathologists ; Specimen Handling
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
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  7. Article ; Online: EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas

    Pop Ruxandra Mihaela / Diaconu Claudia Irina / Rimbaş Mihai / Mateescu Radu Bogdan / Rouhani Farid / Popp Cristiana / Manfrin Erminia / Crinò Stefano Francesco / Cauni Victor

    Romanian Journal of Internal Medicine, Vol 61, Iss 2, Pp 116-

    report of two cases

    2023  Volume 124

    Abstract: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often ... ...

    Abstract Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.
    Keywords endoscopic ultrasound-guided fine needle aspiration ; endoscopic ultrasound-guided fine needle biopsy ; immunohistochemistry ; osteoclast-like giant cell ; pancreatic cancer ; tumor markers ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Rare Pancreatic/Peripancreatic Cystic Lesions Can Be Accurately Characterized by EUS with Through-the-Needle Biopsy-A Unique Pictorial Essay with Clinical and Histopathological Correlations.

    Conti Bellocchi, Maria Cristina / Manfrin, Erminia / Brillo, Alessandro / Bernardoni, Laura / Lisotti, Andrea / Fusaroli, Pietro / Parisi, Alice / Sina, Sokol / Facciorusso, Antonio / Gabbrielli, Armando / Crinò, Stefano Francesco

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 24

    Abstract: Due to their aspecific macroscopic appearance, uncommon pancreatic cystic lesions (PCLs) are often misdiagnosed as mucinous lesions and improperly resected. We aimed to evaluate the endoscopic ultrasound (EUS)-guided through-the-needle biopsy (TTNB) ... ...

    Abstract Due to their aspecific macroscopic appearance, uncommon pancreatic cystic lesions (PCLs) are often misdiagnosed as mucinous lesions and improperly resected. We aimed to evaluate the endoscopic ultrasound (EUS)-guided through-the-needle biopsy (TTNB) capacity of the preoperative diagnosis of uncommon PCLs. Overall, 136 patients with PCLs who underwent EUS-TTNB between 2016 and 2022 were retrospectively identified. Common histotypes (e.g., IPMN, serous cystadenoma, and mucinous cystadenoma) were excluded and 26 (19.1%) patients (15 female, mean age 52.9 ± 10.4) were analyzed. The EUS findings, adverse events (AEs), and TTNB outcomes in uncommon PCLs were evaluated. The cysts histotype was accurately diagnosed by TTNB in 24/26 (92.3%) cases (seven cystic neuroendocrine tumors, four squamoid cysts, three acinar cells cystadenomas, two lymphoepithelial cysts, two mucinous non-neoplastic cysts, two bronchogenic cysts, two cystic lymphangiomas, one solid-pseudopapillary neoplasm, and one schwannoma). In the remaining two cases, lymphangioma was eventually diagnosed after resection. Surgery was performed in 15/26 (57.7%) patients. The mean follow-up of non-surgical patients was 32.5 months. One severe acute case of pancreatitis (3.8%) that required surgery occurred after EUS-TTNB. Uncommon pancreatic/peripancreatic lesions represent the 19.1% of PCLs in our series, with mainly benign histotypes. TTNB demonstrated a high diagnostic performance with a low rate of AEs in this setting, representing a reliable tool with which to avoid useless surgery.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13243663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Two-Center Experience.

    Facciorusso, Antonio / Ramai, Daryl / Conti Bellocchi, Maria Cristina / Bernardoni, Laura / Manfrin, Erminia / Muscatiello, Nicola / Crinò, Stefano Francesco

    Cancers

    2021  Volume 13, Issue 12

    Abstract: There is scarce and conflicting evidence on the comparison between endoscopic ultrasound (EUS) and percutaneous (PC)-guided liver biopsy (LB). The aim of this study was to compare the two approaches in a series of patients with parenchymal and focal ... ...

    Abstract There is scarce and conflicting evidence on the comparison between endoscopic ultrasound (EUS) and percutaneous (PC)-guided liver biopsy (LB). The aim of this study was to compare the two approaches in a series of patients with parenchymal and focal liver lesions. Fifty-four patients undergoing EUS-LB in two high-volume centers between 2017 and 2021 were compared to 62 patients who underwent PC-LB. The primary outcome was diagnostic adequacy rate. The secondary outcomes were diagnostic accuracy, total sample length (TSL), number of complete portal tracts (CPTs), procedural duration, and adverse events. Variables were compared using the Chi-square and Mann-Whitney test. Median age was 56 years (interquartile range 48-69) in the EUS-LB group and 54 years (45-67) in the PC-LB group with most patients being male. Indication for LB was due to parenchymal disease in 50% of patients, whereas the other patients underwent LB due to focal liver lesions. Diagnostic adequacy was 100% in PC-LB and 94.4% in the EUS-LB group (
    Language English
    Publishing date 2021-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13123062
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  10. Article: Endoscopic Ultrasound Through-the-Needle Biopsy for the Diagnosis of an Abdominal Bronchogenic Cyst.

    Cassiani, Jessica / Crinò, Stefano Francesco / Manfrin, Erminia / Rivelli, Matteo / Gabbrielli, Armando / Guglielmi, Alfredo / Pedrazzani, Corrado

    Clinical endoscopy

    2021  Volume 54, Issue 5, Page(s) 767–770

    Abstract: A 57-year-old woman with epigastric pain was diagnosed with a 6-cm abdominal cystic lesion of unclear origin on cross-sectional imaging. Endoscopic ultrasound (EUS) demonstrated a unilocular cyst located between the pancreas, gastric wall, and left ... ...

    Abstract A 57-year-old woman with epigastric pain was diagnosed with a 6-cm abdominal cystic lesion of unclear origin on cross-sectional imaging. Endoscopic ultrasound (EUS) demonstrated a unilocular cyst located between the pancreas, gastric wall, and left adrenal gland, with a regular wall filled with dense fluid with multiple hyperechoic floating spots. A 19-G needle was used to puncture the cyst, but no fluid could be aspirated. Therefore, EUS-guided through-the-needle biopsy (EUS-TTNB) was performed. Histological analysis of the retrieved fragments revealed a fibrous wall lined by "respiratory-type" epithelium with ciliated columnar cells, consistent with the diagnosis of a bronchogenic cyst. Laparoscopic excision was performed, and the diagnosis was confirmed based on the findings of the surgical specimen. Abdominal bronchogenic cysts are extremely uncommon, and a definitive diagnosis is commonly obtained after the examination of surgical specimens due to the lack of pathognomonic findings on cross-sectional imaging and poor cellularity on EUS-guided fine-needle aspiration cytology. EUS-TTNB is useful for establishing a preoperative histological diagnosis, thus supporting the decision-making process.
    Language English
    Publishing date 2021-02-17
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2643507-X
    ISSN 2234-2443 ; 2234-2400
    ISSN (online) 2234-2443
    ISSN 2234-2400
    DOI 10.5946/ce.2020.195
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